갑상샘눈병증 환자의 안와감압술에서 2차원 안와 전산화 단층촬영의 4가지 parameter의 유용성

이종석,이화,장민욱,백세현,이태수,Jong Suk Lee,Hwa Lee,Min Wook Chang,Sehyun Baek,Tae Soo Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.9

Purpose: To present easily measurable 2D orbit computed tomography (CT) reference data that can be used in a preoperative study for orbital decompression and classification of individual orbital morphologies. Methods: The study sample was composed of 77 patients with orbital contusion (42 Asian males + 35 Asian females = 154 orbits) who visited the emergency room of the Korea University Guro Hospital from September 2012 to June 2013. Patients with orbital wall fracture, retrobulbar hemorrhage, or eyeball rupture were excluded. Medical records including 2D orbit or facial bone CT were retrospectively reviewed and 4 orbital parameters (orbital length, OL; globe length, GL; GL/OL ratio and 2D cone angle) were measured. Results: The average OL was 42.53 ± 2.46 mm (35.63-49.09 mm) and average GL was 24.83 ± 1.09 mm (22.75-28.13 mm). The average GL/OL ratio using these 2 parameters was 0.59 ± 0.04 (0.50-0.68). The posterior cone angle was on average, 45.96 ± 5.91° (29.35-60.04°). Conclusions: Simple measurement of 4 parameters using 2D orbit CT and classification of Asian individual orbital morphology may help in the choice of the most effective surgical technique for decompression surgery in thyroid eye disease patients. J Korean Ophthalmol Soc 2014;55(9):1267-1271

온수양생을 이용한 초고강도 콘크리트의 강도 조기 추정에 관한 실험적 연구

이종석,명로언,공민호,백민수,이영도,정상진,Lee, Jong-Seok,Myung, Ro-Oun,Gong, Min-Ho,Paik, Min-Su,Lee, Young-Do,Jung, Sang-Jin 대한건축학회 2011 대한건축학회논문집 Vol.27 No.5

In this study, prediction of later-age compressive strength of ultra-high strength concrete, based on the accelerated strength of concrete cured in hot water was investigated. Comparing other acceleration method, hot water curing method is relatively easy and intuitive to use in the real construction site. The amount of time for evaluation of the concrete strength using the hot water curing method in KS and JIS is too long to predict the strength of the ultra-high strength concrete that are used in the tall building structure. For that reason, curing temperature of 40, 50, $60^{\circ}C$ 3 levels were examined to shorten the amount of time for the evaluation of the strength. When curing in warm water, different strength characteristics are verified from the experiment. In case of F3 substituting 30% fly ash in combination, because of the curing temperature sensitivity of fly ash, differences of strength expression velocity was verified according to the curing temperature at the same age. In case of B4 substituting 40% ground granulated blast furnace slag, there were no big strength expression velocity differences of the specimen cured in 3 different level of curing temperature(40, 50, $60^{\circ}C$). The results show reliable accuracy by regression relation between 28day strength cured by standard curing method and accelerated strength of concrete cured in warm water.(y=1x-0.0002 $R^2$=0.9866) As a result, the feasibility of 3day-prediction was confirmed using warm water curing method with accelerated strength of concrete cured for three days in warm water.

포스터 발표 - 생물공학분과 / 펄프 , 제지 , 피혁분과 / 유지 , 계면활성제분과 / 접착제 , 도료 잉크분과 / 정밀화학분과 : 피혁 제조 공정에서 바이오테크 처리방법의 적용에 관한 연구

이종석,서교택,김영채,문세기 ( J . S . Lee,G . T . Seo,Y . C . Kim,S . K . Moon ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1990 No.3

약침용(藥鍼用) 봉독액(蜂毒液)의 국소독성시험(局所毒性試驗)에 관(關)한 연구(硏究)

이종석,고형균,김창환,Lee, Jong-Seok,Koh, Hyung-Kyun,Kim, Chang-Hwan 대한한의학회 1995 대한한의학회지 Vol.16 No.1

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

악성 말초신경막 종양의 치료와 생존율

이종석,전대근,조완형,이수용,오정문,김진욱,Lee, Jong-Seok,Jeon, Dae-Geun,Cho, Wan-Hyung,Lee, Soo-Yong,Oh, Jung-Moon,Kim, Jin-Wook 대한근골격종양학회 2003 대한골관절종양학회지 Vol.9 No.2

