미국발(發) 2차 금융위기 가능성과 영향

박덕배,Park, Deok-Bae 한국시멘트협회 2009 시멘트 Vol.182 No.-

바울형 미분기 베인휠에서의 유속 불균일 개선에 관한 연구

박덕배,허진혁,문승재,Park, Deok-Bae,Hur, Jin-Huek,Moon, Seung-Jae 한국플랜트학회 2010 플랜트 저널 Vol.6 No.2

The stability of coal pulverizer in the 800 MW coal-fired plants is vital to maintain their performance. Thus, this study analyzed the uneven abrasion of the deflector and coal spillage due to the air velocity maldistribution in the vane wheel of a bowl-type pulverizer as it is a possible cause for problems of facility using pulverized coal. In addition, air flow in the underbowl of a bowl-type pulverizer was studied to check air velocity maldistribution in the vane wheel using numerical method. In an attempt to correct the maldistribution of air velocity, air flow of the modified duct vane was studied as enlarging the length of the duct vanes installed at the air inlet duct of the pulverizer and increasing the angle of inclination. It was found that modified duct vane make the velocity distribution at the vane wheel uniform. formed by the duct vanes installed at the air inlet duct of the pulverizer and swirling flow is the major factor in making the velocity distribution of vane wheel exit uniform. This can prevent the uneven abrasion of the deflector, which is one of the components inside the pulverizer and coal spillage.

Effects of Extracellular $Ca^{++}$ on PKC or cAMP-stimulated Increases in LH Release and $LH{\beta}$ Subunit mRNA Levels in Rat Anterior Pituitary Cells

박덕배,김창미,천민석,유경자,Park, Deok-Bae,Kim, Chang-Mee,Cheon, Min-Seok,Ryu, Kyung-Za The Korean Society of Pharmacology 1996 대한약리학잡지 Vol.32 No.3

We examined the effects of EGTA and verapamil on phorbol ester-and forskolin-stimulated LH releases and $LH{\beta}$ subunit mRNA levels in order to verify the role of extracellular $Ca^{++}$ on PKC- or cAMP-induced increases in LH release and $LH{\beta}$ subunit mRNA levels in cultured anterior pituitary cells of rat. Forskolin-stimulated $LH{\beta}$ subunit mRNA levels as well as LH release were all suppressed by prevention of $Ca^{++}$ mobilization from extracellular environment, after the treatment of EGTA as a $Ca^{++}$ chelator or verapamil as a $Ca^{++}$ channel blocker. PMA-stimulated $LH{\beta}$ subunit mRNA levels were also suppressed by the treatment of EGTA and verapamil, while PMA-induced LH release was not affected. From the present study, it is, therefore, suggested that PKC activation and cAMP elevation all stimulate $LH{\beta}$ subunit mRNA levels and these are extracellular $Ca^{++}$-dependent. However, LH releases by PKC activation and cAMP increase seem to be different each other. LH release by PKC activation is thought to be independent of extracellular $Ca^{++}$. On the other hand, cAMP stimulated-LH release is thought to be dependent on the entry of extracellular $Ca^{++}$. 흰쥐 뇌하수체 전엽배양세포에서 PKC나 cAMP에 의한 LH 분비와 $LH{\beta}$subunit mRNA 증가과정에서 세포외 $Ca^{++}$의 역할을 검증하기 위하여 phorbol ester와 forskolin에 의해 촉진된 LH 분비와 $LH{\beta}$ subunit mRNA 수준에 미치는 EGTA와 verapamil의 영향을 조사하였다. Forskolin에 의해 촉진된 LH 분비와 $LH{\beta}$ subunit mRNA 수준은 $Ca^{++}$ chelator인 EGTA나 $Ca^{++}$ 채널차단제인 verapamil의 처리로 세포외부로부터 $Ca^{++}$의 이동을 억제시켰을때 모두 감소하였다. PMA에 의해 유도된 LH 분비는 EGTA와 verapamil 처리에 의해 영향을 받지 않았으나 PMA에 의해 촉진된 $LH{\beta}$ subunit mRNA는 억제되었다. 따라서 본 연구에 의하면 PKC 활성화나 세포내 cAMP 농도 증가는 $LH{\beta}$ subunit mRNA 수준을 증가시키며 이러한 과정은 세포외 $Ca^{++}$ 의존적인 것으로 생각된다. 그러나 PKC 활성화나 cAMP 증가에 의한 세포외 $Ca^{++}$의 역할이 서로 다른 양상을 보인다. PKC 활성화에 의한 LH 분비는 세포외 $Ca^{++}$에 비의존적이나 cAMP에 의해 촉진된 LH 분비는 세포외 $Ca^{++}$ 유입의 영향을 받는 것으로 사료된다.

