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Streptococcus dysgalactiae subspecies dysgalactiae와 Herpes Simplex Virus에 의한 신생아 수막염 1예
임지예,박윤선,김민성,김기환,김상용,정승연 대한소아감염학회 2019 Pediatric Infection and Vaccine Vol.26 No.3
Streptococcus dysgalactiae has two main subspecies: S. dysgalactiae subsp. equisimilis (SDSE) and S. dysgalactiae subsp. dysgalactiae (SDSD). SDSE often colonizes and causes infections in humans; however, SDSD is an animal pathogen which often causes pyogenic infection in domestic animals. We present a case of meningitis with SDSD and herpes simplex virus in a 22-day-old newborn baby who had no exposure to animals. Streptococcus dysgalactiae subsp. dysgalactiae (SDSD)에 의한 사람 감염병을 보고한 사례가 많지 않으며, S. dysgalactiae subsp. equisimilis (SDSE)에 의한 감염병이 대부분이다. 저자들은 생후 22일 된 신생아에서 SDSD와 단순포진 바이러스의 동시감염에 의한 수막염을 경험하였으며, 뇌경색 및 경막하삼출 등이 합병되어 총 4주간의 항균제를 투여하고 치료를 완료하였다. 본 증례의 원인 균주가 소아의 침습감염의 원인으로 알려진 바가 없으나, 오염된 동물을 통한 감염 뿐 아니라, 돌발 감염의 원인균이 될 수 있을 것으로 생각되어 1예를 보고하는 바이다.
β-carotene regulates the murine liver microenvironment of a metastatic neuroblastoma
임지예,김유리,김유선 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.4
Background: The anticarcinogenic effects of β-carotene (BC) have been well-characterized. However, the effect of BC on the microenvironment of a tumor remains to be investigated, especially since normal tissue proximal to a tumor has been shown to play a critical role in cancer progression and metastasis. For young children, neuroblastoma (NB) is the most common extracranial solid cancer diagnosed. Therefore, in the present study, effect of BC on the murine liver microenvironment of a metastatic NB was evaluated. Methods: Using a mouse model, three experimental groups were established: control mice, mice receiving an injection of SK-N-BE(2)C cells (TC), and mice receiving an injection of SK-N-BE(2)C cells plus 2 mg/kg BC twice a week (BC). Eight weeks after the injection of tumor, liver tissues were collected from all three groups, with the TC and BC tissues collected proximal to the metastatic NBs. Results: Compared to control tissues, BC tissues exhibited lower levels of proliferation, apoptosis, and metastasis. Assays for these processes included the detection of lower levels of proliferating cell nuclear antigen (PCNA), Bax, MMP2, and MMP9. In addition, higher levels of Bcl-2 were detected. Fewer cells undergoing an epithelial mesenchymal transition (EMT) were also observed in the BC group. Furthermore, BC tissues were associated with reduced expression of cancer stem cell marker, delta-like 1 homologue (DLK1), lower levels of VEGF mRNA and fewer CD31-positive cells. Finally, The antioxidant capability of the tumor microenvironment for the BC group was enhanced with higher expression levels of glutathione peroxidase (GPX), catalase, and manganese superoxide (MnSOD) detected. Conclusion: These data suggest that BC affects the microenvironment of a tumor, and this enhances the anti-cancer effects of BC.
어린이 영양지수를 이용한 아동의 식행동 특성 평가 - 서울지역 일부 초등학생을 중심으로 -
임지예,김정현,민성희,이명희,이민준,Lim, Ji Ye,Kim, Jung Hyun,Min, Sung Hee,Lee, Myung Hee,Lee, Min June 한국식품조리과학회 2016 한국식품조리과학회지 Vol.32 No.1
This study investigated the food behavior and nutritional status of children using the Nutrition Quotient (NQ). The subjects for this study were 974 students and their parents who lived in Seocho-gu, Gwanak-gu, and Dongjak-gu, Seoul. The average NQ score of the subjects was 68.3, which was a medium grade. The mean scores for balance and moderation were above the thresholds, whereas the mean scores for diversity, regularity, and practice did not reach the thresholds. According to the results of evaluation by NQ, the subjects may have insufficient intake of calcium, iron, potassium, zinc, vitamin A, and vitamin C. NQ and NQ factors were different according to the general characteristics and home background characteristics of the subjects. The mean scores for the moderation factor was significantly lower as the eating out frequency increased (p<0.001). The mean scores for balance, moderation, and regularity factors were significantly higher, with higher parents educational level. It is necessary to choose diverse side dishes, vegetables and also foods with balanced nutrition when eating out.
연구논문 : 서울지역 일부 초등학생의 식이효능감과 아동의 특성 및 어머니 양육효능감과의 관련성 연구
임지예 ( Ji Ye Lim ),민성희 ( Sung Hee Min ),이민준 ( Min June Lee ) 한국식생활문화학회 2015 韓國食生活文化學會誌 Vol.30 No.6
The purpose of this study was to determine the relationship between children’s dietary self-efficacy, general characteristics and mother’s parenting self-efficacy among elementary school students. Mother’s parenting self-efficacy was significantly higher as parents’ educational levels increased (p<0.001), as family monthly income level increased (p<0.001), and when father’s job was professional or managing work (p<0.001). Children’s dietary self-efficacy was meaningfully higher when parents’ educational levels were higher (p<0.01), and family income level was higher (p<0.01). Mother’s parenting selfefficacy showed a correlation with children’s dietary self-efficacy (p<0.001). All factors comprising parenting self-efficacy, such as ‘general parenting self-efficacy’ (p<0.001), ‘healthy parenting self-efficacy’ (p<0.001), ‘communication parenting self-efficacy’ (p<0.001), ‘educational parenting self-efficacy’ (p<0.001), and ‘control parenting self-efficacy’ (p<0.001) showed correlation with children’s dietary self-efficacy. It is suggested that in order to improve children’s dietary self-efficacy and mothers’ parenting self-efficacy, families, schools, and communities must put forth a concerted effort. By complementing existing nutritional programs focusing on nutritional knowledge, one can develop a education program and social support to enhance children’s dietary self-efficacy and mothers’ parenting self-efficacy.
탈미네랄화된 골분/히알루론산을 이용한 조직공학적 지지체의 제조 및 특성분석
임지예 ( Ji Ye Lim ),김순희 ( Soon Hee Kim ),소정원 ( Jeong Won So ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.3
Demineralized bone particle(DBP) that affects to cell proliferation and differentiation has been used to clinical trial as natural material. hyalunonic acid(HA) called natural moisturizer can be used as biomaterials. In this study, we tried to design and characterize novel DBP-HA sponge. DBP-HA sponge were prepared by freeze-drying method after addition of 1 wt% HA solution into fabricated DBP sponge. Sponge was crosslinked with 1-ethyl-(3- 3-dimethyl aminopropyl) carbodiimide hydrochloride(EDC) solution with 50 mM concentration for 24 hrs and lyophilized. We seeded cells in DBP-HA sponge. Cellular attachment was assayed by 3-(4,5-dimethylthiazole-2-yl)- 2,5-diphenyltertazolium-bromide(MTT) test. DBP-HA sponges were characterized by scanning electron microscopy, fourier transeform infrared spectrometer and water ubsorption ability. We demonstrated presence of HA in DBP-HA sponge from C-O functional group observed by the FT-IR analysis. Moreover, we confirmed high water uptake ability and high cell viability in DBP-HA sponge. Therefore, we could expect that DBP-HA scaffolds are applicable for the tissue regeneration.