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민지원,이지현,김민정,유봉구 대한임상신경생리학회 2005 Annals of Clinical Neurophysiology Vol.7 No.1
We report a case of thoracolumbar radiculopathy presented with first symptom of leptomeningeal metastasis. A 65- year old man with non-Hodgkins lymphoma with complete remission was referred for further investigation of dull pain and numbness of right lower quadrant of abdomen. Electromyogram revealed right thoracolumbar radiculopathy. After two weeks, he complained severe continuous bilateral frontal dull headache. An examination of the cerebrospinal fluid revealed malignant lymphoid cells. We would like to emphasize that radiculopathy sometimes presents with first symptom of leptomeningeal metastasis.
민지원,이혜영,최범순,박철휘,양철우,김용수,최영진,오은지,정병하 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.5
Background: Evidence of antibody-mediated injury in the absence of donor-specific HLA antibodies (HLA-DSA) has recently emerged, suggesting a role of antibodies in targeting non-HLA antigens expressed on renal allograft tissue. However, the clinical significance of pre-transplant non-HLA antibodies remains unclear. We compared the histological and clinical impact of pre-transplant HLA-DSA and non-HLA antibodies, especially angiotensin II type I receptor (anti-AT1R) and MHC class I-related chain A (anti-MICA), in kidney transplant patients. Methods: Pre-transplant HLA-DSA, anti-AT1R, and anti-MICA were retrospectively examined in 359 kidney transplant patients to determine the effect of each antibody on allograft survival and clinical characteristics. Results: Pre-transplant HLA-DSA, anti-AT1R, and anti-MICA were detected in 37 (10.3%), 174 (48.5%), and 50 patients (13.9%), respectively. Post-transplant antibody-mediated rejection was associated with a pre-transplant HLA-DSA (+) status only. The development of microvascular inflammation (MVI) was associated with pre-transplant HLA-DSA (P=0.001) and anti-AT1R (P=0.036). Anti-AT1R (+) patients had significantly lower allograft survival compared with anti-AT1R (−) patients (P=0.042). Only pre-transplant anti-AT1R positivity was an independent risk factor for allograft failure (hazard ratio 4.824, confidence interval 1.017–24.888; P=0.038). MVI was the most common histological feature of allograft failure in patients with pre-transplant anti-AT1R. Conclusions: Pre-transplant anti-AT1R is an important risk factor for allograft failure, which may be mediated by MVI induction in the allograft tissue.
민지원,유봉구,김광수,유경무 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1
Background & Purpose : Patients with complex partial seizure have impaired cognitive performance. The aim of this study was to evaluate the cognitive function of patients with epilepsy using Korean version of Mini-Mental State Examination (K-MMSE). Methods : We measured the K-MMSE in 23 patients with complex partial seizure and 22 normal controls. Frequency matching was done about age, sex and residence between the two groups. The evaluation of cognitive function was assessed with K-MMSE. Results : Compared with controls, patients with epilepsy showed significantly lower in total score of K-MMSE and attention-calculation item(P=0.008, P=0.014). There were no differences in the score of other items of K-MMSE between the two groups. Conclusions : These results showed that epileptic patients have impaired cognitive function, especially in attention-calculation performance.
민지원 고려대학교 중국학연구소 2010 中國學論叢 Vol.27 No.-
照二系在近古时期不论二等还是三等介音已经全部消失,在≪古今韵会举要≫中就出现在没有介音的字母韵裏。这可以说在进入近古时期之前中古时期介音已经开始脱落了。本文从内外转的角度出发对中古三等照二系进行一系列的分析,着重考察了其介音在中古时期是怎样消失的。≪廣韵≫外转三等照二系大部分也有同摄二等的读音,并且二等韵的又韵照二等字與三等字的字意相同。这说明同一個汉字既有二等的读音也有三等的读音。可以看出这时期外转照二系的介音已经开始消失。内转照二系在慧琳≪一切经音义≫中仍大多以C2类字为反切下字,这说明这时期内转三等照二系仍保存着三等介音。可是,止摄照二系就有所不同。韩国和越南的汉字音裏就與其他声母不同。同时慧琳≪一切经音义≫的反切具有照二系只切照二系的倾向。从而可以看出止摄内转照二系的介音已经开始消失。宕摄也有與此相仿的现象出现,≪古今韵会举要≫和≪西儒耳目资≫照二系就被纳入到独立的字母韵裏。
카바마제핀 치료 중 발생한 항이뇨호르몬 부적합 분비증후군 1예
민지원,이지현,유봉구,김광수,유경무 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1
Introduction : Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is associated with hyponatremia and water retention caused by several drugs, including carbamazepine and diseases. Case : A 41 year-old man was admitted because of gait ataxia and both hands asterixis for 1 month. On the past history, he was presented with temporal lobe epilepsy for twenty seven years. He had aura with unpleasant feeling before loss of consciousness. He was treated with carbamazepine, valproate and zonisamide for 3 years. He showed hyponatremia and it was corrected by water restriction and oral sodium supplement without tapering of the drug. Conclusion : We report a case presenting SIADH associated with carbamazepine treatment.