인간 유래 폐 세포주별 담배연기 분획의 염증 반응 민감도 비교

유지혜,손형옥,박철훈,이형석,장미,현학철,신한재,Yoo, Ji-Hye,Sohn, Hyung-Ok,Park, Chul-Hoon,Lee, Hyeong-Seok,Jang, Mi,Hyun, Hak-Chul,Shin, Han-Jae 한국연초학회 2010 한국연초학회지 Vol.32 No.1

The aim of this study is to compare the sensitivity of both two NCI-H292 and A549 cell types to acute inflammatory responses induced by cigarette smoke. For this, we treated two kinds of smoke fractions derived from 2R4F reference cigarettes: total particulate matter(TPM) collected onto a Cambridge filter pad and gas/vapor phase(GVP) prepared by bubbling through in buffer solution. When we measured cellular cytotoxicity by neutral red uptake assay after treatment for 24 hours, TPM and GVP induced cytotoxic effect in a dose-dependent manner in the range of 10-$100{\mu}g$/mL and 60-$300 {\mu}g$/mL., respectively, in both cell types without any cellular difference. Additionally, when we examined acute inflammatory responses by analyzing cytokines secreted into culture media including tumor necrosis factor-$\alpha$ (TNF-$\alpha$), interleukin-8(IL-8), and transforming growth factor-$\alpha$(TGF-$\alpha$) as well as matrix metalloproteinase-1(MMP-1), the treatment with smoke fractions increased those marker proteins in a dose-dependent manner in NCI-H292. Meanwhile, in A549 cells only MMP-1 was observed to be increased in a dose-dependent fashion. Collectively, our data indicate that NCI-H292 cell type is more sensitive to cigarette smoke-induced inflammatory response than A549 cells. This suggests that NCI-H292 could be useful as an in vitro evaluation tool to assess harmful effects of cigarette smoke.

온라인 학습공동체 프로그램 참여 대학생의 자기주도학습 능력과 학습몰입의 관계에서 사회적 실재감의 매개효과

유지혜,배을규,박상오 인하대학교 교육연구소 2023 교육문화연구 Vol.29 No.6

본 연구의 목적은 코로나 이후 비대면 상황에서 학습자의 학습성과를 제고하는 방안을 모색하고자 온라인 학습공동체 프로그램 참여 대학생의 자기주도학습 능력과 학습몰입의 관계에서 사회적 실재감의 매개효과를 규명하는 것이다. 이를 위해 배을규, 이민영(2010)의 자기주도학습 능력, 김정주(2009)의 사회적 실재감, Jackson과 Marsh(1996)의 학습몰입측정 도구를 활용하여, I 대학교의 교수학습개발센터에서 2021년 1학기에 운영한 A 프로그램 참여 대학생 355명을 대상으로 설문조사를 실시하였다. 총 301부가 회수되었으며(회수율: 84.8%) 회수된 모든 응답을 유효자료로 활용하였다(100.0%). 주요 분석 결과는 다음과 같다. 첫째, 온라인 학습공동체 프로그램 참여 대학생의 자기주도학습 능력, 학습몰입,사회적 실재감은 정적인 상관관계를 갖는 것으로 나타났다. 둘째, 온라인 학습공동체 프로그램 참여 대학생의 사회적 실재감은 자기주도학습 능력과 학습몰입의 관계를 매개하는 것으로 나타났다. 상기 분석결과를 토대로 온라인 학습공동체 프로그램 참여 대학생의 자기주도학습 능력, 학습몰입, 사회적 실재감에 대한 이론적 논의와 학습몰입 증대를 위한 실천적 시사점을 제안하였다. The purpose of this article was to investigate the mediation effects of social presence between self-directed learning ability and learning flow for online learning community program participant's in colleges. For doing so, this study used a survey instrument of self-directed learning ability(Bae & Lee, 2010), social presence scale(Kim, 2009), and learning flow scale(Jackson & Marsh, 1996). Survey respondents were participants in online learning community program of I university CTL, and 301 data was used for testing hypotheses. The results of this article were the following: First, self-directed learning ability, social presence and learning flow have positive correlations. Second, social presence has mediating effects between self-directed learning ability and learning flow in online learning community program participant's in colleges. Based upon these results, several implications were then suggested for designing online learning community program. to achieve learning effectiveness

광조건별 백수오의 종자 발아 특성 및 초기생육 비교

유지혜,김철중,최재후,이기혜,임정대,유창연,이재근,김창흠,안영섭,박충범 한국약용작물학회 2013 한국약용작물학술대회 발표집 Vol.2013 No.10

