SNA기법을 이용한 북핵 네트워크 중심 식별 및 대응 우선순위 결정 방안 연구

지용배 육군사관학교 화랑대연구소 2024 한국군사학논집 Vol.80 No.1

As a methodology for carrying out North Korea's countering nuclear and other WMD operations, this study attempted to systematically analyze the structure of NK's nuclear network to identify the operational center of gravity and to carry out operations according to countering priorities. For research purposes, the analysis was conducted on NK's nuclear development and production related facilities disclosed in the media, and conducted by analyzing the structure of NK's nuclear network according to the nuclear weapons manufacturing process using the US JIPOE's center of gravity identification method and SNA technique. As a result, it was analyzed that the operational center of gravity is the Yongbyon cluster, and that uranium conversion, processing, and enrichment facilities should be prioritized when countering operations. In the future, it is expected that this study will be used to actively conduct research on the identification of NK’s overall nuclear network center of gravity and countering priorities. 본 연구는 북한의 핵·WMD대응 작전 수행을 위한 방법론으로서 북핵 네트워크의 구조를 체계적으로 분석하여 작전적 중심과 대응 우선순위를 식별하는 방안을 제시하고자 하였다. 연구 목적상 언론에 공개된 북핵 개발 및 생산 관련 시설을 대상으로, 핵무기 제조 공정에 따른 북핵 네트워크 구조를 미국 합동작전환경정보분석(JIPOE)의 중심 식별 방법과 SNA(Social Network Analysis) 기법을 이용하여 분석하였다. 분석 결과, 작전적 중심은 영변 지역 클러스터로 식별되었고, 대응 작전 시에는 우라늄 전환, 가공, 농축시설을 우선 고려해야 할 것으로 분석되었다. 향후, 본 연구를 이용하여 전반적인 북핵 네트워크의 중심 식별과 대응 우선순위 결정에 대한 연구가 활발하게 진행되기를 기대한다.

갑상선 결절의 분자생물학적 진단

지용배 대한이비인후과학회 2018 대한이비인후과학회지 두경부외과학 Vol.61 No.9

Fine needle aspiration cytology is gold standard for diagnosis of thyroid nodule. However, it isnot perfect and its results are cytologically indeterminate nodules (Bethesda classification IIIV)in 15-30%, which remains diagnostic challenges. So, the method that provide informationabout cancer risk is necessary to establish management strategy. As results of studies aboutgenetic changes in thyroid cancer, remarkable advances have been achieved in understandingthyroid carcinogenesis, which produced applications of molecular biomarkers and profilingpanels for diagnosis of thyroid nodule. These tests help clinicians make decision regarding theneed for surgery and the surgical extent. In this review, published researches related to moleculardiagnosis of thyroid cancer are reviewed and performance of the diagnostic tests and itsinterpretation were discussed. Korean J Otorhinolaryngol-Head Neck Surg 2018;61(9):445-52

Feasibility of intraoperative neural monitoring of external branch of superior laryngeal nerve in transoral robotic and endoscopic thyroidectomy

지용배 대한신경모니터링학회 2020 KINMoS 학술대회 발표자료 Vol.2020 No.11

비부비동 암종의 수술에서 안구 보존의 의의

지용배,송미나,성윤식,이용섭,김경래,태경 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.4

Background and Objectives:Preservation of orbital contents during surgery of paranasal sinus malignant tumors encroaching on the orbit remains a controversial issue. The purpose of this study is to investigate significance of orbital preservation in the surgery of sinonasal malignancies abutted orbit in view of oncological safety and functional outcome. Subjects and Method: A retrospective review was conducted using medical records of 41 patients who underwent surgery between Mar 1991 and Feb 2006 for sinonasal malignancies abutting or eroding orbit. Results:Among 41 cases of sinonasal tract malignancies abutting or invading into the orbit, thirty-four of 41 tumors were amenable for surgical treatment with orbital preservation and the remaining 7 underwent orbital exenteration. 71.4% (5/7) of the patients whose orbit was exenterated had local recurrence, compared with 20.5% (7/34) of the patients whose orbit was preserved. The 5-year survival rate was 50.0% in the orbit exenterated group and 59.9% in the orbit preserved group. This difference was not statistically significant (p>0.05). In the preservation group, local recurrence rate was 27.1% (2/9) in the periorbita involvement group, 22.2% (2/9) in the bony destruction group and 14.3% (2/14) in the abutting orbit group. There is no statistically significant difference among three groups. Although some patients had problems, the fact that all patients retained their orbit demonstrates adequate visual acuity. Conclusion:Local recurrence and survival rate were not significantly different between the orbital preservation and exenteration group and also between the bony destruction and periorbita involvement group. So, in the selected case of periorbita invasion, orbital preservation could be considered.

