Clinical Characteristics of Auricular Keloids Treated with Surgical Excision

박소영,오정훈,Guen-Ho Lee,Jung Mee Park,Sang-Gyun Jin 대한청각학회 2012 Journal of Audiology & Otology Vol.16 No.3

Background and Objectives: Differences in morphology of auricular keloids possibly contribute to distinct results of treatment. The aim of this study was to evaluate clinical characteristics of the auricular keloids according to the modified Chang-Park classification and to compare the results of treatment including recurrence rate between the subgroups. Subjects and Methods: Clinical data of 15 patients of auricular keloids were retrospectively reviewed. The keloids were classified according to modified Chang-Park classification. Clinical characteristics, the presence of recurrence, and the duration required for the recurrence were compared. Results: Eight out of 15 patients (53.3%) were single sessile type (type II), followed by 4 patients of pedunculated type, 1 patient of multiple sessile type, 1 patient of buried type, and 1 patient of mixed type, respectively. Recurrent keloids after previous surgeries were noted in 7 out of 15 patients and most of them (6 of 7, 85.7%) were sessile type. Three patients who underwent surgery at our department showed recurrence. Conclusions: The classification of auricular keloids according to morphologic patterns can assist surgeons in choosing the appropriate management.

습지생태공원의 갈대확장 조절 기술 개발

성기준 ( Ki June Sung ),이용민 ( Yong Min Yee ),정용현 ( Yong Hyun Chung ),박소영 ( So Young Park ) 한국환경보건기술학회(구 한국환경복원녹화기술학회) 2010 한국환경복원기술학회지 Vol.13 No.5

It is very difficult to control the expansion of reed at a wetland ecological park due to their aggressive reproduction capability. Therefore, proper topography and wetland hydrology should be provided before the construction of a wetland ecological park. Appropriate measures should be taken at the initial stages to prevent reed expansion. Field experiments were conducted at the newly constructed wetland ecological park for 15 months to develop methods to control the reproduction and expansion of Phragmites communis. A complete shading method had the best effect on the prevention of reed reoccurrence among other methods. Complete removal of the rhizomes controlled the reed growth to a greater extent than cutting the aboveground shoots. Water-level manipulation was also better than a half-shading method for the prevention of reed reproduction. These results indicated that soil properties and edge effects can influence the reed growth. Cutting only the aboveground shoots facilitates the growth of reed. These results suggest that reed control should be implemented repeatedly and an alteration in the wetland topography and hydrology may be more effective in the long term. Combination of treatments such as water-level management with shading should be considered to control the growth of reed. Adoptive management for created or restored ecosystem might be considered for accomplishment of its original purpose.

F-125 : Free Paper Presentation ; Effect of Prone Positioning in Adult Patients with Acute Hypoxemic Respiratory Failure: A Meta-analysis

