부산, 경남 일부 지역 주민들의 생선 섭취량과 혈중 수은 농도의 관련성

김찬우,김영욱,채창호,손준석,김자현,박형욱,강윤식,김장락,홍영습,김대선,정백근,Kim, Chan Woo,Kim, Young Wook,Chae, Chang Ho,Son, Jun Seok,Kim, Ja Hyeon,Park, Hyoung Ouk,Kang, Yune-Sik,Kim, Jang-Rak,Hong, Young Seoub,Kim, Dae-Seon,Jeong 한국농촌의학지역보건학회 2012 농촌의학·지역보건 Vol.39 No.4

Objectives: The objective of this study was to identify the relationship between fish consumption and blood mercury levels in a sample of adult Koreans. Methods: The study subjects were 299 residents of Busan (male: 65, female: 234) and 185 residents of Namhae (male: 69, female: 116), South Korea. Demographic characteristics, current smoking, current drinking, fish consumption per week, past history of amalgam treatment, and residential district were recorded by trained interviewers in June and July, 2009. We considered a portion of fish to be equivalent to 70 gm weight, and calculated amounts of fish consumed per week. Using chi-square tests, t-tests, ANOVA, and multiple linear regression analysis, we estimated the relationships between blood mercury levels and amount of fish consumed per week and other factors. Results: The mean blood mercury level of our subjects was 6.61 ${\mu}g/L$, higher than the criterion defined by the United States Environmental Protection Agency (EPA) (5.8 ${\mu}g/L$). In multiple linear regression analysis, residential district and amount of fish consumed per week were associated with blood mercury levels. However, marital status, current drinking, and gender, and age were not associated with blood mercury levels. Conclusions: In conclusion, we suggest the implementation of systematic and periodic population-based studies to decrease the risks of mercury poisoning among South Koreans who consume fish as a regular part of the diet. 본 연구는 직업적으로 수은에 노출되지 않는 일반 인구 군에서 생선 섭취량과 혈중 수은 농도 사이의 관련성을 파악하기 위하여 수행되었다. 이를 위하여 부산광역시 2개 동과 남해군 3개 마을에 거주하는 사람들 중 본 연구 참여에 동의한 484(남자: 134명, 여자: 350명)명을 최종 연구대상으로 하였다. 설문조사는 2009년 6월 말부터 7월초까지 연구 참여 희망자들을 대상으로 훈련된 조사자가 면접설문조사를 실시하였다. 설문 조사의 주요 내용은 성별, 연령, 학력, 결혼상태, 직업, 현재 흡연 여부, 현재 음주 여부, 일주일간 생선 섭취량, 아말감 치료, 거주지역 등이었다. 단변량 분석에서 성별, 나이, 결혼상태, 현재 음주 여부, 일주일간의 생선 섭취량, 그리고 거주지역이 혈중 수은 농도와 유의한 관련성이 있었다. 혈중 수은 농도를 종속 변수로 한 다중선형회귀분석에서 일주일간의 생선 섭취량, 그리고 거주지역이 혈중 수은 농도와 유의한 관련성이 있었다. 생선 섭취량과 혈중 수은 농도 간에는 통계적으로 유의한 관련성이 있다. 앞으로 혈중 수은 농도와 건강 장애간의 관련성을 비롯한 추가적인 연구를 통하여 생선 섭취와 연관된 수은 노출 기준, 실제적인 생선 내 수은 잔류 기준, 생선 섭취빈도와 생선 섭취량에 관한 여러 가지 권고안들을 마련하기 위한 근거 기반을 마련해야 할 것이다.

구강암 세포에서 혈관내피성장인자 수용체-3 억제제의 항종양 효과

김찬우,김성곤,박영욱,Kim, Chan-Woo,Kim, Seong-Gon,Park, Young-Wook 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.4

