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Some Exact Solutions of a Nonintegrable Toda-type Equation
김찬주 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.9
We study a Toda-type equation with two scalar fields which is not integrable and construct two families of exact solutions which are expressed in terms of rational functions. The equation appears in U(1) Chern-Simons theories coupled to two nonrelativistic matter fields with opposite charges. One family of solutions is a trivial embedding of Liouville-type solutions. The other family is obtained by transforming the equation into the Taubes vortex equation on the hyperbolic space. Though the Taubes equation is not integrable, a trivial vacuum solution provides nontrivial solutions to the original Toda-type equation.
자궁경부암 동물 모델에서 PEG/PLLA copolymer sysetm을 사용한 Paclitaxel 국소 투여의 효과
김찬주,이용석,이근호,정병문,김태우,강태흥,김희숙,박종섭 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.1
Objective : Paclitaxel is one of the most effective antineoplastic drugs. HPV-related cervical lesions have only managed with invasive procedure or observation. After the introduction of PHV prophylactic vaccine, there are no remarkable improvements. This ineffectiveness can in part be attributed to inadequate durg and delivery methods. Topical drug administration with temperature sensitive copolymer gels are useful approaches to clinical situation. In this study, we evaluated the activity of multiblock copolymers of PEG/PLA (poly(L-lactic acid)/polyethylene glycol) gels with paclitaxel (PTX) formulation administered by topical treatment to mice bearing human cervical cancer cell lines (HeLa). Methods : We have synthesized gels of PEG/PLLA (poly(L-lactic acid)/polyethylene glycol) multiblock copolymers containing Paclitaxel which have temperature-sensitivecharacteristics. This Paclitaxel- containg copolymers has the sol-gel-sol transition temperature at body temperature. The efficacy of PTX in PEG/PLA mutiblock copolymer micelle were conducted in HeLa-tumor bearing Balb/c Nu/Nu athymic mice at an equivalent paclitaxel dose of 10 mg/kg with 48 hr interval. The inhibition of tumor growth was evaluated after 8days of treatment. Tumors were harvested at day 10 and stained with hematoxylin and eosine to measure tumor. RESULTS: PTX-containing PEG/PLA mutiblock copolymer significantly decreased tumor growth at day 8, as measured by tumor size; ie, PEG/PLA mutiblock copolymer only goup ; 1.43+0.26m versus intraperitoneal treatment of Paclitaxel : 0.75+0.07mm and topical treatment of PTX-containing PEG/PLA copolymer containing Paclitaxel : 0.28mm (Min; 0.1mm-Max:0.8mm) CONCLUSION: This demonstration that PTX-containing PEG/PLA mutiblock copolymer have a useful topical drug deliversy system carrying temperature sensitive characetersitics in HPV-related cervical lesions. 목적 : Paclitaxel은 최근 널리사용되는 가장 효과적인 항암제이다. HPV관련성 자궁 경부 질환은 최근 개발된 HPV예방백신이 있지만, 침습적인 수술방법이나 관찰외에는 뚜렷한 치료법이 없다. 그 이유는 현재까지 개발된 효과적인 치료 약물과 부작용이 적은 약물 투여법이 없기 때문이다. 이에 온도 민감성 copolymer 젤을 국소적으 로 투여하는 방법이 효과적인 임상 적용에 유리하다. 이에 Paclitaxel(PTX)을 함유하고 체온 범위에서 젤이 되 는 온도 민감성 PEG/PLA (poly(L-lactic acid)/polyethylene glycol) 을 HPV양성인 자궁 경부암 세포주(HELa) 의 성장 억제에 효과가 있는지 알아보았다. 방법: Paclitaxel을 함유한 PEG/PLLA (poly(L-lactic acid)/polyethylene glycol) multiblock copolymer중 체 온 범위에서 젤이 되도록 만들어 사용하였다. Paclitaxel-PEG/PLLA 젤의 효과는 Balb/c Nu/Nu athymic mice에 대하여 주입된 HeLa 세포주의 크기 변화를 측정하였다. 48시간 간격으로 2회 Paclitaxel (10mg/kg)을 투여 한 뒤8일째까지 종양 크기를 측정하고, 마지막날 종양을 적출하여 헤마톡실린-에오신 염색으로 크기를 확인하였 다. 결과:Paclitaxel- PEG/PLA 다원 공중합체를 투여한 지 8일째에, 쥐에서 xenograft tumors (HeLa cells; HPV-18 positive state)의 종양성장 억제가 관찰이 되었다. PEG/PLA 다원 공중합체만 투여한 경우에는 종양의 크기가 1.43+0.26mm 이였으며, Paclitaxel을 복강내 주사한 경우에는 0.75+0.07mm 였다. Paclitaxel-PEG/PLA copolymer 를 경피적으로투여한 경우에 0.28m (최소 0.1mm-최대 0.8mm)였다. 결론 : HPV-관련성 자궁 경부 질환의 치료에 Paclitaxel을 함유한 PEG/PLA mutiblock copolymer는 체온 범위에 서 젤이 되는 성질을 가진 유용한 약물치료법이 될 것이다.
김찬주,조은영,오상균,김정길 대한건축학회지회연합회 2005 대한건축학회지회연합회 학술발표대회논문집 Vol.1 No.1
In this paper we studied the kind and the legal standards of the floor impact sound and also understood a fundamental conception of the floor impact sound is based on the research and analysis of the literature written in the inside and outside the country. And a range of the paper is to grasp to actual state of the floor impact sound through a survey and field and present legal, material and structural solutions on the floor impact sound of apartment houses. The result is as follows.; Most apartment house tenants have suffered severe damage from a floor impact sound demands on substitutes and a method of construction have been increased. Constructors have pointed out many problems concerning the standard floor system of the government but normally they have applied a government bill considering all sorts of civil appeal on the construction environment sand a legal strife getting increased recently. Actually the standard floor system has been not satisfied with the first grade standard on the sound insulation and it will be required the necessity of certification on diverse floor structure system based on the related materials for a buffer or a shock-absorbing device and technical development to the future.
Unstable D-branes and String Cosmology
김찬주,권오갑,Yoonbai Kim,이종오,김항배 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1
The cosmological implications of rolling tachyons are reported in the context of effective field theory. With a brief review of rolling tachyons in both at and curved spacetimes, we study the string cosmological model with both tachyon and dilaton. In the string frame, at space solutions of both initial-stage and late-time are obtained in closed form. In the Einstein frame, every expanding solution is decelerating. When a Born-Infeld U(1) gauge field is coupled, enhancement of the efolding of the scale factor is also discussed by numerical analysis.