대뇌연수척수간 차단의 1예 : "Locked-In" 증후군 The 'Locked-In' Syndrome

오세문,정희원,한대희,최길수 대한신경외과학회 1977 Journal of Korean neurosurgical society Vol.6 No.2

The 'Locked-in' syndrome, first described by Plum and Posner in 1966 as a brain stem stroke due to bilateral basis pontis infarction with limb and pseudobulbar paralysis, but with unimpaired consciousness communicating intelligently by vertical eye movement had become contradistinctive to the state of 'akinetic mutism', coined by Cairns et al in 1941, which can be described as unresponsive patients who appear to be awake but are not aware of the environment, lacking response to command but having the ability to move his extemities. Recently there has been interest in this disorder, both pathologically and clinically with regard to its anatomical location of the lesion at various levels of the brain stem and its clinical characteristics including the ocular signs, the electroencephalogram. the outcome of the disorder etc. , respectively. We have experienced a case of brain stem stroke that was compatible with the 'Locked-in' syndrome, determined by clinical evaluation alone. Postmortem examination was not granted. A brief review of the literatures is added and the difference between the 'Locked-In' syndrome and classical akinetic mutism is discussed, also stressing differentiation of the Locked-In patient from the comatose patient.

나노공정에서 SEU 및 PVT로 인한 오류에 대해 강인한 플립플롭의 설계

오세문,김진상,조원경 경희대학교 경희정보통신 SoC연구소 2008 경희정보통신SOC연구소 논문집 Vol.9 No.-

나노 공정을 적용하는 회로에 작은 대기 중의 입자의 충돌만으로도 회로 내에 일시적인 값의 변화가 얼어날 수있으며 이를 single event upset (SEU)라고 부른다. 이러한 값의 일시적인 변화는 회로의 오작동을 유발할 수 있으며 특히 값을 저장하는 플립플롭의 경우 잘못된 값을 저장할 수 있는 가능성이 많으므로 이러한 오류를 감지하고 복원하는 플립플롭의 설계가 필요하다. 기존에 연구되었던 razor 플립플롭은 병렬의 추가적인 래치로 동일한 입력을 받아 두 값을 비교함으로써 오류를 감지하는 방법이나 오류 정정을 위해서는 다음 클럭 주기 때 정정된 출력이 나가기 때문에 한 클럭 주기를 소비해야 한다. scan-chain을 재사용한 디자인의 경우 병렬의 추가 플립플롭을 이용하여 오류를 검사하고 정정하지만 공정특성의 변화가 원인이 되어 발생하는 지연 증가로 인한 입력신호 지연오류를 감지하지 못한다. TMR(triple modular redundancy)방법은 병렬의 추가 플립플롭을 두 개를 이용하여 오류 정정율을 높였지만 하드웨어의 면적이 크기 때문에 일반적인 용도로는 부적합하다 .본 논문에서 제안하는 디자인은 일반적인 시스템의 용도에 적합한 플립플롭으로 입력되는 신호를 비교하여 나노공정의 특생변화에 따른 압력 지연 오류를 감지할 수 있고 추가적인 클럭의 소비 없이 오류를 정정할 수 있다. 또한 clocked-CMOSf를 응용한 회로를 이용하여 회로 내부에서 발생한 오류를 출력단으로 전달하는 것을 방지할 수 있고 기존에 연구되었던 디자인들에 비해 적은 수의 트랜지스터가 필요하다는 장점이 있다. 65nm 공장의 HSPICE를 이용하여 제안된 플립플롭의 기능을 검증하였다.

리뷰 - 제초제 사용 40년, 수도용 제초제 생산과 잡초발생 양상(1)

오세문,O, Se-Mun 한국작물보호협회 2009 자연과 농업 Vol.247 No.-

1990년 중반이후 저항성 잡초에 대한 방제체계가 확립되지 못함에 따라 제초제의 사용량이 더욱 늘었다. 그러다가 2000년 이후부터 단위 면적당 투여량이 적은 제초제가 늘면서 유효성분 함량이 낮은 약제끼리 합제로 개발되고 있어 성분이 낮은 제초제가 많이 늘어나고 있다.