Purpose: We analyzed our malignant peripheral nerve sheath tumor (MPNST) cases to find out their oncologic results following by each treatment modalities. Materials and Methods: Thirty four patients with MPNST were registered in Korea Cancer Center Hospital from Feb. 1986 to Nov. 1996. Seventeen cases were male and 17, female. Average age was 41 years (range 18 to 74). Location of the tumor was as follows; 17 in lower extremity, 11 upper extremity, 4 trunk, and 2 retroperitoneum. Following the AJC classification, stage IA were 2 cases, stage IIA 2, stage IIB 6, stage III 16 and stage IV 8. Twenty six patients took operations and adjuvant chemotherapy and/or radiation therapy, 3 operation only and 3 adjuvant chemotherapy or radiation therapy. Average follow up period was 33.5 months (5.6 to 146.1). Kaplan-Meiyer method was done for survival curve, and log rank test for comparison analysis. Results: Fourteen cases were continuous disease free, 2 no evidence of disease, 2 alive with disease and 14 dead of disease states at final follow up. Actual 5-year and 10-year survival rates were 53.5%, 35.7%. Local recurrence rate after operation was 24.1%. 5-year survival rates of stage I/II/III were 100/85.7/55.9% and 2-year survival rate of stage IV was 14.3% (p=0.04). In 21 cases operated with stage II-III, wide margin (15cases) had 76.0% 5-year survival rate, and marginal or intralesional marigin (6cases) had 40.0%. The actual 5-year survival rate of the group which were done 4 or more cycles chemotherapy (8cases) was 71.4% and the actual 3-year survival rate less than 4cycles chemotherapy (6cases) was 83.3% (p=0.96). In 19 cases operated with stage II-III and which had no radiotherapy, marginal or intralesional margin (5cases) had 3 cases of local recurrences (60.0%), though wide margin (14cases) had 4 cases recurrences (28.6%). There was no local recurrence in 8cases which had pre-or post-operative radiotherapy. Conclusions: Surgical margin is an important factor in local recurrence. Resection margin has a tendency to influence the survival despite insufficient statistical significance. Conventional chemotherapy has no defnite statistical sigficance in the effect on local control and survival. Preoperative and postoperative radiotherapy has some positive effect on local control. 서론: 악성 말초 신경막 종양(Malignant peripheral nerve sheath tumor, MPNST)에 대하여 수술, 항암제 투여, 방사선 치료 등을 시행하고 이에 따른 종양학적 결과를 분석하여 보다 합리적인 치료 방법을 알아보고자 하였다. 재료 및 방법: 1986년 2월부터 1996년 11월까지 본원에 등록된 MPNST 환자 34례를 대상으로 하였다. 남자가 17례, 여자가 17례였고 평균연령은 41세(18세~74세)였다. 종양의 위치는 하지가 17례, 상지 11례, 체간부 4례, 후복막 2례였다. AJC(American Joint Committee on Cancer) 분류에 의한 종양의 병기는 stage IA가 2례, stage IIA 2례, stage IIB 6례, stage III 16례, 그리고 stage IV가 8례였다. 치료 방법으로는 26례에서 수술과 항암제 투여 그리고 때에 따라서 방사선치료를 시행하였고 3례에서는 수술만, 3례에서는 항암제 투여나 방사선 치료만 시행하였다. 평균 추시 기간은 33.5개월(5.6개월~141.1개월)이었다. Kaplan-Meiyer 법으로 생존율을 구하였고, log rank test로 비교 분석 하였다. 결과: 최종 추시상 질병 상태는 14례에서 CDF(continuous disease free)였고, 2례가 NED(no evidence of disease), 2례 AWD(alive with disease), 그리고 14례가 DOD(died of disease)였다. 실제(actuarial) 5년 생존율과 10년 생존율 은 53.5 %와, 35.7%였다. 수술 후의 국소 재발율은 24.1%였다. 병기별 5년 실질 생존율은 stage I이 100%, stage II 85.7%, stage III 55.9%였고 stage IV의 경우 2년 실질 생존율이 14.3%였다(p=0.04). Stage II, III에서 수술한 경우 21례에서, 광범위 이상의 절제연을 얻었던 경우가 15례로 5년 실질생존율이 76.0%였고 병소내이거나 변연부 절제연의 경우는 6례로 40.0%였다(p=0.26). 4회차 이상의 항암화학요법제를 투여한 군(8례)의 5년 실질생존율은 71.4%였고 3회차 이하의 불충분한 항암제투여를 시행한 군(6례)의 3년 실질생존율은 83.3%였다(p=0.96). Stage II, III 중 방사선 치료 없이 수술 받은 19례에서 병소내 절제나 변연부 절제를 시행했던 5례는 3례가 국소 재발하였고(60.0%) 광범위 절제를 시행한 14례는 4례가 국소 재발하였다(28.6%). 수술 전 또는 후에 방사선치료를 시행하였던 8례에서는 국소재발이한 예도 없었다. 결론: 외과적 절제연(surgical margin)이 국소 재발에는 중요한 요인이었고, 통계적으로 의미있는 수치는 아니었지만 생존율에도 영향을 주는 경향이 있는 것으로 생각된다. 기존의 항암제 투여는 국소 재발이나 생존율상에 통계적으로 의미있는 차이를 보이지 못하였다. 수술전과 수술후 시행하였던 방사선치료는 국소 재발을 줄이는데 어느 정도의 효과를 보였다.

