Synthesis of Benzoisoxazole Derivatives and Evaluation of Inhibitory Potency against Cholinesterase for Alzheimer's Disease Therapeutics

박정열,신수정,김재관,Kyoung Chan Park,박정호 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.9

To improve Alzheimer's disease (AD) therapeutics, we have designed and synthesized new benzoisoxazole derivatives that are potent inhibitors of cholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BuChE]). Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective ways of treating AD patients, many new classes of ChE inhibitors have been synthesized. To identify a new type of cholinergic drug, the benzoisoxazole moiety which is the pharmacophore moiety of Risperidone was coupled with natural antioxidants. Some benzoisoxazole derivatives (26–28 and 30) were found to effectively inhibit BuChE (IC50 < 20 μM), and some (20 and 26–28) to moderately inhibit AChE (IC50 < 100 μM). Furthermore, compound 28 showed better inhibitory activity against BuChE (IC50 = 0.72 ± 0.11 μM) than galantamine (IC50 = 8.4 ± 0.1 μM). The new benzoisoxazole derivatives showing BuChE inhibitory activity represent a new class of ChE inhibitor and can be used to create novel compound derivative drugs for treating AD patients.

Laparoscopic versus open radical hysterectomy in patients with stage IB2 and IIA2 cervical cancer

박정열,김대연,김종혁,김용만,김영탁,남주현 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

To compare survival and surgical outcomes of laparoscopic (LRH) and open radical hysterectomy (ORH) in patients with stage IB2 and IIA2 cervical cancer. A retrospective analysis was performed on 303 patients with stage IB2 and IIA2 cervical cancer who underwent LRH (n=115) or ORH (n=188). Two patients (1.7%) in the LRH group required conversion to laparotomy. There was no difference with respect to operating time, perioperative change in hemoglobin level, and need for transfusion. However, in the LRH group, estimated blood loss (p=0.003) was significantly lower, time to recovery of bowel movement (p<0.001) and length of postoperative hospital stay (p<0.001) were significantly shorter, and postoperative complications were significantly less frequent (p=0.036). The 5-year disease-free survival was 78% in the LRH group and 77% in the ORH group (p=0.718), and 5-year overall survival was 83% in both groups (p=0.746). There were no differences in pattern of recurrence (p=0.225) and median time to recurrence (12 vs. 13months; P=0.240). LRH has similar therapeutic efficacy to ORH in patients with bulky early-stage cervical cancer. However, LRH has more favorable surgical outcomes. Therefore, LRH is not only a reasonable alternative to ORH but also the preferred surgical procedure for these patients.

A Study on the Utilization of Existing Innovation Information to the Improvement of Korea’s National Innovation System (NIS)

박정열 한국물류학회 2022 물류학회지 Vol.32 No.3

The main aim of the study is to show how existing innovation studies have helped in the widespread of information needed to give better improvement for Korea’s national innovation system (NIS). Korea was selected as the study’s backdrop since it is very successful nations in building a NIS. We chose various papers published in two major innovation journals (the Journal of Korea Technology Innovation Society (J-KOTIS) and the Journal of Technology Innovation (JTI)) in Korea and assessed the essential subjects of these articles from the viewpoint of NIS research using a systematic review technique. Overall, We discovered that this study aided in the establishment of a knowledge foundation required for the growth of the NIS in Korea. The finding showed that the focus of the research worked from designing the NIS to implementing it for a long time. The industrial areas that sectoral innovation systems (SIS) were given attention to changing with Korea’s economic progress all the time as a subsystem of the NIS. This research adds to the sector of innovation studies by providing a complete picture of findings from NIS studies in Korea’s innovation literature, as well as a theoretical framework for organizing it. The NIS has been regarded as a useful instrument for comparing and measuring creative performance and economic outcomes, and this work adds to our understanding of it.

