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RISS 인기검색어
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- 저자 : 최경선 (검색결과 173 건)
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최경선,최철희 대한암학회 2009 Cancer Research and Treatment Vol.41 No.1
Purpose ; Malignant astrocytomas are among the commonest primary brain tumors and they have a grave prognosis, and so there is an urgent need to develop effective treatment. In this study, we investigated the molecular mechanisms that are responsible for the anti-tumor effect of ginsenosides on human astrocytoma cells. Materials and Methods ; We tested 13 different ginsenosides for their anti-tumor effect on human malignant astrocytoma cells in conjunction with Fas stimulation. In addition, the cell signaling pathways were explored by using pharmacological inhibitors and performing immunoblot analysis. DCF-DA staining and antioxidant experiments were performed to investigate the role of reactive oxygen species as one of the apoptosis-inducing mechanisms. Results ; Among the 13 different ginsenoside metabolites, compound K and Rh2 induced apoptotic cell death of the astrocytoma cells in a caspase- and p38 MAPK-dependent manner, yet the same treatment had no cytotoxic effect on the primary cultured human astrocytes. Combined treatment with ginsenosides and Fas ligand showed a synergistic cytotoxic effect, which was mediated by the reduction of intracellular reactive oxygen species. Conclusion ; These results suggest that ginsenoside metabolites in combination with Fas ligand may provide a new strategy to treat malignant astrocytomas, which are tumors that are quite resistant to conventional anti-cancer treatment.
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반도체 광증폭기를 이용한 OR/NOR 다기능 전광 논리소자
최경선,전영민,박진우,변영태 한국물리학회 2008 새물리 Vol.56 No.6
An OR/NOR bi-functional all-optical logic gate has been constructed by using cross-gain modulation (XGM) in SOAs (semiconductor optical amplifiers). We have shown that the OR/NOR bi-functional all-optical logic gate operates well with RZ input signals at 10 Gbit/s. Only 2 SOAs and 1 circulator have been used to perform the OR/NOR bi-functional all-optical logic operation. 반도체 광증폭기 내의 교차이득변조 (XGM: Cross Gain Modulation)를 이용하여 OR와 NOR의 논리연산을 동시에 수행하는 다기능 전광 논리소자를 구성하였다. 다기능 전광 OR/NOR 논리소자는 RZ 입력신호로 10 Gbit/s 전송 하에서 동작 가능함을 증명하였다. 논리연산 OR와 NOR를 동시 수행하기 위해 오직 2개의 반도체 광증폭기와 1개의 광순환기를 사용하였다.
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