박소영,( Yun Su Sim ),( Hyun Jung Kim ),( Sei Won Lee ),( Eun Kyung Kim ),( Yee Hyung Kim ),( Moon Ji Yong ),( Kyung Hoon Min ),( Sung Soo Park ),( Yong Bum Park ),( Kwang Ha Yoo ),( Jin Woo Lee ),( Seok 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Purpose: Prone position ventilation for acute hypoxemic respiratory failure improves oxygenation but the effect of survival is not yet clearly defined. Recently, large randomized controlled trial showed mortality reduction with prone ventilation. We reviewed the effectiveness of prone position as compared with supine position, with respect mortality, improvement in oxygenation, incidence of ventilator associated pneumonia and adverse effect. Method: Randomized control trials comparing 6≥hrs of prone position with supine position in adult patients with acute hypoxemic respiratory failure. Data were combined in a meta-analysis using random effect models. Results: 7 trials met inclusion criteria. We did not find any significant differences in mortality (risk ratio (RR), 0.76, 95% confidence interval (CI) 0.56-1.03; p=0.08 ). However, prone position reduced mortality in patients with PaO2/FiO2 <200 mmHg [RR, 0.71, 95% CI 0.52-0.97; p=0.03]. Prone positioning also showed significant improvement in PaO2/FiO2 mmHg [weighted mean difference 32.22; 95% CI 16.76-47.67 ; p<0.0001]. But increased the risk of pressure sore (RR 1.23, 95%CI 1.06-1.42, 0.006) and loss of venous access (RR 1.98, 95%CI 1.11-3.55, 0.02) in prone position group. There was no significant difference in incidence of pneumonia, endotracheal tube displacement and cardiac arrest. Conclusions: Prone position ventilation in adult patients with acute respiratory failure reduces mortality in patients with PaO2/FiO2 <200 mmHg, and it is associated with improvement of oxygenation.Purpose: Prone position ventilation for acute hypoxemic respiratory failure improves oxygenation but the effect of survival is not yet clearly defined. Recently, large randomized controlled trial showed mortality reduction with prone ventilation. We reviewed the effectiveness of prone position as compared with supine position, with respect mortality, improvement in oxygenation, incidence of ventilator associated pneumonia and adverse effect. Method: Randomized control trials comparing 6≥hrs of prone position with supine position in adult patients with acute hypoxemic respiratory failure. Data were combined in a meta-analysis using random effect models. Results: 7 trials met inclusion criteria. We did not find any significant differences in mortality (risk ratio (RR), 0.76, 95% confidence interval (CI) 0.56-1.03; p=0.08 ). However, prone position reduced mortality in patients with PaO2/FiO2 <200 mmHg [RR, 0.71, 95% CI 0.52-0.97; p=0.03]. Prone positioning also showed significant improvement in PaO2/FiO2 mmHg [weighted mean difference 32.22; 95% CI 16.76-47.67 ; p<0.0001]. But increased the risk of pressure sore (RR 1.23, 95%CI 1.06-1.42, 0.006) and loss of venous access (RR 1.98, 95%CI 1.11-3.55, 0.02) in prone position group. There was no significant difference in incidence of pneumonia, endotracheal tube displacement and cardiac arrest. Conclusions: Prone position ventilation in adult patients with acute respiratory failure reduces mortality in patients with PaO2/FiO2 <200 mmHg, and it is associated with improvement of oxygenation.

유산균들의 콜레스테롤 저하성, 내산성, 내담즙성, 항생제 내성 비교

박소영,고영태,정후길,양진오,정현서,김영배,지근억,Park, So-Young,Ko, Young-Tae,Jeong, Hoo-Kil,Yang, Jin-Oh,Chung, Hyun-Seo,Kim, Young-Bae,Ji, Geun-Eog 한국미생물 · 생명공학회 1996 한국미생물·생명공학회지 Vol.24 No.3

For a probiotic yoghurt it is desirable to utilize lactic acid bacteria with a high survival rate and beneficial function to human beings. We have examined a variety of lactic acid bacteria to assess the acid and bile tolerance and antibiotic resistance. In addition, an in vitro culture experiment was performed to evaluate their ability to reduce cholesterol levels in the growth medium. Thirteen strains were selected from in vitro cholesterol assays and fed to Sprague-Dawley rats with a high-cholesterol diet. Among the 13 strains tested, 8 strains were shown to reduce serum cholesterol levels significantly after 24 days of administration in vivo. Rats were fed lyophilized yoghurt powder fermented with a combination of 3 selected strains: Bifidobacterium infantis AM-220, Lactobacillus AM-245, and Styeptococcus MA-1. The levels of total cholesterol and low density lipoprotein were significantly lower (p$\leq$0.05) in rats fed the yoghurt powder compared with control group. These studies suggest that yoghurt fermented with appropriately selected lactic acid bacteria may have a anticholesterolemic effect.

CO-I 유전자 기반 국내 유통 Corbicula 속 패류의 종 동정

박소영,강세원,황희주,정종민,송대권,박홍석,한연수,이준상,강정하,이용석,Park, So Young,Kang, Se Won,Hwang, Hee Ju,Chung, Jong Min,Song, Dae Kwon,Park, Hong Seog,Han, Yeon Soo,Lee, Jun-Sang,Kang, Jung-Ha,Lee, Yong Seok 한국패류학회 2016 The Korean Journal of Malacology Vol.32 No.2