심볼 생성기용 소프트웨어 개발

박덕배(Deok-Bae Park),이재억(Jae-Uk Lee) 한국항공우주학회 2003 韓國航空宇宙學會誌 Vol.31 No.9

흰쥐 뇌하수체 전엽세포에서 PKC나 cAMP에 의한 LH 분비 및 LHβ Subunit mRNA 증가에 미치는 Ca⁺⁺의 영향

박덕배(Deok-bae Park),김창미(Chang-mee Kim),천민석(Min-seok Cheon),유경자(Kyung-za Ryu) 대한약리학회 1996 대한약리학잡지 Vol.32 No.3

흰쥐 뇌하수체 전엽배양세포에서 PKC나 cAMP에 의한 LH 분비와 LHβsubunit mRNA 증가과정에서 세포외 Ca⁺⁺의 역할을 검증하기 위하여 phorbol ester와 forskolin에 의해 촉진된 LH 분비와 LHβ subunit mRNA 수준에 미치는 EGTA와 verapamil의 영향을 조사하였다. Forskolin에 의해 촉진된 LH 분비와 LHβ subunit mRNA 수준은 Ca⁺⁺ chelator인 EGTA나 Ca⁺⁺ 채널차단제인 verapamil의 처리로 세포외부로부터 Ca⁺⁺의 이동을 억제시켰을때 모두 감소하였다. PMA에 의해 유도된 LH 분비는 EGTA와 verapamil 처리에 의해 영향을 받지 않았으나 PMA에 의해 촉진된 LHβ subunit mRNA는 억제되었다. 따라서 본 연구에 의하면 PKC 활성화나 세포내 cAMP 농도 증가는 LHβ subunit mRNA 수준을 증가시키며 이러한 과정은 세포외 Ca⁺⁺ 의존적인 것으로 생각된다. 그러나 PKC 활성화나 cAMP 증가에 의한 세포외 Ca⁺⁺의 역할이 서로 다른 양상을 보인다. PKC 활성화에 의한 LH 분비는 세포외 Ca⁺⁺에 비의존적이나 cAMP에 의해 촉진된 LH 분비는 세포외 Ca⁺⁺ 유입의 영향을 받는 것으로 사료된다. We examined the effects of EGTA and verapamil on phorbol ester-and forskolin-stimulated LH releases and LHβ subunit mRNA levels in order to verify the role of extracellular Ca⁺⁺ on PKC- or cAMP-induced increases in LH release and LHβ subunit mRNA levels in cultured anterior pituitary cells of rat. Forskolin-stimulated LHβ subunit mRNA levels as well as LH release were all suppressed by prevention of Ca⁺⁺ mobilization from extracellular environment, after the treatment of EGTA as a Ca⁺⁺ chelator or verapamil as a Ca⁺⁺ channel blocker. PMA-stimulated LHβ subunit mRNA levels were also suppressed by the treatment of EGTA and verapamil, while PMA-induced LH release was not affected. From the present study, it is, therefore, suggested that PKC activation and cAMP elevation all stimulate LHβ subunit mRNA levels and these are extracellular Ca⁺⁺-dependent. However, LH releases by PKC activation and cAMP increase seem to be different each other. LH release by PKC activation is thought to be independent of extracellular Ca⁺⁺. On the other hand, cAMP stimulated-LH release is thought to be dependent on the entry of extracellular Ca⁺⁺.

