치주질환에 대한 한의치료의 환자성과, 연구 가능성, 예비 효과, 안전성 및 경제성 평가를 위한 예비 연구 프로토콜

이지윤,한경선 대한한방안이비인후피부과학회 2024 한방안이비인후피부과학회지 Vol.37 No.2

Objectives : The purpose of this study is to assess the feasibility of conducting a study on traditional Korean medicine treatments for periodontal diseases, specifically gingivitis and mild periodontitis. Methods : This study will employ a randomized, controlled, parallel-group design. Subjects with gingivitis and mild periodontitis will be recruited in one university hospital. In total, 45 subjects will be randomized into three arms (Acupuncture therapy group, herbal mouthwash group and usual care group), and will be followed up for 4 weeks. We will assess clinical variables such as, pocket depth, bleeding on probing, gingival index, plaque index, visual analog scale, uroqol-5 dimensions-5 levels to analyze changes in microbial flora before and after the intervention. Results : The protocol for this study was approved by the Institutional Review Board (IRB) of Dongguk University Ilsan Oriental Medicine Hospital, and registered with the Korean Clinical Trial Registry on March 29, 2024. Conclusions : This study is the first clinical research on periodontal diseases conducted in a Korean traditional medicine institution. The research aims to broaden the scope of traditional Korean medicine and is expected to serve as crucial data for future large-scale studies.

애매모호한 브랜드 네임이 소비자의 제품선호도에 미치는 영향 - 태그라인 및 조절초점의 상호작용효과를 중심으로 -

이지윤,박지환 한국브랜드디자인학회 2014 브랜드디자인학연구 Vol.12 No.2

본 연구는 브랜드 네임의 유형과 제품의 태그라인 유형 및 소비자 조절초점간 상호작용효과가 소비자의 제품 선호도에 미치는 영향을 살펴보고자 하였다. 이를 위해 총 두 차례에 걸쳐 실험을 실시하였다. 1차 실험에서는 89명의 여대생들을 대상으로 2(브랜드 네임의 유형: 애매모호한 브랜드 vs. 명확한 브랜드)×2(태그라인의 유형: 적당 불일치 vs. 일치) 완전요인 설계(Between-Subjects Full Factorial Design)를 사용하여 설문조사를 실시하였고, 2차에서는 대학생 153명(남=53명, 여=100명)을 대상으로 2(브랜드 네임의 유형: 애매모호한 브랜드 vs. 명확한 브랜드)×2(태그라인의 유형: 적당 불일치 vs. 일치)×2(조절초점: 향상 vs. 예방) 완전요인 설계로 설문을 실시하였다. 본 연구의 분석결과를 요약하면 다음과 같다. 첫째, 제품 선호도에 대한 브랜드 네임의 유형과 태그라인 유형의 상호작용효과 분석결과, 일치한 태그라인의 경우 브랜드 네임의 유형에 따라 제품 선호도에 차이가 없는 것으로 나타난 반면, 적당 불일치한 태그라인일 때는 소비자가 명확한 브랜드 네임보다 애매모호한 브랜드 네임에서 제품을 더 선호하는 것으로 나타났다. 둘째, 소비자의 제품 선호도에 대한 브랜드 네임의 유형과 조절초점의 상호작용효과 분석결과, 예방초점 소비자는 브랜드 네임의 유형에 따라 제품선호도에 차이가 없는 것으로 나타난 반면, 향상초점 소비자는 명확한 브랜드 네임보다 애매모호한 브랜드 네임에서 제품 선호도가 더 높게 나타났다. 마지막으로 본 연구의 시사점과 한계점 및 향후 연구를 위한 제언을 제시하였다. This study aims to investigate the interaction between brand name's type and taglines and regulatory focus on consumer's product preference. The results of this study are summarized as follows. First, the results of examining the effects of the interaction between tagline types(moderately incongruous vs. congruous) and brand name types(ambiguous brand vs. common descriptive brand) showed that, with moderately incongruous taglines, consumers' product preference was greater for ambiguous brand names than for common descriptive brand names, whereas with congruous taglines, there was no significant difference among brand name types. Second, the results of examining the effects of the interaction between brand name types and regulatory focus(promotion vs. prevention) showed that the product preference of consumers with promotion focus was greater for ambiguous brand names than for common descriptive brand names. On the other hand, in the case of consumers with prevention focus, there was no significant difference in their preference according to brand name types. Theoretical and practical implications of these findings are discussed. Also, limitations of this study and future directions are addressed.

