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인지 장애 진단ㆍ평가ㆍ분석을 위한 생체신호 장비 개발에 대한 수요조사: 한방신경정신과학회 회원들을 대상으로
최유진,김지혜,김가혜,김재욱 대한한방신경정신과학회 2020 동의신경정신과학회지 Vol.31 No.2
Objectives: The purpose of this study was to identify the needs of bio-signal devices for the diagnosis, assessment, and analysis of neurocognitive disorder in Korean medicine (KM) hospitals and clinics.Methods: A questionnaire was developed to survey the current status of medical device use, and diag-nosis and interventions for patients with cognitive disorders in KM hospitals and clinics. November 11∼December 2, 2019, 114 responses (71.9% completed) were collected by internet-based ques-tionnaires from the members of the Korean society of Oriental Neuropsychiatry.Results: The clinical requests were in the descending order of hematology analyzer, ultrasound imag-ing system, and electroencephalography among the 15 most commonly used devices of which re-search would support for their clinical usability. The biosignal-based devices showed the highest re-search demands for patients with mild cognitive impairment rather than more severe stages of cogni-tive impairment. Prevention rather than diagnosis, or several treatment regimens was the strongest clinical area of the KM for patients with neurodegenerative cognitive impairment. Many responded that five to 10 minutes of test duration and 20,000 won to 30,000 won of cost would be appropriated for a new device to be developed.Conclusions: There were strong demands for the development of bio-signal devices for neurocognitive disorders among the KM doctors. Specifically, it showed high needs for the technology that can be used in the prevention area of cognitive disorders. Additionally, new medical devices to assess cogni-tive functions and to obtain KM pattern-related information were the high needs.
처음 진단된 삼출 나이관련황반변성에서 애플리버셉트 치료의 임상적 결과
최유진,최영제,조용운,유웅선,정인영 한국망막학회 2021 Journal of Retina Vol.6 No.2
Purpose: To evaluate the 1-year outcomes of the treat-and-extend regimen using intravitreal injection of aflibercept for treatment-naive exudative age-related macular degeneration (AMD) and the clinical results of switching to ranibizumab within the same period. Methods: The change in best-corrected visual acuity (BCVA), central macular thickness (CMT) and number of injections was evaluated in 36 eyes first diagnosed with exudative AMD and treated with the treat-and-extend regimen using intravitreal injection of aflibercept, as well as 16 eyes switched from aflibercept to ranibizumab for improved efficacy within the same period. Results: Mean BCVA improved significantly from 0.57 ± 0.28 logarithm of the minimum angle of resolution (logMAR) to 0.39 ± 0.29 logMAR at 12 months (p = 0.015) and mean CMT decreased significantly from 406.34 ± 69.18 μm to 269.58 ± 83.15 μm at 12 months in the 36 eyes on the treat-and-extend regimen of aflibercept (p = 0.004). The average number of injections per year was 6.8 ± 0.5. Of the 16 eyes that underwent a change in medication, seven eyes (63.6%) exhibited improvement or maintenance of initial visual acuity; mean CMT decreased significantly from 415.27 ± 73.63 μm prior to drug switch to 289.63 ± 62.78 μm after drug switch in the 11 eyes that received three injections of ranibizumab (p = 0.009). Conclusions: A treat-and-extend regimen of intravitreal aflibercept injection was effective for exudative AMD in a clinical setting. Switching to ranibizumab for improved efficacy led to anatomical improvement and could help stabilize vision. 목적: 처음 진단된 삼출 나이관련황반변성에서 유리체내 애플리버셉트 치료 및 연장 방법의 1년 결과와 같은 기간 내 라니비주맙으로 변경한 경우의 임상 양상의 변화를 알아보고자 하였다. 대상과 방법: 삼출 나이관련황반변성으로 처음 진단되고 유리체내 애플리버셉트주입술을 치료 및 연장 방법으로 치료하였던 36안과같은 기간 내 효과가 부족하여 라니비주맙으로 변경하였던 16안을 대상으로 최대교정시력 변화, 중심황반두께 변화, 주사 횟수를 분석하였다결과: 애플리버셉트 치료 및 연장 방법으로 치료한 36안은 평균 최대교정시력 초기 0.57 ± 0.28 logarithm of the minimum angle of resolution (logMAR)에서 12개월째 0.39 ± 0.29 logMAR로 유의한 시력 호전을 보였으며(p = 0.015), 평균 중심황반두께는 초기 406.34 ± 69.18 μm에서 12개월째 269.58 ± 83.15 μm로 유의한 중심황반두께 감소를 보였다(p = 0.004). 1년간 평균 주사 횟수는 6.8 ± 0.5회였다. 약제를 변경한 16안 중 라니비주맙 3회 이상 주사를 시행한 11안에서 초기 시력이 호전되거나 유지할 수 있었던 경우는 7안(63.6%)이었으며 평균 중심황반두께는 약제 전환 전 415.27 ± 73.63 μm에서 전환 후 289.63 ± 62.78 μm로 유의한 감소를 보였다(p = 0.009). 결론: 삼출 나이관련황반변성에서 유리체내 애플리버셉트 치료 및 연장 방법은 실제 임상에서 효과적이었고, 또한 애플리버셉트에 효과가 부족하여 라니비주맙으로 변경한 경우 해부학적 호전을 보였으며 시력 안정화에 도움을 줄 수 있었다.
최유진,박진우,Choi, Yu-Jin,Park, Jin-Woo 한국항공운항학회 2015 한국항공운항학회지 Vol.23 No.4
The purpose of this study is to explore structural relationship between cognitive factors and emotional factors in predicting behavioral intention of duty-free users. This study conducted questionnaire survey on 246 users of duty-free shops and analyzed it by using structural equation. As the result of the study, attitude was significantly associated with both desire and behavioral intention. Subjective norm had a significant impact on desire, but had no significant imfact on behavioral intention. Whereas perceived behavioral control did not have a significant influence on desire and intention. Desire, which plays mediating role as a major variable in goal-directed behavioral model, turned out to not only have significant impact on behavioral intention but has the strongest effect as well. This study has its academic meaning in that it explored factors which have effect on decision-making process of duty-free users focusing on goal-oriented behavioral model, which is one of integrated psychological models. In practical terms, this study can be used as a basic material for corporations to establish goals in domestic duty-free shops.