원내의약품집 발행과 유지

문순란 한국병원약사회 1996 병원약사회지 Vol.13 No.1

IEEE 80211e환경에서 전송계층 프로토콜의 성능 분석

김두용,문순란 순천향대학교 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

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서울대학교 병원에서의 약품 식별업무 현황 및 제약회사 대상 실태조사

김귀숙,문순란,김민정,박경호,조남춘 한국병원약사회 1997 병원약사회지 Vol.14 No.2

When doctor meets a new patient who is administering already prescribed-medicines, it's important to identify those drugs to avoid the overdose of same drug or drugs which have same pharmacological effects. But most of tablets and capsules available in our country have no identification code on drugs, many medical doctors usually ask phrmacists to identify the drugs which patients have been administering. In present study, the importances of drug identification services in clinical units were reviewed by analyzing the Question & Answer(Q & A) services in the department of pharmacy, Seoul National University Hospital(SNUH), from 1991 to 1995. And questionnaires were conducted on drug identification coding to 209 pharmaceutical companies. From the results of Q & A services, it was noted that about 50% of questions were focused on drug identifications which were mainly requested from medical doctors. The average time to solve those questions was 14.4 minutes. If all tablets and capsules have identification code, the drug identification will be easily solved, but because most of drugs have no identification code, pharmacist contacted other hospitals and pharmacies where the drugs were prescribed. And according to the questionnaires to pharmaceutical companies, only 73 companies responded among 209 companies (34.9%), and 65 companies suggested the needs of drug identification coding, but most of companies (n=49) raised the difficulties to apply that drug identification coding system to their companies. The main reasons were technological and economic problems.

서울대학교병원에서 Cisapride 허가사항 변경에 관한 홍보 전후의 약물사용평가

이승희,문순란,임영근,박경호,손인자 한국병원약사회 2001 병원약사회지 Vol.18 No.4

Cisapride is a treatment for severe nighttime heartburn in patient with gastroesophageal reflux disease(GERD) who do not adequately respond to other therapies. But as of December 31, 1999, use of cisapride has associated with 341 reports of serious cardiac arrhythmias including 80 reports of death. Most of these adverse events occurred in patients who were taking other medications or suffering from underlying conditions known to increase risk of cardiac arrhythmias associated with ciaspride. In consultation with FDA, Janssen Pharmaceutica has decided to discontinue marketing cisapride as of July 14, 2000 and make it available only through an ivestigational limited-access program. KFDA has modified the information of cisapride by three times of March 31, July 13, and September 20 and distributed prescription guide to doctors. Seoul National University Hospital (SNUH) has distributed the prescription guide and information of safety of cisapride to doctors and inserted warning sign of electrocardiogram(ECG) and laboratory test to screen for contraindicated risk factors if they prescribe cisapride in medical information system(MIS). We investigated the amount used, contraindication drugs used of cisapride, and ECG reports before cisapride was prescribed from December 1, 1999 to June 30, 2000. Amount and frequency of cisapride use in SNUH has remarkably decreased in April, 2000 when we informed prescription guide. But doctors prescribed contraindication drugs with cisapride as before. Pharmacists should actively inform doctors of new drug informations and especially drug interaction.

류마티스 환자를 대상으로 한 NSAID제제의 부작용 비교

조윤정,문순란,박경호,조남춘,송영욱 한국병원약사회 1998 병원약사회지 Vol.15 No.2

Comparative side effects of NSAIDs, such as salsalate, choline magnesium trisalicylate, fenoprofen, naproxen, aspirin and indomethacin was assessed using the Stanford Toxicity Index (STI) consisting of weighted symptoms, laboratory abnormalities in 100 rheumatoid arthritis patients from out patient clinic of Seoul National University Hospital. All patients were enrolled in one physician who is recording any side-effects of drug on patient's medical chart. Two pharmacists evaluated the randomly selected patient's medical chart, and checked the recording of side effects, such as dizziness, pruritus, rash, edema, tinnitus, hearing difficulty, nausea, upper abdominal pain, constipation, dyspepsia, ear fullness, epigastric fullness, mild liver toxicity, hyperuricemia and headache. From the results of this study, it was found that common side effects were tinnitus, hearing difficulty and ear fullness for salsalate, gastrointestinal disturbances for choline magnesium trisalicylate, fenoprofen and naproxen, and gastrointestinal disturbances and hearing difficulty for aspirin, and headache for indomethacin. Scores of STI ranged from 0.32 for aspirin to 2.56 for salsalate. Also occurrence rate of side effects of NSAIDs was evaluated according to period of drug administration. It was noted that most of side effects were common within 1 year of drug administration, but naproxen and indomethacin had even distributional occurrence of side effects according to period of drug administration.

