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최홍석,최낙봉,송대현,김애정,조경목 대한금속재료학회 1999 대한금속재료학회 학술대회 개요집 Vol.1999 No.1
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Medullary Thyroid Carcinoma with Ectopic Adrenocorticotropic Hormone Syndrome
최홍석,김민주,문채호,윤종호,구하라,강건욱,나임일,이승숙,이병철,박영주,김홍일,구윤휘 대한내분비학회 2014 Endocrinology and metabolism Vol.29 No.1
Ectopic adrenocorticotropic hormone (ACTH) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare etiology of ectopic ACTH syndrome. We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48-year-old male. He was diagnosed with MTC 14 years ago and underwent total thyroidectomy, cervical lymph node dissection and a series of metastasectomies. MTC was confirmed by the pathological examination of the thyroid and metastatic mediastinal lymph node tissues. Two years after his last surgery, he developed Cushingoid features, such as moon face and central obesity, accompanied by uncontrolled hypertension and new-onset diabetes. The laboratory results were compatible with ectopic ACTH syndrome. A bilateral adrenalectomy improved the clinical and laboratory findings that were associated with Cushing syndrome. This is the first confirmed case of ectopic ACTH syndrome caused by MTC in Korea.