비소세포폐암종에서 Cyclin E 경로 단백들(cyclin E, cdk2,p21, p27, p57)의 발현 및 예후 지표 인자로서 의의

정지한,박경신,이명아,변재호,정찬권,이희정,이교영,심상인,강창석 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.1

Background : The aberrant expression of cyclins, cdk and cdk inhibitor has been shown to be involved in oncogenic transformation. The aim of this study was to investigate the expression of the cyclin E-pathway proteins (cyclin E, cdk2, p21, p27, p57) in human non-small cell lung carcinomas (NSCLC) and also to evaluate the clinical significance of these expressions. Methods : A total of 203 consecutive patients with completely resected pathological stage IIII NSCLC were retrospectively reviewed. The expressions of cyclin E, cdk2, p21, p27 and, p57 was examined by performing immunohistochemistry with using the tissue microarray method. Results : In the total cases, the expression levels of cyclin E, cdk2, p21, p27 and p57 were 39.9% (81/203), 48.3% (98/203), 68.0% (138/203), 32.5%(66/203) and 2.7% (5/203), respectively. The overexpression of cyclin E and cdk2 was significantly and inversely correlated with the histologic differentiation in the adenocarcinoma (p<0.05), but not in the squamous cell carcinoma. Among the clinicopathologic factors, the stage and lymph node metastasis were associated with overall survival (p<0.05). Among these proteins, the negative expression of p21 was significantly correlated with a shortened survival rate (p<0.05). Conclusions : These data suggest that the overexpression of cyclin E and cdk2 and the loss of p21 and p27 are associated with tumor progression in NSCLC. The aberrant expression of p21 is correlated with a poor prognosis. Therefore the immunohistochemical analysis of this protein as well as the clinical stage and, lymph node metastasis may be useful tools for evaluating the prognosis of NSCLC patients.

중신방 기원 부난소낭에서 발생한 경계영역성 유두상 장액성 낭선종 - 1예 보고 -

정지한,이연수,강석진,김병기,심상인 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.6

간석증과 동반된 간내 담관 방선균증 -1예 보고-

정지한,최현주,유진영,강석진,강창석 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.2

Actinomycosis is a chronic suppurative infection caused by Actinomyces, a filamentous, gram-positive, anaerobic bacterium that is a normal inhabitant of the oral cavity and gastrointestinal tract. Actinomycosis of the biliary duct is very rare and the pathogenesis of this infection is poorly understood. We report here on a case of actinomycosis in the intrahepatic bile duct that was superimposed on hepatolithiasis. A 55-year-old woman presented with epigastric discomfort and episodic upper abdominal pain for 1 year. The radiologic findings revealed multiple hepatolithiasis and cholelithiasis. On performing left lateral segmentectomy of the liver, the markedly dilated intrahepatic bile duct contained several brown pigmented stones, and periductal chronic inflammation with fibrosis and proliferation of the bile ductules were observed. In addition to the intrahepatic stones, there were sulfur granules with neutrophilic infiltration and necrotic debris. The gram stain and methenamine silver stain revealed tangled filamentous and branching bacteria, which were consistent with Actinomyces. Acid-fast staining result was negative and no malignancy was detected.

위장관 B세포림프종의 분류 및 Cyclin D1, bcl-2, bcl-6 및 p53 단백과 PCNA의 발현

정지한,이안희,강창석,김병기 대한병리학회 2000 Journal of Pathology and Translational Medicine Vol.34 No.6