전통 노리개에 사용된 보석의 현대적 변용 연구

이지윤,정양희 한국귀금속보석학회 2013 한국귀금속보석학회지 Vol.7 No.4

인류의 역사와 함께 성장해온 장신구는 단순히 몸을 아름답게 치장하기 위해서 뿐 아니라 자신의 사회적 지위와 신분을 나타내기 위해서 또는 간절한 염원이나 신앙을 담은 도구로 사용되었다. 그렇기 때문에 장신구에는 그 민족의 미의식과 생활관, 문화, 사회성이 내재되어 있다고 해도 과언이 아니다. 선사시대, 삼국시대를 지나면서 우리 선조들은 화려하면서도 다양한 종류의 장신구들을 제작ㆍ착용하였다. 특히 조선시대에는 노리개, 떨잠, 비녀 등의 장신구가 발전하였고 금ㆍ은 등의 금속류와 함께 옥, 산호, 호박 등의 보패류를 사용하여 장신구를 제작하였다. 궁중 왕실에서부터 평민에게까지 전 계층의 여인네들이 즐겨 착용했던 전통 장신구는 외국의 복식ㆍ장식문화의 유입과 함께 큰 변화를 겪게 된다. 즉, 일상에서 늘 착용하던 장신구에서 박물관 전시물, TV사극 속 소품 그리고 장인들의 재연품으로 그 의미가 바뀌게 되었다. 또한 맹목적인 서구형 장신구의 제작과 사용은 우리 고유의 독창성이 담긴 전통 장신구의 발전을 저해하는 요소가 되고 있다. 현대 장신구의 특징은 독특한 재료와 제작기법을 사용하여 제작자와 착용자간의 소통과 착용자의 개성과 미적 감각을 보여주는 수단으로 인식되어 하나의 예술분야로 자리잡고 있는 것이다. 본 연구에서는 전통 장신구 중 노리개를 응용하여 개성과 감성을 중시하는 현대적 장신구로의 변용 가능성과 활용방안을 제시하고자 한다. 노리개는 여성의 가슴을 장식한다는 점에서 현대 여성들이 즐겨 착용하는 브로치, 목걸이와 그 용도가 유사하여 현대적 변용의 활용도가 높을 것으로 간주된다. 또한 노리개에 사용된 보석을 살펴봄으로써 그 속에 담긴 의미와 조형성을 현대 장신구에 접목시켜 장신구 제작 시 보석선택의 폭을 넓힐 수 있는 계기를 마련하고자 한다.

T Lymphocyte Development and Activation in Humanized Mouse Model

이지윤,한아름,이동율 한국발생생물학회 2019 발생과 생식 Vol.23 No.2

Humanized mice, containing engrafted human cells and tissues, are emerging as an important in vivo platform for studying human diseases. Since the development of Nod scid gamma (NSG) mice bearing mutations in the IL-2 receptor gamma chain, many investigators have used NSG mice engrafted with human hematopoietic stem cells (HSCs) to generate functional human immune systems in vivo, results in high efficacy of human cell engraftment. The development of NSG mice has allowed significant advances to be made in studies on several human diseases, including cancer and graft-versus-hostdisease (GVHD), and in regenerative medicine. Based on the human HSC transplantation, organ transplantation including thymus and liver in the renal capsule has been performed. Also, immune reconstruction of cells, of the lymphoid as well as myeloid lineages, has been partly accomplished. However, crosstalk between pluripotent stem cell derived therapeutic cells with human leukocyte antigen (HLA) mis/matched types and immune CD3 T cells have not been fully addressed. To overcome this hurdle, human major histocompatibility complex (MHC) molecules, not mouse MHC molecules, are required to generate functional T cells in a humanized mouse model. Here, we briefly summarize characteristics of the humanized mouse model, focusing on development of CD3 T cells with MHC molecules. We also highlight the necessity of the humanized mouse model for the treatment of various human diseases.

