정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

Rat periodontal ligament cell에서의 RANKL mRNA의 발현

김현수,정현주,김영준,김옥수,Kim, Hyun-Soo,Chung, Hyun-Ju,Kim, Young-Joon,Kim, Ok-Su 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

스카이브릿지 설치위치에 따른 고층건물의 진동제어 성능평가

김현수,박용구,고현,이의현,이동근,Kim, Hyun-Su,Park, Yong-Koo,Ko, Hyun,Lee, Ui-Hyun,Lee, Dong-Guen 한국공간구조학회 2010 한국공간구조학회지 Vol.10 No.3

In this study, the vibration control effect according to the installation location of the sky-bridge and the difference of natural periods of the connected buildings has been investigated. To this end, 40-story and 50-story building structures connected by a sky-bridge were used as example structures and the equivalent modeling method was used. Boundary nonlinear time history analyses were performed using El Centro and Taft earthquakes to investigate the dynamic behavior of the example structures and vibration control effect of the sky-bridge. Based on numerical results, it has been shown that displacement responses can be effectively controlled as the installation floor of the sky-bridge increases and acceleration responses can be effectively reduced when the sky-bridge is installed on the mid-stories of the example building. 본 연구에서는 스카이브릿지 설치위치 및 연결된 구조물의 고유진동주기 차이에 따른 전체 구조물의 진동제어 효과를 분석하였다. 이를 위하여 스카이브릿지로 연결된 40층과 50층 구조물을 예제 구조물로 사용하였고, 등가모형화기법을 이용하여 예제 모델을 구성하였다. El Centro 및 Taft 지진을 사용하여 경계비선형 시간이력해석을 수행하였고 구조물의 동적거동과 진동제어 효과를 분석하였다. 해석결과 변위응답은 스카이브릿지를 상부층에 설치할수록 더 효과적으로 제어할 수 있었고 가속도응답은 구조물의 중간층부근에 설치할 때 더 효과적으로 저감시킬 수 있었다.

Monascus SP . 가 생산하는 황색색소에 관한 연구 (제2보) 황색 색소의 분리 및 정제

김현수,장욱,이희인,배종찬,유주현 ( Hyun Su Kim,Uk Chang,Hee in Yi,Jong Chan Bae,Ju Hyun Yu ) 한국미생물생명공학회 1980 한국미생물·생명공학회지 Vol.8 No.3

요소 응력을 이용한 겹침 용접부의 피로 강도 평가에 관한 연구

김현수,신상범,김명현,박동환,Kim, Hyeon-Su,Shin, Sang-Beom,Kim, Myung-Hyun,Park, Dong-Hwan 대한용접접합학회 2014 대한용접·접합학회지 Vol.32 No.1

The purpose of this study is to evaluate the applicability of the element stress to establish S-N design curve for the welded lap joint with thin plates below 2mm thickness. In order to do it, the extensive fatigue tests of the welded lap joints with INVAR alloy were performed. With the results, the deign S-N curves for the lap-weld were established by using the reference stresses such as the nominal stress range at the weld throat area, hot spot stress range and element stress range, and compared with regard to the standard deviation. The standard deviation of S-N curves with element stress range was less than that of S-N curves with other reference stresses. In addition, FEA results show the amount of the element stress is less sensitive to mesh size. Based on the results, it can be concluded that the element stress is to be used as the reference stress for the design S-N curves of the welded lap joint.

스카이브릿지로 연결된 고층건물의 진동제어 성능평가

김현수,양아람,이동근,안상경,오정근,Kim, Hyun-Su,Yang, Ah-Ram,Lee, Dong-Guen,Ahn, Sang-Kyung,Oh, Jung-Keun 한국공간구조학회 2008 한국공간구조학회지 Vol.8 No.4

In this study, the vibration control performance of high-rise building structures connected by a sky-bridge has been investigated. The philosophy of vibration control using sky-bridges is to allow structures with different dynamic characteristics to exert control forces upon one another through sky-bridges to reduce the overall responses of the system. The the high-rise building structure connected by sky-bridge with 49 and 42 stories was used in this study to investigate the displacement, acceleration, reaction of bearings and stress of sky-bridge by analytical methods. To this end, historical earthquakes, an artificial earthquake and wind force time histories obtained from wind tunnel tests were used. Based on the analytial results, the use of sky-bridge can be effective in reducing the structural responses of high-rise buildings against wind and seismic loads. 본 연구에서는 sky-bridge로 연결된 고층건물의 진동제어성능을 검토하여 보았다. Sky-bridge를 이용한 진동제어의 원리는 서로 다른 동적특성을 가진 구조물이 sky-bridge를 통하여 제어력을 발휘함으로써 전체 시스템의 응답을 줄이는 것이다. 본 연구에서는 실제 건설 중인 sky-bridge로 연결된 고층건물(49층 및 42층)을 대상으로 구조물의 변위, 가속도 및 베어링반력, sky-bridge의 응력 등을 해석적인 방법으로 검토하였다. 이를 위하여 역사지진, 인공지진 및 풍동실험을 통해서 얻은 풍하중 시간이력을 사용하였다. 해석결과 sky-bridge를 사용하여 고층건물의 풍응답 및 지진응답을 효과적으로 줄일 수 있는 것을 확인하였다.

