http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 차봉연 ( Bong Youn Cha ) (검색결과 15 건)
- 무료
- 기관 내 무료
- 유료
-
소의 대동맥 내피세포에서 산화저밀도 지단백에 의한 아포프토시스에 백일해 독소 및 콜레라 독소가 미치는 영향
손호영(Ho Young Son),강성구(Sung Ku Kang),강무일(Moo Il Kang),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee),장상아(Sang Ah Chang),최윤희(Yoon Hee Choi),문성대(Sung Dae Moon),안유배(Yoo Bae Ahn),손현식(Hyun Sik Son),윤건호(Kun Ho Yoon) 대한내과학회 1999 대한내과학회지 Vol.56 No.5
Objectives : Oxidized LDL is thought to play a key role in atherogenesis. Among their wide variety of biological properties, oxidized LDL injures the endothelium as an early event of atherogenesis. However, the mechanisms by which oxidized LDL injures endothelial cells are not definitely known. In order to evaluate the involvement of GTP-binding protein on the mechanism of apoptosis, we studied the effects of pertussis and cholera toxin on oxidized LDL-induced apoptosis in bovine aortic endothelial cells(BAECs). Methods : Oxidized LDL elicited apoptosis in cultured BAECs as shown by characteristic morphological and biochemical changes. Chromatin condensation and nucleus fragmentation were visualized by using fluorescence microscopy of intact cells staining by acridine orange/ ethidium bromide. DNA fragmentation was quantified by an ELISA with specific antibody for bromodeoxyuridine- labelled DNA fragments and confirmed with DNA ladder formation. Results : Studies using a combination of bacterial toxins which change the function of GTP-binding protein suggest that oxidized LDL-induced apoptosis was regulated by GTP-binding protein. Oxidized LDL-induced apoptosis was not changed by pretreatment of BAECs with pertussis toxin. In contrast, pretreatment with cholera toxin completely prevented the oxidized LDL- induced apoptosis. Conclusion : These results show that oxidized LDL induces apoptosis of BAECs and suggest that cholera toxin-sensitive G-proteins are involved in signal transduction of oxidized LDL-induced apoptosis of BAEC.
-
-
-
정상한국인에서 혈중 호모시스테인과 엽산 농도 및 Methylenetetrahydrofolate Reductase 유전자 다형성
오기원(Ki Won oh),이원영(Won Young Lee),안유배(Yoo Bae Ahn),송기호(Ki Ho Song),유순집(Soon Jib Yoo),윤건호(Kun Ho Yoon),강무일(Moo Il Kang),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee),손호영(Ho Young Son),강성구(Sung Ku Kang) 대한내과학회 1999 대한내과학회지 Vol.57 No.6
Background : Hyperhomocysteinemia is an independent risk factor for cardiovascualr disease. Recently, a mutation (677C→T) was identified in the methylenetetrahydrofolate reductase gene leading to the substitution of valine(V) for alanine(A). This mutation causes a reduced folate-dependent enzyme activity which leads to increased homocysteine. In this study, we examined the association between the V allele of the methylenetetrahydrofolate reductase gene and serum total homocysteine and folate concentrations in Korean healthy subjects. Methods : In 198 healthy subjects, the methylenetetrahydrofolate reductase genotypes were analyzed by polymerase chain reaction followed by HinfI digestion. Serum total homocysteine and folate concentrations were measured in age- and sex-matched 14 healthy subjects in each of three methylenetetrahydrofolate reductase genotypes. Results : Homozygosity for 677C→T mutation in the methylenetetrahydrofolate reductase gene was found in 31 (15.7%) of 198 healthy subjects. In healthy subjects, those bearing the VV genotype tend to have higher serum total homocysteine concentrations 1.5 μmol/L(18.6%) than AA genotype but this was not statistically significant. Correlation between serum total homocysteine concentrations and other clinical variables showed that serum folate and creatinine were significant. Conclusion : We conclude that although the frequency of VV genotype in Korean healthy subjects is higher than that of other reports, this mutation is not associated with increased serum total homocysteine concentrations in Korean healthy subjects. (Korean J Med 57:1030-1036, 1999)
-
박훈준(Hun Jun Park),정정(Jung Jung),이관형(Kwan Hyung Lee),김재욱(Jae Uk Kim),조재완(Jae Wan Cho),문성대(Sung Dae Moon),손현식(Hyun Sik Son),윤건호(Kun Ho Yoon),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee),손호영(Ho Young Son),강성구(S 대한내과학회 2001 대한내과학회지 Vol.61 No.2
Empty sella is defined as a sella which, regardless of its size, is completely or partly filled with cerebrospinal fluid (CSF), and is divided into two groups, primary or secondary. Secondary empty sella syndrome is associated with a prior surgery, radiation therapy or medical treatment of pituitary gland, and otherwise primary. The endocrine function of primary empty sella syndrome is usually normal, but sometimes, this syndrome is associated with complete or partial pituitary insufficiency and rarely pituitary hypersecretion. In the cases of hypersecretion of pituitary hormones, hyperprolactinemia, acromegaly and hypersecretion of adrenocorticotrophin (ACTH) has been reported. But, hypersecretion of ACTH is rarely reported. We describe a patient of primary empty sella syndrome combined with Cushing's disease. So we present this case with a review of the literature.(Korean J Med 61:178-183, 2001)
-
간세포암종의 자연적 파열로 유발된 고삼투압성 고혈당 상태
