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오지선,장찬호,김정상 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.1
The well-demonstrated bioefficacy of phytochemicalsin spite of their paradoxically low bioavailabilityhas long puzzled scientists. Glyceollins, a family of soyderivedphytoalexins, have been reported to exert a varietyof biological effects in vitro and in vivo systems in spite ofpoor systemic bioavailability after oral administration,suggesting that secondary messengers generated in gastrointestinaltract would transfer signals to target organsand tissues to manifest any effect. This review focuses onthe potential mechanisms of how the poorly bioavailableglyceollins could still exert in vivo biological effects.
코로나19(COVID-19)시기에 SNS 감사일기프로그램이 의료기관 종사자의 감사성향, 직무만족과 삶의 만족에 미치는 효과
오지선,김자숙,박순명,김자옥 중소기업융합학회 2022 융합정보논문지 Vol.12 No.5
Purpose: This study was done to examine the effects of the SNS Gratitude Diary Program during the COVID-19 period on grateful disposition, job satisfaction and life satisfaction of medical institution workers. Methods: The study was a nonequivalent control group pre-post test design. The participants were 58 medical institution workers of which 28 were assigned to the experimental group and 30 to the control group. Data were collected from June 3 to August 10, 2020 and analyzed using SPSS Win 18.0 version program. The intervention was conducted 5 times a week for 8 weeks. Results: There were significant differences in reported grateful disposition between the two groups. However, the issue of job satisfaction and life satisfaction were not significant. Conclusion: The SNS Gratitude Diary Program using SNS during the COVID-19 period can be utilized as an effective intervention for grateful disposition. It will be a good solution to lead successful psychological health management. 본 연구는 코로나19 시기에 SNS 감사일기프로그램이 의료기관 종사자의 감사성향, 직무만족과 삶의 만족에 미치는 효과를 확인하기 위하여 시도되었다. 실험군 28명, 대조군 30명 총 58명을 연구 대상으로 한 비동등성 대조군 전후설계 유사실험 연구이다. 데이터는 2020년 6월 3일부터 8월 10일까지 수집하였으며 실험처치는 8주간 5회/주 수행되었고 SPSS Win 18.0을 사용하여 분석하였다. SNS 감사일기프로그램 실시 후 실험군이 대조군보다 감사성향 정도는 증가하였지만 직무만족과 삶의 만족에서는 통계적으로 유의한 차이가 없었다. 이러한 연구결과는 코로나19 시기에 SNS 감사일기프로그램이 의료기관 종사자의 감사성향을 증가시키는 효과적인 중재로 활용될 수 있으며 심리적 건강관리를 위한 좋은 해결방안이 될 수 있음을 시사한다.
Affective computing 분야의 지식생산, 지식구조와 네트워킹에 관한 분석 연구
오지선,김문구,박종현,이덕희 한국감성과학회 2020 춘계학술대회 Vol.2020 No.-
경제 불안정과 고령화, 경쟁격화 및 개인 가치관의 변화 등 사회 문제가 점점 심각해질 가능성이 있다. 이러한 상황에서 감성컴퓨팅은 이를 해결가능한 방안 중 하나로써 관련 연구가 증가하고 있다. 이에 본 연구는 감성컴퓨팅 연구 키워드를 중심으로 국내 및 글로벌 연구의 지식구조와 주요 키워드, 연구생산 현황 및 국가간 협력관계 및 주요 키워드별 네트워크 등을 파악하였다. 이를 위해 전문 학술데이터 베이스(SCOPUS)로부터 해당 키워드를 중심으로 논문을 검색하였으며, 서지분석과 네트워크 분석을 실시하였다. 중국과 미국이 Affective computing분야에서 지식생산이 활발하였고, 한국은 약 10%정도로 저조한 상황이다. 주요 키워드는 affective computing을 중핵으로 주로 컴퓨팅 처리 및 감성분석, 인식을 분류하는 연구 및 사용자들의 모델링, 심리 분석이 주요 연구 키워드이다. 국가간 협력구조는 중국과 미국이 가장 큰 클러스터를 형성하고 있고, 그 외에 영국, 독일, 스위스, 스페인, 캐나다 등이 협력을 주도하고 있다. 한국의 연구협력은 다양하지 않고 연구생산도 저조한 결과를 보였다. Affective computing분야의 연구발전을 위해 미국, 중국 등 주요국과의 연구협력 강화와 연구파트너의 다양화를 위한 시사점을 결론으로 제언하였다.
Clinical Features and Outcomes of Microscopic Polyangiitis in Korea
오지선,이창근,김용길,나성수,문희범,유빈 대한의학회 2009 Journal of Korean medical science Vol.24 No.2
Microscopic polyangiitis (MPA) is a systemic vasculitis affecting small vessels. To determine the clinical features and outcomes of MPA in Korean patients, we retrospectively reviewed the medical records of patients diagnosed with MPA at a single medical center in Korea between 1989 and 2006. The 18 patients who met the Chapel Hill criteria for MPA had a mean (±SD) age at the time of diagnosis of 62.4± 12.7 yr. Renal manifestations and general symptoms were the most common features of MPA, with lung involvement also very common. Antineutrophil cytoplasmic antibodies (ANCA) were present in 17 of the 18 patients (94%). Of 17 patients treated with steroids and cyclophosphamide, 11 (65%) had stable or improved course. One patient treated with steroids without cyclophosphamide showed disease progression. Ten of the 18 patients (56%) died at a median follow-up of 8 months. MPA in Korean patients was distinguished by a higher rate of lung involvement, especially alveolar hemorrhage, which was the leading cause of death in our patients. Korean patients were also older at MPA onset and were more likely positive for ANCA. Other overall clinical manifestations did not differ significantly.
Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability
오지선,Seong Bin Jeon,이유리,이혜지,김주,권보라,유강열,차정단,황승미,최경민,정용섭 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
Red ginseng (Panax ginseng C.A. Meyer) is the most widely recognized medicinal herb due to its remedial effects in various disorders, such as cancers, diabetes, and heart problems. In this study, we investigated the anticancer effect of fermented red ginseng extract (f-RGE; provided by Jeonju Biomaterials Institute, Jeonju, South Korea) in a parallel comparison with the effect of nonfermented red ginseng extract (nf-RGE; control) on several cancer cell lines—MCF-7 breast cancer cells, HepG2 hepatocellular carcinoma cells, and reprogrammed MCF-7 cells (mimicking cancer stem cells). Cells were cultured at various concentrations of RGE (from 0.5 up to 5 mg/mL) and their viabilities and proliferative properties were examined. Our data demonstrate the following: (1) nf-RGE inhibited cell viability at ≥ 1 mg/mL for MCF-7 cells and ≥ 2 mg/mL for HepG2 cells, (2) in the presence of a carcinogenic agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), nf-RGE treatment in combination with paclitaxel synergistically decreased MCF-7 as well as HepG2 cell viability, (3) f-RGE (which contained a greater level of Rg3 content) more effectively decreased the viability of MCF-7 and HepG2 cells compared to nf-RGE, and (4) f-RGE appeared more potent for inhibiting cancerous differentiation of reprogrammed MCF-7 cells in a synergistic fashion with paclitaxel, especially in the presence of TPA, compared to nf-RGE. These findings suggest that f-RGE treatment may be more effective for decreasing cancer cell survival by inducing apoptotic cell death and also presumably for preventing cancer stem cell differentiation compared to nf-RGE.