양극성장애와 조현병 환자의 분노대응 방식 비교

권민정(Min Jung Kwon),문은수(Eunsoo Moon),박제민(Je Min Park),이병대(Byung Dae Lee),이영민(Young Min Lee),이재민(Jae Min Lee),김정범(Jung Bum Kim) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2

Objectives:This study aimed to compare anger coping strategies between bipolar I disorder and schizophrenia, and to explore the relationship between impulsivity and anger coping strategies. Methods:Forty three bipolar patients who met DSM-IV criteria for bipolar I disorder and forty three schizophrenia controls who were matched by age and sex were included. Anger coping strategies were measured by Anger Coping Scale(ACS), and the levels of impulsivity were also measured by Barratt Impulsiveness Scale(BIS). Independent t-test was used to compare anger coping strategies between two groups, and analysis of covariance(ANCOVA) to adjust the influence of impulsivity. Results:Score of problem-solving coping strategy was significantly higher in bipolar I disorder than schizophrenia (t=-2.047 p=.044). Problem-solving strategy was negatively correlated with total impulsivity in both bipolar patients and schizophrenic controls(bipolar I disorder r=-.376 p=.013 ; schizophrenia r=-.395 p=.009). There was no significant difference of problem-solving coping strategy between two groups after adjusting impulsivity(F=2.385 p=.126). Conclusion:These results suggested that bipolar I patients have a tendency to use more problem-solving coping strategy for anger situation than schizophrenia, which can be influenced by the level of impulsivity.

신체형 장애에서의 Testosterone과 통각 역치의 상관관계

박재홍,김명정,박제민,김용기,한귀원,박성화,윤경일,정영인,김성곤,Park, Jae-Hong,Kim, Myung-Jung,Park, Je-Min,Kim, Yong-Ki,Han, Kwi-Won,Park, Seong-Hwa,Yun, Kyung-Il,Chung, Young-In,Kim, Sung-Gon 한국정신신체의학회 1998 정신신체의학 Vol.6 No.1

DSM-IV 진단 기준에 의하여 신체화 장애, 미분화 신체형 장애, 그리고 달리 분류되지 않은 신체형 장애여성 환자 13명과 정상 여성 20명을 대상으로 압통에 대한 통각 역치와 혈청 testosterone을 측정하여 다음과 같은 결과를 얻었다. 1) 가변 하중 압통 예민도 측정기 (Variable Weight Pressure Algometer)로 측정한 통각 역치는 환자군이 153.8${\pm}$39.5gm/$0.05mm^2$로서 대조군의 197.5${\pm}$66.7gm/$0.05mm^2$보다 유의하게 낮았다(p<0.05). 2) 혈청 testosterone치는 환자군에서는 0.175${\pm}$0.081ng/ml였고, 대조군에서는 0.174${\pm}$0.108ng/ml로서 양군간에 유의한 차이가 없었다. 3) Testosterone과 통각 역치와의 상관관계를 보면, 환자군에서는 혈청 testosterone치와 통각 역치 사이에 유의한 정적 상관관계가 있었으나(r=0.632, p<0.05, two tailed, Pearson's correlation test), 대조군에서는 유의하지 않았다(r=-0.405). 이상의 결과로 보아 신체화 장애 환자와 정상인 사이에 통각 예민도 조절 기전이 서로 다를 수 있다고 사료 된다. Thirteen female patients of somatization disorder, undifferentiated somatoform disorder and somatoform disorder, NOS, diagnosed by DSM-IV were studied for their pain threshold and serum testosterone and the results were compared with the respective data of 20 control females. The results are as follows : 1) The pain threshold as measured by Variable Weight Pressure Algometer was significantly lower in the patient group(153.8${\pm}$39.5 gm/$0.05mm^2$) as compared to the control group(197.5${\pm}$66.7 gm/$0.05mm^2$)(p<0.05). 2) There was no significant difference of serum testosterone between the patient(0.175${\pm}$0.081 ng/ml) and the control(0.174${\pm}$0.108 ng/ml) groups. 3) A significant positive correlation was noted between the pain threshold and serum testosterone in the patient group(r=0.632, p<0.05, two tailed, Pearson's correlation test), but not in the normal control group(r= -0.405). From these results, it was suggested that the role of testosterone in endogenous pain control system might be more important in somatoform disorders than normals.

남성화된 암컷 생쥐의 통각반응 양상과 에스트로겐-α 수용체의 발현 양상

제영묘(Young-Myo Jae),박제민(Je-Min Park),백선용(Sun-Yong Baek),최병무(Byung-Moo Choi),김명정(Myung-Jung Kim) 대한생물치료정신의학회 2005 생물치료정신의학 Vol.11 No.1

