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Conjugation strategies of DNA to gold nanoparticles
최다연,김수현,오정욱,남좌민 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.12
DNA-modified gold nanoparticles (NPs) have been extensively explored in vari- ous applications including the construction of three-dimensional (3D) assembly architectures and biomedical applications. As ligand molecules, DNA strands can facilitate the building block function of gold NPs due to the inherent nature of DNA bonding, that is, Watson–Crick base pairing. In addition, the negative electrostatic character of DNA backbones renders colloidal gold NPs stability and robustness under various aqueous environments. Therefore, DNA conjugation to gold NP surfaces is a key step for stabilizing, controlling, and uti- lizing DNA-modified gold NPs, and the working conjugation strategy should be employed and implemented for a specific application. This review covers vari- ous DNA conjugation strategies to gold NPs with fundamental binding features of DNA strands with varying functional groups to gold NP surfaces. DNA graft- ing density and directional grafting strategies on gold NPs are also discussed, which is a key factor to construct 3D NP assembly architectures via DNA hybridization.
Aye Aye Myint,임원규,남좌민,김재훈,이윤우 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.66 No.-
We report the synthesis of water-soluble and environmentally friendly fluorescent carbon dots (CDs) using the renewable resource lignin as a precursor, which is a waste emitted from pulp and paper industries and lignocellulosic biofuel production, using a compressed liquid CO2 antisolvent method followed by carbonization and chemical oxidation with an acid mixture (H2SO4:HNO3 = 1:3, v/v) at 90 °C for 8, 16, and 24 h. The as-synthesized CDs emitted bright yellow fluorescence (FL) under argon laser excitation at 458 nm with excitation-wavelength-independent and excitation-wavelength-dependent FL emission characteristics. Moreover, the CDs exhibited excellent stability in a highly concentrated NaCl solution, photostability with pH-dependent FL emission activities, and cellular imaging capability with very low cytotoxicity. Notably, the FL emission intensities of the as-synthesized CDs increased with longer reaction times, indicating high degree of oxidation on the CD surface and consequently, high quantum yield of 13% was achieved. Therefore, the as-synthesized CDs can be used as promising fluorescent probes for bioimaging applications in vitro and in vivo.
황재호,Nitin Kumar Singhal,임동권,남좌민 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.3
It is critical to design and synthesize plasmonic nanostructures that can generate very strong and quantitative surface-enhanced Raman scattering (SERS) signals that could be amplified by multiple laser wavelengths to realize the full potential of SERS nanoprobes. Here, we report the synthesis of Au-nanobridged nanogap cucumbers (Au-NNCs) from DNA-modified Au nanorods and comparison of their SERS signals with three different Raman dyes with our recently reported Au-nanobridged nanogap spheres (Au-NNSs). Although the Au-NNSs generate highly stable and reliable signals, these spherical nanogap structures with a smooth surface produce strong SERS signals (SERS enhancement factor at ~108) only with 633 nm excitation laser. The Au-NNCs with a bumpy surface generated up to ~3-, ~23-, and ~130-fold higher SERS signals with 514, 633, and 785 nm excitation laser wavelengths, respectively, compared to the Au-NNSs.
Radionuclide-labeled nanostructures for In Vivo imaging of cancer
Rhim Won-Kyu,Kim Minho,HARTMANKEVIN LAURENCE,강건욱,남좌민 나노기술연구협의회 2015 Nano Convergence Vol.2 No.10
Molecular imaging plays an important role in the non-invasive diagnosis and the guiding or monitoring of disease treatment. Different imaging modalities have been developed, and each method possesses unique strengths. While a variety of molecules have been used previously in nuclear imaging, the exceptional properties of nanostructures in recent research enable the deployment of accurate and efficient diagnostic agents using radionuclide-nanostructures. This review focuses on the radionuclide labeling strategies of various nanostructures and their applications for multimodality tumor imaging.