In-situ Synthesis of Poly(aniline) Within Poly(urethane-co-styrene) Films

신동현,인교진,김주영 한국공업화학회 2004 한국공업화학회 연구논문 초록집 Vol.2004 No.-

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value

신동현,이철희,박경두,김희발,조광현 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.3

Objective: Holsteins are known as the world's highest-milk producing dairy cattle. The purpose of this study was to identify genetic regions strongly associated with milk traits (milk production, fat, and protein) using Korean Holstein data. Methods: This study was performed using single nucleotide polymorphism (SNP) chip data (Illumina BovineSNP50 Beadchip) of 911 Korean Holstein individuals. We inferred each genomic estimated breeding values based on best linear unbiased prediction (BLUP) and ridge regression using BLUPF90 and R. We then performed a genome-wide association study and identified genetic regions related to milk traits. Results: We identified 9, 6, and 17 significant genetic regions related to milk production, fat and protein, respectively. These genes are newly reported in the genetic association with milk traits of Holstein. Conclusion: This study complements a recent Holstein genome-wide association studies that identified other SNPs and genes as the most significant variants. These results will help to expand the knowledge of the polygenic nature of milk production in Holsteins.

유전성비용종성대장암의 수술 전 선별검사로서 내시경조직 면역화학염색법의 유용성

신동현,장동경,김영호,이풍렬,김재준,이종철,박철근,김종원,윤성현,이우용,전호경 대한소화기학회 2006 대한소화기학회 추계학술대회 Vol.2006 No.-

항바이러스 치료를 받은 만성 C형 간염 환자에서 치료종료반응 도달 후 재발 예측 인자 분석

신동현,백승운,이소영,신수린,곽금연,최문석,이준혁,고광철,유병철 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-

Simplifi ed Estimation Method for Collective Uncertainty-Propagations of Hysteretic Energy Dissipating Device’s Properties

신동현,김형준 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.5

Hysteretic energy dissipating devices (HEDDs) have been increasingly applied to building construction to improve the seismic performance. The seismic responses of such damped structures are signifi cantly aff ected by HEDD’s structural properties. An accurate investigation on the propagation of HEDD’s structural properties is required for reasonable evaluation of the seismic performance of a structure. This study aims to develop simplifi ed methods that can estimate the collective uncertainty-propagation to the seismic response of damped structures employing HEDDs. To achieve this, three- and six-story steel moment-resisting frames were selected and the propagations of the individual HEDD’s property-uncertainties were evaluated when they are subjected to various levels of seismic demand. Based on the result of individual uncertainty-propagations, a simplifi ed method is proposed to evaluate the variation of seismic response collectively propagated by HEDD’s property-uncertainties and is verifi ed by comparing with the exact collective uncertainty-propagation calculated using the Monte Carlo simulation method. The proposed method, called as a modifi ed SRSS method in this study, is established from a conventional square root of the sum of the squares (SRSS) method with the relative contributions of the individual HEDD’s property-uncertainty propagations. This study shows that the modifi ed SRSS method provides a better estimation than the conventional SRSS method and can signifi cantly reduce computational time with reasonable accuracy compared with the Monte Carlo simulation method.

삼일열 말라리아 환자에서 발생한 비장파열 1예

신동현,김규식,김용주,이상현,김세종,조철균,신종희,양동욱,이재혁 대한감염학회 1999 감염 Vol.31 No.2

Extent of linkage disequilibrium and effective population size of Korean Yorkshire swine

신동현,Kyeong Hye Won,Sung-Hoon Kim,Yong-Min Kim 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.12

Objective: We aimed to characterize linkage disequilibrium (LD) and effective population size (Ne) in a Korean Yorkshire population using genomic data from thousands of individuals. Methods: We genotyped 2,470 Yorkshire individuals from four major Grand-Grand-Parent farms in Korea using the Illumina PorcineSNP60 version2 BeadChip, which covers >61,565 single nucleotide polymorphisms (SNPs) located across all chromosomes and mitochondria. We estimated the expected LD and inferred current Ne as well as ancestral Ne. Results: We identified 61,565 SNP from autosomes, mitochondria, and sex chromosomes and characterized the LD of the Yorkshire population, which was relatively high between closely linked markers (>0.55 at 50 kb) and declined with increasing genetic distance. The current Ne of this Korean Yorkshire population was 122.87 (106.90; 138.84), while the historical Ne of Yorkshire pigs suggests that the ancestor Ne has decreased by 99.6% over the last 10,000 generations. Conclusion: To maintain genetic diversity of a domesticated animal population, we must carefully consider appropriate breed management methods to avoid inbreeding. Although attenuated selection can affect short-term genetic gain, it is essential for maintaining the long-term genetic variability of the Korean Yorkshire population. Continuous and long-term monitoring would also be needed to maintain the pig population to avoid an unintended reduction of Ne. The best way to preserve a sustainable population is to maintain a sufficient Ne.

