경구용 장티푸스백신 Salmonella typhi 균주 Ty 21a

정성균,정대균 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.24 No.-

장티푸스를 일으키는 원인 균은 Samonella typhi이다. 이 장티푸스균은 1880년 Eberth(Germanier, 1972)에 의해 환자의 장간 림프절 (mesenteric lymph nodes)에서 처음으로 발견되었으며, 1884년 Gaffky에 의해 처음으로 분리되었다. Samonella typhi는 그람음성의 운동성이 있는 박테리아로 장내세균과(Enterobacteriaceae) 군에 속한다. 이 균은 발효를 할 수 있다는 점과 3가지 종류의 표면 항원 구조에 의해 다른 Salmolnella 종과는 구별되어진다. 3가지 항원은 H, O, Vi으로 H 항원은 flagellar 구조를 하고 있다. O항원의 특이성은 세포벽의 lipopolysaccharide를 구성하고 있는 다당류의 당 성분에 기인한다. O 항원이 결여된 Salmonella는 이 항원을 가진 균에 비해 훨씬 덜 독성을 가지기 때문에 O 항원은 Salmonella가 병원성이 되게 하는데 중요한 요소이다. Vi 항원은 Enterobacteriaceae 중 소수만이 함유하는 가장 바깥의 다당류 층을 구성한다. S. typhi의 Vi 항원은 N-acetylgalactosaminuronic acid로만 구성된 homopolymer이다. Vi 항원은 생쥐에서의 병원성과 연관되어 있고 S. typhi 면역성을 부여하기도 한다. 그러나 사람에서도 Vi가 독성을 유발하는지는 분명치 않다.

경구용 장티푸스백신 Salmonella typhi 균주 Ty 21a

정성균,정대균 경희대학교 생명자원과학연구원 2005 생명자원과학연구원 연구논문집 Vol.24 No.-

MgO와 I.M이 크링카 품질과 색도에 미치는 영향(냉각 조건에 따른 검토)

정성균 한국시멘트협회 1978 시멘트 심포지움 Vol.6 No.-

Analysis of Cracks Emanating from a Circular Hole in[0<SUB>n</SUB>/90<SUB>m</SUB>]<SUB>s</SUB> Laminates under Uniform Stress

정성균,홍창선 한국항공우주학회 1988 한국항공우주학회 학술발표회 논문집 Vol.- No.-

직교이방성 무한평판 내부의 두 원공사이에 존재하는 균열의 해석

정성균,홍창선,Cheong, S.K.,Hong, C.S. 대한기계학회 1993 대한기계학회논문집 Vol.17 No.7

This paper investigates the problem of a crack approaching two circular holes in an orthotropic infinite plate. The stress intensity factors were obtained by using the modified mapping-collocation method. The present results show excellent agreement with existing solutions for a crack approaching two circular holes in an isotropic infinite plate. In the numerical examples, various types of cross-ply laminated composites were considered. To investigate the effect of orthotropy and geometry(d/R and a/(d-R)) on crack tip singularity, stress intensity factors were considered as functions of the normalized crack length. It is expected that the modified mapping-collocation method can be applied to the analysis of various kinds of cracks existing around the stress-concentration region of composite laminate.

쇼트피닝 가공한 평기어의 피로특성

정성균,정동건,박충식,김태형,이재헌 서울産業大學校 2002 논문집 Vol.53 No.1

In this paper, the effect of shot peening on the fatigue characteristics have been investigated. Two types of specimens were used to obtain the experimental results. One type of specimen was made by machining and heat-treating SCM415 steel. The other type of specimen was made by machining, heat-treating, and shot peening SCM415 steel. The hydraulic testing machine was used to do the fatigue test (R=0.1, 10Hz). The experimental results show that the fatigue life and strength of shot peened gear were largely improved compared with the unpeened gear.

고 $C_3A$ 시멘트 특성 및 제조 가능성 검토

정성균 한국시멘트협회 1977 시멘트 Vol.66 No.-

석회석과 고로수재 slag을 1.6 : 1로 혼합 분쇄한 원료를 1,450$^{\circ}C$에서 소결하여 고$C_3A$ clinker를 얻었다. 이 clinker 중에는 $C_3S$ 40$\%$, $C_2S$ 31$\%$, $C_3A$ 22$\%$, $C_4AF$ 2$\%$를 함유하고 있으며 보통 크링카 보다 $C_3A$ 함량이 2$\~$3배 정도 높고, clinker 색은 연두색을 띄는 것이 특색이다. 이와 같이 $C_3A$ 함량이 높은 시멘트의 특성 및 제조 가능성을 검토한 결과는 다음과 같다. 1) 석회석과 slag를 1.6 : 1(61.5$\%$ : 38.5$\%$)로 사용할 경우 보통 시멘트 제조시 석회석 사용량 보다 약 28$\%$ 정도 절감되나 고품위의 석회석이 요구된다. 2) 동일 free CaO 0.4$\%$를 기준으로 소성할 경우 고$C_3A$ clinker가 보통 clinker 보다 소성 시간이 20분 단축된다. 3) carbonate 분해열을 비교하면 고$C_3A$ 시멘트 원료가 보통 시멘트 원료보다 116Kcal/$\cal{kg}$-cl 절감된다. 4) $C_3A$ 함량이 높아 가소성이 저하되고 표준연도의 시멘트 paste를 얻기 위하여서는 보통 시멘트 보다 많은 물량이 요구되며 응결시간도 빠르다. 5) Blaine 3,000$cm^3$/g으로 분쇄한 고$C_3A$ 시멘트의 3 일강도는 보통 시멘트 보다 40$\~$50$\cal{kg}$/$cm^3$ 더 높으나 28 일 강도는 다소 저하되는 경향이며 Blaine 5,000$cm^2$/g으로 분쇄한 고$C_3A$ 시멘트는 조강 시멘트와 같은 강도 수준이다.

