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정용덕 ( Yong Duk Jeong ),최혁환 ( Hyuk Whan Choi ),조현오 ( Hyun O Cho ),최성진 ( Sung Jin Choi ),유재연 ( Jae Yeon Yoo ),정현식 ( Hyun Sik Jeong ),송국현 ( Kuk Hyun Song ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
저자들은 심한 혈소판감소증 외 특이소견 없는 환자에서 유주비장이 관찰되었고, 비장적출술 후 혈소판 수치 정상화 된 1예를 국내에서 처음으로 경험하였기에 문헌고찰과 함께 보고하는 바이다. Wandering spleen (ectopic spleen) is a very rare disease, and wandering spleen with thrombocytopenia is rarely reported. A splenectomy is the treatment of choice, and it`s result is good. We experienced a case of wandering spleen with severe thrombocytopenia in 15-year-old boy. He was diagnosed with the abdominal sonography and abdominal CT scaning. A splenectomy was performed, and then the thrombocytopenia was disappear. After splenectomy, he was well being. Therefore, we report this case with a brief review of literature. (Korean J Med 69:S924-S928, 2005)
박현덕(Hyun Duk Park),정현식(Hyun Sik Jeong),박정식(Jeung Sik Park),임성호(Sung Ho Lim),이은정(Eun Jung Lee),윤중원(Jung Won Yun),정수석(Su Suk Jung),신호철(Ho Cheol Shin),이승세(Seung Sei Lee) 대한내과학회 2002 대한내과학회지 Vol.62 No.4
목적 : 폐암에 대한 종양표지자로서는 암태아성 항원 (CEA), 편평세포암 항원 (SCC Ag), 신경원 특이성 에놀라제 (NSE) 등이 있으나 Cyfra 21-1은 최근에 발견된 종양표지자로서 비소세포성 폐암에 민감도가 우수한 것으로 보고되고 있다. 본 연구에서는 폐암에서 Cyfra 21-1의 민감도를 알아보고 폐암의 병기와의 관계를 알아 보았다. 대상과 방법 : 환자는 강북삼성병원에 입원하여 조직학적 및 세포병리검사상 확진된 폐암환자 110명을 대상으로 연구하였고 환자의 혈청에서 CEA, SCC Ag, NSE, Cyfra 21-1을 측정하였다. 결과 : 전체 폐암 환자에서 종양표지자의 민감도는 Cyfra 21-1이 51.8%였다. Cyfra 21-1의 양성율은 선암에서 63.2%, 편평세포암에서 54.1%, 소세포암에서 40.0%였고, 소세포암에 비해 선암과 편평세포암에서 통계학적으로 유의하게 (p<0.05) 높게 측정되었다. 병기에 따른 Cyfra 21-1의 민감도는 다른 종양표지자보다 양성율이 높고 T 병기가 진행하면서 높아지는 경향이 있었지만 통계적인 유의성은 없었고 림프절의 전이와 타장기로의 전이 유무에 따른 Cyfra 21-1의 양성율도 통계적으로 유의한 차이는 없었다. 선암과 편평세포암에서 병기에 따른 Cyfra 21-1의 평균치는 병소의 크기가 증가함에 따라 증가하지만 통계적인 유의성이 없었고 림프절 침범과 타장기로의 전이 유무에 따른 Cyfra 21-1의 농도의 변화도 통계적으로 유의한 차이는 없었다. 결론 : 본 연구에서 Cyfra 21-1은 폐암에서 기존의 종양표지자와 비교해 볼 때 상대적으로 가장 높은 양성율을 보이며 특히 비세포암에서 선별검사시 기존의 종양표지자와 함께 사용하면 더욱 유용하게 사용할 수 있다. 종양의 크기에 따라서 Cyfra 21-1 측정치도 증가하는 경향을 보이지만 통계적인 유의성은 없었고 조직학적인 아형에 따라서는 선암의 경우가 편평세포암의 경우보다 높게 나와 다른 기관의 연구와 상의한 결과를 보였다. Background : Cytokeratins are epithelial markers whose expressions are not lost during malignant transformation. The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 110 patients with lung cancer. The aims of this study were to confirm sensitivity of Cyfra 21-1 in detecting non-small cell cancer, to assess the potential relationship between Cyfra 21-1 and disease stage of the lung cancer. Methods : We measured serum levels of four tumor marker (NSE, CEA, SCC Ag, Cyfra 21-1) in 110 patients with lung cancer. The measurement of serum level of Cyfra 21-1 was performed with a cut off value of 3.3 ng/mL. An immunoradiometric assay was used to detect a fragment of the cytokeratin 19. The patients were grouped according to the stage of the disease and tumor type. Results : Overall sensitivity of Cyfra 21-1 was relatively high (51.8%) than others tumor markers. Sensitivity of this marker was especially high for adenocarcinoma (63.2%) and squamous cell carcinoma (54.1%). In contrast, sensitiviy of Cyfra 21-1 was relatively low for small cell lung carcinoma (40.0%). Serum levels of Cyfra 21-1 were higher in advanced nonsmall cell lung cancer than early stage disease. Conclusion : We conclude that Cyfra 21-1 is a sensitive tumor marker of nonsmall cell lung cancer, especially adenocarcinoma and also may be a useful adjunctive marker for disease monitoring.(Korean J Med 62:415-421, 2002)
