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Silk Fibroin based Hydrogel for Regeneration of Burn Induced Wounds
주형우,이옥주,문보미,Faheem A. Sheikh,이정민,김정호,박현정,김동욱,이민채,김수현,박찬흠,이혜란 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.3
The present study deals with fabrication of hydrogel composed of silk fibroin, calcium alginate and car-boxymethyl cellulose. A simple mixing of calcium alginate and carboxymethyl cellulose and silk fibroin wasadopted to fabricate new silk fibroin based hydrogel (SFH) type. The adhesive strength, water content and cytotox-icity of fabricated hydrogel was comparatively investigated against standard control as medical gauze (C) andPurilon Gel®(PG). The results from the adhesive strength indicated that presented hydrogels had least adhesivestrength but had good cell viability than the C and PG. The cell toxicity results after 1 day of culturing NIH 3T3fibroblasts indicated that prepared hydrogels comparably promoted cellular growth. The in vivoexperiments usingSprague-Dawley were done by creating a second-degree burn on the back of rats to study the effect of healing pro-cess. The gross examination investigations at 1, 3, 7, 14 and 21 days indicated a progressive effect induced by theSFH. The histological examinations using Hematoxylin and eosin (H&E) and Masson’s trichrome (MT) stainingafter 3, 7, 14 and 21 days indicated the complete collagen deposition and dermic formation using the presented SFH. Our results suggest that SFH can be considered as promising new candidate matrices for burn wound regeneration.
사례 연구를 통한 BIM 전환설계 프로젝트의 설계오류 이슈 분석
김범준(Kim Beom Jun),주형우(Ju Hyung Woo),장문석(Jang Moon Seok),김병주(Kim Byeoung Ju),진상윤(Chin Sang Yoon) 한국BIM학회 2016 KIBIM Magazine Vol.6 No.2
Recently, the introduction and spread of BIM technology has been actively promoted at the domestic level and abroad. However, the BIM adoption and diffusion rate in the whole construction industry has been slower than expected, this is because they applied to construction projects in a way that does not meet the basic objective of BIM adoption. The objective of this paper is to derive a BIM adoption strategy that can provide benefits and efficiency from the design phase, by analyzing issues related to design errors identified in two real world projects based on the 2D to BIM conversion process. Types of issues, type distribution, and degree of BIM contribution to find issues were analyzed in a quantitative way, and then a BIM adoption strategy was derived. As a result, this paper identified that there obviously exists a limit in the 2D to BIM conversion process by repeating the problems that occur in the traditional 2D design process. Therefore, the authors of this paper insist that the design firms should adopt BIM-based design processes, fully, to get financial benefits as well as to improve the design quality.
효율적 U-City 구축을 위한 정보통신망 선정방안에 관한 연구 - 자가망과 임대망 경제성 분석을 중심으로 -
박상수,박승희,김성아,진상윤,주형우,Park, Sang-Soo,Park, Seung-Hee,Kim, Seong-Ah,Chin, Sang-Yoon,Joo, Hyeong-Woo 한국BIM학회 2015 KIBIM Magazine Vol.5 No.1
The Cities that recently developed have been applied to private network for establishing information communication network system. The local governments planning or pursuing U-City construction should also choose the private network in consideration of operation and maintenance. In viewpoint of agency operating u-City, it is necessary to integrate traditional and new network. However, there has been lack of guides to choose U-City network considering the economic analysis between private and leased network. This study analyzed the characteristics of private and leased network, and the cost-benefit by estimating the network cost and communication demand focused on U-services that are recently applied. This study purpose a guide for efficient U-City information network selected by estimating ROI(Return On Investment) and BEP(Break Even Point) for establishing private and leased network.