기업 ESG활동이 내부종사원의 조직결속과 조직시민행동에 미치는 효과에 관한 연구

이지윤,왕의니,김재영,안대천 한국유통경영학회 2022 유통경영학회지 Vol.25 No.5

Purpose: Drawing upon the recent findings and theories in CSR research, this study intends to test the effects of corporate ESG activities on organizational commitment of employees and their organizational citizenship behavior. Specifically, the effects of employees’ perceptions of the three dimensions for ESG activities, environmental protection, social responsibility practices, and governance on their affective, calculative, and normative commitment and the resulting effects on organizational citizenship behavior were examined. Research design, data, and methodology: Measurement items were measured using a Likert-type 5-point scale based on previous studies. An online survey was conducted in a large firm and 300 samples were used for the final analysis. Reliability test and confirmatory factor analysis were performed for research validity and reliability. Results: The results show that a firm’s environmental protection activities significantly influence all the three dimensions of organizational commitment. It was also found that social responsibility practices have a positive effect on calculative commitment and governance have a positive effect on normative commitment. Additionally, Affective and calculative commitment were found to have positive effects on corporate citizenship behavior. On the other hand, it was found that normative commitment had no significant effect on corporate citizenship behavior. Implications: These findings have theoretical implications in that it newly highlights the potential effects of ESG activities on employees’ organizational commitment and, moreover, multi-dimensional nature of organizational commitment may better explain the differential effects of ESG activities on employees’ corporate citizenship behavior. The significant role of affective commitment in explaining the relationship between ESG activities and corporate citizenship behavior may add new theoretical implications, too. Practically, the study findings suggest that managers need to pay attention to the different role of organizational commitment in augmenting the internal marketing effects of their own ESG activities.

Changes in Urinary MDA and 8-OHdG Concentrations due to Wearing Personal Protective Equipment and Performing Protective Behaviors among Agricultural Workers in Korea

이지윤,지경희,김보경,박석환,김판기 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.6

Objectives: Oxidative stress and DNA damage have been proposed as mechanisms linking pesticide exposure to health effects such as cancer and neurological diseases. We investigated whether protective measures could significantly reduce the levels of biomarkers for oxidative stress and DNA damage in agricultural workers. Methods: In the present study, the levels of malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8OHdG), biomarkers related to oxidative stress and DNA damage, respectively, were analyzed in urine samples collected from agricultural workers in two provinces of Korea (n=60). The influence of wearing personal protective equipment (PPE) and performing protective behaviors on the levels of these two biomarkers was also evaluated. Results: The median urinary levels of MDA and 8-OHdG were 10.45 nmol/mg creatinine and 14.42 ng/mg creatinine in subjects living in region A, while they were 6.25 nmol/mg creatinine and 24.77 ng/mg creatinine in subjects living in region B, respectively. The levels of MDA and 8-OHdG were higher in male farmers. Farmers wearing greater numbers of PPE and performing more protective behaviors had significantly lower levels of MDA. Greater numbers of protective behaviors was significantly associated with lower levels of 8-OHdG. Conclusion: The results of the present study indicate that pesticide exposure could induce oxidative stress and DNA damage in agricultural workers, and that protective measures are important for mitigating pesticide exposure.

