포스터 전시 발표 : 소화기 ; 관내 내시경 초음파로 감별 진단한 조기 담관암 2예

박세은,조재희,문지애,박영수,송시영,정재복,강진경,박승우 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10

MENIN 유전자 돌연변이를 동반한 제1형 다발성 내분비선종 1 예

박세은,강은석,이현주,김소헌,김형진,도미영,강신애,한승진,안철우,차봉수,임승길,김경래,김일진,이현철 대한내분비학회 2005 Endocrinology and metabolism Vol.20 No.1

Multiple endocrine neoplasia type 1(MEN 1) is an autosomal dominantly inherited syndrome, characterized by the combined occurrence of tumors of the parathyroid glands, endocrine pancreas, and anterior pituitary gland. The MENIN gene, which is a kind of tumor suppressor gene, is located at the chromosomal locus 11q13. It consists of one untranslated exon and nine exons encoding the menin protein. We report a case of a 22-yearss-old woman with MEN type 1, who was proven to have a mutation in the MENIN gene. The patient was admitted because of repeated hypoglycemia. The fasting plasma glucose level was 32mg/dL. Seventy two hours fasting test showed an the insulin/glucose ratio as 0.33. Endoscopic ultrasonography detected multiple masses on the pancreas. The arterial -stimulated venous sampling(ASVS) with calcium showed sudden step up of insulin at the head and tail portions of the pancreas. The sellar MRI showed a pituitary mass that produced prolactin. Instead of a pathologic diagnosis from operational specimen, the genetic analysis revealed a mutation in the MENIN 1 gene(exon 2, 200~201insAGCCC) 저자들은 공복 시 발생하는 어지러움증, 발한을 주소로 내원한 22세 여자 환자에서 호르몬 검사와 방사선 검사 및 칼슘자극 선택정맥혈채혈검사 등을 통해 췌장 인슐린종, 프로락틴 분비 뇌하수체선종, 부갑상선 기능항진증을 함께 보인 제1형 다발성 내분비선종을 진단하고 유전자 검사결과를 통하여 이를 확진하였다. 이에 문헌 고찰과 함께 보고하는 바이다

Reality /Virtualy

박세은 서울대학교 인문대학 미학과 1998 美學硏究 Vol.5 No.-

세탁과 건조에 따른 양모 위편성물의 편성조직별 형태 변화

박세은,백성필,박명자 한국의상디자인학회 2022 한국의상디자인학회지 Vol.24 No.2

The purpose of this study is to analyze the structural properties of 100% wool fabrics knitted with various stitch types and to evaluate dimensional stability from shrinkage in wet cleaning and drying. Materials were weft-knitted from twenty-four different stitches with 7 gauge using a computerized flatbed knitting machine. Weight, thickness, density, and length were measured. A domestic washing machine and a tumble dryer were used for the shrinkage test. The results are as follows: Knitted fabrics were divided into 3 groups based on weight per unit area. Porous knits show light weight whilst milano, pintuck, rib stitches belong to the heaviest group. A positive correlation between weight and thickness was found and the same result was obtained for wale density and weight. Dimensional shrinkage of knitted fabrics was increased during repetitive wet cleaning and drying regardless of knit stitches. Especially, fabrics knitted with float, tuck, cable, and links & links stitches samples were contracted more than 15% in the first treatment whereas 2x1 rib stitch showed 1% shrinkage rate. Fisherman and milano stitches contracted in both course and wale direction with similar shrinkage rates. However, porous knits with float and tuck stitches shrank in course direction by 20% as well as cable samples contracted from 5% to 20% after repeated washing and drying. On the other hand, 30% and 15% contraction of wale direction occurred in orderly float and links & links stitches, respectively. Machine dried knits have a higher shrinkage rate than air-dried knits, but the drying method did not affect to the direction of contraction. In conclusion, variations of knit, tuck, and float stitches affect knit construction and dimensional stability from shrinkage in wet cleaning and drying of wool knitted fabrics.

유산균 복합배양 양배추 발효물의 항염증 효과

박세은,최준희,김기만 한국식품저장유통학회 2022 한국식품저장유통학회지 Vol.29 No.1

In this study, we investigated the anti-inflammation effect of cabbage (Brassica oleracea L var. capitata) fermented with a mixed culture of lactic acid bacteria (FCMC) and elucidated the underlying mechanism. The mixed culture included Lactobacillus plantarum and L. acidophilus. The cell viability of RAW264.7 macrophages were confirmed by MTT assay, and the results revealed no toxicity following treatment with FCMC at concentrations of up to 1,000 μg/mL. The anti-inflammatory effect of FCMC was evaluated by stimulating RAW264.7 macrophages with lipopolysaccharide (LPS) to induce the production of inflammation-related factors, which were measured by an nitric oxide (NO) assay, enzyme-linked immunosorbent, and Western blot. FCMC dose-dependently inhibited the production of NO, PGE2, and the pro-inflammatory cytokines IL-1β and TNF-α in LPS-stimulated RAW264.7 macrophages without any cytotoxicity. FCMC also reduced the protein expression levels of iNOS and COX-2 and inhibited the nuclear translocation of NF-κB and degradation of IκB in the LPS-stimulated cells. These results collectively suggest that FCMC may suppress the inflammatory reaction in LPS-stimulated RAW264.7 macrophages by regulating the NF-κB signaling pathway and function as an anti-inflammatory material.

