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염화제일철 매염제로 손상된 배양 NIH3T3 섬유아세포에 대한 석잠풀 추출물의 항산화 효과
손영우,유선미,Sohn, Young-Woo,Yoo, Sun-Mi 중소기업융합학회 2021 융합정보논문지 Vol.11 No.8
본 연구 목적은 염화제일철(FeCl2)의 세포독성과 석잠풀(SJ) 추출물의 항산화 효과 및 FeCl2의 독성을 산화적 손상 측면에서 조사하였다. 이를 위해, 세포 생존율을 비롯한 과산소음이온(SAR)-소거능과 슈퍼옥사이드(SOD)-유사 활성능을 분석하였다. 본 연구에서 FeCl2는 처리 농도에 비례하여 유의한 세포 생존율의 감소를 보였으며, 중간 독성으로 나타났다. 또한, caffeic acid는 FeCl2로 감소 된 세포 생존율에 대해 유의한 증가를 보였다. FeCl2의 독성에 대한 SJ 추출물의 처리는 세포 생존율의 유의한 증가와 함께 SAR-소거 능과 SOD-유사 활성 능과 같은 항산화 효과를 보였다. 결론적으로, SJ 추출물과 같은 천연소재는 항산화제와 같은 대체물질 개발에 있어 기초자료로서의 활용적 가치가 클 것으로 생각된다. The aim of this study was to examined the dermatoxicity of ferrous chloride (FeCl2) and the antioxidative effect of Stachys japonica Miq (SJ) extract on FeCl2-induced cytotoxicity. For this study, superoxide anion-radical (SAR)-scavenging and superoxide dismutase (SOD)-like abilities with cell viability were done. FeCl2 showed a significant decrease of cell viability in dose-dependent manner, and it was mid-toxic. The caffeic acid showed a significant increase of cell viability against FeCl2-induced cytotoxicity. In the protective effect of SJ extract on FeCl2-induced cytotoxicity, it showed SAR-scavenging and SOD-like abilities with a significant increase of cell viability. From these results, the cytotoxicity of FeCl2 is correlated with oxidative stress, and SJ extract effectively protected the cytotoxicity of FeCl2 by antioxidative effect. Conclusively, the natural resources like SJ extract may be a useful fundamental materials for the development of an alternative antioxidant.
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환경오염원인 납의 신경독성에 대한 NMDA 수용체 길항제의 보호 효과
손영우,임요섭,서영미,Kim, Young-Wo,Rim, Yo-Sup,Seo, Young Mi 한국산업보건학회 2017 한국산업보건학회지 Vol.27 No.3
Objectives: This study was performed to evaluate the neurototoxicity of the environmental pollutant lead acetate(LA) and the protective effect of the D-2-amino-5-phosphonovaleric acid(APV), N-methyl-D-aspartate(NMDA) receptor antagonist on LA-induced cytotoxicity in cultured C6 glioma cells. Materials and Methods: For this study, cell viability in cultured C6 glioma cells was assessed by XTT assay and antioxidative effect, such as lactate dehydrogenase(LDH) activity, by LDH detection kit. Results: LA significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was determined to be 33.3 uM of LA. The cytotoxicity of LA was deemed highly toxic according to Borenfreund and Puerner's toxic criteria. The vitamin E antioxidant significantly increased cell viability damaged by LA-induced cytotoxicity in these cultures. For the protective effect of APV on LA-induced cytotoxicity, APV significantly increased not only cell viability, but also inhibition of LDH activity. From these results, it is suggested that oxidative stress is involved in the neurotoxicity of LA, and APV effectively protected against LA-induced cytotoxicity via an antioxidative effect as an inhibotory activity of LDH. Conclusions: Natural resources like APV may be putative therapeutic agents for the toxic diminution of environmental pollutants such as LA correlated with oxidative stress.