포타슘 이온 하이브리드 슈퍼커패시터를 위한 커피 폐기물 유래 계층형 다공 전극재 개발

이지윤,황종국 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

한아름2호 × 운광 재조합 집단을 이용한 수량 관련 형질 QTLs 분석

이지윤,강주원,조준현,이종희,여운상,송유천,박동수,고종민 한국육종학회 2019 한국육종학회지 Vol.51 No.4

The rice recombinant inbred lines derived from Hanareum2 and Unkwang (HURILs) cross were used in genetic mapping and QTL analysis studies using the inclusive composite interval mapping (ICIM) method. In this study, we constructed the genetic map using 241 SNP markers based on the SNPs in the whole genome region between these varieties. As a result, the total genetic distance and average distances were 1,142 cM and 4.7 cM, respectively. Both heading date and plant height are important traits related to grain yield in rice. Twelve heading date QTLs were detected under natural condition in Korea. A major QTL qDTH3-2 for heading date and qCL1-2 for plant height explained 25.8~27.4% and 30.8~56.9% of the phenotypic variations in the HURIL populations. Four panicle traits, grain number (GN), panicle length (PL), number of panicle per plant (NPP), grain filling ratio (GFR) were evaluated for QTL effects in HURILs population during two years. Results showed that a total of twelve QTLs for GN, PL, NPP, and GFR were detected on chromosome 2, 3, 4, 6, 7, 8. A major QTL qGNP4 for GN was detected in HURIL populations with LOD score 7.7-19.3 and explained 6.7-17.69% of phenotypic variations. Twenty-five QTLs for the four traits TGW, GL, GW, and GT were identified in the HURIL populations for two years (2014~2015). The three QTLs, qTGW8, qGL8-2, and qGW8-2, shared the same interval between id8007093 and id8007764 on chromosome 8 with explained 4.8-4.1%, 4.2-6.8%, and 5.3-10.5% of phenotypic variations, respectively. Furthermore, two QTLs, qTGW3-2 and qGL3-2, were detected in the same chromosomal interval at the same position. These findings will benefit breeding design for development of high yielding variety in rice.

여름철 천수만 해수에서 담수 대량 방류에 따른 영양염, 유기물 및 미량금속의 변화

이지윤,최만식,송윤호,LEE, JI-YOON,CHOI, MAN-SIK,SONG, YUNHO 한국해양학회 2019 바다 Vol.24 No.4

여름철 인공호수(간월호, 부남호)로 부터의 담수방류시 천수만 수질(영양염, 유기물, 미량금속)에 미치는 영향을 평가하기 위해 2011년 6, 7, 8, 10월에 평상시와 담수방류 시기 각 2회씩의 해수를 채취하였다. 담수가 방류되면 용존 무기 질소(DIN)의 농도가 만내의 모든 수층에서 약 3-4배 증가하였고, 평상시 암모니아성 질소(NH₄⁺-N)가 우세하다가 담수방류시 질산성 질소(NO₃^--N)가 우세하였다. 용존 무기인(DIP)의 경우 내만 표층에서 절반으로 감소하였고 저층에서는 1.5배 증가하였으며 규산염(Si(OH)₄)은 내만 저층에서 2배 증가하는 모습을 보였다. Redfield ratio는 담수 방류시 인 제한 환경으로 바뀌었다. 용존 유기 탄소(DOC) 및 질소(DON)는 약 2배 증가하였고, 입자상 유기 탄소(POC), 질소(PON), 인(POP) 및 생물기원 규소(Bio-SiO₂)는 내만 표층에서 약 2배 이상 증가했다. 용존 금속(Fe, Co, Ni, Cu)은 내만의 표층에서 증가하였으나, 용존 Cd의 경우 만의 표층에서 절반으로 감소하였다. 이와 같은 결과로 미루어 볼 때 영양염, 유기물 및 금속 농도가 높은 인공호수의 물이 만으로 유입되면, 천수만 내의 영양염 및 용존 유기물, 금속농도가 증가하고, 식물플랑크톤 대증식이 발생하여 표층에서 산소 과포화, 저층에서 빈산소를 발생시킨다. 빈산소와 함께 내만의 저층에서는 매우 높은 농도의 영양염(DIN, DIP, Si(OH)₄) 농도가 존재하였다. 수질 평가 지수값을 통해 천수만의 부영양화 정도를 평가한 결과, 평상시에는 3등급 이하로 나타나다가 방류시 5등급으로 바뀌게 됨을 알 수 있었다. When the fresh water from the artificial lakes (Ganwolho and Bunamho) were discharged to Cheonsu Bay in summer to prevent the flood over the reclaimed farmland near the lakes, the impact on water qualities (nutrients, organic matters, trace metals) within the bay was investigated through four surveys (June, July, August and October, 2011). Dissolved inorganic nitrogen (DIN) increased about as much as 3-4 times over the whole water column when the freshwater was discharged. And the main species composition of DIN changed from ammonia to nitrate. Dissolved inorganic phosphorus (DIP) decreased as much as 2 times in surface waters, but increased as much as 1.5 times in deep waters, and also silicate concentrations increased as much as 3-4 times in deep waters of the inner bay. The N/P ratios in Chunsu bay seawaters were much higher (2 to 7 times) than the Redfield ratio when the freshwaters were discharged, which indicated the phosphorus limiting in the phytoplankton growth. Dissolved organic carbon (DOC) and nitrogen (DON) increased as much as about 2 times. In addition, particulate organic matters (POC, PON, POP, Bio-Si) increased as much as above 2 times in the surface waters of the inner bay. Trace metals (Fe, Mn, Co, Ni, Cu) increased in the surface waters of the inner bay, but dissolved Cd concentrations decreased as much as 2 times. Therefore, when the contaminated fresh waters from the artificial lakes were discharged into the bay, nutrients, organic matters and trace metals generally increased compared to normal period. Since the phytoplankton bloom occurred in the surface waters of the inner bay, dissolved oxygens at the surface waters were oversaturated and hence hypoxic in the deep waters. Highly enriched nutrients concentrations were found in deep waters of the inner bay, which was accompanied with the hypoxic condition. Finally, the water quality in the inner bay of the Chunsu bay was deteriorated from less than grade 3 in normal periods to grade 5 when the freshwaters from the artificial lakes were discharged in summer.

