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송현범,우세준,정철규,이윤종,안지윤,박규형,권오기 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.5
Livedoid vasculopathy (LV) is characterized by a long history of ulceration of the feet and legs and histopathology indicating a thrombotic process. We report a case of acute central retinal artery occlusion in a 32-year-old woman who had LV. She showed no discernible laboratory abnormalities such as antiphospholipid antibodies and no history of cerebrovascular accidents. Attempted intra-arterial thrombolysis showed no effect in restoring retinal arterial perfusion or vision. The central retinal artery occlusion accompanied by LV in this case could be regarded as a variant form of Sneddon’s syndrome,which is characterized by livedo reticularis and cerebrovascular accidents.
Comparison of ELISA and Urine Microscopy for Diagnosis of Schistosoma haematobium Infection
송현범,김지영,Yan Jin,이진수,정후근,이영하,Abd Al Wahab Saeed,홍성태 대한의학회 2018 Journal of Korean medical science Vol.33 No.33
Background: Schistosoma haematobium which causes urogenital schistosomiasis (UGS) is highly prevalent in African countries. Urine microscopy (UM) is the first-line diagnostic method of UGS. Enzyme-linked immunosorbent assay (ELISA) is a common method for screening many parasite infections primarily or alternatively. The present study established an in-house diagnostic system by ELISA and evaluated its diagnostic efficacy in comparison with UM for screening UGS in White Nile State, Republic of Sudan, 2011–2013. Methods: A total of 490 participants were screened by UM or ELISA, and 149 by both. The in- house ELISA system was established employing soluble egg antigen of S. haematobium and the cut-off absorbance was set at 0.270. Results: Of the 149 subjects, 58 participants (38.9%) were positive by UM, 119 (79.9%) were positive by ELISA and 82 (55.0%) showed consistently positive or negative results by both methods. The diagnostic sensitivity of ELISA was 94.8% and specificity was 29.7% based on UM results. The ELISA positive serum samples also cross-reacted with egg antigens of Schistosoma mansoni and Schistosoma japonicum. Conclusion: We have established in-house ELISA for screening serum immunoglobulin (Ig) G antibodies by employing soluble egg antigen of S. haematobium for diagnosis of UGS with 94.8% sensitivity and 29.7% specificity. The ELISA system can supplement the conventional diagnosis by UM.
Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
송현범,이덕호,Yan Jin,Jinwoo Kang,조신형,박민선,박진호,송우정,강혜련,이상협,홍성태,최민호 대한기생충학ㆍ열대의학회 2020 The Korean Journal of Parasitology Vol.58 No.4
Eosinophilia occurs commonly in many diseases including allergic diseases and helminthic infections. Toxocariasis has been suggested as one cause of eosinophilia. The present study was undertaken to examine the prevalence of toxocariasis in patients with eosinophilia and to identify the risk factors for toxocariasis. This prospective cohort study recruited a total of 81 patients with eosinophilia (34 males and 47 females) who visited the outpatient clinic at Seoul National University Hospital from January 2017 to February 2018 and agreed to participate in this study. The prevalence of toxocariasis was examined by T. canis-specific ELISA, and the various risk factors for toxocariasis were evaluated by a questionnaire survey. Among 81 patients with eosinophilia, 18 were positive for anti-T. canis antibodies (22.2%); 88.9% were male (16/18) and 11.1% were female (2/18). Multivariate statistical analysis revealed that males (OR 21.876, 95% CI: 1.667–287.144) with a history of consuming the raw meat or livers of animals (OR 5.899, 95% CI: 1.004–34.669) and a heavy alcohol-drinking habit (OR 8.767, 95% CI: 1.018–75.497) were at higher risk of toxocariasis in patients with eosinophilia. Toxocariasis should be considered a potential cause of eosinophilia when the patient has a history of eating the raw meat or livers of animals in Korea. A single course of albendazole is recommended to reduce the migration of Toxocara larvae in serologically positive cases with eosinophilia.