제주산 주요 품목 수출경쟁력 강화방안 : 대중수출 우선순위 도출을 중심으로

정지형(Jung, Ji-Hyung)(鄭智馨),김형근(Kim, Hyung-Geun)(金亨根) 대한중국학회 2020 중국학 Vol.73 No.-

제주의 대중 수출은 2018년 기준 2,283만 달러로 연평균 38% 씩 증가하고 있는 실정이나. 수출액은 타 지자체에 비해 미미한 수준이다. 본 연구에서는 대중 수출을 위한 제주 상품의 경쟁력 분석을 위해 제주산 주요 수출 품목군 선정과 함께 우선 순위를 도출하고자 하였다. 이는 향후 제주의 대중 수출에 대해 행정적인 측면에서도 선택과 집중을 통해 수출을 활성화하기 위함이다. 본 연구에서는 무역특화지수와 시장비교우위지수를 활용하여 제주의 대중 수출 경쟁력을 분석하였으며, 제주의 수출 성장에 대한 주요 품목별 대중 수출 기여도를 산출하였다. 또한 상기 분석된 무역특화지수와 시장비교우위지수, 수출 기여도를 통해 Z-SCORE 가중치를 적용하여 제주지역의 대중 수출 우선순위 품목을 선정하였다. 연구결과 기초화장품(330499) 제1위, 소주 등 증류주(220890) 제2위, 기타혼합주스(200990) 제3위, 감귤류과실(200830)제4위, 기타녹차(미발효)(090220) 제5위, 기타조제식품류(210690) 제6위, 기타어종-갈치(030389) 제7위, 기타당류제품(170490) 제8위로 나타났다. In 2018, the amount of Jeju‘s export to China added up to 22,830,000 dollars, and it has been increasing at an average of 38% every year. However, it is at a far lower level when compared to that of other local government in Korea. This study aims at selecting and prioritizing the major export items produced in Jeju, so that the competitiveness analysis of the products exported to China could be carried out. The results of analysis will be used to activate the exports to China even in administrative aspect through selecting and concentrating on promising items. In this study, the export competitiveness has been analyzed by using of the Trade Specialization Index and Market Comparative Advantage Index, and the rate of contribution of each major item to the Jeju’s export growth has been calculated, as well. In addition, the Jeju region s priority items exported to China have been selected by assigning the weighted Z-score on the basis of the Trade Specialization Index and Market Comparative Advantage Index mentioned above. The results of this study show that basic cosmetics take the first place(330499), followed by hard liquors such as ‘Soju’(220890), mixed juice(200990), orangescitrus fruits (200830), other green tea (non-fermented)(090220), other delicatessen food(210690), other fishes-cutlassfish(030389), and other sugar-based foods(170490), in order of priority.

IgA 신증과 동반된 막사구체신염 -6예 보고-

정지한,최영진,김용수,장윤식,방병기,심상인,강창석 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.4

IgA nephropathy (IgAN) and membranous glomerulonephritis (MGN) are common in adults. However, it is unlikely that these two distinct glomerulonephrites coexist in a renal biopsy. Here, we report clinical and pathological data of six patients with concomitant existence of IgAN and MGN in renal biopsy specimens from 1990 to 2004. Five patients were male and one was female, and their ages ranged from 29 to 71 years. Four patients had microscopic hematuria, five had nephrotic range proteinuria, three had hepatitis B virus infections, three had rheumatoid factors, one had antinuclear antibodies. Two cases were developed after kidney transplant. Immunofluorescence microscopy showed characteristic findings of mesangial IgA deposits and granular IgG deposits on the capillary walls. These were confirmed by electron microscopic findings of immune-type electron-dense deposits in the mesangium and subepithelial capillary basement membranes. The pathogenesis and prognosis of the patients are discussed in this report.

갑상선의 원주세포형 유두상 암종의 세침흡인 세포학적 소견 - 1예 보고 -

정지한,강창석,심상인,김병기,이교영,Jung, Ji-Han,Kang, Chang-Suk,Shim, Sang-In,Kim, Byung-Kee,Lee, Kyo-Young 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.2

