http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Prediction of Perineural Invasion and Its Prognostic Value in Patients with Prostate Cancer
이준택,이승수,윤창진,전병주,김정만,하홍구,이완,정문기 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.11
Purpose: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer. Materials and Methods: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion. Results: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p= 0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726). Conclusions: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer. Purpose: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer. Materials and Methods: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion. Results: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p= 0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726). Conclusions: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer.
원격진료(Telecare)의 안전한 서비스를 위한 “정보보호기술”에 관한 고찰
이준택 한국산업보안연구학회 2014 한국산업보안연구 Vol.4 No.1
네트워크의 활용 범위가 의료 기관 내에서의 보험청구 처리나 전자차트에 머 물지 않고 지역에서의 의료 기관 간의 네트워크의 구축까지 확대되면, 의료기관 내에서의 관계자뿐만이 아니라 외부의 행정기관이나 환자의 이용도 상정할 필요 가 있다. 여러 입장의 사용자가, 안심하고 안전하게 이용할 수 있는 네트워크 환 경을 고려할 때 제일 첫째 조건으로서 제시되는 명제는 보안일 것이다. 이에 따 라 본 논문에서는 원격진료의 안전한 서비스를 위한 기존의 정보보호기술에 대 한 심도 깊은 고찰을 수행하였다. Once the application range of the network is expended to build a network of medical facilities in the region in stead of staying in insurance claims processing or electronic chart in the medical institution, external use of government agencies and patients as well as officials in the medical institutions should be assumed. The first proposition would be security considering the network environment multiple positions of users can safely use. Thereby, in this paper we performed a deep discussion about the existing information security technologies for secure services of Telecare.
Study of the Neutron Sensitivity for the Double Gap RPC of the CMS/LHC by Using GEANT4
이준택,M Jamil,홍병식,D.G. Koo,이경세,심광숙,박성근,S.J Hong,이석재,남순권,S.Y. Bahk,Y.J. Kim,Y.U. Kim 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I
GEANT is a toolkit for simulating the passage of particles though matter. It contains a complete range of functionality, including tracking, geometry, physics models, and hits. In this article, an attempt to use a GEANT4 Monte Carlo code to watch the resistive plate chamber’s (RPC) response to neutrons is presented. The simulation calculations for the RPC have been evaluated as a function of neutron energy in the range 1 × 10.10 MeV . 10 GeV. In order to evaluate the response of the RPC detector in the large hadron collider (LHC) background environment, we have taken into account the neutron energy spectrum expected in the compact muon solenoid (CMS) muon barrel. A hit rate due to neutrons of about 0.5 Hz/cm2 has been estimated for a 20 × 20 cm2 RPC in the MB1 station.