구강암의 수술적 접근법

지용배,박건,김종민,태경,전하정,이명자,김승우,김춘동 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.3

Background and ObjectivesZZIn the treatment of oral cancer, appropriate surgical approaches should be chosen in order to eradicate cancer while preserving the function of oral cavity and facial contour. This study was performed to evaluate the usefulness and effectiveness of various surgical approaches in the surgical treatment of oral cancer. Subjects and MethodZZA total of 112 oral cancer patients, excepting those with lip cancer, and who underwent surgery from 1994 to Aug 2008, were enrolled. We reviewed medical records retrospectively and analyzed the primary sites, stage, surgical approaches, management of mandible and neck, reconstruction methods, recurrence and survival rates. ResultsZZOf the 112 patients, 64 were transoral, 23 pull-through, 6 mandibular lingual releasing,6 upper cheek flap , 5 lower cheek flap , 6 mandibulotomy and 2 visor flap approach. Most of T1, T2 lesions could be resected by transoral (71.6%) or pull-through approach (21.0%). In the advanced T3, T4 lesions, transoral (21.9%), pull-through (37.5%), cheek flap (21.9%),mandibulotomy (15.6%) were used. There was no statistically significant difference with respect to locoregional recurrence and survival rate according to surgical approach. ConclusionZZThe transoral approach was the effective method for the surgery of T1, T2 and part of T3 oral cancer. The pull-through or mandibular lingual releasing approach was the effective method of surgery for T2, T3 tongue or floor of mouth (FOM) cancer while avoiding mandibulotomy. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:159-65

Postoperative Hypoparathyroidism and the Viability of the Parathyroid Glands During Thyroidectomy

지용배,송창면,성의석,정진혁,이창범,태경 대한이비인후과학회 2017 Clinical and Experimental Otorhinolaryngology Vol.10 No.3

Objectives. To prevent hypoparathyroidism after thyroidectomy, preservation of the parathyroid glands and their vascularity are essential. The aim of this study was to determine the association between postoperative parathyroid function and the viability of the parathyroid glands during thyroidectomy. Methods. We prospectively analyzed 111 patients who underwent total thyroidectomy and in whom all 4 parathyroid glands were preserved in situ during the operation. The surgeons scored the viability of each parathyroid gland from 0 (normal) to 3 (severely compromised viability) based on its gross appearance and vascularity intraoperatively. The index of parathyroid viability score (IPVS) was defined as the sum of the viability scores of the 4 parathyroid glands. We evaluated the relationship between postoperative parathyroid function and IPVS. Results. Transient hypoparathyroidism occurred in 25 patients (22.5%), and permanent hypoparathyroidism in 4 patients (3.6%). The IPVS were significantly different in the three groups: 2.87±1.46 in the normal group, 3.68±1.41 in the transient hypoparathyroidism group and 7.50±1.00 in the permanent hypoparathyroidism group. The rates of transient hypoparathyroidism were 13.6% in patients with IPVS 0–2, 23.8% in patients with IPVS 3–4, and 42.9% in patients with IPVS 5–6. All the patients with IPVS of 7 or more had permanent hypoparathyroidism. Conclusion. IPVS is correlated with the incidence of hypoparathyroidism. It could be a good quantitative indicator of the probability of hypoparathyroidism after thyroidectomy.

Efficacy of Trans-cartilaginous Electrode for Intraoperative Neural Monitoring during Thyroid Surgery

지용배 대한신경모니터링학회 2020 KINMoS 학술대회 발표자료 Vol.2020 No.11

Tips and pitfalls of IONM to avoid RLN injury

지용배 대한신경모니터링학회 2020 KINMoS 학술대회 발표자료 Vol.2020 No.11

Tip for nerve monitoring equipment: Medtronic vs Inomed

지용배 대한신경모니터링학회 2020 KINMoS 학술대회 발표자료 Vol.2020 No.7

XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck in a Korean Sample

지용배,태경,이윤서,이승환,김경래,박철원,Byung Lae Park,신형두 대한이비인후과학회 2010 Clinical and Experimental Otorhinolaryngology Vol.3 No.1

Objectives. XPD is a major player in nucleotide excision repair, which is one of the basic pathways of DNA repair. The objective of this study was to investigate the association of XPD single nucleotide polymorphisms (SNPs) and the risk of squamous cell carcinoma of the head and neck (SCCHN) in Koreans. Methods. We performed XPD +23591G>A and +35931A>C genotyping in 290 SCCHN patients and 358 controls. Results. The frequencies of the XPD +23591G>A (GG/GA/AA) genotypes were 89.0%/11.0%/0% in the patients and 90.3%/8.8%/0.9% in the controls, respectively. The odds ratio (OR) of the XPD +23591 GA genotype was 1.94 (0.92to 4.08) in reference to the GG genotype. The frequencies of the XPD +35931A>C (AA/AC/CC) genotypes were 86.9%/12.0%/1.1% in the patients and 85.6%/13.8%/0.6% in the controls, respectively. The OR of the XPD +35931 AC and CC genotypes were 0.98 (0.51 to 1.88) and 2.68 (0.71 to 10.1), respectively, in reference to the AA genotype. On the subgroup analyses according to the smoking and drinking statuses, the SNPs and haplotypes of XPD showed no statistically significant association with the risk of SCCHN. Conclusion. The results of this study suggest that the XPD +23591G>A and +35931A>C SNPs are not associated with the risk of SCCHN in Koreans; however, a further study with a larger number of subjects is necessary to verify this conclusion.