항공전자시스템 개발치구 개발

박덕배(Deok-Bae Park),황상현(Sang-Hyun Hwang),이성수(Sung-Soo Lee) 한국항공우주학회 2005 韓國航空宇宙學會誌 Vol.33 No.7

ASDR은 군용 항공기의 주 장비인 ASC와 이에 탑재되는 임무 운용 소프트웨어인 OFP 개발중에는 개발도구로 사용되며 또한 ASC/OFP 개발 후에는 유지/보수용 도구로 사용 될 수 있다. 본 논문에서는 저속통제기용으로 개발된 ASDR의 전체 구조, 기능 및 특히 관성 및 공기 데이터 센서 시뮬레이션 부분에 대하여 기술한다. ASDR(Avionic System Development Rig) is used as a development tool during the design and development of the ASC/OFP and then can be used as a maintenance tool after developing them for a military aircraft. This paper describes the overall structure and the important features of KO-l ASDR, especially about the dynamic simultion of inertial and air data sensors.

순차 제어회로 설계기법을 이용한 무장제어장치 개발

박덕배(Park, Deok-Bae),김형신(Kim, Hyung-Shin) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.3

군용 항공기 탑재 무장제어장치는 무장관리시스템의 핵심장비로 조종사의 무장선택, 항공기 상태 및 외부 장착물 장착 상태 등에 따라 선택투하, 비상 투하 및 로켓발사 신호를 생성하여 외부 장착물을 제어한다. 본 논문은 순차 제어회로 설계기법을 이용하여 개발된 무장제어장치의 설계과정 및 성능검증에 대해 기술한다. On board Weapon Control Unit for a military aircraft, as a core equipment of the Weapon Management System, generates signals for selective jettison, emergency jettison and rocket fire and controls the external stores according to a pilot's weapon selection, aircraft's flight status and external store's installation status. This paper describes about detail design process and performance evaluation for Weapon Control Unit developed by a sequence control circuit design methodology.

정밀유도 비행체 탑재용 전원공급장치 개발

朴德培(Deok-Bae Park),金亨信(Hyung-Shin Kim) 대한전기학회 2008 전기학회논문지 P Vol.57 No.3

A precision guided kit is a GPS/INS guided range extension system to improve the accuracy and availability of existing dumb bombs. The PSD(power supply device) installed in the GPS guided kit supplies electrical power to all electrical loads in the kit. In this paper, design process and test results of the PSD have been presented. Additionally, the performance results of the PSD during actual ground and flight tests have been described.

감귤 내 생리활성성분이 간암세포의 생존에 미치는 영향

김수정,박덕배,Kim, Soo Jung,Park, Deok Bae 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.1

Previous studies have suggested that Citrus fruits might suppress the proliferation of various cancer cells. However, little is known about any specific ingredients in the extract of Citrus fruits to exert its anti-proliferative activity in cancer cells. The present study aimed to identify the active ingredients in Citrus fruits to suppress the proliferation of rat hepatocellular carcinoma cells. Among tested compounds, two polymethoxylated flavones (nobiletin and tangeritin) showed significant anti-proliferative activity whereas other compounds (synephrine, rutin, hesperidin) did not. Interestingly, nobiletin as well as tangeritin also decreased the protein amount of gluconeogenic enzymes, PEPCK and G6Pase. The possible involvement of gluconeogenic activity in the proliferation of hepatocellulacarcinoma cells are further to be investigated.

