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남윤이,김진규,정해리,서준교 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The inhibitory effects of lipid accumulation onethanol extract from stem bark of Japanese horse chestnut(JHC) were evaluated. Exposure to JHC extract (10-100μg/mL) for a 72 h incubation period did not alter cellviability compared to the untreated control. JHC extract,with concentrations of 25, 50, and 100 μg/mL, inhibitedlipid accumulation in 3T3-L1 adipocytes in a dosedependent manner. The expression of PPARγ and C/EBPα,important adpogenic key markers was significantly reducedwhen JHC extract was added to cells for 8 days comparedwith the untreated control group. These results suggest thatJHC extract might be a potential therapeutic agent as anatural anti-obesity material.
남윤의(Yoon-Eui Nahm),石川晴雄(Haruo Ishikawa) 한국산업경영시스템학회 2012 한국산업경영시스템학회지 Vol.35 No.4
At present, the significance of a new manufacturing system that can shift from ‘mass production’ and consider life cycles of a product is pointed out and extremely expected. In such a situation, it is recognized that the modular design, often called ‘unit design,’ is the important design methodology which realizes the new production system enabling ‘cost reduction,’ ‘flexible production of a multi-functional artifact,’ ‘settlement of an environmental issue,’ and so on. A module (unit) of a product is generally defined as ‘the parts group made into the sub-system from a certain specific viewpoint.’ So far, there have been many researches related to the modular design. However, they are often limited to a certain viewpoint (objective). This paper proposes a simple but effective method for multi-objective modular design. In the proposed method, a new design metric, called similarity index, is proposed to evaluate the modular design candidates from the multiple viewpoints.
초기 설계단계에서의 셋 베이스 다목적 설계 최적화(제1보)
남윤의(Yoon-Eui Nahm) 한국산업경영시스템학회 2011 한국산업경영시스템학회지 Vol.34 No.2
The early phase of design intrinsically contains multiple sources of uncertainty in describing design, and nevertheless the decision-making process at this phase exerts a critical effect upon drawing a successful design. This paper proposes a set-based design approach for multi-objective design problem under uncertainty. The proposed design approach consists of four design processes including set representation, set propagation, set modification, and set narrowing. This approach enables the flexible and robust design while incorporating designer’s preference structure. In contrast to existing optimization techniques, this approach generates a ranged set of design solutions that satisfy changing sets of performance requirements.