여대생의 운동행동변화단계별 운동자기효능감 및 신체존중감의 차이

박세은,홍준희 한국리듬운동학회 2017 한국리듬운동학회지 Vol.10 No.2

The purpose of prepose of present study was to investigate the difference in exercise self-efficacy and body-esteem on the stage of exercise behavior change. Participants of this study was selected by conducting convenience sampling among female college students attending 8 universities located at metropolitan area in 2014. Total 339 questionnaires were distributed and 327 were returned usable. Techniques for data analysis were frequency analysis, validity analysis, reliability analysis, and One-way Analysis of Variance and Posteriori Tests Scheffe using SPSS 21.0 programs. The result Exercise Self-efficacy on the Stages of Exercise Behavior Change showed significant difference. Sexual Attractiveness and Weight Concern of Body-esteem on the Stages of Exercise Behavior Change showed no signification difference. There was significant difference only at Physical Condition as the stage was closer to Maintenance. The present study would like to suggest that steady exercise provides the possibility of applying coping ability even at barrier situation of college life by improving satisfaction of healthy body and exercise self-efficacy.

Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea

박세은,서미혜,조정환,권혜미,김양현,한경도,정진형,박영규,이은정,이원영 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.4

Background This study aimed to evaluate the dose-dependent effects of smoking on risk of diabetes among those quitting smoking. Methods We analyzed clinical data from a total of 5,198,792 individuals age 20 years or older who received health care check-up arranged by the national insurance program of Korea between 2009 and 2016 using the Korean National Health Insurance Service database. Cumulative smoking was estimated by pack-years. Smokers were classified into four categories according to the amount of smoking: light smokers (0.025 to 5 smoking pack-years), medium smokers (5 to 14 smoking pack-years), heavy smokers (14 to 26 smoking pack-years), and extreme smokers (more than 26 smoking pack-years). Results During the study period, 164,335 individuals (3.2% of the total population) developed diabetes. Compared to sustained smokers, the risk of diabetes was significantly reduced in both quitters (hazard ratio [HR], 0.858; 95% confidence interval [CI], 0.838 to 0.878) and nonsmokers (HR, 0.616; 95% CI, 0.606 to 0.625) after adjustment for multiple risk factors. The risk of diabetes gradually increased with amount of smoking in both quitters and current smokers. The risk of diabetes in heavy (HR, 1.119; 95% CI, 1.057 to 1.185) and extreme smokers (HR, 1.348; 95% CI, 1.275 to 1.425) among quitters was much higher compared to light smokers among current smokers. Conclusion Smoking cessation was effective in reducing the risk of diabetes regardless of weight change. However, there was a potential dose-dependent association between smoking amount and the development of diabetes. Diabetes risk still remained in heavy and extreme smokers even after smoking cessation.

Effects of a hybrid online and offline program for facilitating father-infant interactions in South Korea: a quasi-experimental study

박세은,Kyung-Sook Bang 한국아동간호학회 2022 Child Health Nursing Research Vol.28 No.2

Purpose: This study examined the effects of an educational program for fathers on improving father-infant interactions, child-rearing knowledge, and attachment. Methods: In this quasi-experimental study, the participants were recruited by convenience sampling among fathers with infants (2-6 months of age) residing in three districts of Seoul. Fifteen participants in the experimental group and 17 participants in the control group completed the follow-up investigation. A 5-week online and offline intervention program with five sessions was provided to the experimental group. The data were analyzed using generalized estimating equations (GEEs). Results: There was a significant difference in the change in father-infant interaction scores of the experimental group, especially in the caregiver aspect with a significance level of .100 in time and group-to-group interactions (B=6.46, p=.051, 95% confidence interval [CI]=-0.02-12.94). The changes between the groups and times were not statistically significant when it came to infant development knowledge and father-infant attachment. Conclusion: We conclude that hybrid online and offline education should be implemented as an effective method to improve fathers’ interactions with their children based on accurate knowledge about infant development.