상업가로경관의 시각적 정보량이 선호도에 미치는 영향 분석 - 컴퓨터 비전 기법을 활용하여

이지윤,박진아 한국도시설계학회 2020 도시설계 : 한국도시설계학회지 Vol.21 No.4

The aim of this study is to find out the visual complexity perception of the streetscape and preferences from street users and to compare the relationship between computer-measured visual complexity to see if a computer can represent a person’s perception. Previous studies about visual complexity have the problem of being arbitrary in defining ‘visual complexity’, so this study attempted to overcome the limitations of previous studies using computer-based mechanical measurement. The results of this study are as follows: First, the relationship between two measurement methods was found to be consistent. As a result, we saw the possibility that computers could represent human perception. Second, as the complexity of the streetscape has increased, people’s preferences have risen and then peaked at medium complexity and then lowered again. Therefore, in order to derive the highest preference of street users, it is important to plan the elevation of the building by selecting the appropriate complexity. 본 연구의 목적은 가로 이용자의 입장에서 경관에 대한 시각적 복잡성 인식과 그에 따른 선호도에 대해 알아보고, 컴퓨터로 측정한 시각적 정보량과의 비교를 통해 컴퓨터가 사람의 인식을 대변할 수 있는지를 알아봄에 있다. 기존의 시각적 복잡성과 관련한 연구들은 ‘시각적 복잡성’을 정의함에 있어 자의적이라는 문제를 가지고 있어 본 연구는 컴퓨터를 이용한 기계측정방식을 사용함으로써 선행연구들의 한계를 극복하고자 하였다. 분석 결과 첫째, 설문을 통한 선호도-복잡성의 관계와 기계측정을 통한 선호도-정보량의 관계가 일치하는 것으로 나타났으며, 이를 통해 컴퓨터 비전 방법론이 사람의 인식을 대변할 수 있다는 가능성을 보았다. 둘째, 가로경관의 정보량이 올라감에 따라 사람들의 선호도가 높아졌다가 중간 정보량에서 정점을 찍고다시 낮아지는 현상을 보였다. 따라서 가로 이용자의 가장 높은 선호도를 이끌어내기 위해서는경관계획을 함에 있어 적절한 시각적 정보량을 선정해 건물 입면계획을 하는 것이 중요하다.