In silico approaches to discover the functional impact of non-synonymous single nucleotide polymorphisms in selective sweep regions of the Landrace genome

신동현,Kyung-Hye Won,Ki-Duk Song 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.12

Objective: The aim of this study was to discover the functional impact of non-synonymous single nucleotide polymorphisms (nsSNPs) that were found in selective sweep regions of the Landrace genome Methods: Whole-genome re-sequencing data were obtained from 40 pigs, including 14 Landrace, 16 Yorkshire, and 10 wild boars, which were generated with the Illumina HiSeq 2000 platform. The nsSNPs in the selective sweep regions of the Landrace genome were identified, and the impacts of these variations on protein function were predicted to reveal their potential association with traits of the Landrace breed, such as reproductive capacity. Results: Total of 53,998 nsSNPs in the mapped regions of pigs were identified, and among them, 345 nsSNPs were found in the selective sweep regions of the Landrace genome which were reported previously. The genes featuring these nsSNPs fell into various functional categories, such as reproductive capacity or growth and development during the perinatal period. The impacts of amino acid sequence changes by nsSNPs on protein function were predicted using two in silico SNP prediction algorithms, i.e., sorting intolerant from tolerant and polymorphism phenotyping v2, to reveal their potential roles in biological processes that might be associated with the reproductive capacity of the Landrace breed. Conclusion: The findings elucidated the domestication history of the Landrace breed and illustrated how Landrace domestication led to patterns of genetic variation related to superior reproductive capacity. Our novel findings will help understand the process of Landrace domestication at the genome level and provide SNPs that are informative for breeding.

효율적인 지적관리를 위한 지상경계화 방안

신동현,전방진 한국지적학회 2010 한국지적학회 학술대회 논문집 Vol.2010 No.2

우리나라의 근대적 지적제도가 도입이 된 시기는 1910년 일제에 의해 추진된 토지.임야조사사업이라 할 수 있다. 당시에 추진된 사업의 성과를 토대로 토지대장, 임야대장, 지적도 및 임야도와 같은 지적공부에 등재하고 이를 바탕으로 토지에 대한 정보를 열람하거나 등본을 발급하였다. 또한 지상의 경계점을 확인 할 수 없을 때는 지적측량을 통해 도면상의 경계를 현지에 복원시킴으로써 필지에 대한 확정력, 공정력 등과 같은 효력이 발생하게 되었다. 다시 말해 도상의 경계를 법률적으로 인정하는 도상경계를 제도적으로 채택하여 현재까지 관리.운영되고 있다. 그러나 이로 인해 점차 경계분쟁 발생건수가 증가하고 분쟁에 따라 자연히 소송건수도 함께 증가하면서 개인에게는 시간과 경제적인 피해를 입게 함은 물론 국가적인 차원에서도 국토개발이 지체되고 경쟁력 약화와 함께 생산적이지 않은 분야에 국력이 낭비되는 악순환이 계속되고 있어, 효율적인 지적관리가 매우 어려운 실정이다. 따라서 본 논문은 효율적인 지적관리를 위하여 토지경계에 대한 이론적 접근과 토지경계의 국내 운영 실태를 조사.분석하여 국내의 지적관리를 운영하는 사회적, 제도적, 법률적 현상에서 경계의 특성을 나타내는 중요성, 정확성 등의 내용을 반영한 지상경계화 방안을 제시하는데 있다.

고령화에 따른 국내 휘발유·경유 소비 변동성의 구조변화 분석: 지역별 패널자료 분석

신동현,임형우 통계청 2018 통계연구 Vol.23 No.4

This paper investigates empirically analyzed the relationship between volatility of gasoline and diesel consumption and aging in Korea. According to the results of analysis, it is confirmed that the change of income elasticity and price elasticity of gasoline and diesel consumption will cause structural change of gasoline and diesel consumption volatility. In the case of gasoline, price elasticity becomes elastic and income elasticity becomes inelastic when the aging progresses. On the other hand, if the level of aging increases, the price elasticity of diesel consumption becomes inelastic, and its income elasticity becomes elastic. Therefore, if the level of aging increases, the price policy that causes changes in the fuel price of gasoline should be avoided in terms of stabilizing the energy consumption volatility of the entire transportation sector. 본 연구는 지역별·연도별 패널자료를 이용하여 국내 휘발유·경유 소비의 변동성에 대한 고령화의 효과를 분석하였다. 임계패널회귀모형에 따른 분석결과에 의하면, 고령화가 진행됨에 따라 휘발유 소비는 가격에 대해 탄력적으로, 소득에 대해서는 비탄력적으로 바뀌었다. 또한, 경유 소비는 가격에 대해 비탄력적으로, 소득에 대해서는 탄력적으로 변하였다. 그러므로 고령 사회에서 소득변화로 인한 충격이 발생하면 휘발유 소비의 변동성 증가는 예상보다 작고, 경유 소비의 변동성은 더 확대할 수 있다. 반대로 고령 사회에서 국제유가 변화, 세제개편 등의 가격충격은 휘발유 소비의 변동성을 크게 확대할 수 있다. 따라서 고령화 수준이 높아지면 에너지 소비 변동성 안정화 측면에서 가격정책보다 기술개발을 통한 효율 향상 정책에 초점을 맞춰야 할 것이다.