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이완,이병도,이강규,고광준 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.1
Purpose: This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. Materials and Methods: The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. Results: The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. Conclusion: These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow. Purpose: This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. Materials and Methods: The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. Results: The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. Conclusion: These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.
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CCD 디지털 방사선사진촬영법의 초기 치아우식증의 진단능 평가에 대한 연구
이완,이병도,Lee Wan,Lee Byung-Do 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.1
Purpose : The purpose of this experiment was to evaluate the diagnostic ability of a CCD-based digital system (CDX-2000HQ) in the detection of incipient dental caries. Materials and Methods : 93 extracted human teeth with sound proximal surfaces and interproximal artificial cavities were radiographed using 4 imaging methods. Automatically processed No.2 Insight film (Eastman Kodak Co., U.S.A.) was used for conventional radiography, scanned images of conventional radiograms for indirect digital radiography were used. For the direct digital radiography, the CDX-2000HQ CCD system (Biomedisys Co. Korea) was used. The subtraction images were made from two direct digital images by Sunny program in the CDX-2000HQ system. Two radiologists and three endodontists examined the presence of lesions using a five-point confidence scale and compared the diagnostic ability by ROC (Receiver Operating Characteristic) analysis and one way ANOV A test. Results: The mean ROC areas of conventional radiography, indirect digital radiography, direct digital radiography, and digital subtraction radiography were 0.9093, 0.9102, 0.9184, and 0.9056, respectively. The diagnostic ability of direct digital radiography was better than the other imaging modalities, but there were no statistical differences among these imaging modalities (p > 0.05). Coclusion : These results indicate that new CCD-based digital systems (CDX-2000HQ) have the potential to serve as an alternative to conventional radiography in the detection of incipient dental caries.
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이완,Hyo-Im Choi,Mi-Jin Kim,박승윤 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the car-cinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not been fuly investigated. To elucidate the asso-ciation of cellular mtDNA content and drug resistance, a marked decrease in cellular mtDNA and ATP content, concomitant with a lack of mRNAs encoded by mtDNA. The mtDNA-depleted cels showed a decreased sensi-tivity and accumulation of anti-cancer drugs, sugest-ing that mtDNA depletion could develop multidrug re-sistance (MDR) phenotype in HCT-8 cells. We found that the expression level of MDR1 mRNA and its trans-lated product P-glycoprotein was increased in the sensitivity and accumulation of anti-cancer drug in the mtDNA-depleted cells might be due to a substantial in-crease in the expression of P-glycoprotein. Further-more, increased expression of MDR1 mRNA and P-gly-coprotein was due to an increase of mRNA stability rather than transcriptional activation. Taken together, these results indicate that mtDNA depletion can induce an increased P-glycoprotein expression via an in-crease of mRNA stability and suggest that the mtDNA depletion in cancer cells plays an important role in the induction of MDR phenotype.
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CCD 디지털 방사선사진촬영법의 초기 치아우식증의 진단능 평가에 대한 연구
이완,신민,이병도 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.2
This study is to evaluate the diagnostic ability of CCD-based digital system(CDX-2000HQ) compared with conventional radiography in the detection of incipient dental caries. The author have taken radiography 93 extracted human teeth with sound proximal surfaces and interproximal artificial cavities. We took a different images using 4 another methods. No. 2 Insight film(Eastman Kodak Co., U.S.A.) were used and automatically processed for conventional radiography. Each films were digitized into a 810×600 pixel×8 bit depth matrix(530 dpi) with a Epson GT-9600 scanner for indirect digital radiography. The CDX-2000HQ system(Biomedisys Co. Korea) were prepared as CCD-based digital radiography. The CCD sensor located perpendicular to the central beam of an X-ray source using specific device and then we took a direct digital image of teeth. The subtraction images were made from two direct digital images by Sunny program in the CDX-2000HQ system. Two radiologists and three endodontists examined the presence of lesions using a five-point confidence scale and compared the diagnostic ability of conventional radiography, indirect digital radiography, direct digital radiography, and digital subtraction radiography. We analyzed the data by ROC(Receiver Operating Characteristic) analysis and one way ANOVA. The obtained results were followed; 1. The mean ROC areas of conventional radiography, indirect digital radiography, direct digital radiography and digital subtraction radiography were 0.9093, 0.9102, 0.9184, and 0.9056, respectively. 2. Diagnostic ability of direct digital radiography was higher than other imaging modalities. But there were no statistically differences among imaging modalities(p>0.05). This results indicated that new CCD-based digital system(CDX-2000HQ??) has the potential possibility as an alternative of conventional radiography in the detection of incipient dental caries.
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