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Drug-induced Hepatotoxicity of Anti-tuberculosis Drugs and Their Serum Levels
정인아,박종선,조영재,윤호일,송정한,이춘택,이재호 대한의학회 2015 Journal of Korean medical science Vol.30 No.2
The correlation between serum anti-tuberculosis (TB) drug levels and the drug-inducedhepatotoxicity (DIH) remains unclear. The purpose of this study was to investigate whetheranti-TB DIH is associated with basal serum drug levels. Serum peak levels of isoniazid (INH),rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) were analyzed in bloodsamples 2 hr after the administration of anti-TB medication. Anti-TB DIH and mild liverfunction test abnormality were diagnosed on the basis of laboratory and clinical criteria. Serum anti-TB drug levels and other clinical factors were compared between thehepatotoxicity and non-hepatotoxicity groups. A total of 195 TB patients were included inthe study, and the data were analyzed retrospectively. Seventeen (8.7%) of the 195patients showed hepatotoxicity, and the mean aspartate aminotransferase/alanineaminotransferase levels in the hepatotoxicity group were 249/249 IU/L, respectively. Among the 17 patients with hepatotoxicity, 12 showed anti-TB DIH. Ten patients showedPZA-related hepatotoxicity and 2 showed INH- or RMP-related hepatotoxicity. However,intergroup differences in the serum levels of the 4 anti-TB drugs were not statisticallysignificant. Basal serum drug concentration was not associated with the risk anti-TB DIH inpatients being treated with the currently recommended doses of first-line anti-TBtreatment drugs.
정인아,우신구 대한건축학회 2019 대한건축학회논문집 Vol.35 No.2
The purpose of this study is to analyze the occurrence characteristics of vacant spaces in the old hillside residential area, focused on 7areas surrounding old downtown in Busan. This study suggests 3 stages of analysis as following. First, after the overall site survey on thevacant spaces in 7 old hillside residential areas in Busan, this study identifies the difference of types of vacant spaces according to eacharea. Second, based upon precedent researches, this study set up 3 perspectives and 9 analysis indices to investigate the areal characteristicsof vacant space occurrence. Third, through the GIS analysis on the vacant spaces, this study tries to analyze the physical, commercial andsocial/institutional conditions of the areas in order to disclose the areal characteristics of vacant spaces occurrence. 본 연구는 우리나라 대도시에서 나타나는 노후경사주거지의 쇠퇴를 유휴공간의 발생특성을 통해 분석하고자, 부산 원도심 배후의 총 7개동 주거지역의 단독주택을 대상으로 하였다. 연구방법은 선행연구고찰, 노후경사주거지의 현황조사 및 유휴공간 유형분류, 유휴공간의 특성분석의 총 3단계로 진행하였다. 이러한 과정을 통해 노후경사주거지 유휴공간의 발생특성을 GIS 공간정보를 활용하여 지형적·입지적, 물리적 특성과, 근린과의 접근성 문제, 건축물 및 대지의 소유방식 및 사회제도적 특성으로 물리적·사회제도적 측면에서 분석하고 결론을 도출하였다.