The natives of the genus Corbicula have shown worldwide dispersion in recent times, which has caused great ecological and economic impacts on the introduced ecosystems. The species reported from the genus have been consumed as food and explored for medicine with pharmacological activity. Consequently, the demand of Corbicula sp. in the South Korean domestic market has increased and so also it's associated import to the country. However, due to the absence of identification keys of imported Corbicula, the market is facing confronting situations. We hypothesized that the mitochondrial Cytochrome Oxidase I gene (CO-I) based molecular profiling could be a necessary technique for identification of Corbicula sp. in the South Korea domestic market. The genetic analysis identified both Corbicula japonica and Corbicula fluminea from the market foods. C. japonica and C. fluminea are inhabitants in Korea, but C. fluminea production has decreased in Seomjingang river basin. Therefore, C. fluminea identified from this study, is expected to be imported from China and would have a mixed sales in Seomjingang river side basin. CO-I서열의 생물정보학적 분석 결과 국내에서 유통되는 재첩류의 연체부는 일본재첩 (C. japonica) 과 재첩 (C. fluminea) 으로 동정되어 두 종이 혼재하여 유통되는 것으로 확인되었다. 일본재첩 (C. japonica) 과 재첩 (C. fluminea) 은 국내에서 서식하고 있으나, 섬진강 유역의 재첩 (C. fluminea) 은 개체수가 감소하여 거의 생산되지 않고 있으므로, 본 연구를 통해 확인된 재첩 (C. fluminea) 은 중국 수입산으로 예상된다.

개인별 평균차를 이용한 최대 엔트로피 기반 감성 인식 모델

박소영,김동근,황민철,Park, So-Young,Kim, Dong-Keun,Whang, Min-Cheol 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.7

In this paper, we propose a maximum entropy-based emotion recognition model using the individual average difference of emotional signal, because an emotional signal pattern depends on each individual. In order to accurately recognize a user's emotion, the proposed model utilizes the difference between the average of the input emotional signals and the average of each emotional state's signals(such as positive emotional signals and negative emotional signals), rather than only the given input signal. With the aim of easily constructing the emotion recognition model without the professional knowledge of the emotion recognition, it utilizes a maximum entropy model, one of the best-performed and well-known machine learning techniques. Considering that it is difficult to obtain enough training data based on the numerical value of emotional signal for machine learning, the proposed model substitutes two simple symbols such as +(positive number)/-(negative number) for every average difference value, and calculates the average of emotional signals per second rather than the total emotion response time(10 seconds). 감성신호는 개인에 따라 그 패턴이 매우 다르게 나타나므로, 본 논문에서는 감성신호의 개인별 특징을 고려한 최대 엔트로피 기반 감성 인식 모델을 제안한다. 제안하는 모델은 보다 정확하게 사용자의 감성을 인식하기 위해서, 단순히 주어진 입력 감성 신호 값만을 사용하지 않고, 긍정 감성 신호 값의 평균과 부정 감성 신호 값의 평균을 입력 감성 신호의 값과 비교하여 활용한다. 또한, 감성 인식에 대한 전문적인 지식이 없이도 감성 인식 모델의 구축이 용이하도록, 제안하는 모델은 성능이 높다고 잘 알려진 기계학습기법의 하나인 최대 엔트로피 모델을 이용한다. 감성 신호의 수치 값을 그대로 사용하면 기계 학습에 필요한 학습 패턴 자료를 충분히 확보하기 어렵다는 점을 고려하여, 제안하는 모델은 평균차를 수치 값 대신 +(양수)와 -(음수)로 단순하게 표현하며, 감성 반응 전체 시간인 10초 대신 초단위로 분할하여 학습 패턴 자료의 양을 늘렸다.