백서에서의 개두술 또는 비개두술적 방법에 의한 영구적 중대뇌동맥 폐쇄술에 관한 비교 관찰 : Evaluation of the Model With or Without Craniectomy

오세문,정병주,이종인,최선길,강성구 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.1

The purpose of our present study was to asses the effectiveness of middle cerebral artery occlusion in producing acute focal cerebral ischemia in rats by use of Bederson's or Longa's method in which occlusion was performed with or without craniectomy respectively. In twenty-nine Spraye-Dawley rats weighing 25@3OOgm, right middle cerebral artery occlusion was achieved by use of either Bederson's method or Long's method. After 4 hours of ischemia. neurological evaluation was performed and then brain water content was determined in the central. intermediate. and outer zones of each cortical mantle. In both groups, a significant neurological deficit caused by focal cerebral ischemia was observed. More severe neurological deficit was achieved by Longa's method than by Ekderson's method(p<0.001). In Bederson's method group. significant brain edema was observed only in the ischemic central and intermediate zones. However, in Longa's method group, significant brain edema was observed in all of the three ischemic zones. And more severe brain edema was achieved by Longa's method in each of three ischemic zones than by Bederson's method (p<o.OOl, respectively). Theses results incicate that Longa's metl-d is more effective and persistent method in producing acute focal cerebral ischemia than Bederson's method. Longa's method is considered as one of a good. less invasive, and technically easy method to achieve focal cerebral ischemia in rats.

대뇌병소에 병발된 급성신부전증 3예

오세문,김현집,한대희 대한신경외과학회 1977 Journal of Korean neurosurgical society Vol.6 No.1

Acute renal failure is a grave complication in patients with intracranial lesions such as severe bead injuries, intracranial hemorrhage, and space occupying lesions. Experimental and clinical data have suggested that altered renal function can be occured by lesions of the brain through a mechanism of renal vasoconstriction. Recently we experienced three cases of acute renal failure in one patient with intracerebral hematoma and two patients with cerebral contusion. So we discussed the significance of this relationship.

백서에서의 실험적 국소 뇌허혈에 의한 신경학적 이상 소견과 뇌부종에 대한 U74389G의 치료효과

오세문 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.9

In the early stage of the development of ischemic brain injury, oxygen free radical-mediated lipid peroxidation is suspected to play an important role. U74389G is considered as one of the effective scavengers of free radicals and inhibitors of lipid peroxidation. However, the cytoprotective effect of U74389G in rodent models of neocorical infarction still remains controversial. Forty-four adult Sprague-Dawley rats weighing 250-300gm were subjected to permanent or transient middle cerebral artery oc치usion(MCAO) using modified Longa's method while anesthrtized with ketamine and xylazine. In the permanent MCAO goups, the animals were subjected to 4-hours of occlusion and were treated with vehicle(control, n = 9), 3mg/kg U74389G(low-dose treatment, n = 9) or 7mg/kg U74389G(high-dose treatment, n = 10) intravenously at the time of occlusion and then half of the initial dose was administered 30 minuites after occlusion respectively. In the transient MCAO groups, the animals were subjected to 0.5 hours of occlusion and 3.5-hours of reperfusion and were treated with vehicle(control, n =8) or 3mg/kg U74389G(treatment, n = 8) intravenously at the time of occlusion and then half of the initial dose was administered at the time of reperfusion respectively. Four hours after occlusion neurological evaluation was performed and then the animals were sacrificed immediately to determine brain water content. In the rats of permanent MCAO, treatment with low and high-dose U74389G did not protect them against neurological deficit ; however, treatment with high-dose U74389G was found to reduce brain edema in the ischemic core(19%, p<0.05) and intermediate regions(23%, p<0.05). In the rats of transient MCAO, treatment with U74389G was found to protect them against neurological deficit(p<0.05) and reduce brain edema in the ischemic core region(58%, p<0.05). These results suggest that free radical-mediated lipid peroxidation plays a significant role in focal ischemic reperfusion brain injury and that 21-aminosteroids might have the potential to be a useful supplementary drug as a cerebral protective agent for the thrombolytic therapy of acute cerebral infarction.

