Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms

신선혜 대한비만학회 2022 Journal of obesity & metabolic syndrome Vol.31 No.2

Long-chain fatty acids (LCFA) modulate metabolic, oxidative, and inflammatory responses, and the physiological effects of LCFA are determined by chain length and the degree of saturation. Adipose tissues comprise multiple cell types, and play a significant role in energy storage and expenditure. Fatty acid uptake and oxidation are the pathways through which fatty acids participate in the regulation of energy homeostasis, and their dysregulation can lead to the development of obesity and chronic obesity-related disorders, including type 2 diabetes, cardiovascular diseases, and certain types of cancer. Numerous studies have reported that many aspects of adipose tissue biology are influenced by the number and position of double bonds in LCFA, and these effects are mediated by various signaling pathways, including those regulating adipocyte differentiation (adipogenesis), thermogenesis, and inflammation in adipose tissue. This review aims to describe the underlying molecular mechanisms by which different types of LCFA influence adipose tissue metabolism, and to further clarify their relevance to metabolic dysregulation associated with obesity. A better understanding of the effects of LCFA on adipose tissue metabolism may lead to improved nutraceutical strategies to address obesity and obesity-associated diseases.

『삼국유사』 속 명절·제의와 음식

신선혜 한국불교사학회 한국불교사연구소 2023 한국불교사연구 Vol.24 No.-

The paper examines the festivals, ancestral rites, and cuisine depicted in Samgukyusa. It particularly focuses on Ogiil(烏忌日) and Jungyangil(重陽 日), exploring how these festivals initially began with ritualistic characteristics but gradually evolved and weakened, eventually settling into secular customs. The study begins by investigating the origins and food associated with the representative festival, Jungwol Daeboreum. It delves into the transformation of Ogiil into a festive event through the lens of Sagumgap(射 琴匣) in the context of Ogiil, and the evolving process of Na-ban(糯飯, glutinous rice) from a form of rice associated with Ogiil into a symbolic representation of plain and medicinal foods. While the common interpretation of Ogiil's glutinous rice is akin to contemporary medicinal food, the paper scrutinizes the documented transformation and distinguishes the differences between Na-ban, Yak-ban(藥飯), and Hyang-ban(香飯). Additionally, through the Gyeongdeokwang Chungdamsa Pyohondaeduk (景德王 忠談師 表訓大德), the paper explores the transformation of Jungyangjeol from a Buddhist ritual during the Silla era into a secular festival. It also investigates the origins of the tea ceremony(茶禮) in the ceremonial practices at Chungdamsa. Finally, by analyzing a passage from the GaRakGukGi(駕洛國記), which provides insights into the ingredients and types of food in the ancestral rites of Silla during that era, the study aims to uncover the relationship between food culture, Buddhism, and the festival of Samjinnal. The author hopes that this paper, by examining not only festival and ancestral rites but also various food-related articles in Samgukyusa, will provide a foundation for research aiming to reconstruct the dietary habits of Silla.