Regulation of $LH{\beta}$ subunit mRNA by Ovarian Steroid in Ovariectomized Rats

김창미,박덕배,유경자,Kim, Chang-Mee,Park, Deok-Bae,Ryu, Kyung-Za The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.2

난소호르몬에 의하여 황체형성호르몬(luteinizing hormone; LH) subunit의 유전자 발현이 어떻게 조절되는가를 조사하기 위하여 성숙한 흰쥐에서 난소를 제거하거나 또한 난소호르몬을 재 투여한 후 ${\alpha}$ 및 $LH{\beta}$ subunit mRNA의 수준을 조사하여 다음과 같은 결과를 얻었다. 1. 난소를 제거한 후 시간이 경과함에 따라 혈중 LH 농도 및 뇌하수체 LH 함량이 급격히 증가하였다. 또한 난소제거 후 14일 후부터 ${\alpha}$ subunit mRNA 수준이 증가하기 시작하였으며, $LH{\beta}$ subunit mRNA 수준은 난소제거 후 1일부터 증가하기 시작하여 혈중 LH 농도와 같은 양상으로 증가하였다. 2. 난소제거 후 21일 경과후에 난소호르몬을 투여하였을때 난소제거로 증가된 혈중 LH 농도와 ${\alpha}$ 및 $LH{\beta}$ subunit mRNA 수준이 감소하였다. Estradiol을 1일간 투여하였을때 부터 혈중 LH 농도 및 ${\alpha}$와 $LH{\beta}$ subunit mRNA 수준이 감소하였으며, progesterone을 4일간 처리하였을때에 혈중 LH농도가 감소하였다. 3. Estrogen 길항제인 LY117018를 estradiol과 동시에 처리하거나, progesterone 길항제인 RU 456을 progesterone과 동시에 처리하였을때 estradiol과 porgesterone에 의하여 감소되었던 혈중 LH 농도 및 ${\alpha}$와 $LH{\beta}$ subunit mRNA 수준이 유의하게 회복되었다. 이상의 결과로 보아 LH 분비에 있어서 $LH{\beta}$ subunit mRHA 수준의 변화가 속도결정단계 (rate limiting step)인 것으로 보이며, 난소홀몬은 ${\alpha}$ 및 $LH{\beta}$ subunit mRNA 수준을 조절하므로써 pretranslation 단계에서 LH 생합성을 조절하는 것으로 생각된다. Pituitary LH release has been known to be regulated by the hypothalamic gonadotropin releasing hormone (GnRH) and the gonadal steroid hormones. In addition, neurotransmitters and neuropeptides are actively involved in the control of LH secretion. The alteration in LH release might reflect changes in biosynthesis and/or posttranslational processing of LH. However, little is known about the mechanism by which biosynthesis of LH subunits is regulated, especially at the level of transcription. In order to investigate if ovarian steroid hormones regulate the LH subunit gene expression, ${\alpha}\;and\;LH{\beta}$ steady state mRNA levels were determined in anterior pituitaries of ovariectomized rats. Serum LH concentrations and pituitary LH concentrations were increased markedly with time after ovariectomy. ${\alpha}\;and\;LH{\beta}$ subunit mRNA levels after ovariectomy were increased in a parallel manner with serum LH concentrations and pituitary LH contents, the rise in $LH{\beta}$ subunit mRNA levels being more prominent than the rise in ${\alpha}\;subunit$ mRNA. ${\alpha}\;and\;LH{\beta}$ subunit mRNA levels in ovariectomized rats were negatively regulated by the continuous treatment of ovarian steriod hormones for $1{\sim}4\;days$ and $LH{\beta}\;subunit$ mRNA seemed to be more sensitive to negative feedback of estradiol than progesterone. Treatment of estrogen antagonist, LY117018 or progesterone antagonist, RU486 significantly restroed LH subunit mRNA levels as well as LH release which were suppressed by estradiol or progesterone treatment. These results suggest that ovarian steroids negatively regulate the LH synthesis at the pretranslational level by modulating the steady state levels of ${\alpha}\;and\;LH{\beta}\;subunit$ mRNA and $LH{\beta}\;subunit$ mRNA seemed to be more sensitive to negative feedback action of estradiol than progesterone.