드라마를 통한 읽기 장애자의 효율적 영어 학습

박정열,조은미 사단법인 인문사회과학기술융합학회 2015 예술인문사회융합멀티미디어논문지 Vol.5 No.2

The intent of this article is to give teachers a better understanding of the effectiveness of drama in teaching literacy to English language learners with dyslexia. There is a need to use creative methodologies as necessary in a given teaching situation to have English language learners with dyslexia achieve optimal results in their learning literacy. This article aims to show that among the diverse methodologies used in the ESL classroom, drama provides unique benefits which justify its place as part of the language learning curriculum. Drama includes the diverse language learning approaches, making it an ideal and unique solution to teaching literacy skills to this specific population. Therefore, drama, by using the systematic multisensory teaching approach, is a very important cross-curricular activity and method for English language learners with dyslexia to improve their language skills. The drama approach benefits those students to develop literacy skills in a safe and supportive environment. 읽기 장애(dyslexia)가 있으면서 영어가 모국어가 아닌 학생들은 학교에서 다양한 내용의 주제를 배우는 동시에 영어를 외국어로써 배워야 하므로 이때 수행되는 학습 과정에서 이중적인 어려움에 처하게 된다. 그들에게 읽기 장애라는 어려움을 극복하도록 도와주면서 제 2 외국어로써 영어를 배우는데 보다 구체적이고 효과적인 방법을 찾아 줄 필요가 있다. 본 논문은 영어를 제 2 외국어로 배우는 영어 학습에서 사용되어지는 다양한 교수 방법 중 드라마가 영어 교육 지도안의 중요한 부분임을 과거의 문헌 연구를 통해 설명하였다. 그리고 드라마를 접목시킨 사회과 수업 (미국 캘리포니아 주도 새크라멘토에 위치한 학교)이 읽기 장애를 가진 영어 학습자들의 학습참여도(learner participation)와 언어사용도(language usage)에 미친 영향이, 드라마를 접목시키지 않은 평범한 수업의 그것과 어떻게 차이가 나는지를 알아보았다. 나타난 명확한 차이점을 통해, 본 논문은 드라마가 다른 어떤 방법론과도 비길 데 없는 효과적인 교수 방법임을 알게 되었고 그것을 알리는데 목적이 있다. 드라마는 특수한 교육이 필요한 학생들에게도 적용될 수 있는 이상적인 수단이고 언어 학습에서 독특한 해결책을 제시해 주는 다양한 언어 지도 방법으로 활용될 수 있다. 즉, 드라마는 다양한 감각의 교수 접근법을 사용함으로써, 일반 학생들 뿐만 아니라, 읽기 장애를 가진 영어 학습자들에게 그들의 영어 학습을 향상 시킬 수 있는 아주 중요하면서도 서로 다른 비교 교육을 할 수 있는 활동이며 방법이다. 따라서 드라마 학습법은 학생들에게 언어 학습 측면에서 친숙하고 편안한 학습 보조 환경으로서 개발되어 활용될 수 있을 것이다.

좋은문화상 : 좋은문화상 (부인종양학)

박정열 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Laparoscopic versus open radical hysterectomy for elderly patients with early-stage cervical cancer

박정열,김대연,김종혁,김용만,김영탁,남주현 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

To compare surgical and survival outcomes of laparoscopic (LRH) versus open radical hysterectomy (ORH) in elderly patients early-stage cervical cancer. A retrospective analysis was performed on elderly patients (≥65years) who underwent either LRH (n=99) or ORH (n=159) stage IA2-IIA2 cervical cancer. One patient (1%) in LRH group required conversion to laparotomy. Operating time (p=0.035), estimated blood loss (P= recovery of bowel movement (p<0.001), and postoperative hospital stay (p<0.001) were significantly shorter or lower in LRH Postoperative complications were significantly less frequent in LRH group (p=0.026). After the median follow-up time of 45 months, 5-year disease-free survival (95% vs. 93%, p=0.350) and overall survival (96% vs. 95%, P=0.361) did not differ between LRH and groups. Elderly patients tolerated well both LRH and ORH. LRH was associated with better surgical outcomes compared to ORH increasing intraoperative complications or decreasing survival.