윤혜은 ( Hye Eun Yoon ),남성민 ( Sung Min Nam ),손태서 ( Tae Seo Sohn ),김창욱 ( Chang Wook Kim ),손현식 ( Hyun Shik Son ),이창돈 ( Chang Don Lee ),차봉연 ( Bong Youn Cha ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Ketoacidosis and hyperosmolar hyperglycemia are the two most serious acute metabolic complications of diabetes, even if managed properly. The mortality rate of patients with hyperosmolar hyperglycemic state still remains high at ~15%. Mortality is associated with advanced age and comorbidity and is usually due to an associated catastrophic illness or to acute complications. Treatment of hyperglycemic states depends critically on the detection and treatment of precipitating illness, as well as prompt attention to fluid and electrolyte disturbances. We report a case of hyperosmlar hyperglycemic state precipitated by spontaneous rupture of hepatocelluar carcinoma. (Korean J Med 69:S879-S883, 2005)
-
증례 / 갈색종양 ( brown tumor ) 골절로 우연히 진단된 상종격동 부갑상선 선종 1예
손호영(Ho Young Son),강성구(Sung Ku Kang),이승규(Seung Kyu Lee),문성대(Sung Dae Moon),김현수(Hyun Su Kim),박은정(Eun Jung Park),안석주(Suk Ju Ahn),한제호(Je Ho Han),강무일(Moo Il Kang),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee) 대한내과학회 1999 대한내과학회지 Vol.56 No.1
Primary hyperparathyroidism is characterized by hypercalcemia and increased intact parathyroid hormone, and associated with reduced bone density and bony change. We experienced the case of a 18-year-old man presenting as fracture of brown tumor. And then ectopic superior mediastinal parathyroid adenoma was detected by preoperative localization studies (Tc-99m sestamibi scan, neck CT). The patient presented with fracture of the right 5th proximal phalanx which was brown tumor, and was diagnosed as having primary hyperparathyroidism due to elevated serum calcium level (12.1 mg/dl) and intact parathyroid hormone levels (1631.8 pg/ml). Ultrasonography, Tl-201/Tc-99m subtraction scan, Tc-99m sestamibi scan, computed tomography was performed, and then revealed an enlarged parathyroid gland in the superior mediastinum. Tumor was removed via a transcervical approach. Pathologically, the tumor was confirmed to be a parathyroid adenoma. After his operation, his calcium level rapidly returned to within normal ranges, and increased bone density and some remineralization of brown tumor has occurred after eight months.
-
다회 인슐린 투여가 당뇨병 환자의 삶의 질, 우울 및 불안 요소에 미치는 영향
박예리 ( Ye Ree Park ),김태석 ( Tae Suk Kim ),박용규 ( Yong Gyu Park ),이성수 ( Seong Su Lee ),김성래 ( Sung Rae Kim ),손현식 ( Hyun Shik Son ),윤건호 ( Kun Ho Yoon ),강무일 ( Moo Il Kang ),차봉연 ( Bong Youn Cha ),이광우 ( Kwang 대한내과학회 2009 대한내과학회지 Vol.77 No.1
Background/Aims: Treatment using multiple daily insulin(MDI) should give diabetic patients many benefits. Nevertheless, few studies have examined the impact of an increased frequency of daily insulin injection on quality of life, anxiety levels, and depression in diabetic patients, and individual`s continued compliance with MDI is unclear. This study examined these issues using standardized questionnaires. Methods: This was a cross-sectional, randomized study. Ninety-nine insulin-treated type 2 diabetic patients (mean age 53.1±12 years, mean duration of diabetes 10.3±6.5 years) were divided a group (n=50) who injected insulin four times daily (mean age 49.6±12.3 years, mean duration of diabetes 6.5±6.4 years) and a group (n=49) who injected insulin once or twice daily (mean age 56.4±11.6 years, mean duration of diabetes 11.5±5.8 years). All patients independently completed the Korean Version of the World Health Organization Quality of Life Scale Abbreviated Version and standardized Hospital Anxiety and Depression Scale for Koreans. Results: No significant differences were evident with respect to age, gender, and duration of diabetes between the two groups (p<0.05). No significant differences were evident in the results of the questionnaires between the two groups, except for the physical health domain (p<0.05). Conclusions: Multiple daily insulin injections had nearly no influence on quality of life, anxiety levels, or depression in type 2 diabetic patients. Therefore, treatment with MDI should be considered for patients who would benefit from this. (Korean J Med 77:60-67, 2009)
-
윤호중,김영우,손호영,차봉연,홍관수,홍대식 대한내분비학회 1986 Endocrinology and metabolism Vol.1 No.1
Excessive TSH secretion from pituitary tumor is one of the least common cause of thehyperthyroidism. Its clinical characteristics are distinguished from hyperthyroidism due to Graves' disease, toxic nodular goiter, subacute or Hashimoto's thyroiditis and subacute lymphocytic thyroiditis by the elevated serum TSH level.We experienced a case of 35-year old female with hyperthyroidism due to TSH-secreting pituitary ademoma. Her thyroid Function studies showed the elevated serum T3, T4 and TSH. Skull X-ray and brain CT revealed a enlarged sellae turcica and pituitary tumor with suprasellae extension. Basal serum cortisol level was lower than normal value. And combined pituitary stimulation test showed the normal response of LH, FSH and PRL, but the response of serum cortisol, growth hormone and TSH were blunted. Serum TSH responses were blunted to TRH stimulation test. The elevated serum TSH level was not suppressed to 8 mg dexamethasone suppression test. So we present thes case with a review of literatures.
-
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