Doritaenopsis 체세포배의 내배수성 특성과 절편체의 내배수성 세포에 기인한 체세포변이의 발생

박소영,백기엽,Park, So-Young,Paek, Kee-Yoeup 한국식물생명공학회 2006 식물생명공학회지 Vol.33 No.4

In general, the proliferation of orchids via somatic embryos has been used for mass production of somatic clones because of high propagation efficiency. In spite of high propagation rate, this method often brings somaclonal variation, especially polyploid frequency. Therefor we here concentrated to investigate the relationship between endopolyploidization patterns of explants and the occurrence of tetraploid variant in clonally proliferated Doritaenopsis via somatic embryo regeneration system. In the fully developed somatic embryo, upper part contained 2C to 16C while middle and lower parts showed 2C to 32C DNA content. Two-week-old embryo contained 2C to 16C, whereas those regenerated after 4 to 10-week-old contained 2C to 64C nuclei. Results showed that endoreduplication was variable depending upon tissue types, ages, and parts in one species. lower part of somatic embryo having high endoreduplication degree increased the regeneration of tetraploid variants by about 3-fold comparing to upper part of somatic embryo culture. polyploid frequency occurrence might be closely related to the high levels of endoreduplication of somatic embryos used as explant. It suggested that the upper part of somatic embryo having comparatively low endoreduplication degree is suitable for the stable in vitro propagation system. 일반적으로 체세포배를 경유한 대량증식은 증식효율이 높다. 그러나 종종 배수성 변이와 같은 체세포 변이를 야기하기도 한다. 본 연구에서는 Doritaenopsis hybrid의 체세포배 증식시 발생하는 배수성 변이체와 체세포배의 세포에 내재되어 있는 내배수화된 세포와의 관계를 구명하여 배수성 변이체 발생 원인을 밝히고자 실시되었다. 내배수성 분석결과 체세포배의 상부는 $2C{\sim}16C$의 DNA를 함유한 세포들로 구성되어 있는 반면, 중부와 하부 조직에는 $2C{\sim}32C$의 내배수성이 높은 세포들이 내재되어 있었다. 또한 체세포배 연령별로는 2주된 체세포배가 $2C{\sim}16C$ 정도의 세포로 구성되어 있는 반면 10주령의 체세포배는 $2C{\sim}64C$까지 고도로 내배수화가 진행된 세포들이 존재하였다. 이는 한 식물체에서도 부위, 연령에 따라 내배수성이 다를 수 있음을 보여주는 결과이다. 체세포배 부위중 내배수성이 낮은 상부와 높은 하부로 절단하여 각각의 절편체를 배양한 결과 배수성 변이체의 발생은 내배수성이 높은 하부를 배양하였을 때 3배 이상 높았다. 본 연구결과는 변수성 변이체의 발생원인이 내배수화된 세포에 있음을 보여주며 이를 기초로 Dtps. hybrid의 안정적인 증식체계를 구축하는데 기초가 되리라 생각된다.

웹문서를 이용한 단계별 한국어 미등록어 인식 모델

박소영,Park, So-Young 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.9

Recently, real documents such as newspapers as well as blogs include newly coined words such as "Wikipedia". However, most previous information processing technologies cannot deal with these newly coined words because they construct their dictionaries based on materials acquired during system development. In this paper, we propose a model to automatically recognize Korean unknown words excluded from the previously constructed dictionary. The proposed model consists of an unknown noun recognition phase based on full text analysis, an unknown verb recognition phase based on web document frequency, and an unknown noun recognition phase based on web document frequency. The proposed model can recognize accurately the unknown words occurred once and again in a document by the full text analysis. Also, the proposed model can recognize broadly the unknown words occurred once in the document by using web documents. Besides, the proposed model fan recognize both a Korean unknown verb, which syllables can be changed from its base form by inflection, and a Korean unknown noun, which syllables are not changed in any eojeol. Experimental results shows that the proposed model improves precision 1.01% and recall 8.50% as compared with a previous model. 신문이나 블로그와 같은 실제 문서에서는 위키백과(Wikipedia)와 같은 기존에 없던 새로운 단어를 포함하고 있다. 그러나, 대부분의 정보 처리 기술은 시스템 개발 당시 확보한 자료를 바탕으로 사전을 구축하므로, 이러한 새로운 단어에 대해 신속하게 대처할 수 없다는 한계가 있다. 따라서 본 논문에서는 사전에 등록되어 있지 않은 한국어 미등록어를 자동으로 인식하는 모델을 제안한다. 제안하는 모델은 전문분석 기반 미등록명사 인식 단계, 웹 출현빈도 기반 미등록용언 인식 단계, 웹 출현빈도 기반 미등록명사 인식 단계로 구성된다. 제안하는 모델은 문서에서 여러 번 나타난 미등록어에 대해 전문분석을 통해 정확하게 인식할 수 있다. 그리고, 제안하는 모델은 문서에 한번 나타난 미등록어에 대해서도 웹문서를 바탕으로 광범위하게 인식할 수 있다. 또한, 제안하는 모델은 기본형이 어절에 그대로 나타나는 미등록명사뿐만 아니라 기본형이 변형하여 나타날 수 있는 미등록용언도 인식할 수 있다. 실험 결과 기존 미등록어 인식방법에 비해 제안하는 접근방법은 정확률 1.01%와 재현을 8.50%를 개선하였다.