암컷 생쥐를 출생 직후 테스토스테론에 노출시키면 성장 후 통각반응과 중추신경계 통각조절부위의 estrogen-α 수용체(ERα)의 발현에 영향을 주는지를 조사하고자 하였다. 갓 태어난 생쥐(Institute for Cancer Research)에게 생후 24시간 이내에 testosterone propionate 100㎍(남성화군) 혹은 sesame oil 50㎕(대조군)씩 복강내 주사하였다. 13주째에 각 군을 반으로 나누고 naloxone HCI 5㎎/㎏ 혹은 동량의 생리식염수를 복강내 주사하였다. 15분 뒤에 Tail immersion test로 통각예민도(TFL, sec)를 2회 측정하였다. 이어서 모든 군에게 testosterone propionate 1㎎/㎏씩 복강내 주사하고, 15분 후에 같은 방법으로 TFL을 측정하였다. 8개월 째 식염수 전처치군의 뇌를 적출하여 일차감각대뇌겉질, 시상, 중간뇌수도관주위회색질, 큰솔기핵 및 허리와 엉치척수분절 부위를 분리하였다. 각 부위별 ERα를 Western blot 분석으로 반정량하였다. 그 결과는 다음과 같다. 생리식염수 전처치군에서 대조-암컷은 기저 TFL과 테스토스테론 투여 후 TFL이 대조-수컷 보다 유의하게 예민하였다. 테스토스테론은 모든 군에서 TFL을 유의하게 연장시켰다. 날록손 전처치-대조-암컷은 수컷이나 남성화-암컷 보다 유의하게 예민하였다. 남성화-암컷은 기저 TFL이 수컷 보다 예민한 경향이 있었고, 날록손이 테스토스테론의 진통효과를 감소시키는 경향이 있었다. 그 외는 수컷과 유사한 반응을 보였다. 남성화-암컷은 대조-암컷 보다 사상의 ERα western band의 광 밀도가 낮은 경향이 있었다. 그 외 부위는 세 군간 차이가 없었다. 대조-암컷은 수컷이나 남성화-암컷에 비하여 다른 부위 보다 시상에 밀집되어 있고, 큰솔기핵에는 적었다. 남성화-암컷은 수컷에 비해 중간뇌수도관주위회색질의 밀도가 다른 부위에 비해 낮은 경향이 있었지만, 다른 부위는 차이가 없었다. 이상의 결과로부터 출생직후 암컷 생쥐를 테스토스테론에 노출시키면 통각에 대한 반응이나 중추신경계 통각조절 부위의 ERα 발현 양상이 수컷과 비슷해진다는 결론을 얻었다. Objectives : The object of this study was to investigate the effects of neonatal exposure to testosterone in female mice on the pain responses and the expression of estrogen-α receptors(ERα) in the pain control areas of the CNS in their later life. Methods : Testosterone propionate 100㎍ or sesame oil 50㎕ was injected intraperitoneally to neonatal mice within 24 hours after birth. In the 13th week of age, animals of each group(Androgenized-Female : AF ; Control-Female : CF ; Control-Male: CM) were divided into two and pretreated with naloxone HCI 5㎎/㎏ or saline 15 minutes before tail immersion test. Tall flick latencies(TFLs) were measured before and 15 min after administration of testosterone propionate 1㎎/㎏ i p.(intra-peritoneal) In the 8th month, mice were sacrificed and brains were dissected into primary sensory cortex, thalamus, periaqueductal gray, nucleus raphe magnus and lumbosacral spinal cord. ER α protein was assayed by Western blot analysis. Results : In saline-pretreated groups, TFLs of CF measured before and after testosterone injection were significantly shorter than those of CM. Testosterone prolonged TFLs signficantly in all subgroups. Among naloxone-pretreated groups, CF was significantly more sensitive than CM and AF. TFL profiles of AF did not differ from that of CM, except that baseline TFLs were slightly shorter and naloxone seemed to decrease analgesic effect of testosterone in AF, though statistically not significant. 66kDa Western bands were detected in all 5 regions. Optic density(OD) of each area did not differ across 3 groups, except that OD of ER α In the thalamus in AF was lower than in CF. Percent OD of a region to sum of the 5 areas(OD%) showed significant difference in the thalamus and nucleus raphe magnus. CF showed higher OD% in the thalamus than in CM and AF, and lower OD% in nucleus raphe magnus than in CM and AF. Western bands profile of AF did not differ from that of CM. Conclusion : These findings suggested that the pain response patterns and the expression of ER α in the pain control areas of CNS are grossly similar between androgenized female and control male mice.

무선 블루투스통신을 이용한 전동기 추진체 응용의 유비쿼터스 활용 가능성 해석

김성식(Sung-Sik Kim),김현준(Hyun-Jun Kim),박제민(Jae-Min Park),신판석(Pan-Seok Shin) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.10

한국어판 PADUA 강박척도 : 신뢰도와 타당도 Reliability and Validity

박제민,김명정,김성곤,박재흥,강철중,김병철,전명호,김재형,양구범 釜山大學校 醫科大學 精神科學敎室 1998 釜山精神醫學 Vol.7 No.-

This study reports the psychometric peroperties and factorial structure of a Korean version of the Padua Inventory (PI) in clinical (35 patients withobsessive-compulsive disorder and 66 with other psychiatric disorders) and non-clinical (458 including 120 undergraduate medical students) samples. The PI total and subscales showed good internal consistency, convergent and known-group validity. Test-retest reliability with interval of one year was superior to that of obsessive-compulsive subscale of SCL-90R. PI scores of non-clinical sample were lower than those reported in western countries, apart from Dutch sample. Principal component analysis on data from whole sample suggested four-factor solutions, which was comparable to that found in other versions of the PI developed in the western cultures. Items asking urges or worries of breaking or stealing things were separated from the factor 'urges and worries of losing control over motor behavior'. Factor analysis on data from non-clinical sample revealed five-factor solution: being contaminated, checking behaviors, doubting, worries of disasters, and ruminations. The first two factors were very same as the western reports, the other three were comparable to 'impaired control over mental activities', but 'urges and worries of losing control over motor behavior' was not extracted as a separate factor in this study. Needs for cross-cultural study including other Asian countries arise to confirm lower PI scores and different factor structures in this sample reflects Korean-specific or Asian-specific culture.

신체형 장애에서의 testosterone과 통각 역치의 상관관계

박재홍,김명정,박제민,김용기,한귀원,박성화,윤경일,정영인,김성곤 日新基督病院 1997 日新基督病院論文集 Vol.12 No.-