실크 피브로인을 함유한 비출혈용 복합 지혈제 개발에 대한 연구
문보미 ( Bo Mi Moon ),주형우 ( Hyung Woo Ju ),박현정 ( Hyun Jung Park ),이정민 ( Jung Min Lee ),이옥주 ( Ok Joo Lee ),박찬흠 ( Chan Hum Park ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.2s
Epistaxis is defined as active bleeding arising from the nasal mucosa. It constitutes one of the most common otolaryngology emergencies and can be severe or even fatal. Hemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel which involves differential sequential events. This system in humans has been the most extensively researched. However, lot of research work is going on and lot more needs to be done to overcome the problem associated with this serious issue. This study was conducted to develop a new sponge type of biomaterial to be used for ideal hemostatic agent. The combination of three biomaterials; Silk fibroin (SF), Hyaluronic acid (HA), Gelatin (Gel) and Polyvinyl alcohol (PVA) as proposed hemostatic agent were tested against commercially available hemostatic pad (ChitoClot®). A comparative study of these silk based hemostasis agents designed in combination of SF/HA/PVA and SF/Gel/PVA sponges were tested on injured model of rats. Each sponge to be tested was made same size of (1×1 cm) then applied on top of injury site while applying a pressure of 5 N for 30 seconds. The In vivo experiments were carried by creating a proximal arterial injury in unilateral femoral arteries of 12 anesthetized SD rats. In conclusion, this study suggest a new developed silk fibroin-based sponges as hemostatic materials, which induced durable hemostasis and an increased blood clotting in animal studies. These initial studies explores the loopholes present in the existing ChitoClot® pad compared with that of fabricated silkbased sponges.
문보미,박찬흠,김동규,박현정,주형우,이옥주,김정호,이정민,이중섭 한국고분자학회 2014 Macromolecular Research Vol.22 No.12
This study described the preparation of three-dimensional (3-D) silk fibroin (SF) scaffolds, which derivedfrom a mixed salt/sucrose leaching without the process of lyophilization. Compared with the previous method, thisfabrication of 3-D SF scaffold is simple and can have more diverse morphological appearances of pores dependingon the different salt/sucrose mixing concentrations. The correlation between pore shape and septum of SF scaffoldsor salt concentration was examined by SEM. Additionally, the effects of salt or glucose concentrations on mechanicalproperties, such as compressive modulus in dry and wet states, were studied. For the materials with rangedbetween 69-88%, water binding capacity decreased with increasing salt or decreasing sucrose. After cell seeding andculture, SEM images of scaffolds showed that cell infiltrations were increased along with increased sucrose concentration. Analysis of Masson’s trichrome staining showed positive findings for collagen deposits in scaffolds of the100% sucrose type. Thus, our new method can fabricate 3-D SF scaffolds with different characteristics, and may beused for various tissue engineering uses.
이옥주,김정호,문보미,Janet Ren Chao,윤재호,주형우,이정민,박현정,김동욱,김승주,박혜상,박찬흠 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.3
Hydrocolloid dressings have been developed for many types of wound healing. In particular, dressing is a critical component in the successful recover of burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally, silk fibroin is the safest material for tissue engineering due to biocompatibility. In this study, we fabricated hydrocolloid dressings incorporating silk fibroin nanoparticles to enhance the efficacy of hydrocolloid dressing and then use this silk fibroin nanoparticle hydrocolloid dressing (SFNHD) in animal models to treat burn wounds. The structures and properties of SFNHD were characterized using tensile strength and Cell Counting Kit-8 assay. The results indicated the structural stability and the cellular biocompatibility of the hydrocolloid dressing suggesting that SFNHD can be applied to the treatment of wounds. To demonstrate the capacity of a silk fibroin hydrocolloid dressing to treat burn wounds, we compared SFNHD to gauze and Neoderm®, a commercially available dressing. This study clearly demonstrated accelerated wound healing with greater wound structural integrity and minimal wound size after treatment with SFNHD. These observations indicate that SFNHD may be an improvement upon current standard dressings such as Gauze and Neoderm® for burn wounds.
Fabrication of Microporous Three-Dimensional Scaffolds from Silk Fibroin for Tissue Engineering
박현정,박찬흠,이중섭,이옥주,Faheem A. Sheikh,문보미,주형우,김정호,김동규 한국고분자학회 2014 Macromolecular Research Vol.22 No.6
Scaffolds derived from silk fibroin are widely used as biomaterials. In this report, a new all-aqueous processis described for the production of three-dimensional porous silk fibroin scaffolds. The process uses poly(ethyleneoxide), and a novel salt leaching technique. The fabricated scaffolds were tested for their physical characteristics. The measured scaffold porosity ranged from approximately 67.95% to 84.7%. Swelling studies demonstrated thatthe fabricated scaffolds had fair hydrophilicity. The mechanical properties of the scaffolds, namely their compressivestrength and compressive modulus, were outstanding, compared to those of previous reports. Tests on the growth of cellcultures demonstrated that the scaffolds provide favorable conditions for the growth of human chondrocytes, withincreases in cell attachment and cell proliferation. The use of this new technique for scaffold fabrication providesclear advantages in the field of biomaterials and related fields.