소아에게 처방되는 정제의 투여 용이성 조사

문정연,김귀숙,문순란,한현주,손인자 한국병원약사회 2003 병원약사회지 Vol.20 No.4

In the Children's Hospital of Seoul National University Hospital it is general practice to prepare and administer powder or liquid formulations to children under 6 and tablet formulations to those older. However, pulverizing tablets to administer powder formulations causes loss of content, change in bioavailability, and difficulty in identification. Consequently, a new principle of dividing highly water-soluble tablets down to quarter segments without having to change formulation type and administrating them even to children under 6 has been established and practiced for instances that allow despite the fact that they may be easily pulverized. This study was performed to classify and investigate the feasibility of original tablet form administration by investigating the solubility of commonly prescribed pediatric medicines. The study has been executed using 51 medicines(sugar, film coated tablets, capsules, coated tablets, powder formulations) out of 116 possible pediatric medicines commonly pulverized for children under 6. Primary research was done with surveys completed by 50 guardians of children who have visited the pediatric clinic. This study has utilized tablet medicines that dissolve under 1 minute on the basis of 42 of these guardians(84%) reporting their preference of waiting no more than 1 minute for a tablet to dissolve before administering to their child. First, tablets were placed in ambient sterilized distilled water and observed in 20-second intervals for solubility. Tablets that took longer than 1 minute to dissolve were stirred 2 times per second as a secondary measure to observe those that took less than a minute to dissolve. In order to establish an objective standard, a shaker was utilized at 950rpm in the verification process. 8(16%) of the test tablets dissolved within the first interval, 11(22%) dissolved within the second interval, none dissolved within the last interval, and 2(4%) dissolved after 60 seconds or within 60 seconds with the aid of the stirrer. Therefore, 21(41%) out of 51 test tablets were determined as capable of being administered in tablet form because of its superior water-solubility. It can be expected that problems from pulverization can be improved with administration of any of these 21 test tablets in its original formulation even to children under 6 while also promoting convenience in the preparation and dispensing of pediatric prescriptions.

3차의료기관 약제부내 의약정보센터의 의약정보 문의에 대한 해결능력 및 정확성 평가

이주연,김민정,문순란,김귀숙,박경호,조남춘 한국병원약사회 1997 병원약사회지 Vol.14 No.1

In the last few decades, the role in phamacy has been extended beyond typical distributive function. One of these extended role involves drug and toxicology information services. Drug information services of Korean hospital pharmacy were adopted since 1969 to provide accurate and timely medication drug information. The objectives of this study were to assess the accuracy of response to drug information request and to determine the relationship between accuracy of answers accuracy of answers and characteristics of Drug Information Centers(DIC) in Korean hospital phamacy. Drug Information Centers located in tertiary care hospital phamacy were contacted by telephone from September to October in 1996. Each DIC received standard request for identification of product, Fosamax^(R)(alendronate), that was a new drug approved by FDA in 1995, but availablee market in Korea at that time. However this drug could be found I AHFS DI 96, Martindale(31th ed), Medline, CCIS other clinical and journals. Each center correctly identifying Fosamax^(R) was asked more questions concerning the recognition of clinical signs of adverse effects. Fosamax^(R) was correctly identified by seventeen hospital drug information centers. (36.2 percent) and thirty centers responded that could not make an identification with a product name. Of the 17 centers correctly identifying with Foamax, only five centers recognized drug adverse effects and offered recommendations. From this study, it was noted that the ability and the accuracy of drug information responses were significantly related with pharmacist's work-load drug information resources.