광양 성불사의 역사문화적 가치와 위상

신선혜 호남대학교 인문사회과학연구소 2022 인문사회과학연구 Vol.65 No.4

본고에서는 광양의 역사와 불교에 대한 관심이 환기되는 기회를 제시하기 위해 성불사가 가진 역사문화적 가치를 살피는 것뿐만 아니라 현재적 역할도 함께 고려해 보았다. 이에 먼저 성불사가 위치한 광양 및 백운산의 위치적 특징과 함께 성불사 출토유물의 역사성을 살폈다. 특히 그간의 연구와 보고들에서 사찰의 창건을 도선과의 관련성 속에서만 언급하면서 성불사의 내력을 고려 이후부터 주목하고 있지만, 위치적 특성 상 후백제와의 관련을 상정할 수 있다는 점을 살펴 역사적 가치를 드러내 보았다. 이러한 시대성은 성불사가 현재 대한불교용화종의 종지를 잇고 있다는 점과도 함께 설명될 수 있다. 용화종은 후백제를 대표하는 사상인 진표(眞表)의 미륵신앙을 계승하고 있을 뿐만 아니라 창종의 과정에서 광양 백운산과의 관련성도 찾을 수 있기 때문이다. 이는 성불사의 한국불교사 상 의미를 찾을 수 있는 대목이기도 하다. 이와 함께 백운산과 그 일대를 ‘도선’이라는 키워드로 묶어 보존과 개발의 병행이 가능함을 제안해 보았다. 이 일대는 이미 ‘도선국사마을’로 지정되어 도선에 대한 선양과 함께 농촌체험마을로 운영되고 있기도 하다. 이에 성불사를 포함한 ‘도선문화벨트’ 조성의 가능성을 궁구해 보았다. 본고를 통해 광양 불교와 함께 성불사의 역사문화적 가치와 위상이 제고되기를 기대해본다. In this paper, in order to present an opportunity to arouse interest in Gwangyang's history and Buddhism, we not only examined the historical and cultural values of Seongbulsa Temple, but also considered its current role. First, the historical characteristics of the relics excavated from the Seongbulsa Temple have been examined along with the locational characteristics of Gwangyang and Baegunsan Mountain where the Seongbulsa Temple is located. In particular, the history of the Seongbulsa Temple has been paying attention since the Goryeo Dynasty, while mentioning the establishment of the Buddhist temple in relation to Doseon in previous studies and reports, and in this paper, the characteristics of the times as a traditional Buddhist temple were revealed by examining the fact that it can be assumed to be related to the Later Baekje due to its location. This characteristic of the times can be explained together with the fact that the Seongbulsa Temple continues the main doctrine of the Yonghwa Order of Korean Buddhism. This is because the Yonghak Order not only inherits the Maitreya belief of 'Jinpyo', an ideology representing the Later Baekje but also finds relevance to Gwangyang Baegunsan Mountain in the process of founding the Order. In addition, this paper proposes that conservation and development can be done simultaneously by tying up Baegunsan Mountain and its surrounding area with the keyword of ‘Do seon.’ This area has already been designated as 'Do seon Guksa Village' and is being operated as a rural experience village along with the exaltation for 'Do seon'. In this regard, this paper has investigated the possibility of creating a ‘Do seon Cultural Belt’ including the Seongbulsa Temple. Through this paper, we look forward to enhancing the historical and cultural value and status of Seongbulsa Temple along with Gwangyang Buddhism.

지면 상태에 따른 자세 균형 유지 시 뇌파 분석

신선혜,고현,권대규 제어로봇시스템학회 2018 제어로봇시스템학회 국내학술대회 논문집 Vol.2018 No.5

F-25 Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex

신선혜,전병우,박혜윤,전경만,권오정,허희재,기창석,이남용,신성재,( Charles L. Daley ),고원중 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

M. avium complex (MAC) and M. abscessus complex (MABC) are the two most important human pathogen causing nontuberculous mycobacterial lung disease (NTM-LD). Some patients have NTM-LD caused by mixed infection with MAC and MABC. This study aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-LD caused by mixed infection with these two major NTM pathogens. Consecutive 71 patients who were diagnosed with NTM-LD caused by mixed infection with MAC and MABC between January 2010 and December 2015 were identified. Mixed NTM lung disease was defined as ≥two positive sputum cultures for each NTM pathogen, with time interval between the first isolation of each pathogen less than six months period. Mixed infection with MAC and M. massiliense (n = 47, 66%) were more common than mixed infection with MAC and M. abscessus (n = 24, 34%). Almost all patients (96%) had nodular bronchiectatic form. M. avium was frequently associated with M. massiliense, while M. intracellulare was commonly associated with M. abscessus. Among 43 (61%) patients who were treated for NTM-LD for more than 12 months, sputum culture conversion was achieved in 25% (3/12) of patients infected with MAC and M. abscessus and 61% (19/31, p = 0.033) patients infected with MAC and M. massiliense. In conclusion, NTM-LD caused by mixed infection with MAC and MABC typically developed in patients with bronchiectasis. Precise identification of etiologic NTM organisms could help predict treatment outcomes in these patients.