Purpose: Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis and lymphangiogenesis including induction of endothelial cell proliferation, migration and capillary tube formation. E7080 (S1164, Selleck chemical, Houston, TX, USA) is a muti-targeted kinase inhibitor, which targets VEGF receptor-2, 3 (VEGFR-2, 3) and inhibits survival and proliferation of tumor cell. The purpose of this study was to determine the anti-tumor effect of E7080 on oral squamous cell carcinoma. Methods: An oral squamous cell carcinoma cell line, SCC-9 was used in this study. E7080 was applied to SCC-9 cells by 3 different concentrations (1, 5, 10 ${\mu}g/mL$). Control means no application of E7080. The cellular growth was evaluated by real-time cell electronic sensing and MTT assay. The signal transduction was evaluated by Western blotting. Results: In experimental group, SCC-9 cell proliferation was decreased and the VEGFR-3 downstream pathways were inhibited compared with control. Furthermore, increasing the concentration of E7080, the ability of E7080 to disturbance of SCC-9 cell proliferation was increased. Conclusion: Proliferation of SCC-9 cells was inhibited by E7080, which was through by inhibition of VEGFR-3 downstream pathway. In vivo study with E7080 will be required to provide therapeutic benefits in oral squamous cell carcinoma.

황함유 리간드의 금속착물(II). 디티오카바메이트류의 백금(II) 착물의 합성과 성질

김찬우,김창수,Chan-Woo Kim,Chang-Su Kim 대한화학회 1993 대한화학회지 Vol.37 No.8

물에서 [PtCl$_4$]^{2-}$의 백금(II)에 결합된 클로로리간드를 디티오카바메이트로 치환시켜 [Pt(A)], [Pt(B)$_2$]Cl$_2$, [Pt(C)$_2$] 및 [Pt(D)(CH$_2$=CH$_2$)Cl]Cl를 합성하였다. 백금 착물은 원소분석, 적외선 및 자외선-가시광선 스펙트럼과 전도도 측정을 하여 이들의 성질을 조사하였따. 이들 백금(II)의 디티오카바메이트류 착물은 물, 알코올, 디메틸술폭시드 및 티메틸포름아미드와 같은 극성용매에 잘 녹았다. 이들 백금(II) 착물의 원소분석과 물리적 측정결과에서부터 그 가능한 구조를 제시하였다. Reactions of [PtCl$_4$]$^{2-}$ with excess of dithiocarbamates in water lead to facile replacement of the chloro ligand by dithiocarbamato ligand to give [Pt(A)], [Pt(B)$_2$]Cl$_2$, [Pt(C)$_2$], and [Pt(D)(CH$_2$=CH$_2$)Cl]Cl. The complexes of platinum have been characterized by elemental analyses, infrared and UV-visible spectra, and conductivity measurements. Platinum(II)-dithiocarbamate complexes were soluble in polar solvents such as water, alcohol, acetone, dimethylformamide, and dimethylsulfoxide etc. The possible structure was proposed on the basis of elemental analyses and physical properties.

디에탄올아민 디티오카바메이트와 트란스-디클로로비스(에틸렌디아민)코발트(Ⅲ)이온의 반응에 대한 속도와 메카니즘

김찬우,김창수,Kim, Chan Woo,Kim, Chang Su 대한화학회 1996 대한화학회지 Vol.40 No.5

디에탄올아민 디티오카바메이트는 염화디스클로로비스에틸렌디아민)코발트(III)와 반응하여 [$Co(dtc)_3$](dtc=디에탄올아민 디티오카바메이트)를 생성한다. 이때 두 황원자는 코발트에 배위된다. 이 착물은 아세톤에 어느 정도 녹으나 이황산산소와 같은 비극성 용매에는 거의 녹지 않았다. 디에탄올아민 디티오카바메이트와 염화디스클로로비스에틸렌디아민)코발트(III)의 반응속도를 측정하고 이들 결과에서 얻어진 활성화 파라미터에서부터 가능한 메카니즘을 제시하고자 한다. Diethanolamine dithiocarbamate is known to react with dichlorobis(ethylenediamine)cohalt(Ⅲ) chloride to form [Co(dtc)3](dtc=diethanolamine dithiocarbamate) in which two sulfur atoms of the dithiocarbamate are bound to cobalt. The complex is moderately soluble in acetone, but sparingly soluble in carbon disulfide. Kinetics and mechanisms of the reaction of dichlorobis(ethylenediamine)cobalt(Ⅲ) chloride with diethanolamine dithiocarbamate have been studied in aqueous solution. Activation parameters have been calculated from the kinetic data for the reaction and from these results a possible mechanism for the reaction has been proposed.