일방향 중공슬래브의 휨강도 산정방법에 관한 연구

김현수,임준호,강주원,Kim, Hyun-Su,Lim, Jun-Ho,Kang, Joo-Won 한국전산구조공학회 2012 한국전산구조공학회논문집 Vol.25 No.6

중공슬래브 시스템은 슬래브 두께가 증가해도 자중은 크게 증가하지 않고, 일반슬래브에 비해서 휨성능이 크게 저하되지 않는 장점이 있다. 이러한 경제적인 건물 설계 및 친환경 구조물 구현을 가능하게 하는 시스템에도 불구하고 중공슬래브의 활용도는 현재로서는 낮다고 할 수 있다. 특히 국내의 건축분야에 있어서는 매우 낮은 편이다. 이러한 현 상황의 가장 큰 이유는 중공슬래브의 적용을 위한 구조 해석 및 설계방법이 일반화되어 있지 않다는 것이다. 본 연구에서는 실질적인 압축영역을 고려하기 위해 가정한 중공 단면형상에서 중립축 위치에 따른 압축응력블럭의 체적으로 휨강도 산정식을 제시하였다. 기존 중공부 상부만을 압축영역으로 고려한 휨강도 산정방법은 가장 보수적인 방법으로 판단되며 2개의 대체단면을 설정하여 휨내력을 산정하는 것이 더 실질적인 방법으로 판단된다. The hollow slab has advantages that its self-weight does not greatly increase notwithstanding the increase of its thickness and its flexural performance does not significantly degrade in comparison with general reinforced concrete slab. However, the utilization of the hollow slab is currently being underestimated in spite of structural system that enables economic design of building and construction of eco-friendly structure. the significant reasons for this situation is that the method of structural analysis and design for hollow slab is not generalized. In this study, to consider practical compressive zone of hollow slab, the equation for its flexural strength is proposed by the volume of compressive stress block according to neutral axis location in hollow section assumed. Existing estimation method of flexural strength of hollow slab considering only compressive zone above hollow part is evaluated as the most conservative method and the method estimating flexural strength by two alternative cross-section of hollow slab is evaluated as more practical method.

다이어그리드 메가프레임 초고층 건물을 위한 효율적인 해석모델의 개발

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2011 한국공간구조학회지 Vol.11 No.3

비정형 초고층건물을 위한 구조시스템 중에서 다이어그리드 구조시스템은 구조적인 효율성 및 조형성 때문에 널리 사용되고 있다. 근래에는 초고층건물을 위한 구조시스템으로 메가부재의 조합을 통하여 횡방향 강성을 효과적으로 발휘할 수 있는 메가프레임 시스템이 널리 사용되고 있다. 두 가지 구조시스템의 장점을 혼합한 다이어그리드 메가프레임 구조시스템은 미래형 초고층건물에 적용될 유망한 구조시스템으로 평가받고 있다. 그러나 이러한 다이어그리드 메가프레임 구조시스템을 적용한 건물의 거동을 예측하기 위해서는 매우 많은 수의 절점과 요소로 이루어진 유한요소 모델을 해석해야 하므로 상당한 양의 해석시간과 엔지니어의 노력이 필요하게 된다. 따라서 본 연구에서는 다이어그리드 메가프레임시스템을 적용한 초고층건물의 거동을 효율적으로 해석할 수 있는 기법을 제안하여 다이어그리드 메가프레임 초고층건물의 해석과 설계에 소요되는 시간과 노력을 줄이고자 한다. 이를 위하여 다이어그리드 메가프레임의 특정을 활용한 효율적인 모형화기법과 행렬응축기법을 사용하여 해석에 사용되는 자유도수를 최소화한 해석기법을 제안하였다. 예제구조물의 해석을 수행하여 본 연구에서 제안된 해석방법과 일반적인 해석방법에 의한 결과와 비교함으로써 제안된 방법의 효율성과 정확성을 검증하였다. Among structural systems for complex-shaped tall buildings, diagrid system is widely used because of its structural efficiency and beauty of form. Recently, mega frame is favorably employed as a suitable structural system for skyscrapers because this structural system has sufficient stiffness against the lateral forces by combination of mega members which consist of many columns and girders. Diagrid mega frame system is expected to be promising structural system for future super tall buildings. However, it takes tremendous analysis times and engineer's efforts to predict the structural behavior of tall buildings applied with diagrid mega frame system because the diagrid mega frame structure has significant numbers of elements and nodes. Therefore, efficient analytical method for all buildings applied with diagrid mega frame system has been proposed in this study to reduce the efforts and time required for the analysis and design of diagrid mega frame structure. To this end, an efficient modelling technique using the characteristics of diagrid mega frame structures and an efficient analytical model using minimal DOFs by the matrix condensation method were proposed in this study. Based on the analysis of an example structure, the effectiveness and accuracy of the proposed method have been verified by the comparison between the results of the proposed method and the conventional method.

