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조영욱,박찬정,박서진,지현숙,장성수,박상혁,서을주,윤덕현,이정희,서철원 대한의학회 2013 Journal of Korean medical science Vol.28 No.4
Multiparametric flow cytometry (MFC) allows discrimination between normal and neoplastic plasma cells (NeoPCs) within the bone marrow plasma cell (BMPC)compartment. This study sought to characterize immunophenotypes and quantitate the proportion of NeoPCs in BMPCs to diagnose plasma cell myeoma (PCM) and evaluate the prognostic impact of this method. We analyzed the MFC data of the bone marrow aspirates of 76 patients with PCM and 33 patients with reactive plasmacytosis. MFC analysis was performed using three combinations: CD38/CD138/-/CD45; CD56/CD20/CD138/CD19; and CD27/CD28/CD138/CD117. The plasma cells of patients with reactive plasmacytosis demonstrated normal immunophenotypic patterns. Aberrant marker expression was observed in NeoPCs, with negative CD19 expression observed in 100% of cases, CD56+ in 73.7%, CD117+ in 15.2%, CD27- in 10.5%, CD20+ in 9.2%, and CD28+in 1.3%. In PCM patients, more than 20% of NeoPCs/BMPCs were significantly associated with factors suggestive of poor clinical outcomes. Patients who were CD27- or CD56+/CD27-, demonstrated shorter overall survival than patients of other CD56/CD27combinations. Our results support the clinical value of immunophenotyping and quantifying NeoPCs in PCM patients. This strategy could help to reveal poor prognostic categories and delineate surrogate markers for risk stratification in PCM patients.
조영욱,이승우,강민주,김은정,이승덕,김갑성 대한침구의학회 2007 대한침구의학회지 Vol.17 No.1
Objectives : We investigated the effects of Hominis placenta Herbal acupuncture on rheumatoid arthritis. Methods : We investigated the Type Ⅱ collagen-induced arthritis test, vascular permeability test, phenyl benzoquinone-induced writhing test, hot plate test, carbon clearance test, determination of prostaglandin E2 content and cyclooxygenase-2 activity test. Results : Hominis placenta Herbal acupuncture suppressed Type Ⅱ collagen-induced arthritis in DBA/ 1J mice and vascular permeability with 10.2% inhibition in ICR mice. We see the phenyl benzoquinone- induced writhing test and the hot plate test in the analgesic activity test. In the phenyl benzoquinone- induced writhing test, Hominis placenta Herbal acupuncture showed that it increased its analgesic effect more than the control(test?) by 85.5%. In the hot plate test, it was also shown that the analgesic effect increased more than the control(test) by 32.1%. In the carbon clearance test, the immuno-stimulatory effect showed more than the control(test) by 8.0%. The formation of prostaglandin E2 was also reduced more than the control(test) by 10.1%. Finally, cyclooxygenase-2 activity was inhibitedwith 36.3%. Conclusions : Hominis placenta Herbal acupuncture may be useful for the treatment of rheumatoid arthritis after injection.
조영욱,황금,변진수,허철,홍순기,김헌주 대한신경외과학회 2004 Journal of Korean neurosurgical society Vol.35 No.3
Objective : A retrospective study is performed on 28 patients with primary intraventricular hemorrhage(PIVH) to examine the outcome and prognostic factors associated with this disorder. Methods : Clinical data collected between 1998 and 2002 was used in the present study. The outcomes of these patients were compared by age, etiology, initial Glasgow Coma Score(GCS), Graeb's score, ventriculocranial ratio(VCR), hemorrhagic dilation of the third ventricle, and hemorrhagic dilation of the fourth ventricle. The Glasgow Outcome Scale(GOS) at discharge was used for the comparison of outcomes. Results : The mean age of these patients was 48.4±17.4 years. The underlying causes of PIVH were hypertension (53.6%), moyamoya disease(17.9%), arteriovenous malformation (10.7%), cerebral aneurysm (7.1%), and unknown (10.7%). The age and etiology were not correlated with outcome. Patients with a GCS of 13-15 showed a good outcome in 90.5%(p<0.05). Those with a higher VCR (≥0.23) showed a poor outcome in 64.3%(p<0.05). Patients with a Graeb's score of 9-12 showed a poor outcome in 87.5%(p<0.05). Those with hemorrhagic dilatation of the third ventricle showed a poor outcome in 80.0%, and those with hemorrhagic dilatation of the fourth ventricle showed a poor outcome in 85.7% (p<0.05). The overall mortality rate was 17.9%. Conclusion : Low initial GCS, high Graeb's score, high VCR, and hemorrhagic dilatation of the third ventricle or the fourth ventricle are correlated with poor outcome in PIVH.
조영욱,김도윤,박홍주 대한이비인후과학회 부산,울산,경남 지부회 2012 임상이비인후과 Vol.23 No.2
Middle ear adenoma is a rare benign tumor of the tympanic cavity. The first report of a adenomatous tumor of middle ear was published in 1976 by Hyams. It can have both neuroendocrine and epithelial differentiation. Immunohistochemical techniques have helped clarify that these tumors all share elements of neuroendocrine differentiation. Due to non specific clinical symptom and imaging finding, preop-diagnosis was difficult. And behavior of middle ear adenoma was not predictable. In the past few years, there have been reports on metastasis of middle ear adenomas. In this study, we present a case of middle ear adenoma of a patient complaining non whirling type vertigo, hearing difficulty, which was diagnosed by histopathologic finding
ASTM D5470 방법으로 연강과 스테인리스강의 열전도도 측정시 열그리스의 영향
조영욱,한병동,이주호,박성혁,백주환,조영래,Cho, Young-Wook,Hahn, Byung-Dong,Lee, Ju Ho,Park, Sung Hyuk,Baeg, Ju-Hwan,Cho, Young-Rae 한국재료학회 2019 한국재료학회지 Vol.29 No.7
Thermal management is a critical issue for the development of high-performance electronic devices. In this paper, thermal conductivity values of mild steel and stainless steel(STS) are measured by light flash analysis(LFA) and dynamic thermal interface material(DynTIM) Tester. The shapes of samples for thermal property measurement are disc type with a diameter of 12.6 mm. For samples with different thickness, the thermal diffusivity and thermal conductivity are measured by LFA. For identical samples, the thermal resistance($R_{th}$) and thermal conductivity are measured using a DynTIM Tester. The thermal conductivity of samples with different thicknesses, measured by LFA, show similar values in a range of 5 %. However, the thermal conductivity of samples measured by DynTIM Tester show widely scattered values according to the application of thermal grease. When we use the thermal grease to remove air gaps, the thermal conductivity of samples measured by DynTIM Tester is larger than that measured by LFA. But, when we did not use thermal grease, the thermal conductivity of samples measured by DynTIM Tester is smaller than that measured by LFA. For the DynTIM Tester results, we also find that the slope of the graph of thermal resistance vs. thickness is affected by the usage of thermal grease. From this, we are able to conclude that the wide scattering of thermal conductivity for samples measured with the DynTIM Tester is caused by the change of slope in the graph of thermal resistance-thickness.
장기간 배양된 대장균 세포에 있어서의 치오레독신 합성의 증가
조영욱,임창진 강원대학교 기초과학연구소 1996 기초과학연구 Vol.7 No.-
대장균의 치오레독신은 다양한 기능을 갖는 단백질로 배양하는 시간이 길어질수록 그 합성이 증가하고 있음을 구명하였다. 영양배지에서보다 최소배지 M9에서 치오레독신의 합성이 높이 나타난다.