대중가요 가사의 문체적 특징 연구-1997∼2019년 여성 가수의 이별 노래를 중심으로

신선혜,고혜원 한국문화융합학회 2020 문화와 융합 Vol.42 No.11

This study examines the changes in women’s perception of separation by analyzing the stylistic elements of lyrics of breakup songs sung by female singers between 1997 and 2019. Since the abolition of the preliminary record review system in July 1996, the content and style of the lyrics of popular songs have shown definite differences from the lyrics before 1996. As for the research method, three songs were selected for each year from Melon Chart. Thus, a total of 69 songs were analyzed based on their final ending and adjectives used. The study concludes the following. First, final ending used Heara-style of declarative sentences in the early 2000s; exclamatory sentences were most likely to be found in the song lyrics of 2010s. Given that the Heara-style of declarative sentence and exclamatory sentence are not listener-conscious, it can be confirmed that women now are more active in expressing their feelings after the separation compared to the past. Second, from the late 1990s to the early 2000s, the usage of adjectives in separation songs’ lyrics have changed from a sorrowful sentiment and reflective tones to a positive sentiment and a critical perspective toward the opponent. These changes confirm that women have begun to recognize separation as an opportunity for a new start, rather than a sad ending. They have started adopting a critical view of their opponent and causes of the breakup. It is meaningful that this study reveals the stylistic characteristics of pop songs under the same gender and theme, thereby confirming the changes in women’s perception of separation.

제4차 교육과정기 고등학교 국사교과서의 고대사 서술 특징과 배경

신선혜 대구사학회 2019 대구사학 Vol.136 No.-

As fourth education curriculum had educational goals and ideologies that emphasize national independence and community spirit, it differs from the third education curriculum which emphasizes national identity. In addition, as the development of education courses was entrusted to the Korea Educational Development Institute which hosts several seminars and other events, willingness to capture opinions from all walks of life. Of course, the extension of the previous curriculum is also found in the fact that national history textbooks still maintained the state-authored version, and that the political intentions of the new military are included in the education content. To examine the characteristics of the fourth curriculum, this study first reviewed the curriculum and the description system of the textbook and analyzed the specific descriptions of the textbooks. As a result, a new perspective was reflected in the large framework of the period classification method and nation development theory, and changes such as Balhae chapter setting were found. This was possible due to the reorganization of textbook researchers and authors, along with the implementation of several research and seminars to revise the curriculum. In the case of Balhae's perception, the educational ideology of the regime, which emphasized national independence and a community spirit, was found to have influenced the change in the chapter setting. The reasons behind this change in the fourth textbook description were largely influenced by both domestic and abroad factors. First, challenge of pseudo history, which has been trying to reflect their arguments in textbook descriptions. They judge the existing historians have not been able to escape the influence of colonial history since the 1960s. As a result, the descriptions of Gojoseon and Han Sa-gun were inevitably affected, and the descriptions of Korea-Japan relations were also changed due to Japan's distorted history textbooks again claimed in 1982. In addition, descriptions of the relics in Jeongok-ri, the change in descriptions with the local system of Baekje and the Silla rank-system are examples that reflect the research achievements of Korean scholars in ancient history that had accumulated up to that time. As such, analyzing the fourth curriculum textbook based on ancient history is important in terms of reaction from the history and education circles to the domestic and international situations of the 1980s. 제4차 교육과정기는 민족 자주성과 공동체 의식을 강조하는 교육 목표 및 이념을 가지고 있었다는 점에서 민족주체성을 강조한 제3차 교육과정기와는 다소의 차이가 발견된다. 아울러 교육과정의 개발이 한국교육개발원에 위탁되어 여러 차례 세미나 등의 자리가 만들어짐으로써 교육 내용에 대한 각계의 의견을 담아내려는 의지가 있었던 점 역시 제4차기의 특징으로 파악할 수 있다. 물론 국사교과서의 경우 여전히 국정화 기조를 유지하였고, 신군부의 정치적 의도가 교육 내용에 포함되어 있다는 점에서는 이전 교육과정기의 연장선적 성격도 발견된다. 제4차 교육과정기 교육 내용의 특징을 살피기 위해 본고에서는 먼저 교육과정 및 교과서의 서술체제를 검토한 후 교과서의 구체적인 서술을 분석해 보았다. 그 결과 시대구분법 및 국가발달론이라는 큰 틀에 있어서 새로운 시각이 반영되었고, 발해 단원 설정의 변화 등의 특징이 발견되었다. 이는 교육과정 개정을 위한 여러 차례의 연구 및 세미나의 실시와 함께 교과서 연구진 및 집필진의 개편을 배경으로 하였고, 발해 인식의 경우 민족 자주성과 공동체 의식의 강조라는 당시 정권의 교육 이념이 단원 구성의 변화에 영향을 미쳤던 것으로 파악되었다. 이러한 제4차기 교과서 서술 변화의 배경에는 학술외적 국내외 요인이 큰 영향을 미쳤다. 먼저 1960년대 이래로 기존 역사학계가 식민사관의 영향을 벗어나지 못하고 있다는 판단 하에 교과서 서술에 그들의 주장을 반영시키고자 했던 유사역사학계의 도전을 들 수 있다. 이로 인해 고조선 및 한사군의 서술은 그 영향을 받을 수밖에 없었고, 아울러 1982년에 다시금 주장된 일본의 역사교과서 왜곡으로 인해 한-일 관계 서술 역시 변화되었다. 이밖에 전곡리 유적에 대한 서술 추가, 백제의 지방제도, 신라 골품제도 관련 서술의 변화는 당시까지 축적된 국내학계의 고대사 연구성과가 교과서 서술에 반영된 사례로 볼 수 있다. 이렇듯 제4차 교육과정과 교과서를 고대사 중심으로 분석하는 것은 1980년을 전후한 시기의 국내외적 상황에 대한 역사학계와 교육학계의 적극적 대응이라는 측면에서 중요하다고 할 수 있다.