전층 각막이식술 후 잔여 고도난시에 대해 각막윤부 이완절개 및 추가 봉합술의 단기 교정효과
송현범,최혁진,김미금,위원량,Hyun Beom Song,Hyuk Jin Choi,Mee Kum Kim,Wong Ryang Wee 대한안과학회 2011 대한안과학회지 Vol.52 No.10
Purpose: To investigate the short-term effect of limbal relaxing incisions accompanied by compression sutures on postoperative astigmatism in penetrating keratoplasty. Methods: The medical records of patients who underwent penetrating keratoplasty, were followed-up for at least 18 months and had residual astigmatism greater than 4.0 diopters (D), were retrospectively analyzed. The patients had paired limbal relaxing incisions on the steep axis and compression sutures on the flat axis. The paired limbal relaxing incision was done for 2 clock hours each with a depth of 85% of the corneal thickness, and the compression sutures with an average of 3.2 bites were added with a Troutman operating keratometer guide. The visual acuities, corneal astigmatism and complications were evaluated at 1 month and 6 months. Results: At 1 month after the surgery, the best corrected visual acuities (log MAR) improved from 0.840 to 0.674 (<em>p</em> = 0.037) except for 1 patient with immediate postoperative rejection and another patient with a pre-existing cataract. The mean corneal astigmatism was reduced from 9.118 ± 3.158 D to 4.982 ± 3.063 D (<em>p</em> = 0.021). At 6 months after the surgery, the mean corneal astigmatism increased to 5.489 ± 2.670 D (<em>p</em> = 0.008), and the effect of surgery became statistically insignificant (p = 0.477). Conclusions: Paired limbal relaxing incisions and compression sutures were effective short-term on reducing residual corneal astigmatism and improving visual acuities in keratoplasty patients with high astigmatism, but became less effective on corneal astigmatism at 6 months. J Korean Ophthalmol Soc 2011;52(10):1142-1149
Case Report of Urinary Schistosomiasis in a Returned Traveler in Korea
이양규,송현범,정봉광,Ghee Young Choe,Min-Ho Choi 대한기생충학ㆍ열대의학회 2020 The Korean Journal of Parasitology Vol.58 No.1
A 23-year-old Korean woman with a residence history in Kenya and Malawi for about 2 years presented with gross hematuria for 1 month. Blood tests were within normal range except eosinophilia. Asymmetrically diffuse wall thickening and calcification were observed at the urinary bladder on CT. Multiple erythematous nodular lesions were observed in the cystoscopy and transurethral resection was done. Numerous eggs of Schistosoma haematobium with granulomatous inflammation were observed in the submucosal layer of the bladder. The patient was diagnosed with schistosomiasis-related cystitis and treated with praziquantel (40 mg/kg/day) twice before and after transurethral resection. This case suggests that S. haematobium infection should be considered as a cause of hematuria in Korea when the patient had a history of traveling endemic areas of schistosomiasis.
서장연,송현일,김정식,고인범,홍광표 대한인터벤션영상기술학회 2009 대한인터벤션영상기술학회지 Vol.12 No.1
목적 본 연구는 삼성서울병원에서 최근 5년간 시행한 뇌혈관 조영술을 비교 분석하여 뇌혈관 질환의 종류별 연령분포, 성별비율, 질환별 증가율, 계절에 따른 질환 발병률 등을 파악하고 생활의 변화와 의료환경의 변화에 따른 뇌혈관 조영술의 추세 흐름을 제시하고자 한다. 대상 및 방법 2004년 1월 1일 부터 2008년 12월 31일 까지 본원에서 뇌혈관 조영술을 시행한 환자 2481명을 대상으로 하였으며 삼성서울병원 전산 의료정보 시스템(SMIS)을 통해 환자 연령별 분포, 성별비율, 뇌혈관 질환별 증감율, 질환의 계절 변화에 따른 민감도 등을 후향적으로 비교 분석하였다. 결과 aneurysm이 843(34%)명으로 가장 많은 비율을 차지 하였고, 뒤를 이어 moya moya 458 (18.4%), tumor 351(14.1%), stenosis 266(10.7%), AVM 237(9.6%), ICH 92(3.7%), stroke 91(3.7%), infarction 77(3.1%), fistula 68(2.7%) 순으로 나타났으며 질환별 증감률은 aneurysm, moya moya, stenosis 환자가 증가 하고 있으나 tumor 환자의 경우는 감소 추세에 있었다. 후천적 질환인 aneurysm, stenosis 환자의 경우 40세 이후 발병률이 높았고 선천적 질환인 AVM, moya moya 환자는 젊은 연령층부터 발병률이 나타났다. 전체적으로 남성보다는 여성 환자 비율이 높았으며 뇌출혈(ruptured An.) 환자는 감소하고 뇌경색 환자는 증가하는 것을 알 수 있었다. 결론 뇌혈관 질환의 종류에 따른 데이터를 분석한 결과 한 병원에 국한된 자료이고 혈관조영실에서 시술을 시행한 환자만을 대상으로 한 자료이기에 우리나라 뇌혈관 질환 환자의 전체 추세라고 단정하기에는 부족한 감이 없지 않지만 서구화 되가는 생활습관과 의료환경의 변화로 인해 바뀌고 있는 뇌혈관 질환의 혈관조영술 추세 흐름을 알 수 있었고 더 나아가 질환별로 깊이 있는 연구, 분석 및 보고 들이 필요할 것으로 생각된다.