기능성 소재 개발을 위한 수집종 억새의 생리활성 검정

유지혜,김철중,최재후,이기혜,임정대,허권,유창연,이재근,김희규 한국약용작물학회 2013 한국약용작물학술대회 발표집 Vol.2013 No.10

참억새의 glucose-6-phosphate isomerase gene(MsGP I )의 transient

유지혜,김희영,김남준,김철중,최재후,이기혜,김시우,박해일,유창연,성은수,이재근,김희규 한국약용작물학회 2014 한국약용작물학술대회 발표집 Vol.2014 No.05

A Study on the Preference of the Contents of Female Users of MMORPG Game–Focusing on the female players of Final Fantasy 14

유지혜,이재영 (사)한국컴퓨터게임학회 2019 한국컴퓨터게임학회논문지 Vol.32 No.2

Recently, the development of Internet culture and digital games are rapidly developing. As a result, platform changes such as PC, video game and smartphone are taking place, and the genre of digital game has also been much subdivided and become a culture for men and women to enjoy. Among other things, multi-player online role-playing games (MMORPG) have grown significantly, and the number of users has skyrocketed. This multi-user online role-playing game (MMORPG) is the most familiar platform, PC platform, where millions of people can meet and play games together in virtual space, and it is best for communication and relationships, such as meeting each other in virtual space and fighting with each other and communicating with each other with a purpose of friendship. In the past, it used to be violent, sensational, meeting the needs of male users, and being the sole object of male users who looked at it from their perspective. Recently, however, the number of female users has steadily increased, with their own culture in MMORPG virtual space. Female users want to study female users' preference for MMORPG game content, which is mainly attributed to male users, regarding which content they prefer and what they want to gain by enjoying it.

한말 신규식의 실업 활동 양상과 의미

유지혜 서울역사편찬원 2023 서울과 역사 Vol.- No.114

This study aims to track the industrial activities of Shin Gyu-sik(1880- 1922) between 1907 and the Great Han Empire, and analyze its characteristics. Since Japan-Korea Treaty of 1905, research and activities to save the country in various ways have exploded as much as the depth of crisis felt by intellectuals. Around 1906, a series of academic societies were established in Korea, and group movements covered the country. Intellectuals also expanded their networks like a huge net by participating in various organizations rather than focusing on one organization. Intellectuals accepted the civilization theory originated in the West and pursued the universalization of civilization. The acceptance of Western production technology was recognized as a means of enlightenment for saving the country, and it became an inevitable task. Shin Gyu-sik entered Industry and activities with his military colleagues. First, with severance pay, he tried to raise capital by establishing the Hwangseong gwangeop Co. Ltd(皇城廣業株式會社) in 1907. In addition, in 1908, he translated Gajeongyanggyesinpeon (家庭養鷄新編), the book of poultry farming to suggest a plan to increase the national finances at the national level. Academically, he actively sponsored the Industrial Research Association organized by students of the Industrial Training Center and participated as the editor of the technical periodical Agency to publish the industrial magazine(工業界) from 1909. Behind the support of his research group was the support of members of the Gi-ho Education Revival Assembly(畿湖興學會). In addition, Shin Gyu-sik aimed to realize the country's industrial development by establishing various large-scale industrial companies, as well as theoretical research, lectures, and education of the Industrial Research Association. Founded for that purpose, the Daehan Industrial Society(大韓工業會) participated in the establishment of the Bunwon Ceramic Stock Company(汾院磁器株式會社) in August 1910. There were various types of people who participated in Industrial activities and gatherings. Soldiers, bureaucrats, journalists, capitalists, and artisan figures who were directly or indirectly together shared the identity of same region of origin. Among them, Shin Gyu-sik was not just for the purpose of economic profit, but was an "activist" who moved as the only way to save the country. The situation changed after the annexation of Korea and Japan. Shin Gyu-sik decided to seek asylum while working for a company and left for Shanghai, China in 1911. And another form of independence movement to save the country began again in China. 본 연구는 1907년부터 국권피탈 사이 申圭植(1880~1922)의 실업 활동을 추적하고 그 특징을 분석하고자 한다. 을사늑약 이후 지식인들이 느낀 위기감의 깊이만큼 저마다 다양한 방식으로 나라를 구하려는 연구와 활동이 폭발적으로 증가하였다. 1906년을 전후로 국내에 연달아 학회들이 세워졌고 단체운동은 전국을 뒤덮었다. 지식인들 역시 하나의 단체에만 집중하기보다 여러 단체에 참가하면서 거대한 그물망처럼 네트워크를 확장해나갔다. 지식인들은 서구에서 유래된 문명 담론을 수용하고 문명의 보편화를 추구하였다. 서양 제작 기술의 수용은 殖産興業을 위해 계몽의 수단으로 인식되었고, 미룰 수 없는 시무가 되었다. 신규식은 한말 서양의 근대분과 학문을 지칭했던 實學, 實業을 배우고 익혀 국권을 수호하자는 사회 분위기에 따라 퇴직 후 육군무관학교 군인 동료들과 함께 실업 활동에 뛰어들었다. 먼저 퇴직금을 가지고 1907년 皇城廣業株式會社를 설립함으로써 자본을 모으고자 하였다. 또한 1908년 家庭養鷄新編 을 번역하여 범국민적 차원에서 국가의 재정을 늘릴 방안을 제시하였다. 학술적으로는 官立工業傳習所 학생들이 조직한 工業硏究會를 적극적으로 후원하였고, 工業月報社의 사장 겸 편집인으로서 직접 참여하여 1909년부터 잡지 工業界 를 발간하는 데 힘썼다. 그의 연구회 지지 뒤에는 畿湖興學會 구성원들의 후원이 있었다. 게다가 신규식은 공업연구회의 이론적 연구와 강연・교육에 그치지 않고 나아가 각종 대규모 공업회사를 설립함으로써 나라의 공업 발전을 현실화하려는 목적을 가졌다. 그런 목적 위에서 세워진 大韓工業會는 1910년 8월 分院磁器株式會社 설립에까지 참여하였다. 실업 활동과 모임에 함께한 사람들의 유형은 다양했다. 직간접적으로 함께한 군인, 관료, 언론인, 자본가, 공인 등은 대부분 기호 출신이라는 정체성을 공유하고 있었다. 이들 가운데서도 신규식은 단순한 경제 이윤의 목적이 아닌, 구국의 유일한 방편으로 움직인 ‘운동가(activist)’였다. 국권피탈 후 상황은 변했다. 신규식은 회사에 다니다가 망명을 결심하고 1911년 중국 상해로 떠났다. 그리고 나라를 구하기 위한 또 다른 형태의 독립운동이 중국에서 다시 시작되었다.