「東京 興輪寺 金堂 十聖에 대한 再論」에 대한 토론문

신선혜 동국대학교 신라문화연구소 2014 신라문화제학술발표논문집 Vol.35 No.-

고대 전북의 해양 신앙과 불교 -부안 죽막동 제사유적을 중심으로-

신선혜 한국고대사학회 2024 한국고대사연구 Vol.- No.115

전북 서해안은 고대부터 현재에 이르기까지 한반도와 중국, 일본을 잇는 동북아시아 교류의 현장이다. 그만큼 이곳에 자리 잡았던 이들은 이른 시기부터 대외교류를 통한 발전을이뤄나갔다. 이러한 환경은 해안가를 중심으로 해양 신앙의 발달을 촉발하였는데, 그 대표적 유적지가 바로 부안 죽막동 제사유적이다. 죽막동 유적에 대해서는 현재까지 발굴된 유물의 출토 양상을 통해 시기적으로 그 특징을 짐작해볼 수 있을 뿐이었으므로, 본고에서는제사 양상의 변화를 불교, 특히 관음신앙과의 관련성 속에서 계기적으로 이해해 보았다. 먼저 죽막동 유적의 유물 출토 현황을 살펴 시기별로 양상이 다르게 나타나는 이유를해당 지역의 마한에서 백제로의 변화와 불교의 전래라는 요인 때문으로 해석하였다. 나아가6세기 중반 이후 해양 제사 비중이 더욱 축소되는 것은 불교의 전래를 넘어 백제 관음신앙의 확산이 영향을 미친 것으로 보았다. 다만 죽막동 제사의 재래신의 역할은 관음신앙의 전래 및 확산과 함께 지속되었다. 신라의 삼국통일이라는 국면 속에서 죽막동 유적은 신라의제사 체계로 편입되지 않는다. 이는 죽막동 제사를 통한 백제인들의 결속을 저지하려는 신라의 의도가 반영된 것으로, 백제 해양 신앙 체계에 대한 견제책이라 할 수 있다. 그러나 신라는 원효의 사상을 백제의 영역에 이식하면서 『법화경』적 관음신앙으로 백제 신앙 체계를포섭하고자 하기도 하였음을 알 수 있다. 이후 8~9세기에 죽막동 제사가 재개되는 것은 동해 낙산사의 해변굴과 함께 죽막동 유적의 해변굴이 관음주처지로 인식되면서 관음신앙처화됨으로써 제사가 재개된 것으로 파악하였다. 이렇듯 죽막동 유적은 마한-백제-신라의 영역에 속하면서 제사의 양상을 달리하였고, 특히 관음신앙의 확산과 변형에 의해 불교와 융합되는 모습을 보였다. The west coast of North Jeolla Province is the site of Northeast Asian exchanges connecting the Korean Peninsula, China, and Japan from ancient times to the present. As such, those who were located here have developed through foreign exchanges from an early age. This environment triggered the development of marine beliefs around the coast, and the representative site is the remains of a ritual in Jukmak-dong, Buan. Since the remains of Jukmak-dong could only be predicted from the time through the excavation of relics excavated so far, this paper tried to understand the change in the aspect of the ritual in relation to Buddhism, especially the Avalokitesvara-faith. First, by looking at the current status of the excavation of relics in Jukmak-dong, the reason why the pattern appears different by period was interpreted as the change from Mahan to Baekje in the region and the transmission of Buddhism. Furthermore, the further reduction in the proportion of marine rituals after the mid-6th century was attributed to the spread of Baekje’s Avalokitesvara-faith beyond the tradition of Buddhism. However, the role of traditional gods in the Jukmak-dong ritual continued with the transmission and spread of the Avalokitesvara-faith. In the face of Silla’s unification of the three countries, the remains of Jukmak-dong are not incorporated into the Silla ritual system. This reflects Silla’s intention to prevent the solidarity of Baekje people through Jukmak-dong rituals, and can be said to be a check on the Baekje marine faith system. However, it can be seen that Silla attempted to embrace the Baekje faith system with a Buddhist monk’s belief while transplanting Wonhyo’s thoughts into Baekje’s realm. After that, it was found that the resumption of Jukmak-dong rituals in the 8th and 9th centuries was due to the recognition of the beach cave of Naksansa Temple in the East Sea and the beach cave of the remains of Jukmak-dong as the place of Avalokitesvara’s religion. As such, it was confirmed that the remains of Jukmak-dong belonged to the realm of Mahan-Baekje-Silla and changed the aspect of the ritual, and in particular, they were fused with Buddhism by the spread and transformation of the Avalokitesvara-faith.