뇌후방 순환계의 조영상

오세문,차희중,최길수,심보성 대한신경외과학회 1976 Journal of Korean neurosurgical society Vol.5 No.2

Our study was designed for two purposes. The first purpose was to evaluate the incidence of the visualization of the identifiable vessels of the posterior fossa on the vertebral angiography and its significance in the diagnosis of the supra and infratentorial lesions. The second purpose is by measuring the position of the important angiograaphic landmarks of the posterior fossa on the vertebral angiography to obtain their normal value and to investigate the correlation between the change of the position of the landmarks and the supra and infratentorial lesions. 91 cases of vertebral angiogram performed at Seoul National University Hospital from June 1974 to September i976 were reviewed. The results were as follows: 1. Generally the vessels of the injected site showed better visualization than the vessels of the opposite site on the Towne's projection and the lateral projection showed better visualization than the Towne's projection with respect to each vessel of the injected site. 2. Reflux of contrast media down the contralateral vertebral artery was seen in about 33% of cases. On the lateral projection, posterior inferior cerebellar artery, precentral cerebellar vein and inferior vermian vein showed high incidence of visualization, which were important in the diagnosis of the posterior fossa lesions. On the Towne's projection posterior choroidal artery, posterior pericallosal artery, precentral cerebellar vein, superior vermian vein and anterior pontomesencsphalic vein showed very low incidence of visualization. 3. For the better visualization of the vessels of the posterior fossa, injection with constant and high pressure, precise serialogram, subtraction and magnification techniques were needed. 4. On the lateral projection the normal value of the distance between the dorsum sellae and the basilar artery was 6.0㎜ (3.0㎜-10.0㎜), and the distance between the midpoint of the clivus and the basilar artery was 3.5㎜ (1.5㎜-10.0㎜), and the distance between the anterior rim of the Foramen Magnum and the vertebral artery was 9.5㎜ (1.0㎜-19.0㎜). In some cases of craniopharyngioma the tip of the basilar artery was displaced posteriorly and in the most cases of the space occupying- lesions of the posterior fossa the basilar artery was displaced anteriorly and compressed to the clivus. 5. On the lateral projection normal value of the distance between the choroidal point and the clivus/IOP line was 9.5㎜ (1.0㎜-19.0㎜). Normal value of the proportion of the distance between the anterior rim of the Foramen Magnum and the point on the clivus/IOP line crossed by a perpendicular line from the choroidal point to the length of the clivus/IOP line was 39% (28%-49%) and in 78% of cases within the range of 35%-43%. Generally in the most cases of the space occupying lesions of the posterior compartment of the posterior fossa the choroidal point was displaced anteriorly, and in the most cases of the space occupying lesions of the anterior compartment of the posterior fossa the choroidal point was displaced posteriorly, and in the most cases of the supratentorial space occupying lesions the choroidal point showed no change. 6. On the lateral projection distance between the copular point and the clivus/IOP line was 7.5㎜ (1.0㎜~11.5㎜). In the most cases of the space occupying lesions of the posterior fossa it was over 11. 5㎜. 7. On the Towne's view the normal position of the bifurcation point of the basilar artery was 0.3㎜ left from the midline and its normal range was 3㎜ left and right from the midline. In the most cases of the cerebellopontine angle tumors and some cases of large cerebellar hemispheric tumors the bifurcation point of the basilar artery was displaced to the opposite of the tumors. 8. On the Towne's projection the maximal width of the ambient segments of the posterior cerebral arteries was 41.0㎜(32.0㎜∼52.0㎜) and the minimal width of the quadrigeminal segments of the posterior cerebral arteries was 17.0㎜ (6.0㎜∼28.0㎜). In the cases of brain stem tumors the widths of the both ambient and quadrigeminal segments were widened, and in the most cases of posterior fossa lesions showing the upward supratentorial herniation and in the all cases of the pineal tumors the width of the quadrigeminal segments of the posterior cerebral artery was widened. 9. On the lateral projection the normal value of the distance between the C-C point and the Twining's line was 11.2㎜ (5.0㎜∼17.0㎜). The normal value of the proportion of the distance between the tuberculum sellae and the the point on the Twining's line crossed by a perpendicular line from the C-C point to the length of the Twining's line was 50% (45%∼54%) and in 76% of cases within the range of 49%∼51%. In the most cases of the pineal tumors, thalamic tumors and the tumors of the anterior compartment of the posterior fossa the C-C point was displaced posteriorly, and in the most cases of the tumors of the posterior compartment of the posterior fossa, the C-C point was displaced anteriorly. 10. On the Towne's projection the normal value of the angle between the midline and the line connecting the torcular Herophili and the copular point was 11˚(6˚∼20˚). In the most cases of the cerebellopontine angle tumors and some cases of the cerebellar hemispheric tumors the angle was closed, and in some cases of the cerebellar vermis tumors the angle was opened. 11. In the most cases of the vascular diseases of the posterior fossa the values of the measurements of the anatomical landmarks of the posterior fossa were within normal limit.