알러젠 제거 옻나무 추출물 투여로 소퇴된 신세포암 유래 부신전이암 1례
정의민,정종수,정현식,박재우,윤성우,Jeong, Ui-Min,Jeong, Jong-Soo,Jung, Hyun-Sik,Park, Jae-Woo,Yoon, Seong-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2
Renal cell carcinoma(RCC) is one of the major malignant renal cell tumors. Although RCC can metastasize to almost every organ, the most common metastatic sites are the lung parenchyma, the bones, the liver, and the brain. Adrenal metastasis from RCC is extremely rare. Adrenal metastasis from RCC shows poor prognosis, with little benefit from chemotherapy, radiation therapy, hormone therapy or immunotherapy. In this report, we describe a case of an RCC patient who showed lung and adrenal metastasis. The patient underwent left nephrectomy and chemotherapy(sunitinib), which were not effective. He refused further conventional medical treatment, and instead started treatment with Traditional Korean Medicine using allergen-removed Rhus verniciflua Stokes. After about 3 months of this treatment, the size of the adrenal tumor had decreased significantly with good performance status. Further study will be needed to demonstrate the tumor regression effect of allergen-removed Rhus verniciflua Stokes on patients with metastatic renal cell carcinoma.
진행성 병기의 소세포폐암에 대한 Etoposide , Cisplatin 복합화학요법치료의 효과
서정열(Jung Yul Suh),정현식(Hyun Sik Jeong),이승세(Seung Sei Lee) 대한내과학회 2001 대한내과학회지 Vol.61 No.6
N/A Background : Small cell lung cancer (SCLC) disseminates early and has poor prognosis. However, SCLC is highly chemosensitive, thus chemotherapy has been established as the primary mode of treatment. This study evaluated the efficacy and toxicity of etoposide in combination with cisplatin in the treatment of extensive stage small cell lung cancer. Methods : Thirty four patients (28 males, 6 females) with previously untreated extensive stage small cell lung cancer were treated with etoposide at a dose of 100 mg/m2, IV on days 1-3 with cisplatin at 100 mg/m2, IV on day 1. The median age was 63 (range 41∼80). This combination chemotherapy was administered every 3-4 weeks. Response rate, response duration, survival, and toxicity were evaluated.Results : The response rate was 50%. The median survival time was 29 weeks. The median response duration was 17.2 weeks in responders. The toxicity was acceptable. Conclusion : This study illustrated that the combination of etoposide and cisplatin is effective in the treatment of extensive stage small cell lung cancer, and can be administered with acceptable toxicity. Although this study was not designed to be a formal comparative trial, the efficacy and toxicity observed with this regimen were found to be comparable to previous reports.(Korean J Med 61:590-596, 2001)
수술이 힘든 고령의 직장-S상결장암 환자에 대한 알러젠 제거 옻나무 추출물 위주의 한방치료 1례
권은미,정의홍,김경석,정현식,전성하,어완규,최원철,이상헌,Kwon, Eun-Mi,Jeong, Yee-Hong,Kim, Kyung-Suk,Jung, Hyun-Sik,Cheon, Seong-Ha,Eo, Wan-Kyu,Choi, Won-Cheol,Lee, Sang-Hun 대한암한의학회 2010 大韓癌韓醫學會誌 Vol.15 No.1
