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Relaxin을 분비하는 아데노바이러스가 피판의 생존에 미치는 영향
윤인식,박용순,전영우,전여름,이원재,윤채옥,나동균,Yun, In-Sik,Park, Yong-Sun,Cheon, Young-Woo,Jeon, Yeo-Reum,Lee, Won-Jai,Yun, Chae-Ok,Rah, Dong-Kyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.5
Purpose: Of various effects of relaxin, we assumed that anti-fibrotic effects, neovascularization effects and vasodilatation effects of relaxin might enhance the survival rate of skin flap. In the current study, we used adenovirus expressing relaxin genes to examine whether these genes could enhance the survival rate of a skin flap. Methods: A total of 30 Sprangue-Dawley rats were divided into three groups: RLX group (10; relaxin virus injected group), CTR group (10; no gene coded virus injection group), and PBS group (10; PBS injected group). Each group was intradermally injected with the virus ($10^7$ PFU) and PBS 48 hours before and immediately before the flap elevation. A distally based flap $3{\times}9\;cm$ in size was elevated on the dorsal aspect of each rat. Following this, a flap was placed in the original location and then sutured using a #4-0 Nylon. A surviving area of the flap was measured and then compared on postoperative days 3, 7 and 10. Using a laser Doppler, the amount of blood flow was measured. On postoperative day 10, tissues were harvested for histologic examination and the number of blood vessels was counted. Results: There was a significant increase in the area of the flap survival in the RLX group on postoperative days 3 and 7. The Doppler measurement also showed significantly increased blood flow immediately after the operation and on postoperative days 7 and 10. The number of blood vessels was significantly greater in the RLX group in the tissue harvested on postoperative day 10. The VEGF concentration was significantly higher in the RLX group than others in the tissues harvested on postoperative day 10. Conclusion: Following an analysis of the effects of relaxin-secreting adenovirus on the survival of a flap, the surviving area of the flap and the blood flow also increased. A histopathology also showed an increase in the number of blood vessels and the concentration of VEGF.
위상공간-주파수 영역을 고려한 레일 용접부의 결함 평가
윤인식,권성태,장영권,정우현,이찬석 한국철도학회 1999 한국철도학회논문집 Vol.2 No.2
This study proposes the analysis and evaluation method of time series ultrasonic signal using the phase space-frequency domain. Features extracted from time series signal analyze quantitatively characteristics of weld defects. For this purpose, analysis objectives in this study are features of time domain and frequency domain. Trajectory changes in the attractor indicated a substantial difference in fractal characteristics resulting from distance shifts such as parts of head and flange even though the types of defects are identified. These differences in characteristics of weld defects enables the evaluation of unique characteristics of defects in the weld zone. In quantitative fractal feature extraction, feature values of 3.848 in the case of part of head(crack) and 4.102 in the case of part of web(side hole) and 3.711 in the case of part of flange(crack) were proposed on the basis of fractal dimension. Proposed phase space-frequency domain method in this study can integrity evaluation for defect signals of rail weld zone such as side hole and crack.
골괴사를 동반한 만성 방사선 궤양의 치료를 위한 피판술
윤인식,이원재,정희선,유대현,탁관철 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.2
Purpose: While radiotherapy remains an essential part of the multidisciplinary treatment of cancers, it may cause unwanted consequences such as tissue break down and chronic non-healing wounds as a result of hypoxia, hypovascularity, and hypocellularity. The conservative treatment of osteoradionecrosis was effective only in the early stages or has a limited result. The surgical treatment of osteoradionecrosis includes various local fasciocutaneous flaps, local myocutaneous flaps and different kinds of free flaps with cancellous bone graft or alloplastic material after removal of all devitalized tissue. This study reviews recent cases of osteoradionecrosis in Severance hospital and investigates the use of various flaps for reconstruction of osteoradionecrosis.Methods: From 2000 to 2006, a total of 29 patients, nine men and twenty women with a mean age of 60.4 years were identified and included in the study. Fasciocutaneous flaps were used on 7 patients and myocutaneous flaps were used on the remaining patients. Mean follow-up period was 10.4 months.Results: In the fasciocutaneous flap group, we noted two complications including total flap failure and a partial flap necrosis. In the myocutaneous flap group, four complications were noted including a partial flap necrosis and 3 cases of wound dehiscence. Considering the complications noted in this study, the natural history of progression to flap necrosis appeared to follow the following sequence of events: marginal flap necrosis, infection, wound dehiscence, flap floating and partial flap necrosis, serially. Conclusion: Successful surgical treatment of osteoradionecrosis includes wide radical debridement and reconstruction with a well vascularized flap like myocutaneous flap or fasciocutaneous flap.
레일 용접부의 결함 검출을 위한 어트랙터의 구성 및 해석에 관한 연구
윤인식,고준빈,박성두 대한용접접합학회 2000 대한용접·접합학회지 Vol.18 No.5
This study proposes the analysis and evaluation method of time series ultrasonic signal using the attractor analysis. Features extracted from time series signal analyze quantitatively characteristics of weld defects. For this purpose, analysis objective in this study is fractal dimension and attractor quadrant feature. Trajectory changes in the attractor indicated a substantial difference in fractal characteristics resulting from distance shifts such as parts of head and flange even though the types of defects are identified. These difference in characteristics of weld defects enables the evaluation of unique characteristics of defects in the weld zone. In quantitative fractal feature extraction, feature values of 3.848 in the case of part of head(crack) and 4.102 in the case of part of web(side hole) and 3.711 in the case of part of flange(crack) were proposed on the basis of fractal dimensions. Proposed attractor analysis and DAC in this study can enhance the precision rate of ultrasonic evaluation for defect signals of rail weld zone such as side hole and crack.
윤인식,유영철,김스티브성,게리리드 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1
Many cast iron parts are welded and suffer from improper pre-heating and poor welding skills which destroy the castings due to new cracks, deformations etc. This is due mainly to the lack of understanding of the properties of cast iron. Welding, however impractical, was the only alternative for many years. Locks are used to add strength across a crack. Special drilling jigs are used to create a precise hole pattern that locks are driven into. Our locks have a unique ability to pull the sides of a crack together. Bottom locks are stacked or laminated to a depth of 80% of the casting thickness. Thicker surface locks finish off lock installation, allowing repairs in irregular shapes and contours. Installing products can be done quickly with pneumatic tools. Up to one inch of repair can be done in 5 minutes in 1/4" thick cast iron.
3차원 컴퓨터단층촬영 영상을 이용한 전두동 발달의 연구
윤인식,나동균 대한두개안면성형외과학회 2009 Archives of Craniofacial Surgery Vol.10 No.2
Purpose: Although there are many reports on the development of paranasal sinuses, few studies were performed with respect to the frontal sinus with 3D CT, especially in Korean children. In this study, we evaluated the normal development of frontal sinus in Korean children with 3D CT imaging. Methods: A total of 301 patients under the age of 20 were reviewed retrospectively. Maximal AP (anteroposterior) length, height and width were measured with the aid of computer device. The volume of frontal sinus was also evaluated. Results: At the age of more than 4, the pneumatization of frontal sinus was detected. Frontal sinus developed continuously and was observed in almost every children at the age of more than 17. The AP length, height, width and volume of frontal sinus were enlarged continuously until the age of 20. And the maximal growth of frontal sinus was observed at puberty. The width and volume of frontal sinus showed high correlation coefficient (r=0.8) relative to height or AP distance. Conclusion: The results of this study may be helpful in the comprehension of normal development of frontal sinus in Korean children.