특별강연 및 학술연구 발표요지 : 외래잡초 발생 현황과 관리 대책

오세문 한국잡초학회 2007 한국잡초학회 별책(학술대회 초록집) Vol.27 No.2

무선 센서 인터페이스 모듈과 NCAP 구조의 구현

오세문,금민하,김동혁,김진상,조원경 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.12

This paper presents an implementation of the Network Capable Application Processor (NCAP) and the Wireless Transducer Interface Module (WTIM) architectures based on the new IEEE P1451.5 standard. Proposed architecture is implemented using a computer for NCAP, an FPGA board, a sensor board and two radio modules, which communicate through the ZigBee wireless communication technology between the NCAP and the WTIM based on the IEEE 1451.0 and the IEEE 1451.5 interfaces. In this paper, two experiments has been done to verify operations of proposed architecture. From the experimental results, we verify that the proposed architecture performs the wireless sensor communication functions efficiently. 본 논문은 최근 표준화가 완성된 IEEE 1451.5 표준을 적용한 네트워크 접속가능한 응용프로세서(NCAP: network capable application processor)와 무선 트랜듀서 접속 모듈(WTIM:wireless transducer interface module)의 구현에 대한 연구이다. PC와 무선통신 모듈로 구성되는 NCAP부와, FPGA, 센서 보드, 무선 통신모듈로 구성되는 WTIM 부로 구성된다. NCAP부의 구현에는 C++ 언어가 사용되었고 WTIM 구현에는 FPGA를 이용하여 Verilog-HDL이 사용되었으며 NCAP과 WTIM과의 무선통신은 Zigbee를 이용하였으며 Zigbee의 기능구현을 위하여 nesC를 이용하였다. 본 논문에서는 NCAP과 WTIM은 IEEE 1451.0와 IEEE 1451.5 표준을 통하여 서로 통신하도록 구현하였으며 표준에 근거하여 두 가지 실험을 실시하였다. 실험을 통하여 제안된 구조가 IEEE 1451.5 표준의 기능적인 부분을 효과적으로 수행하는 것을 검증하였다.

불안정 경추손상 23례의 치료후 안정성 복원에 관한 임상적 고찰

오세문,최선길 한림대학교의료원 1989 人間科學 Vol.13 No.3