Accuracy of frozen section diagnosis and factors associated with final pathological diagnosis upgrade of mucinous ovarian tumors

박정열,이상훈,김규래,김영탁,남주현 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: To determine the accuracy of frozen section diagnosis and factors associated withfinal pathological diagnosis upgrade in patients with mucinous ovarian tumors. Methods: This study included 1,032 patients with mucinous ovarian tumors who underwentfrozen section diagnosis during surgery. Sensitivity, specificity, and diagnostic accuracy offrozen section diagnosis was calculated. Univariate and multivariate regression analyses wereperformed to determine factors associated with diagnosis upgrade in the final pathology report. Results: The sensitivity and specificity of frozen section diagnosis were 99.1% (95%confidence interval [CI]=98%–99.6%) and 82.2% (95% CI=77.9%–85.7%), respectively, forbenign mucinous tumors; 74.6% (95% CI=69.1%–79.4%) and 96.7% (95% CI=95.2%–97.8%),respectively, for mucinous borderline ovarian tumors; and 72.5% (95% CI=62.9%–80.3%)and 98.8% (95% CI=97.9%–99.3%), respectively, for invasive mucinous carcinomas. Themultivariate analysis revealed that mixed tumor histology (odds ratio [OR]=2.8; 95%CI=1.3–6.3; p=0.012), tumor size >12 cm (OR=2.5; 95% CI=1.5–4.3; p=0.001), multiloculartumor (OR=2.9; 95% CI=1.4–6.0; p=0.006), and presence of a solid component in the tumor(OR=3.1; 95% CI=1.8–5.1; p<0.001) were independent risk factors for final pathologicaldiagnosis upgrade. Conclusions: Mixed tumor histology, tumor size >12 cm, multilocular tumor, and presence ofa solid component in the tumor were independent risk factors for final pathological diagnosisupgrade based on frozen section diagnosis.

기업의 여가친화 사례: 일과 삶의 균형에 영향을 미치는 조직관련 변인의 영향력

박정열,박수정 한국가족자원경영학회 2014 한국가족자원경영학회 학술대회논문집 Vol.2014 No.10

나노스케일 동전기를 이용한 광촉매 반응 향상연구

박정열 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-

We propose a novel microfluidic reactor assisted by nanoelectrokinetics for enhancing the photocatalytic reaction. The proposed reactor uses a porous carbon cloth as a substrate for coating TiO2 nanoparticles to improve photocatalytic activity owing to high surface-to-volume ratio, high oxygen permeability from high porosity and activity of carbon-doping source enabling to narrow the bandgap of TiO₂. Concentration polarization, nanoelectrokinetic phenomena under the forward potential bias was utilized to improve the mass transfer and increase the contact between photocatalyst and ion/ molecules. The resulting high ionic conductance in fluid channel by the applied potential bias caused large potential drop across the photocatalyst film, which can address the problem of the recombination of photo-excited electrons and holes and induce the synergistic effect of photocatalysis and electrocatalysis.

자궁경부에 발생한 배아성 횡문근육종 2예

박정열,조준식,김대연,이동헌,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3

횡문근육종은 소아와 청소년기에 가장 흔한 연부조직 육종이다. 발생 부위는 일반적으로 두부 및 경부, 그 다음으로 비뇨생식계이다 조직학적으로 배아성 횡문근육종, 국화상 육종, 폐포성 횡문근육종, 다형성 횡문근육종으로 나누어진다. 횡문근육종의 약 20%가 비뇨생식기에서 발생하고, 50% 이상이 배아성 횡문근육종이다. 여성 생식기의 배아성 횡문근육종은 드문 악성 종양으로,주로 유소아의 질에서 발생하며, 자궁경부에서 발생하는 횡문근육종은 청소년기에 흔하고, 질에서 기원하는 횡문근육종이 자궁경부에 기원하는 경우보다 5배 정도 많다. 폐경기여성에서는 자궁체부에서 가장 흔히 발생한다. 비뇨생식기의 횡문근육종의 치료는 과거에는 골반장기 적출술만으로 치료를 시도하였으나. 서서히 다중 항암화학요법, 방사선요법, 근치적 절제술을 포함한 병합요법으로 바뀌어가고 있으며, 이에 따라 생존율이 현저하게 향상되었다. 이에 저자들은 최근 본원 산부인과에서 자궁경부에 발생한 배아성 횡문근육종 2예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다. Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and young adult. Genitourinary tract is the econd most common site of rhabdomyosarcoma. Rhabdomyosarcoma can be classified into one of four major types; embryonal, alveolar, pleomorphic and undifferentiated. Embryonal rhabdomyosarcoma of the female genital tract is rare malignant tumor and usually occurs during childhood in the vagina. In rare cases, rhabdomyosarcoma can originate in the uterine cervix, with a peak incidence in the second decade. Recently we have experienced two cases of embryonal rhabdomyosarcoma of the uterine cervix. These cases are presented with a brief review of the literature.