[Essay 1] 시간과 사람을 초대하는 놀이

유지혜 샘터사 2022 월간 샘터 Vol.623 No.-

Medical students’ satisfaction with clinical clerkship and its relationship with professional self-concept

유지혜,Su Kyung Lee,Miran Kim,Su Jin Chae,임기영,장기홍 한국의학교육학회 2019 Korean journal of medical education Vol.31 No.2

Purpose: Medical students construct their identity as a student physician through clinical clerkship. However, there is a lack of research on the effect of clinical clerkship on professional self-concept formation. The aim of this study is to analyze and ascertain the relationship between medical students’ satisfaction with clinical clerkship and professional self-concept. Methods: This investigation studied 84 third- and fourth-year medical students enrolled in the Ajou University School of Medicine and Graduate School of Medicine. Study measures tools included satisfaction with clinical clerkship and professional self-concept measurement. For data analyses, a descriptive analysis of the research variable characteristics was applied, gender differences in variables by years of medical school were analyzed with t-tests, and correlation analysis was used to check for relationships between variables. Results: We found no statistically significant differences between satisfaction with clinical clerkship with respect to medical school year and gender. While professional self-concept did not show significant differences by year of medical school, we observed statistically significant differences by gender with respect to the subscales of professional practice and communication factor. In addition, satisfaction with clinical clerkship and professional self-concept demonstrated statistically significant positive correlation. The present research was able to confirm that there exists a correlation between medical students’ clinical clerkship experience and professional self-concept formation. Conclusion: Our study outcomes shows that provision of positive assistance as a measure to enhance satisfaction with clinical clerkship via the curriculum and environmental improvement is envisaged to lead to medical students’ professional self-concept formation.

Virus-associated Rhabdomyolysis in Children

유지혜,이진아,박영서,이주훈 대한소아신장학회 2017 Childhood kidney diseases Vol.21 No.2

Purpose: Virus-associated rhabdomyolysis is very rare. We report 15 patients with rhabdomyolysis caused by various viruses. Methods: Fifteen patients who were diagnosed with rhabdomyolysis and a viral infection were included in this study. Clinical, laboratory, and radiologic findings were evaluated through retrospective chart reviews. Results: Chief complaints were severe bilateral lower leg pain and leg weakness. The median age was 5.7 years. The male:female ratio was 2:5. The viral infections were caused by influenza virus B, parainfluenza virus, and rhinovirus. One patient with influenza virus B had coinfection with coronavirus. Median initial laboratory values and ranges were as follows: serum creatinine, 0.4 (0.1-0.5) mg/dL; serum aspartate transaminase, 124 (48-1,098) IU/L; serum alanine transaminase, 30 (16- 1,455) IU/L; serum creatine kinase, 2,965 (672-16,594) IU; serum lactate dehydrogenase, 400 (269-7,394) IU/L; serum myoglobin, 644 (314-3,867) ng/mL; urine myoglobin, 3 (3-10,431) ng/mL. All patients recovered without complications. Conclusion: This is the first report of the simultaneous occurrence of rhabdomyolysis caused by various viruses. This is also the first report of rhinovirus-associated rhabdomyolysis.