『삼국유사』 탑상편 「백률사」조의 종합적 검토

신선혜 동국대학교 신라문화연구소 2015 신라문화제학술발표논문집 Vol.36 No.-

In the article of ‘Baekryulsa(栢栗寺)’ containing in the fascicule of ‘Tapsangpyeon(塔像篇)’ of ‘Samkuk Yusa (三國遺事)’, there is a story of divine power of the ‘Gwaneum Statue(觀音像)’ which brought the kidnapped ‘Buryerang(夫禮郞)’ along and restored the lost Manpasikjeok(萬波息笛) and harp(Geomungo) disappeared contemporaneously. For the comprehensive understanding of this article, this study intended to find the reasons why and how the article of ‘Baekryulsa’ was inserted into the fascicule of ‘Tapsangpyeon’ of ‘Samkuk Yusa’, and thereby, the faith in Gwaneum(觀音) in the early days of its introduction was identified that it was not centered around contemporary Buddhist temples; but contrarily, the appearance of three Spots(三所)’ of the faith in Gwaneum including the ‘Baekryulsa’ during the mid-age of Silla(新羅) dynasty was identified that the faith in Gwaneum began to settle down as a faith joined with those in contemporary Buddhist temples. Besides, the faith in Gwaneum described in ‘Samkuk Yusa’ reveals varied aspects accorded with respective scriptures of Buddhism, and the faith originated by Uisang(義湘) and propagated in the region of Naksan(洛山) was interpreted that it was adopted neither by the contemporary society of Buddhists in the capital area nor by the regality in the mid-age of Silla dynasty. On the contrary, the faith in Gwaneum propagated in the capital area was based on the scripture of Beophwagyeong(法華經) which had been circulated since the Middle Ancient period of Silla dynasty by which the ‘Baekryulsa’ in the Sogeumgangsan(小金剛山) and realized the harmony with indigenous faith, was selected as one of centers of this faith. The faith in Gwaneum propagated in the area of capital with its nature to relieve the present world since the early to mid-age of Silla dynasty was centered around the ‘Baekryulsa’ and was brought to the fore under the reign of King Hyoso(孝昭). And it seems that the intention of King Hyoso was reflected in the context behind this situation in that he exploited the faith in Gwaneum of ‘Baekryulsa’ as means of the breakthrough to get over the unstable political situation. That is, it was estimated that the King Hyoso relied on the faith in Gwaneum based on the scripture of Beophwagyeong that propagated around the area of contemporary capital to gain the control over his counterforce who had another style of the faith in Gwaneum based on the scripture of Hwaeomgyeong(華嚴經) that propagated in the area of Naksan placed in the mid-East coast of Korean peninsula.