피페리딘 디티오카바메이트의 구리(II)의 착물합성과 분석적 응용

김찬우,김창수,Kim, Chan-Woo,Kim, Chang-Su 한국분석과학회 1999 분석과학 Vol.12 No.1

구리(II)이온과 피페리딘 디티오카바메이트(Pipdtc)의 반응에서[$Cu(Pipdtc)_2$]를 합성하였다. 이 착물은 디메틸포름아미드, 디메틸술폭시드의 극성 유기용매에 잘 녹는다. 원소분석, 몰전도도, 적외선 흡수스펙트럼, 전자흡수스펙트럼 및 핵자기공명스펙트럼에서 부터 평면 사각형의 구조를 가짐을 알 수 있었다. 수용액에서 부터 사염화탄소에 의한 Cu(II)-Pipdtc착물의 추출은 pH가 6.0~10범위에서 이루어졌다. 구리(II)의 피페리딘 디티오카바메이트 용액은 pH 9.0에서 ${\sim}8.0{\times}10^{-5}M$까지 Beer의 법칙에 따랐다. Copper(II) complex of piperidine dithiocarbamate (Pipdtc) was synthesized from the reaction of Cu(II) and piperidine dithiocarbamate. The possible structure of the complex was proposed on the basis of elemental analysis, molar conductivity, infrared spectroscopy, electronic absorption spectroscopy, and $^{13}C-NMR$ studies. The extraction of copper(II)-Pipdtc complex by carbon tetrachloride can be achieved in the pH range of 6.0~10. The solution of copper(II) with piperidine dithiocarbamate was bey Beer's law in the concentration up to ${\sim}8.0{\times}10^{-5}M$ at pH 9.0.

실라스틱(Silastic$^{(R)}$) 배액관을 이용한 간편한 봉합고정 드레싱

김찬우,박상순,이용직,심정수,박대환,Kim, Peter Chan Woo,Park, Sang-Soon,Lee, Yong-Jig,Shim, Jeong-Su,Park, Dae-Hwan 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.3

Purpose: Tie-over dressing is widely used to secure skin grafting on face, body, or extremities. It can be a rather complicated task and is not easy to make compressive dressing again if performed in a conventional method. So, we hereby introduce an easy reproducible tie over dressing method. Methods: After completing the skin graft, Cut the silastic drainage longitudinally in half and spread to the grafted skin margin. Drainage is fixed by using the stapes or sutures. A fluffy gauze bolus dressing is placed over a furacin impregnated gauze and wrapped around. After suturing the distal margin of silastics with opposite side using the silk thread either 5 - 0 or 3 - 0, knot of suturing, which is pressed down against the dressing while the threads are tightened, is made into center of each sides. Results: It can make dressing again after observing the grafted skin, and it can also make pressure on the grafted area evenly until the grafted skin is taken. Conclusion: This dressing method makes the surgeons and patients comfortable. To surgeons, it provides more rapid and easier way to do dressing, and to patients, it eliminates pain caused by redressing.

[화학] 피페리딘 디티오카바메이트의 구리(Ⅱ)의 착물합성과 분석적 응용

김찬우(Chan-Woo Kim),김창수(Chang-Su Kim) 한국분석과학회 1999 분석과학 Vol.12 No.1

레스토랑 브랜드이미지가 HMR(가정간편식) 구매행동과 고객만족에 미치는 영향

김찬우(Kim, Chan Woo),김성수(Kim, Seong Soo) 한국외식산업경영학회 2016 외식산업경영연구 Vol.12 No.1

The This study was conducted for 20 days between April 1 and April 20, 2016. The data was collected based on self-administered questionnaire that was filled out by customers who live in Seoul and Gyeonggido and have experience in purchasing a home meal replacement (HMR) manufactured by a restaurant brand. First, the disrinctivenes was B=0.311(p<.001), which suggests a significant positive effect on purchase behavior. However, reliability and familiarity did not have any effect on purchase behavior. Second, analysis of the effect of HMR purchase behavior on satisfaction showed that purchase behavior has B=0.577(p<.001) with a significant positive effect on satisfaction. Third, analysis of the effect of a restaurant brand image on customer satisfaction showed that familiarity has B=0.222(p<.05) and disrinctivenes B=0.336(p<.001), with a positive effect on satisfaction. However, reliability did not have any effect on satisfaction.

