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Effects of Antioxidant and Anticancer by Phytoestrogen in Human Breast Cancer Cells
이명선,오광석 한국엔터테인먼트산업학회 2017 한국엔터테인먼트산업학회논문지 Vol.11 No.2
Breast cancer is the most common form of cancer diagnosed in women worldwide. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. There are growing interests in the health benefits associated with consumption of fruits and vegetables, especially for the prevention of cancer, cardiovascular or other chronic diseases. Antioxidants and phytochemicals in vegetables are known to provide health benefits. Strategies that enhance these properties are expected to increase the nutritional values of vegetables. Epidemiological studies and clinical trials suggest that these health benefits are strongly associated with phytochemicals found in fruits and vegetables including phytoestrogen. However the (anti)estrogenic properties of phytoestrogens have also raised concerns since they might act as endocrine disruptors, indicating a potential to cause adverse health effects. The objective of this research is to assess the effects of antioxidant and anticancer by phytoestrogen as three different kinds of soybean, red ginseng(RG), and kudzu. Extract of these was determined to scavenge free radicals. All five extracts showed antioxidant activity at 50mg/ml of concentration. In flow cytometry assay, RG and kudzu exhibited the highest apoptotic activity(IC50: 99.3 ±6.38 and 98.9 ±4.87) in MDA-MB-231 respectively. Bisphenol A(BA) alone promoted the cell viability of MDA-MB-231 cells. On the other hand, RG and kudzu significantly suppressed BA-induced cell growth. Statistical analyses revealed RG and kudzu exhibited significantly higher (P < 0.05) cytotoxicity in MDA-MB-231 cells. These findings indicate that RG and kudzu may serve as novel therapeutic agents for breast cancer treatment and future leads for drug development.
Effects of Kadzu and Moringa on Hormone-Sensitive Human Prostate Cancer
이명선 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.2
Prostate cancer(PrCa) is a leading cause of cancer-related death in man. Medicinal plants are exploited for many drugs to treat various ailments. The drugs derived from the plants promote health, augmented the resistance of the body against disease. Pueraia lobata(wild) Ohwi(P. Lobata), kudzu, which is a twining perennial woody herb native to China, Korea, Japan, India, and the United States. Plants such as Moringa oleifera, have hypoglycemic properties and other beneficial properties. The objective of the study was to analyze the effects of kadzu and moringa, natural plant products on antioxidant activity and proliferation of the hormone-sensitive prostate cancer LNCaP cells. MTT assay, flow cytometry analysis were employed to investigate the anticancer mechanism and DPPH assay was determined to the antioxidant activity to scavenge free radicals in extract of these. All two extracts showed significantly antioxidant activity at 10 and 50mg/ml of concentration. kadzu and moringa reduced LNCaP cell viability in a dose dependent manner. Specially moringa extract was more potent cytotoxic than kadzu extract. Statistical analyses revealed kadzu and moringa exhibited significantly higher (P < 0.05) cytotoxicity and antioxidant activity in LNCaP. The finding of this study provides a scientific basis for using kadzu and moringa in future development of chemotherapeutic drugs against hormone-sensitive prostate cancer.
Evaluation of Antioxidant and Anticancer Activity of Guarana and Graviola in Human Colon Cancer
이명선 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.1
Colon cancer is the most common form of cancer diagnosis in worldwide. There are growing interests in the health benefits associated with consumption of fruits and vegetables, especially for the prevention of cancer, cardiovascular or other chronic diseases. The objective of the present study was to investigate the antioxidant and anticancer activities of natural product, guarana(GR) and graviola(GV) in human colon carcinoma HCT-116 cells. MTT assay, flow cytometry analysis were employed to investigate the anticancer mechanism and DPPH assay was determined to the antioxidant activity to scavenge free radicals in extract of these. All two extracts showed significantly antioxidant activity at 50mg/ml of concentration. GR and GV reduced HCT-116 cell proliferation in a dose dependent manner. Specially GR treatment(96.65±3.71) also significantly increased the sub-G1 population more than GV(79.58±2.87) treatment in HCT-116 at the concentration of 10mg/ml, as shown by flow cytometry assay. Statistical analyses revealed GR and GV exhibited significantly high (P < 0.05) cytotoxicity in HCT-116. These findings indicate that GN and GV may serve as novel therapeutic agents for colon cancer treatment and future leads for drug development.
Health Habits and Health Promotion Among Rural Workers in Korea
이명선,Lee, Myung-Sun 한국농촌의학.지역보건학회 1997 농촌의학·지역보건 Vol.22 No.2
창원지역 산업장 근로자의 생활습관과 건강증진의 관련성을 분석하고자 창원에 위치하는 중공업 근로자 1,374명을 대상으로 1993년 7월 7일-7월 17일까지 10일간 자기기입식 설문조사를 이용하여 조사한 결과 다음과 같은 결론을 얻었다. 1. 연령이 20세 미만이며 근무년수가 2년 미만인 근로자의 건강상태는 연령이 30세 이상이며 근무년수가 긴 근로자에 비하여 양호하지 못하였으며 이 차이는 통계학적으로 유의하였다(p<0.05). 2. 건강과 관련된 생활습관을 4~5가지 또는 6~7가지 실천하고 있는 근로자의 건강상태는 건강과 관련된 좋은 생활습관을 3가지 이하로 실천하고 있는 근로자에 비하여 양호하였고 이 차이는 통계학적으로 유의하였다(p<0.01). 3. 단계별회귀분석 결과에 의하면 건강상태는 좋은 생활습관을 더 많이 형성할수록, 연령이 높을수록, 근무년수가 길수록 건강상태가 양호하였으며 이들 변수도 근로자의 건강상태를 21.11% 설명할 수 있다($R^2$=21.11).