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라텍스개질 콘크리트의 물-시멘트비에 따른 건조수축 특성
정원경,김성환,김동호,이주형,이봉학 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A
Drying shrinkage cracking which may be caused by the relatively large specific suface is a matter of grave concern for latex modified concrete(LMC) overlay and rapid-setting cement latex modified concrete(RSLMC) overlay. LMC and RSLMC were studied for field applications very actively in terms of strength and durability in Korea. However, there were no considerations in drying shrinkage. Therefore, the purpose of this dissertation was to study the drying shrinkage properties of LMC and RSLMC with the main experimental variables such as cement types(ordinary portland cement, rapid setting cement), water-cement ratios and curing days at a same controlled environment of 60% of relative humidity and 20℃ of temperature. The drying shrinkage for specimens was measured with a digital dial gauge of Demec. The test results showed that the drying shrinkage of LMC and RSLMC were considerably lower with low water-cement ratio, respectively. This might be attributed to the interlocking of hydrated cement and aggregates by a film of latex particles, water retention due to hydrophobic, and colloidal properties of the latexes resulting in reduced water evaporation.
소아 급성림프구성백혈병 환자에서 Trimethoprim-Sulfamethoxazole과 Methotrexate 병용 투여 시 약물 부작용 평가
정원경,구현준,윤정이,강진숙 한국병원약사회 2023 병원약사회지 Vol.40 No.1
Background : As maintenance therapy for pediatric acute lymphoblastic leukemia (ALL), oral methotrexate (MTX) and mercaptopurine (6-MP) are administered to prevent relapses. In addition to these anticancer drugs, oral trimethoprim-sulfamethoxazole (TMP-SMX) is usually prescribed to reduce the risk of Pneumocystis jiroveci Pneumonia. However, concomitant use of MTX and TMP-SMX may result in an increase of toxicity of MTX. As a matter of fact, a new contraindication against the use of TMP-SMX with MTX has been announced by the Ministry of Health and Welfare in December 2020. The objective of this study was to evaluate adverse drug reactions associated with concomitant use of TMP-SMX and MTX in pediatric ALL. Methods : Sixty-five patients received a maintenance therapy between January 2016 and July 2021 at Seoul St. Mary’s Hospital. Patient’s medical records and histories from the beginning to the end of maintenance therapy were reviewed retrospectively. We analyzed each patient’s basic characteristics, incidence and severity of adverse drug reactions (myelotovicity, hepatotoxicity and nephrotoxicity), methotrexate (MTX) reduction or discontinuation according to adverse drug reactions and completion of maintenance therapy. Results : Incidence rates of chemotherapy cycles that have myelotoxicity, hepatotoxicity, and nephrotoxicity were 100%, 92.3%, and 63.1%, respectively. Majority (90.9%) of these adverse events fell into grade 1 or 2. All patients completed the maintenance therapy successfully. Conclusion : Despite recently announced contraindication against concomitant use of MTX and TMP-SMX, the maintenance therapy including both MTX and TMP-SMX for pediatric ALL patients might be safe when adverse drug reactions are carefully monitored.
정원경,이영희 병원간호사회 2016 임상간호연구 Vol.22 No.3
Purpose: This study was done to develop an evidence-based external ventricular drainage (EVD) nursing practice guideline in order to provide standardized nursing and prevent EVD related complications. Methods: We used the standardized methodology for nursing practice guideline adaptation developed by Korean Hospital Nurses Association for the guideline adaptation process in this study. Results: The newly developed EVD nursing practice guideline was adapted to the American Association of Neuroscience Nurses (AANN)’s clinical practice guideline which is 'Care of the patient undergoing intra-cranial pressure monitoring/external ventricular drainage of lumbar drainage.' There were 61 recommendations documented in the preliminary guideline all evaluated by 9 experts based on acceptability and applicability. The final practice guideline was composed of 3 domains with 57 recommendations. The three domains of nursing were the insertion, maintenance, and removal of the EVD. The number of recommendations in each domain was 8 in EVD insertions, 39 in EVD maintenance, and 10 in EVD removals. Of the 57 recommendations 3.5% were level 1, 31.5% were level 2, and 65% were level 3. Conclusion: The standardized practice guideline can improve nurses' performance and accuracy. It can also be used as the foundation for effective communication between all medical staff.