웹기반 프로그래밍 언어 강의 지원 시스템의 설계 및 구현

박소영,Park, So-Young 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.12

본 논문에서는 강사가 학생에게 프로그래밍 언어를 효과적으로 가르칠 수 있도록 지원하는 웹기반 프로그래밍 언어 강의 지원 시스템을 제안한다. 제안하는 시스템은 오류 분석 단계와 검사 수행 단계로 구성된다. 먼저, 오류 분석 단계에서는 학생들이 제출한 프로그램에 컴파일 오류나 실행 오류가 있는지 확인한다. 이 때, 오류가 있으면 학생들이 이를 수정할 수 있도록 친절한 피드백을 제공한다. 그리고, 오류가 없으면 제출한 프로그램에 대해 소스 코드의 스타일 검사, 주석 검사, 표절 검사를 수행하고, 학생에게 검사결과에 대한 신속한 피드백을 제공한다. 따라서, 학생은 프로그램 과제물을 제출하고 바로 검사결과를 확인할 수 있다. 제안하는 시스템을 C 언어 수업에서 활용한 결과 학생들이 보다 적극적으로 프로그램 과제물을 제출하려는 경향이 나타났다. In this paper, we propose a web-based programming class support system to help a lecturer to teach a programming language to students effectively. The proposed system is composed of a error analysis step and a verification step. The error analysis step checks whether there are compile time errors or run time errors in each student's submitted program. Given some errors, the system provides helpful feedback for the student to fix the errors. On the contrary, the system provides quick feedback after checking the source code style, comments, and plagiarism in the submitted program. As soon as the student submits the program, the student can see the check results. According to the result of utilizing the proposed system in a C programming language class, students tend to submit program assignments actively.

동양달팽이 (Nesiohelix samarangae) 의 expressed sequence tags (ESTs) 로부터 분리한 2종류의 Serpin 유전자 분석

박소영,정지은,황희주,왕태훈,박은비,김용민,이준상,한연수,양승하,이용석,Park, So Young,Jeong, Ji Eun,Hwang, Hee Ju,Wang, Tae Hun,Park, Eun Bi,Kim, Yong Min,Lee, Jun-Sang,Han, Yeon Soo,Yang, Seung-Ha,Lee, Yong Seok 한국패류학회 2014 The Korean Journal of Malacology Vol.30 No.2

동양달팽이의 EST 에서 serpin 유전자는 2가지 type이 추정되었다. Ns-serpin type 1 (partial) 서열의 코딩 영역은 총 819 bp 이었으며, 272개의 아미노산으로 이루어져 있었으며, Ns-serpin type 2 (partial) 의 코딩영역은 총 555 bp, 185개의 아미노산으로 이루어져 있었다. Laminarin 처리 전에는 Ns-serpin type 1이 2개 발현되었으며 처리 후에는 Ns-serpin type 2가 1개 발현되고 있었다. BLAST 결과를 바탕으로 유사도가 높은 17개의 참고 서열과 동양달팽이의 Ns-serpin type 1, 2의 아미노산 서열을 MEGA6 프로그램의 clustalW 엔진을 이용하여 multiple sequence alignment 를 수행한 결과, 척색동물의 포유강 9종, 조류강 1종, 양서강 1종과 척색동물인 해초강, 절지동물의 거미강 1종과 곤충강 1종이 같은 군으로 묶였으며, 연체동물문의 경우 동양달팽이의 두 가지 type 을 포함한 복족강 4종이 같은 군으로 묶이는 것을 확인하였다. Psipred 프로그램을 활용하여 예측한 2D 구조도 multiple align 및 phylodendrogram 결과와 연관이 있음을 확인할 수 있었다. EST를 통해 밝힌 동양달팽이의 두 가지 type의 Ns-serpin 서열은 Aplysia californica 등의 근연종들의 서열과 유사하였다. 본 연구에서는 무척추동물에서의 선천성 면역과 연관이 있는 것으로 잘 알려진 두 종류의 serpin 유전자 서열을 동양달팽이 EST 결과에서 발굴 하였으며, 동양달팽이에서도 여러 가지 type의 serpin 이 존재 할 수 있음을 입증하였다. Serpins are a group of proteins involved in the regulation of serine and other type of proteases, and have been identified in many kinds of organisms from invertebrates to vertebrates. Serpins are known to regulate the proteolytic cascades of the innate immune pathways in addition to their roles in blood coagulation, angiogenesis, fibrinolysis, inflammation and tumor suppression. In this study, we have isolated two partial serpin gene fragments from expressed sequence tags (ESTs) of Nesiohelix samarangae. Dotplot analysis indicates that they are of two different types, Ns-serpin type 1 and Ns-serpin type 2. Ns-serpin type 1 has 819 bp coding region (272 amino acids), whereas Ns-serpin type 2 has 555 bp coding region (185 amino acids). Molecular phylogenetic analysis shows that the identified serpins have high similarities to their counterparts in the California see slug, Aplysia californica. Yet, the precise biological and immunological roles of these Ns-serpins remain to be further investigated using RNA interference and other molecular techniques.