A Concise and Rapid Approach to the Marine Natural Product Streptochlorin and its Analogues

이종석,신준호,이희승,신희재,Yeon-Ju Lee 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.2

초급성 허혈성 뇌졸중에서 관류 전산화단층촬영의 임상적 적용에 대한 연구

이종석,유병규,권대철,Lee, Jong-Seok,Yoo, Beong-Gyu,Kweon, Dae-Cheol 한국의학물리학회 2007 의학물리 Vol.18 No.3

초급성 허혈성 뇌졸중 환자를 대상으로 관류 전산화단층촬영(CT)의 임상적 적용을 평가하였다. 뇌졸중 증상 발현 62명의 환자를 대상으로 하였고, 관류 CT는 소뇌 기저부위에서 8 cm 상방으로 스캔하여 후처리 과정을 거쳐 뇌혈용적(cerebral blood volume, CBV), 뇌혈류량(cerebral blood flow, CBF), 평균 조영제 통과시간(mean transit time, MTT) 및 조영제 최고 도달시간(time to peak, TTP) 등의 네 가지 지도의 영상을 얻었다. 관류 CT의 CBV, CBF, MTT, TTP 지도에서 병변을 평가하였으며, 병변 부위와 정상측 대칭부위에서 MTT와 TTP를 측정하여 차이를 비교하였다. 관류 CT의 네 가지 지도 모두에서 관류결손을 인지할 수 있었고, 관류 결손이 인지되는 부위에서 MTT와 TTP의 현저한 지연이 있었다. 관류 CT의 MTT와 TTP영상이 초급성 허혈성 경계부위의 페넘브라를 반영하였다. 관류 CT의 네 가지 지도를 이용하면 뇌졸중의 조기 진단, 허혈 중심부, 허혈 페넘브라를 알 수 있게 되어 관류결손 부위의 혈류역동학적 평가가 가능함으로써, 허혈성 뇌졸중 환자의 진단 및 효과적인 치료를 위해 관류 CT가 유용하여 임상적 적용이 가능하다. Recent advent of 64-multidetctor (MD) CT enables more coverage of Z-axis in the perfusion imaging. The purpose of this study was to evaluate the clinical usefulness of perfusion CT by using 64-MD CT in detecting the lesion in patients with acute stroke. The perfusion CT was performed by using 64-MD CT in 62 consecutive patients who were initially suspected to have subacute ischemic stroke symptoms during the period of recent 9 months. These patients had subacute stroke (n=62). CT scanning was conducted with Jog Mode which provided 16 imaging slices with 5 mm of slice thickness, and 8 cm of coverage in Z-axis. Scan interval was 1 seconds for each imaging slice and total 15 scans were repeated. After CT scanning, perfusion maps (CBV, CBF, MTT and TTP) were created at Extended Brilliance Workstation. The CBV and CBF maps showed that lesions were smaller images. While on the MTT and TTP map lesions were seen to be larger fifty-one were large than they appeared on these images. Two slices of perfusion maps obtained at the level of the basal ganglia were chosen to simulate conventional older perfusion CT with 8 cm of coverage in Z-axis. TTP and MTT maps may be clinically useful for evaluation of the penumbral zone in cases of aubacute cerebral ischemic stroke. The perfusion CT is useful in the assessment of acute stroke as an initial imaging modality.

總流砂量의 算定을 위한 流砂濃度式의 導出

이종석,김진규,차영기,Lee, Jong-Seok,Kim, Jin-Gyu,Cha, Yeong-Gi 한국수자원학회 1996 물과 미래(한국수자원학회지) Vol.29 No.1

충적수로에서 유사량의 정량적인 산정은 초기운동개념이나 유사이송개념에 의한 방법에 기초하여 구하고 있다. 본는 연구에서는 유사이송개념에 의한 결정방법중의 하나인 회귀분석법에 의해 총유사량을 산정할 수 있는 유사농도에 관한 관계식을 유도하였다. 관계식의 유도에는 135개의 현장자료와 225개의 실험자료가 포함된 360개의 실측자료가 이용되었다. 또한 다중회귀분석법에 의한 관계식은 수심, 평균유속, 수로경사, Froude 수 및 하상재료의 중앙입경을 독립변수로 하여 유도되었다. Quantitative computation of sediment discharge in alluvial channels is conducted by the determined method based on the incipient motion or the sediment transport concept. The derived formulation of sediment concentration in this study was developed in order to compute the total sediment discharge by a regression analysis method, one of the determined methods by the sediment transport concept. The used data set in derived formulation consists of the total 360 data including 135 and 225 measured data in natural channels and experimental channels, respectively. Also, the formulation by the multiple regression analysis was composed of independent bariables of flow depth, mean velocity, channel slope, Froude number and median diameter in bed materials.

총유사량 산정을 위한 유사농도식의 도출

이종석,김진규,차영기,Lee, Jong-Seok,Kim, Jin-Gyu,Cha, Yeong-Gi 한국수자원학회 1996 물과 미래(한국수자원학회지) Vol.29 No.4

피혁 제조 공정에서 바이오테크 처리방법의 적용에 관한 연구

이종석,서교택,김영채,문세기 ( J . S . Lee,G . T . Seo,Y . C . Kim,S . K . Moon ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1997 No.0