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증례 : 내분비 ; PET-CT에서 우연히 발견된 비기능성 뇌하수체 거대선종 1예
송윤미 ( Youn Mi Song ),임동준 ( Dong Jun Lim ),문성대 ( Sung Dae Moon ),한제호 ( Je Ho Han ),한치화 ( Chi Wha Han ),김성훈 ( Sung Hoon Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
FDG-PET은 많은 종류의 암에서 질병의 범위를 판정하거나, 치료효과 판정 및 재발병소 진단에 유용한 영상기법이다. FDG-PET을 시행하여 뇌하수체 부위에 우연히 섭취가 증가된 소견이 있을 경우 추가적인 영상 검사와 내분비 기능 검사를 시행하여 기능성 또는 비기능성 종양 여부를 결정하고 적절한 치료를 시행해야 한다. 저자들은 우연히 FDG-PET에서 발견되어 확진 검사 후 비기능성 뇌하수체 선종으로 진단한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Whole-body positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (18F-FDG) is a tomographic imaging technique that uses a radiolabeled analog of glucose, 18F-FDG, to image relative glucose uptake rates in various tissues. Since the glucose uptake is increased in many malignancies, 18F-FDG PET is a sensitive method for detecting, staging, and monitoring the effects of therapy on many malignancies. However, it is uncommon to discover an asymptomatic non-functioning pituitary tumor unexpectedly as a hypermetabolic lesion in PET studies. Here, we report a pituitary tumor that was detected incidentally by FDG-PET and ultimately turned out to be a non-functioning pituitary macroadenoma. (Korean J Med 76:374-379, 2009)
양훈주,송윤미,김리연,오지혜,조태형,김인숙,황순정,Yang, Hoon Joo,Song, Yoon Mi,Kim, Ri Youn,Oh, Ji Hye,Cho, Tae Hyung,Kim, In Sook,Hwang, Soon Jung 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.1
Purpose: Maxilla and mandible have different patterns of cortical and trabecular bone and different bone mineral densities, even though both are components of the jaw bone. However, cellular differences between maxilla- and mandible derived osteoblasts (OBs) have rarely been studied. We hypothesize that maxilla- and mandible-derived OBs show different responses to $17{\beta}$-estradiol (E2), which is one of the critical factors for bone formation. This study compares skeletal site-specific cell responses between maxilla- and mandible-derived human OBs to E2. Methods: Maxilla- and mandible-derived OBs derived from an identical donor were separately isolated from a total of five normal healthy subjects aged 18~44 years old, cultured with a treatment of 100 nM estrogen. The responses between maxilla- and mandible-derived OBs to E2 were evaluated and compared using cell proliferation, alkaline phosphatase (ALP) activity and gene expression of osteoprotegerin (OPG), ALP, insulin-like growth factor-1 (IGF-1), and estrogen receptor ${\alpha}$ ($ER{\alpha}$). Results: E2 did not have any distinct effects on the proliferation of both types of OBs. Mandible-derived OBs exhibited higher ALP activity than maxilla-derived OBs in the non-treated condition, which was common in all tested individuals. ALP activities of both types of OBs showed a minor increasing tendency with the treatment of E2, even though there was no statistical significance in some specimens. The gene expression of OB by E2 was diverse, depending on the individuals. There was increased expression of OPG, IGF-1, or $ER{\alpha}$ gene in the part of subjects, which was more repeated in maxilla-derived OBs. In particular, OPG or ALP induction by E appeared less frequently in mandible-derived OBs. Conclusion: Current results revealed that E2 affects maxilla- and mandible-derived OBs into facilitating the osteogenic process despite individual differences. Mandible-derived OBs are less sensitive to bone-forming gene expression by E2.
70세 남자환자에서 발생한 장 무회전증에 의한 중장염전
지병수 ( Byung Soo Jie ),김은옥 ( Eun Ok Kim ),김진석 ( Jin Seok Kim ),이화정 ( Hwa Jeong Lee ),송윤미 ( Youn Mi Song ),김영신 ( Young Shin Kim ),정성훈 ( Sung Hoon Jung ),오정환 ( Jung Hwan Oh ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.5
Intestinal malrotation is a congenital disorder that results from the failure of normal bowel rotation and fixation during the 5th gestational week. The incidence of intestinal malrotation is <0.2%, but prompt diagnosis is important because this anomaly can cause midgut volvulus and lead to fatalities. Compared to infants presenting with acute symptoms, such as abdominal pain, vomiting, or diarrhea, adult patients complain of intermittent self-limited abdominal pain. We present a case of intestinal malrotation complicated by midgut volvulus improved with conservative care in a 70-year-old man. The diagnosis was suggested on the basis of imaging findings.