결합부 해석을 이용한 전기자동차 구조물의 모델링 및 최적화

이광원(K. W. Lee),이권희(K. H. Lee),박영선(Y. S. Park),박경진(K. J. Park) 한국자동차공학회 1998 한국 자동차공학회논문집 Vol.6 No.1

Currently, computational analysis is a popular technology in automobile engineering. Finite eleanalysis is an excellent method for body analysis. For finite element analysis, accurate modis very important to obtain precise information. Stick modeling is a convenient way in that it is easy and simple. When a stick model is utilized. the joints are modified in the tuning process. A tuning method for the joint has been developed. The joints are modeled by designated beam eleand the beam properties are tuned to have target values which are evaluated from ex peri ments. An optimization method called Goal Programming is employed to impose the target valWith the tuned joints, the entire optimization has been carried out. Using the Recursive Quadratic Programming algorithm, the optimization process determines the €Onfiguration of the entire structure and sizes of all the sections. For example, the structure of an electrical vehicle is modeled and analyzed by the method. The stick model works well since the structure is made of aluminium frames. Although the example handles an electrical vehicle, this method can be applied to general vehicle structures.<br/>

THP-1 Cell과 HUVEC을 이용한 Co-Culture Model System에서 최종당화산물에 의한 Cytokines와 RAGE 발현

이광원(Kwang-Won Lee),이현순(Hyun-Sun Lee) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.3

Glyceraldehyde를 이용하여 제조된 AGEs 화합물(glycer-AGEs)을 단구세포인 THP-1, 혈관내피세포인 HUVEC 및 이 두 세포가 동시에 배양된 system에서 100 ㎍/mL로 처리후 24시간까지 처리시간을 달리하여 처리하였다. 배양시간동안 각 세포와 배양액을 회수하여 TNF-α와 IL-1β의 발현을 mRNA 수준에서 조사하였다. 그 결과, THP-1의 경우 배양 2시간에서 TNF-α나 IL-1β의 mRNA 발현이 대조구에 비해 증가되었으나 혈관내피세포인 HUVEC의 경우에는 24시간 배양하는 동안 유의적인 차이가 없었다. 그러나 두세포를 동시에 배양한 system에서 혈관내피세포인 HUVEC의 경우에는 배양 4시간에서 대조구보다 TNF-α의 발현은 4.4배, IL-1β의 경우 5.5배 정도 증가되는 것을 확인할 수 있었다. TNF-α와 IL-1β의 배지 내에서의 농도를 측정해 본 결과, THP-1만 배양한 경우 대조구의 배지 내 TNF-α 함량이 배양 6시간에 98.2 pg/mL로 대조구 53.8 pg/mL보다 증가하였으며 HUVEC의 경우 배양 8시간에 93.3 pg/mL로 증가하였다. 그러나 co-culture의 경우 배양 4시간부터 증가하여 배양 8시간에 199.2 pg/mL로 증가하였다. RAGE는 TNF-α와 IL-1β의 발현 pattern과 다르게 단독 및 coculture에서 배양 16시간에 대조구에 비해 각각 1.6배, 24시간에 1.9배 증가하였다. 따라서 본 연구 결과 최종당화산물에 의해 혈관내피세포의 기능상실의 연구에 있어 coculture 조건이 유용하며, 특히 mRNA 수준에서는 4시간에, protein 수준에서는 8시간에 효능을 측정하면 유효성 있는 연구 성과를 얻을 있을 것으로 예측할 수 있었다. Although monoculture methods have been remarkably useful due to their simplicity, they have serious limitation because of the different types of cells communication with each other in many physiological situations. We demonstrated levels of markers of endothelial dysfunction such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) as well as stimulation of receptor of advanced glycation endproducts (AGEs) on monoand co-culture system such as only monocyte (THP-1) cultivation system, only endothelial cell (HUVEC) cultivation system, and co-cultivation system of THP-1 and HUVEC. The mRNA levels of TNF-α and IL-1β on HUVEC increased by the co-culture with monocyte after 4 hr at 100 ㎍/mL glyceraldehyde-AGE. The secreted protein contents into medium of TNF-α and IL-1β increased after 8 hr approximately 2~2.5 times compared to mono-cultivation. In contrast, the mRNA level of receptor of AGE (RAGE) was relatively insensitive on the co-culture system. The mediators by which monocytes activate endothelial cell have not been fully elucidated. In this study we confirmed production of soluble cytokines such as TNF-α and IL-1β by monocytes. Use of monocyte conditioned medium, which contains both cytokines, can activate endothelial cell.

견관절 재발성 전방 탈구에 대한 관절경적 술식과 관혈적 술식의 단기 및 중장기 결과 비교

이광원 ( Kwang Won Lee ),이승훈 ( Seung Hun Lee ),양동현 ( Dong Hyun Yang ),김용인 ( Yong In Kim ),최원식 ( Won Sik Choy ) 대한스포츠의학회 2007 대한스포츠의학회지 Vol.25 No.2