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프랑스의 중앙집권적 국가와 시민사회의 상관성에 관한 연구
손영우 한양대학교 제3섹터연구소 2004 시민사회와 NGO Vol.2 No.2
The French Revolution prohibited the corporation for the political philosophical demand which attempt to obstruct the collective association in order to realize the sovereignty of people. At the same time, it was also a political economical demand that tried to change from the feudal association centered by the masters to the capitalist organization in order to develop the bearing capitalism. Besides, it went hand in hand with the realistic revolutionary demand that did away with feudal political priority of the masters and emancipated the liberal mobilization of force of labor from the patriarchal restriction. However, in spite of this early revolution mind, this‘association prohibition policy’was deteriorated as a means of maintaining the political structure of the nineteenth century when the thought of democracy in the middle of sovereignty of people changed to the representative democracy and the exploitation of the capitalists to the proletariats continued. In the long run, the writer abstracts elements of the authoritarianism and the sovereignty of people from characters of the centralized state during the revolution period in order to find the possibility that will be able to combine the civic society and the direct democracy by the maximization of the sovereignty of people. 본 논문은 소위 ‘자코뱅주의(jacobinisme)’라고 불리는 프랑스의 중앙집권화된 국가의 기원과 특징을 고찰하는 것을 목적으로 한다. 프랑스 혁명 당시 결사 금지 조치는 직접적인 인민주권의 실현을 , 위해 결사라는 ‘논리상의 이단자’를 처단하려는 정치철학적 요구와 신생자본주의의 발전을 위해 장인 중심의 봉건적 생산조직을 노동자 중심의 자본주의적 조직으로 변화시키고자 하는 정치경제학적 요구의 중첩이었다. 이것은 현실적으로도 장인들의 봉건적인 정치적 특권을 폐지하고, 노동력의 자유로운 이동을 가부장적 구속으로부터 해방시키려는 혁명적 요구에 부응하는 것이기도 하였다. 하지만 이러한 초기 혁명정신에도 불구하고, 인민주권적 민주주의 사상이 대의적 민주주의로 변화하고, 자본소유자에 의한 노동자들의 착취가 지속되는 19세기에도 이러한 결사 금지 정책은 그 본질적 이념은 달리 한채, 정치 체제를 유지하기 위한 수단으로 사용되면서 변질된다. 이에 필자는 혁명시기 중앙집권화된 국가의 성격을 인민주권적 요소와 권위주의적 요소를 구분하여 중앙집권화된 국가의 인민주권적 요소를 극대화하고자 한다. 이러한 노력은 직접민주주의 요소를 원초적으로 제외하고 있는 토크빌의 자유주의적 시민사회와 달리 현대 시민사회와 직접민주주의를 결합시킬 수 있는 가능성을 살펴보기 위함이다.
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The Pattern Recognition System Using the Fractal Dimension of Chaos Theory
손영우 한국지능시스템학회 2015 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.15 No.2
In this paper, we propose a method that extracts features from character patterns using the fractal dimension of chaos theory. The input character pattern image is converted into timeseries data. Then, using the modified Henon system suggested in this paper, it determines the last features of the character pattern image after calculating the box-counting dimension, natural measure, information bit, and information (fractal) dimension. Finally, character pattern recognition is performed by statistically finding each information bit that shows the minimum difference compared with a normalized character pattern database.
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손영우,박수애,김용석,김찬 한국항공운항학회 2007 한국항공운항학회지 Vol.15 No.3
This research examined how pilots perceive risks when faced with emergency flight situations. We had 116 commercial airline pilots evaluate riskiness of 39 non-routine flight situations. The pilots' risk perception was analyzed as a function of their position (captain vs. first officer), expertise (expert vs. novice), and military flight experience (with vs. without military experience). Results showed that captains evaluated potential-risk situations and low-risk situations more dangerous than first officers. However, there were no differences between experts and novices, and between pilots having military flight experience and pilots not having military flight experience in risk perception. The analysis of multi-dimensional scaling revealed that the pilots used controllability as a key dimension for evaluating riskiness, though the other dimensions they used varied with their position, expertise, and military flight experience.
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