Elemental analysis of the fluoride varnish effects on root caries initiation

박세은,이기욱,김혜영,손호현,장주혜 大韓齒科保存學會 2011 Restorative Dentistry & Endodontics Vol.36 No.4

Objectives: The usage of fluoride varnish for a moderate to low caries-risk group has not been well validated. This study aimed to evaluate the preventive and therapeutic efficacies of fluoride varnish on the initiated root caries. Materials and Methods: Ten premolars were sectioned into quarters, further divided into two windows, one of which was painted with Fluor Protector (1,000 ppm fluoride, Ivoclar Vivadent). An initial lesion with a well-preserved surface layer was produced by pH cycling. Scanned line analysis using energy dispersive spectrometry determined the weight percentages of Ca and P in the demineralized layer. Scanning Electron microscopy and confocal laser scanning microscopy (CLSM) evaluated the varnish-applied root surfaces. Results: The mean lesion depth (SD) was 12.3 (2.6) (single cycling) and 19.6 (3.8) (double cycling). Double cycling extended the lesion depth, but induced no more mineral loss than single cycling (p < 0.05). The mean weight percentages of Ca and P between groups with and without varnish were not significantly different (p < 0.05). A CLSM showed varnish remained within 15 of the surface layer. Conclusions: When a mild acid challenge initiated root tissue demineralization, the application of low-concentration fluoride varnish did not influence the lesion depth or the mineral composition of the subsurface lesion. 연구 목적: 우식 저 위험군에서 저 농도 불소 바니쉬가 초기 치근 우식 예방 및 치료에 미치는 영향을 검증하고자 한다. 연구 재료 및 방법: 건전한 하악 소구치 10개를 준비하여 치관부를 제거하고 협설, 근원심 방향으로 치아 장축에 평행하게 절단 후 백악-법랑질 경계부 4 mm 하방에서 절단하여 40개의 시편을 제작하였다. 각각의 치근 표면에 형성된 4 mm 1 mm 크기의 창에 Fluor Protector (1,000 ppm 불소 함유)를 도포하였다. 한 치아에서 나온 4 개의 시편을 다음과 같은 4개 실험군에 각각 배정하였다. A군: pH cycling 없이 불소 바니쉬 도포; B군: pH cycling시행 후 불소 바니쉬 도포; C군: 불소 바니쉬 도포 후 pH cycling시행; D군: pH cycling을 시행한 뒤 불소 바니쉬 도포 후 pH cycling 재 시행. 시편을 정중부에서 절단하고 단면 부위를 연마한 뒤 전자현미경으로 표면을 관찰하였다. X선 분광분석을 통하여 Ca과 P의 중량 비를 측정하고 공 초점 레이저 현미경으로 바니쉬가 도포된 치근 면을 관찰하였다. 결과: 치근 표면에는 평균 12.3 (2.6) (single cycling) 과 19.6 (3.8) (double cycling) 깊이의 우식이 형성되었다. 표층의 칼슘 함량은 정상 치근에 비해 유의할만한 차이가 없었으나(p > 0.05), 표층 하 탈회 영역의 칼슘 함량은 유의할만하게 감소하였다(p < 0.05). 불소 바니쉬의 적용은 건전한 치근이나 초기 우식이 있는 치근에 적용했을 경우 모두에서 유의할만한 차이를 가져오지 않았다(p > 0.05). 바니쉬의 치근 상아질 투과 깊이는 표면 15 이내에 한정되었다. 결론: 표층이 건전한 20 이내의 초기 치근 우식 병소의 양상과 산 공격에 대한 변화를 관찰한 결과, 저 농도의 불소 바니쉬를 단기간 적용하는 것은 치근의 탈회 반응에 영향을 주지 못하였다.

보건소 영양사의 직무만족도가 조직몰입과 이직의도에 미치는 영향

박세은,서민영,김원경,류경 대한영양사협회 2020 대한영양사협회 학술지 Vol.26 No.1

This study examined the job satisfaction of nutritionists, and its effect on organizational commitment and turnover intention in public health centers. The response data of 174 nutritionists were analyzed. The overall average of job satisfaction was 3.94 out of 7 points, which was determined to be below ‘normal’; however, the job suitability of sub-factors scored 5.26, which was more than ‘normal’. The variables affecting job satisfaction that were provided by the respondents included job-related licenses (P<0.01) and co-nutritionists (P<0.01). Organizational commitment ranked ‘normal’ with a score of 4.35. Normative commitment (4.90) of the sub-factors was ‘normal’ or more, and differed when considering ‘age’ (P<0.01), ‘employment status’ (P<0.01), ‘salary per year’ (P<0.05), and ‘working area’ (P<0.05). The turnover intention was analyzed to be below ‘normal’ with 3.88 points, and the variables affecting turnover were significantly higher for subjects in their 20s (P<0.01), less than two job-related licenses (P<0.05), and less than two co-nutritionists (P<0.01). The four variables of job satisfaction, ‘business discretion’ (P<0.05), ‘work environment’ (P<0.01), ‘job suitability’ (P<0.01), and ‘reward’ (P<0.01), positively affected the organizational commitment. Moreover, organizational commitment had a mediating effect (P<0.01) on job satisfaction and turnover intention. Taken together, our results suggest that public health centers need to develop improvement plans for business discretion, work environment, job suitability and reward.