The columnar cell variant of papillary carcinoma is a rare tumor of the thyroid, associated with aggressive behavior, early metastasis, and a rapidly fatal course. We present the fine needle aspiration cytologic(FNAC) findings of columnar ceil variant of papillary carcinoma with cytohistologic correlation. In the smears, the tumor fragments showed mainly papillary pattern and a few scattered individual cells were present around the papillary fragments. The tumor cells were columnar or cuboidal and exhibited pseudostratification of the nuclei. The nuclei were oval to elongated with finely stippled chromatin and inconspicous nucleoli. Neither nuclear grooves nor intracytoplasmic inclusion was found. The FNAC diagnosis was consistent with papillary carcinoma. Total thyroidectomy was done and the histologic finding of the mass showed a predominantly papillary and focal solid proliferation of columar cells with marked nuclear pseudostratification. The unique histopathologic features and highly aggressive nature of columnar ceil variant of papillary carcinoma require that this variant should be differeniated from common papillary carcinoma of the thyroid.

암종으로 오진하였던 모기질종의 세침흡인 세포학적 소견 - 1예 보고 -

정지한,김영신,이교영,강창석,심상인,Jung, Ji-Han,Kim, Young-Shin,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1

Sometimes a pilomatrixoma on upper neck can be misdiagnosed as primary salivary gland tumor, skin adnexal tumor or metastatic carcinoma. On fine needle aspiration cytology(FNAC), characteristic features are ghost cells, basaloid cells, and calcium deposits, among which presence of ghost cells seems to be the key to recognize it. Here we present a cytologically misdiagnosed case of pilomatrixoma. A 32-year-old man presented a subcutaneous mass on the right posterior neck. It has grown slowly for 1 year, and was nontender, well circumscribed, hard, and movable mass. An Initial FNAC yielded only monomorphic population of highly mitotic basaloid cells, without anucleated ghost cells, chronic inflammatory cells or foreign-body giant cells, suggestive of a poorly differentiated carcinoma. However, that was inconsistent with patient's clinical findings. For further correct diagnosis, FNAC was repeated, which yielded the basaloid cells and foreign-body giant cells. The diagnosis of pilomatrixoma could be made and the mass was excised. This case demonstrates that the pilomatrixoma should be considered in the differential diagnosis of subcutaneous aspirates containing not ghost cells but a dominant population of basaloid cells.

Schwannoma Arising in a Lymph Node - A Brief Case Report -

정지한,유진영,강석진,이교영 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.3

Intranodal schwannomas are extremely rare and only three cases have currently been reported in the English language literature. We report here on a case of a schwannoma that arose in a retroperitoneal lymph node. A 59-year-old male patient had experienced abdominal discomfort for two months. An abdominal CT scan demonstrated a heterogeneous density mass in the retroperitoneum. Histological examination of the mass identified it as a lymph node due to the presence of a peripheral rim of compressed lymphoid tissue that contained a well-demarcated benign spindle cell tumor in its center. The spindle cells were positive for S-100 protein, and they were negative for smooth muscle actin, desmin, and CD 34. Although an intranodal schwannoma is histologically benign, it is important to distinguish this lesion from an intranodal metastasis of a spindle cell tumor and other common benign spindle cell tumors that can arise in a lymph node.

초자-혈관형 Castleman병의 특이한 간질 풍부 변종- 1예 보고 -

정지한,박경신,최현주,유진영,강석진,이교영 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.4

The stroma-rich variant of Castleman’s disease of the hyaline-vascular type (CDHV) is a rare entity that shows overgrowth of a variety of stromal cells in the widened interfollicular (IF) area. We report here on a case of a stroma-rich variant of CDHV in an 18-year-old man who presented with an asymptomatic solitary neck mass he’d had for 1 year. Histologically, an enlarged lymph node fulfilled the criteria of CDHV, along with vague nodularity of a widened IF area. The nodular lesion consisted of numerous vessels and a proliferation of spindle cells. Immunohistochemically, the spindle cells were positive for vimentin and smooth muscle actin, they were negative for desmin, CD21, CD34, CD68, ALK-1, and S-100 protein. This stromal lesion is typically hyperplastic and clinically benign, and it must be distinguished from neoplastic stromal proliferation associated with Castleman’s disease because of its potential for recurrence and metastasis.