집단적 의사결정 수업을 적용한 학급 규칙 만들기 사례연구

이광원(Lee Kwang-Won) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.2

이 연구는 일화를 활용한 구조화된 개인-집단 의사결정 수업을 적용한 학급 규칙 만들기의 과정을 살펴보기 위한 실행연구의 과정이다. 학급 규칙 만들기는 학생자치 활동의 일환으로 학급 구성원간 협의와 실천적 참여의 과정으로 시민성 형성의 중요한 기재로 이해되고 있다. 하지만 전통적 학급 규칙 제정과정은 일반적으로 교사의 제안과 학생들의 수용 형태로 이루어짐으로 인해 많은 부분에서 학생자치 활동이나 시민성 형성과 등치시킬 수 없는 한계를 지니고 있다. 이에 본 연구에서는 학급 규칙 만들기 과정에서 학습자의 숙의과정과 집단적 의사결정 과정의 적용을 통해 공동체 문제해결을 시도하고자 2018년 9월부터 11월까지 약 12주간 사례연구과정을 운영하였다. 이러한 과정은 학습자의 시민성 형성을 경험할 수 있는 하나의 수단이 될 수 있다. 이를 구체화하기 위해 첫째, 학급 규칙의 제정과정이 학생자치 활동과 학습자 민주시민성 향상과 밀접한 관련이 있음을 살펴본다. 둘째, 학급 규칙 제정과정에서 경험하게 되는 반성적 통찰을 토대로 실행한 집단적 의사결정 수업의 적용과정과 학급 규칙 만들기 과정을 살펴본다. 셋째, 학급 규칙을 만들고 고치는 과정에서 반성적으로 경험하고 확인한 의미들을 재정리 하였다. This study is an action research process conducted to observe class rule making processs applying structured individual-then-group decision-making episodes. The establishment of school rules is understood to be the process of discussions among class members and practical participation as a part of student self-government activities. However, traditional class rule establishment processes are based on teacher-centered approaches so in many aspects they have limitations that keep them from being equivalent to student self-government activities or the formation of citizenship. At this, through the application of learner deliberation processes and group decision-making processes in class rule establishment processes, this study attempts to solve community problems. Such processes can be a way to experience the formation of citizenship of learners. This can be considered to be another way to increase the will of participation and democratic citizenship of elementary students. The case study course was run for 12 weeks from September to November 2018. To actualize this, this study consists of three parts. First, it makes observations of whether the establishment process of class rules has a close relation to student self-government activities and learner democratic citizenship enhancement. Second, it observes the application process of group decision-making episodes executed based on reflective insight that is experienced in class rule establishment processes along with class rule establishment processes. Third, it reorganizes meanings that are reflectively experienced and verified in class rule establishment and revision processes.

스포츠 손상과 비스포츠 손상에 의한 상부 관절와 순 전후방(SLAP) 병변의 비교

이광원(Kwang Won Lee),이승훈(Seung Hun Lee),양동현(Dong Hyun Yang),감병섭(Byoung Sup Kam),최원식(Won Sik Choy) 대한견주관절의학회 2007 대한견주관절학회지 Vol.10 No.2

지하생활공간에 있어서 유.출입 풍속변화에 따른 열유동 특성에 관한 실험적 연구

이광원(Lee, Gwang-Won),김영노(Kim, Young-No),정찬우(Jung, Chan-Woo),김화중(Kim, Wha-Jung) 한국화재소방학회 2007 한국화재소방학회 학술대회 논문집 Vol.2007 No.추계

軍人의 法的 性格

이광원(Lee Kwang-Weon) 한국국가법학회 2010 공법논총 Vol.6 No.1

The application of constitutionalism(“Rule of law”) is not excluded even from the area of army, and the gist of that application to the army is the ruling of military service. On this issue, there has been “Special power relation theory” or “Revisionism”. But this theory has critical defect. Because this theory suggests that the constitutionalism is not applied to the army and, in addition, basic human rights are categorically excluded from the military personnel. That is why “Special administrative legal relationship theory” emerged. But this has also much problems. According to “Special administrative legal relationship theory”, the constitutionalism is also applied to the military personnel, but the depth and length of that application is(and should be) different from that in the realm of general administrative legal territory. Nevertheless, there has been no satisfactory answer on why(and to the what extent) that different application is valid. So, this thesis is, above all, mainly focused on investigation about the ground of such different application. To this purpose, we will also research the right and obligation of military personnel. I from the present paper first made clear the ground of the special rule about the military personnel, and explained the right and the duty of the military personnel. The ground of the special rule about the military personnel is the legal character of the military personnel. The military personnel has the character of the citizen, the government employee, the national defense obligatory accomplishment person, the warfare accomplishment person, the belligerent. The military personnel who is a citizen has the basic human rights. But these rights are restricted because of national defense duty and warfare accomplishment duty. The military personnel has the right and duty of government employee. These most part are Occupational right and duty. The military personnel is supported with the form which is various. It is compensation about national defense obligatory accomplishment and warfare accomplishment. The military personnel who is a belligerent has the right which will be able to attack the enemy. The belligerent is protected in terms of the international law, when he becomes a prisoner of war. According to many kinds character of the military personnel, we will be able to classify the right and the duty of the military personnel. Also we will be able to understand those contents and limit.

Vero 세포배양을 이용한 뉴캐슬병 바이러스 생산

이광원(Kwang-Won Lee),김익환(Ik-Hwan Kim),김동일(Dong-Il Kim) 한국생물공학회 1995 KSBB Journal Vol.10 No.3

양방향 Amplify and Forward MIMO 중계 시스템을 위한 선형 필터 설계

이광원(Lee Kwang Won),이남윤(Lee Namyoon),이인규(Lee Inkyu) 한국통신학회 2009 한국통신학회 학술대회논문집 Vol.2009 No.11

국내·외 건축물 피난관련 규정 비교 및 개선방안에 관한 연구

이광원(Lee, Gwang-Won),이수호(Lee, Soo-Ho),최준호(Choi, Jun-Ho),홍원화(Hong, Won-Hwa) 대한건축학회 2014 대한건축학회 학술발표대회 논문집 Vol.34 No.2