경사진 다이어그리드 비정형 초고층 건물에 대한 스마트 TMD의 제진성능평가

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2011 한국공간구조학회지 Vol.11 No.4

근래에 들어와서 3T (Twisted, Tapered, Tilted)로 대별되는 비정형 초고층 건축물이 다수 계획되고 있다. 이러한 비정형 초고층 건물을 위해서 구조적인 효율성 및 조형성 때문에 다이어그리드 구조시스템이 현재까지 가장 널리 사용되고 있는 구조시스템 중의 하나이다. 건축적인 조형미 등의 이유로 경사진 비정형 초고층 건물에 대한 계획안이 다수 발표되고 있으며 다수의 구조물들이 다이어그리드 구조시스템을 활용하고 있다. 경사진 비정형 초고층 건물은 횡하중뿐만 아니라 자중에 의해서도 횡방향 변위가 발생한다. 따라서 정형적인 초고층 건물보다 횡방향 응답을 저감시카는 젓이 더 중요한 문제로 대두된다. 본 연구에서는 경사진 다이어그리드 비정형 초고층 건물의 지진응답을 저감시키기 위하여 스마트 TMD를 적용하였고 그 제어성능을 평가하였다. 스마트 TMD를 구성하기 위하여 MR 감쇠기를 사용하였으며 스마트 TMD는 그라운드훅 제어알고리즘을 사용하여 제어하였다. 100 층의 예제구조물에 대하여 제어를 하지 않은 경우와, 일반적인 TMD를 사용한 경우, 그리고 스마트 TMD를 사용하여 제어한 경우를 비교 검토하였다. 수지해석결과 스마트 TMD가 변위 응답 제어에는 우수한 성능을 나타냈지만 가속도응답제어에는 효과적이지 못했다. Recently, complex-shaped tall buildings represented by 3T(Twisted, Tapered, Tilted) are planed largely. A diagrid structural system is one of the most widely used structural system for complex-shaped tall buildings because of its structural efficiency and formativeness. Plans for tilted tall buildings are largely presented because of beauty of a sculpture and many of buildings use diagrid structural systems. Lateral displacements of tilted tall buildings are induced by not only lateral loads but also self weight. Therefore, reduction of lateral responses of tilted tall buildings is as important as typical tall buildings. In this study, a smart TMD is introduced to reduce seismic responses of tilted diagrid tall buildings and its control performance is evaluated. MR damper is employed for the smart TMD and ground-hook controller is used as a control algorithm for the smart TMD. 100-story tall building is used as an example structure. Control performances of uncontrolled case, controlled case with TMD and controlled case with smart TMD are compared and investigated. Numerical simulation has shown that smart TMD presented good control performance for displacement response but acceleration response was not controlled well.

스마트 TMD의 최적설계를 위한 파라메터 연구

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2017 한국공간구조학회지 Vol.17 No.4

A smart tuned mass damper (TMD) was developed to provide better control performance than a passive TMD for reduction of earthquake induced-responses. Because a passive TMD was developed decades ago, optimal design methods for structural parameters of a TMD, such as damping constant and stiffness, have been developed already. However, studies of optimal design method for structural parameters of a smart TMD were little performed to date. Therefore, parameter studies of structural properties of a smart TMD were conducted in this paper to develop optimal design method of a smart TMD under seismic excitation. A retractable-roof spatial structure was used as an example structure. Because dynamic characteristics of a retractable-roof spatial structure is changed based on opened or closed roof condition, control performance of smart TMD under off-tuning was investigated. Because mass ratio of TMD and smart TMD mainly affect control performance, variation of control performance due to mass ratio was investigated. Parameter studies of structural properties of a smart TMD was performed to find optimal damping constant and stiffness and it was compared with the results of optimal passive TMD design method. The design process developed in this study is expected to be used for preliminary design of a smart TMD for a retractable-roof spatial structure.