부직포를 삽입한 Graphite/Epoxy 복합재료의 충격 특성

정성균,서유원,이승환 한국결정학회 1998 韓國結晶學會誌 Vol.9 No.2

본 논문에서는 부직포를 삽입한 Gr/Ep 복합재료의 충격 흡수 특성을 연구하였다. 계면(interface) 층에 유리 부직포 또는 탄소 부직포를 삽입하여 복합적층판을 제작하였다. 저속충격 시험을 수행하였으며, 충격에 의한 층간분리(delamination)를 C-Scan과 현미경을 사용하여 관찰하였다. 실험결과 계면에 부직포를 삽입함으로써 충격에 의한 층간분리 면적이 감소함을 알 수 있었다.

B형 간염바이러스 항원 preS 및 S부위가 안정적으로 발현되는 CHO세포주 선별

정성균,한만덕,정대균 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

In order to develop vaccines against HBV, 10 different plasmids expressing various regions of hepatitis B surface antigen (HBsAg) were constructed, first. Then, CHO cells were transfected with the plasmids and examined their HBsAg expression levels. We then established CHO transfectants expressing dhfr and HBsAg using pIEsp2878-dhfr plasmid and treated them with methotrexate (MTX). Finally, we selected IY-CHO-2 and IY-CHO-11 cell lines showing the amplified expression of HBsAg containing pre-S2 and S region. These cell lines expressed expected correct size (about 1 kb in lengte) of HBsAg mRNA.

65세 이상 고령환자에서 TLIF 시행 후 발생한 합병증 분석

정성균,김경태,김영백 대한척추신경외과학회 2010 Neurospine Vol.7 No.3

Objective: The purpose of this study was to analyze the surgical complications of transforaminal lumbar interbody fusion (TLIF) with pedicle screw fixation(PSF) in elderly patients. Methods: A retrospective analysis of 210 patients who underwent TLIF & PSF was performed via the paraspinal transmus- cular route from January 2004 to October 2007. Forty-one patients aged 65 years or more at the time of operation (Group 1) and 169 patients under the age of 65 years(Group 2) were involved in this study. Intraoperative and postoperative complications were investigated. Results: The series included 94 men and 116 women. The mean age of the patients at the time of operation was 70.9± 5.4 years in Group 1 and 49.3±9.5 years in Group 2. The minimum follow-up period was 24 months, and the mean follow- up period was 40.7±11.5 months. In Group 1, intraoperative complication occurred in 3 patients(7.3%; dural tear), and postoperative complications were postoperative delirium(5 patients, 12.2%), acute myocardial infarction(2 patient, 4.9%), transient ischemic attack(2 patient, 4.9%), spondylodiscitis(3 patients, 7.3%), adjacent segment disease(7 patients, 17.1%) and pedicle screw loosening(4 patients, 9.8%). In Group 2, intraoperative complication occurred in 3 patients(1.8%; dural tear), and postoperative complications were postoperative delirium(3 patients, 1.8%), acute myocardial infarction(1 patient, 0.6%), transient ischemic attack(1 patient, 0.6%), spondylodiscitis(4 patients, 2.4%), adjacent segment disease(4 patients, 2.4%), pedicle screw fracture(5 patients, 3.0%) and pedicle screw loosening(2 patients, 1.2%). Among various complica- tions, dural tear, postoperative delirium, spondylodiscitis, adjacent segment disease and pedicle screw loosening were statistically more frequent in the elderly patients. Conclusion: As the TLIF and PSF procedures yielded a relatively high complication rate in elderly patients, delicate intrao- perative and postoperative care is needed. Objective: The purpose of this study was to analyze the surgical complications of transforaminal lumbar interbody fusion (TLIF) with pedicle screw fixation(PSF) in elderly patients. Methods: A retrospective analysis of 210 patients who underwent TLIF & PSF was performed via the paraspinal transmus- cular route from January 2004 to October 2007. Forty-one patients aged 65 years or more at the time of operation (Group 1) and 169 patients under the age of 65 years(Group 2) were involved in this study. Intraoperative and postoperative complications were investigated. Results: The series included 94 men and 116 women. The mean age of the patients at the time of operation was 70.9± 5.4 years in Group 1 and 49.3±9.5 years in Group 2. The minimum follow-up period was 24 months, and the mean follow- up period was 40.7±11.5 months. In Group 1, intraoperative complication occurred in 3 patients(7.3%; dural tear), and postoperative complications were postoperative delirium(5 patients, 12.2%), acute myocardial infarction(2 patient, 4.9%), transient ischemic attack(2 patient, 4.9%), spondylodiscitis(3 patients, 7.3%), adjacent segment disease(7 patients, 17.1%) and pedicle screw loosening(4 patients, 9.8%). In Group 2, intraoperative complication occurred in 3 patients(1.8%; dural tear), and postoperative complications were postoperative delirium(3 patients, 1.8%), acute myocardial infarction(1 patient, 0.6%), transient ischemic attack(1 patient, 0.6%), spondylodiscitis(4 patients, 2.4%), adjacent segment disease(4 patients, 2.4%), pedicle screw fracture(5 patients, 3.0%) and pedicle screw loosening(2 patients, 1.2%). Among various complica- tions, dural tear, postoperative delirium, spondylodiscitis, adjacent segment disease and pedicle screw loosening were statistically more frequent in the elderly patients. Conclusion: As the TLIF and PSF procedures yielded a relatively high complication rate in elderly patients, delicate intrao- perative and postoperative care is needed.