We report a case of an 85-year old man with an adenocarcinoma of the rectosigmoid colon (clinical stage II). Though tumor was resectable, the patient was considered to be inoperable because of old age and comorbidities such as asthma, diabetes and old myocardial infarction. He wanted to receive alternative care, so he was exclusively treated with standardized Allegern-removed Rhus verniciflua Stokes (aRVS) extract and other herbal medicine such as BOJUNGIKGI-TANG GAMIBANG. During 18 months, he has shown good performance status without transfusion. This report suggests that herbal treatment including standardized aRVS for rectosigmoid colon cancer could be an alternative treatment option when it is unabled to be treated by surgical resection.
전이성 유두상 갑상선암 환자를 대상으로 투여한 알러젠 제거 옻나무 추출물의 종양 소퇴 1례
이진수,정의민,정종수,박재우,정현식,윤성우,Lee, Jin-Soo,Jerng, Ui-Min,Jeong, Jong-Soo,Park, Jae-Woo,Jung, Hyun-Sik,Yoon, Seong-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3
Papillary thyroid carcinoma is the most common type of thyroid malignancy. It has better prognosis and rarer incidence of distant metastasis than other types of thyroid malignancy. However, once distant metastasis happens, its result will be bad. They mostly spread to the lungs and bones. and rarely to the brain. We report a patient with a papillary thyroid carcinoma metastasis to the lymph nodes. the ribs. the brain, and the lungs. The patient underwent total thyroidectomy, radioiodine ablation, rib partial resection, and lung wedge resection. However, upon progress of metastasis. the patient insisted on being treated with traditional Korean medical treatment using allergen-removed Rhus Verniciflua Stokes (A-RVS) instead of the conventional treatment including chemotherapy. The size of the tumor partly decreased, and the patient showed no side effects. This case report brings forth the importance of a thorough study in papillary thyroid carcinomas and their metastasis from the traditional Korean medical point of view, along with the long-term effect of allergen-removed Rhus Verniciflua Stokes (A-RVS).
알러젠 제거 옻나무 추출물 투여로 호전된 악성흑색종(惡性黑色腫) 환자 1례
정종수,김경석,박재우,정현식,윤성우,Jeong, Jong-Soo,Kim, Kyung-Suk,Park, Jae-Woo,Jung, Hyun-Sik,Yoon, Seong-Woo 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3
Malignant melanoma is rare in Asians and one of the poorer prognostic diseases. Malignant melanoma accounts for only a small ratio of all skin cancers, but it causes the greatest number of skin cancer - related deaths worldwide. Melanoma incidence has continued to increase worldwide and in Korea, like other countries, the number of patients has increased compared with previous cancer incidence data. In this case report, we describe a case of a malignant melanoma patient who showed neck node metastasis (right supraclavicular area) after wide excision of facial melanoma 2 years before the diagnosis of relapse. The patient refused to get conventional western medical treatment including chemotherapy and the size of cancer increased over the 5 months of clinical follow-up. After 4 months of traditional Korean medical treatment using allergen-removed Rhus verniciflua Stokes(A-RVS), however, the size of cancer mass decreased and the patient showed no side effects. Further study will be needed in order to determine the long-term effect of allergen-removed Rhus verniciflua Stokes on patients with malignant melanoma.