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수술 소견과 자기공명영상 소견을 통한 발목터널 증후군의 원인 연구
손민기,박홍기,이영배 대한임상신경생리학회 2011 Annals of Clinical Neurophysiology Vol.13 No.2
Background: Tarsal tunnel syndrome (TTS) is an entrapment neuropathy that occurs in the ankle. Previous studies reported that this disease was due to physiologic factors and structural lesions in the ankle or foot. The authors investigated the causative factors of TTS and their frequency via operative findings. The diagnostic value of MRI was also evaluated based on the concordance between the operative findings and the MRI findings. Methods: This study was performed in retrospective by using medical record of the patients who underwent operations with TTS from August 2003 to May 2010. Physical examination, nerve conduction study, and MRI were conducted on patients who visited department of neurology or orthopedic surgery due to pain and sensory abnormality of their ankle and foot. Results: 34 patients underwent the operation. Ganglion accounted for the largest portion of the operative findings. In addition, varicose veins, intrinsic foot muscle hypertrophy, tenosynovitis, and fascia thickening were mainly observed. Of the 34 patients, 33 patients underwent pre-operative MRI, of whom 18 patients showed MRI findings consistent with the operative findings. Conclusions: Space-occupying lesions accounted for the majority of the causative factors in TTS patients who underwent the surgical treatment. In this study, the MRI appeared useful for identifying causes of TTS.
손민기,김석선 한국정신간호학회 2023 정신간호학회지 Vol.32 No.2
Purpose: The purpose of this study is to identify and prioritize educational needs for psychiatric nursing competencies among 142 non-psychiatric nurses from general hospitals. Methods: Data were collected from November 13 to 19 2022 through self-administered questionnaires consisting of measures of psychiatric nursing competencies. Data were analyzed using descriptive statistics, paired t-test, Borich's needs assessment model, and the Locus for Focus model to determine the priority of educational needs. Results: Non-psychiatric nurses reported that enhancing skills in psychiatric nursing were more significant than improving knowledge and attitude using Borich’s Needs Assessment Model and the Locus for Focus Model. The highest priority educational needs were ‘Skill to distinguish whether symptoms in psychiatric patients are symptoms of mental illness or side effects of psychiatric drugs’, ‘Skill to calm and supportive communication in psychiatric emergency when psychiatric patients are at risk of harm’, ‘Attitude to remain calm about the psychotic behaviors of psychiatric patients’, and ‘Knowledge of non-therapeutic communication that interferes with effective communication with psychiatric patients’. These items should be considered as priorities among the 39 items to improve psychiatric nursing competencies. Conclusion: Results of this study suggest that developing intervention programs to enhance psychiatric nursing competencies are needed among non-psychiatric Nurses.
알칼리슬러지를 이용하여 총인을 제거할 수 있는 MBR 하수처리공정의 개발
손민기,차운오,김진만,최정훈,권혁,박정훈 한국막학회 2015 한국막학회 총회 및 학술발표회 Vol.2015 No.05
최근 방류수 수질 강화에 따라 총인 처리시설의 설치와 응집제 사용량이 증가하고 있다. 본 연구는 유입하수에 포함된 응집제 성분(Al3+, Fe3+ 등)을 활용하여 PO43-와 응집시킴으로써 하수처리공정에 별도의 응집제 주입 없이 총인 농도를 0.2mg/L 이하로 제거할 수 있는 MBR 하수처리공정을 개발하는 것이다. 활성슬러지와 차아염소산나트륨으로 제조한 알칼리슬러지를 MBR 공법의 생물반응조에 주입하여 적정 pH를 유지시킴으로써 유입하수 중의 용존성 이온을 상호 응집시켜 고형화 하였고 분리막으로 고액 분리하여 하수처리수의 총인 농도를 0.2mg/L이하로 달성하였다. 이 연구를 통해 개발한 공법은 응집제 주입 없이 하수처리수의 총인 농도를 0.2mg/L이하로 제거하여 약품비용을 절감에 기여할 것으로 예상된다.
내경동맥 협착 환자의 경대퇴뇌혈관조영술을 통해 분석한 측부순환 형태
손민기,김재명,황희영,신동진 대한뇌졸중학회 2012 Journal of stroke Vol.14 No.3
Background: In recent studies, by utilizing single photon emission computed tomography (SPECT) and magnetic resonance angiography (MRA), anatomical and functional evaluation became possible. Although MRA is increasingly being used to evaluate vascular status, conventional angiography is still gold standard for investigating anatomical structures. We studied the correlation between internal carotid artery (ICA) stenosis, patterns of collateral pathway, and cerebrovascular reserve using transfemoral cerebral angiography (TFCA) and SPECT. Methods: We studied 54 patients with symptomatic ICA stenosis who were visit to our hospital between Sep 2009 and May 2011. Forms of collateral pathway were classified into primary and secondary pathway group. Severity of ICA stenosis was divided into 4 stages. Vascular reserve on SPECT was classified into favorable and poor groups. Results: As a result of TFCA, collateral pathways were observed in 44 of 54 patients. Collateral flow via anterior communicating artery (AcoA) pattern occupied the highest proportion and other major patterns were collaterals via posterior cerebral artery-middle cerebral artery (PCA-MCA) and via posterior communicating artery (PCoA) pattern. Twentyeight patients were primary pathway group and 16 patients were secondary pathway group. In both groups, most patients had moderate or severe ICA stenosis. As a result of SPECT, favorable vascular reserves were observed in 17 of 54 patients. Most of them had mild ICA stenosis and/or primary collateral pathway. Contrarily, most of secondary pathway group had poor vascular reserve even if their ICA stenosis severity was mild. Conclusion: In patients with symptomatic ICA stenosis with collateral pathways, rate of primary collateral pathways was higher than secondary collateral pathways. Secondary collateral pathways had insufficient compensatory effect about reduced cerebral blood perfusion.
손민기,진선임,신동진 대한뇌졸중학회 2011 Journal of stroke Vol.13 No.1
A male patient aged 54 came to the neurology department complaining of weakness and tingling sensation in the left lower extremity during squatting exercises for the previous four days. A neurological examination revealed left proximal leg weakness and hypesthesia on the medial side of the left lower leg. In eight hours after onset, he took brain and lumbar MRIs at a local clinic and the results were normal. In order to identify possible causes, we performed a follow-up lumbar MRI, femoral angiography, electromyography, and nerve conduction study but failed to obtain any abnormal findings. Finally, a recent infarction of right corona radiata was observed by a follow-up brain MRI which was taken 16 days after onset of the symptom. Leg monoparesis caused by cerebral infarction is known to be rare and in particular combines motor and sensory deficits limited to one extremity. (Korean J Stroke 2011;13:45-47)
Tryptamine–Triazole Hybrid Compounds for Selective Butyrylcholinesterase Inhibition
손민기,이하늘,전철민,강유정,박찬인,이근우,박정호 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.6
Tryptamine?triazole hybrid compounds (11?18) were synthesized via click reaction between tryptamine azide and propargylated natural compounds. Their cholinesterase inhibitory activity was evaluated. Among the eight compounds, compound 11 showed the most potent inhibitory activity [IC50?=?0.42?±?0.29??M for equine butyrylcholinesterase (BuChE) and 1.96?±?0.15??M for human BuChE]. From the molecular modeling study, compound 11 was bound to the catalytic anionic site, anionic subsite, peripheral anionic subsite, acyl-binding pocket, and oxyanion hole of human or horse BuChE by forming a hairpin or U-shaped structure. The Lineweaver-Burk plot of compound 11 against BuChE suggests a mixed type of inhibition which corresponds well with the molecular modeling study.