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가토 퇴행성 관절염에서 성장호르몬과 히알루론산의 효과 비교
김상범,이경우,하남진,이종화,김영동,조양래,김대철 대한재활의학회 2008 Annals of Rehabilitation Medicine Vol.32 No.3
Objective: To explore whether the growth hormone is effective in the treatment of degenerative cartilage of knee in rabbits. Method: Thirty New Zealand white rabbits were administered intra-articular injection with monosodium iodoacetate (Sigma, St. Louis, USA) 2.5 mg and divided into 3 groups. Each group was administered with hyaluronic acid (Hyruan plusⓇ, LG life science, Seoul, Korea)(group A) 0.6 ml, growth hormone (DeclageⓇ, LG life science, Seoul, Korea) (group B) or saline (group C) 0.6 ml intra-articulary once a week for 4 weeks, beginning 4 weeks after the degeneration induction. All rabbits were killed 9 weeks after degeneration induction. The histologic morphology was observed by optical microscope with knee cartilage. Results: Mankin score was 2.4±1.3 in group A, 3.9±1.7 in group B, 7.4±0.8 in group C. Yoshimi score was 1.5±0.7 in group A, 2.2±0.9 in group B, 4.4±0.6 in group C. Gross and microscopic morphologic findings showed that group C represented the more severe than group A & B (p<0.01), also group A was better than group B (p<0.05). Conclusion: Growth hormone is effective on degenerative knee cartilage in rabbit model, but less than the hyaluronic acid. Objective: To explore whether the growth hormone is effective in the treatment of degenerative cartilage of knee in rabbits. Method: Thirty New Zealand white rabbits were administered intra-articular injection with monosodium iodoacetate (Sigma, St. Louis, USA) 2.5 mg and divided into 3 groups. Each group was administered with hyaluronic acid (Hyruan plusⓇ, LG life science, Seoul, Korea)(group A) 0.6 ml, growth hormone (DeclageⓇ, LG life science, Seoul, Korea) (group B) or saline (group C) 0.6 ml intra-articulary once a week for 4 weeks, beginning 4 weeks after the degeneration induction. All rabbits were killed 9 weeks after degeneration induction. The histologic morphology was observed by optical microscope with knee cartilage. Results: Mankin score was 2.4±1.3 in group A, 3.9±1.7 in group B, 7.4±0.8 in group C. Yoshimi score was 1.5±0.7 in group A, 2.2±0.9 in group B, 4.4±0.6 in group C. Gross and microscopic morphologic findings showed that group C represented the more severe than group A & B (p<0.01), also group A was better than group B (p<0.05). Conclusion: Growth hormone is effective on degenerative knee cartilage in rabbit model, but less than the hyaluronic acid.
상지 단순반복작업 근로자의 수근관 증후군 유병률에 관한 조사
손지언,장태원,김윤규,홍영습,정갑열,김동일,이강진,하남진,김상범,김준연 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3
목적 : 본 연구는 수근관 증후군의 발생위험이 높은 작업형태에 종사하는 상지 단순반복작업근로자로서 육류 및 어류 가공 사업장과 목재소 근로자에서 근전도검사를 이용하여 수근관 증후군의 유병률을 조사하고자 하였다. 방법 : 상지 단순반복작업근로자로서 육류 및 어류 가공 사업장 근로자 69명과 목재소 근로자 17명을 실험군으로, 관리직, 경리, 경비등 상지의 단순반복작업이 없는 근로자 28명을 대조군으로 선정하여, 작업적 및 병력조사, 이학적 검사와 근전도검사를 통해 수근관 증후군의 유병률을 조사하였다. 결과 : 수근관 증후군의 유병률은 육류 및 어류 가공 사업장과 목재소에서 각각 26.09 % (18명)와 29.41 %(5명)로 조사되었으며, 육류 및 어류가공사업장과 목재소 근로자를 '7년 이상과 미만의 작업기간'으로 층화하여 비교한 결과 '상지부위의 통증 호소 유무', 'Visual Analogue Scale(VAS: 총 10점) 4점 이상 여부', 'Tinel teat 양성 유무', 'Phalen test 양성 유무'는 모두 단기 작업근로자군에서 양성의 빈도가 증가되었고 '수근관 증후군 유무'는 장기작업근로자군에서 양성의 빈도가 증가되었다. 결론 : 육류 및 어류 가공 사업장과 목재소의 수근관 증후군 유병률은 각각 26.09 %와 29.41 %로 육류 및 어류 가공 사업장과 목재소는 1996년 OSHA가 지정한 바와 같이 위험한 작업요인이 있는 작업장으로 분류하여 관리되어야 할 것으로 생각된다. Objectives : This study was carried out to survey on the prevalence of Carpal Tunnel Syndrome(CTS) in high risk jobs(meat and fish processing plant and wood plant), by application of Nerve Conduction Study(NCS), a confirmatory diagnostic method. Methods : Experimental group was 69 workers sampled from meat and fish processing plants and 17 workers sampled from wood plants, who were simple, repetitive workers using upper extremities and control group was 28 workers sampled from managers, secretaries and keepers. All employees were examined through work history, physical examination and NCS. Results : 18 workers(26.09%) in meat and fish processing plants, and 5 workers(29.41%) in wood plants had compatible findings to NIOSH diagnostic criteria for CTS. The experimental group had more symptoms (complaint of upper extremities, Visual Analogue Scale ≥4(VAS: total 10 point)), signs(Tinel and Phalen test) and prevalence of CTS than control group(p<0.05). The prevalence of symptoms and signs were higher in short term workers(<7 years), but the prevalence of CTS was higher in long term workers(≥7 years). Conclusions : The prevalence of CTS in meat and fish processing plant and wood plant were 26.09% and 29.41% respectively. Authors propose that meat and fish processing and wood plants should be managed as a risk job category which were designated by OSHA in 1996
만성 무릎 퇴행성관절염 환자의 Q각 변화에 따른 보행의 변화
채정병 ( Jung Byung Chae ),조현래 ( Hyun Rae Cho ),하남진 ( Nam Jin Hwa ),김용훈 ( Yong Hun Kim ) 대한물리의학회 2010 대한물리의학회지 Vol.5 No.1
Purpose:To investigate of gait change as Q-angle in chronic knee osteoarthritis patients. Methods:Participated osteoarthritis disease patients(n=16) and normal adults(n=16). gait measure was used by GaitRite and Q-angle measure was used by tape measurement Results:SPSS for win version 12 was used for statistic analysis and independent t-test used to find between the two groups. In the comparison of Q-angle between groups were not significant(p>.05). In the comparison of temporal parameter of gait between groups, the swing phase, stance phase, single support, double support was significant decreased in arthritis groups(p<.05). In the comparison of spatial parameter of gaits between groups, BOS and step angles were significant increased in arthritis groups(p<.05), in the velocity, stride length and FAP(functional ambulation profile) were significant decreased in arthritis groups (p<.05) Conclusion:In the osteoarthritis disease patients gait showed temporal, spatial, general gait component variable changes comparison normal adults. therefore, it was seems to very important considerable function at gait training in clinical intervention.