노인복지서비스 증진을 위한 지방정부의 역할정립에 관한 고찰

김찬우(Chan Woo Kim) 한국노인복지학회 2015 노인복지연구 Vol.0 No.67

본 연구는 노인복지 서비스의 지방분권화 흐름과는 반대로 2008년부터 도입된 중앙정부 중심의 노인장기요양보험제도 실시라는 상충된 정책 환경 변화에 대한 지방과 중앙 정부 간의 역할 조정 문제 및 지방정부의 대응방안에 대해 고찰하고자 실시되었다. 최근 지방분권 화의 지자체 사회복지 지출증감에 대한 영향력이나 복지전달체계에 관한 연구의 증가와는 달리 노인복지 서비스와 지방정부의 역할을 연관시켜 온 연구는 부재해왔다. 본 연구는 관련문헌연구, 2011년 전국노인실태 조사결과분석 및 돌봄 정책 사례분석을 통해 수행되었다. 주요 연구결과는 다음과 같다. 첫째, 선행연구 분석을 통해 파악된 노인복지관련 지방정부의 중점영역은 노인여가 · 문화, 주거환경 및 복지관 활성화로 나타났으며 이와 관련한 실태분석 결과, 지역 공원부지 확보 및 관리, 경로당 활성화 필요성이 요구됨을 알 수 있었다. 또, 주거환경 개선, 연령 및 기능상태 별 노인복지관 프로그램의 차별화에 대한 필요도 나타났다. 둘째, 2008년 도입된 노인장기요양보험과 노인돌봄서비스의 관계 분석 결과 중앙정부, 국민건강보험공단 및 지방정부간의 유기적 연계부재로 발생한 돌봄 사각지대 감소가 절실히 필요한 것으로 나타났다. 결론적으로 본 연구에서는 고령사회 대응을 위해 지방정부의 노인복지 중점영역에 대한 적극적이고 효율적 관리가 필요하며, 동시에 지역중심 노인 돌봄 서비스의 지속적 관리를 위해서는 중앙정부와의 협의체 신설, 주거요양 공동체 구축 등의 필요성을 제언하고 있다. The purpose of this paper is to examine the roles of local governments in regard to providing the welfare services for older adults in an aging society. Despites the rapid increase of older adults and their welfare needs, both the current localization trend and the centralized National Long-term Care Insurance(NLTCI) raise the challenges to meet welfare service needs of community-living elders. In the first section, this study discussed and analyzed welfare-related characteristics of older adults by using the data of and 2011 National Survey of the Elderly by The Korean Institute of Health and Social Affairs (KIHASA). In the second section, by focusing on the change of policy environment during the post-NLTCI, the study discussed the desirable relationship between NLTCI and local social care services for older adults. Lastly, the study suggests that more integrative ways to coordinate welfare delivery systems of local and central government in order to cope with increasing welfare needs of older adults living in the community.

한국 여성의 정상 두피에서 횡단 절편 소견을 이용한 모낭 분석

김찬우 ( Chan Woo Kim ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),김기홍 ( Ki Hong Kim ),김극준 ( Keuk Jun Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.3

Background: To date there has not been a study of the histologic data of hair pollicles in scalp hairs of healthy Korean female adults. It is better to evaluate follicular structures in horizontal histologic sectioning than in vertical sectioning. Objective: To obtain histologic data of hair follicles in scalp hairs in healthy Korean female adults. Methods: 20 healthy Korean female volunteers with a normal scalp were analyzed. The age range was 22∼29 years (mean 25.7±2.3). Transverse sections of 4 mm punch biposy specimens from the vertex were examined at various levels from the papillary dermis to the subcutis. Follicular counts of terminal/vellus hairs and anagen/ telogen hair were evaluated. Results: The total number of total hairs, terminal hairs, vellus hairs, average follicular units, and follicular structures/ mm2 were 17.5±2.6, 15.8±2.5, 1.8± .7, 9.0±1.6, and 1.4±0.2 respectively. Terminal hair:vellus hair ratio was 9:1 and percentage of anagen hairs among total hairs was 95%. Hair density in Korean female was found be significantly lower than that of white females and African American females. Conclusion: This data can be used as a guideline for interpreting transverse sections of scalp biopsy specimens in Korean female adults. (Korean J Dermatol 2008;46(3):341∼346)