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김재호 慶星大學校 1996 論文集 Vol.17 No.4
As an interest in enviornmental pollution rises, there is much discussion of whether American pokeweed(Phytolacca americana) is a threat to the ecosystem. To see any relationships between the American pokeweed and soil acidity, the survey of distribution of the plant and the measurement of soil acidity of Mt.Hwangryung was conducted. Mt.Hwangryung is located in the very middle part of Pusan which is the second largest city of Korea. Though there was a big deviation in the number of plants found, the american pokeweed was distributed widely from the foot to the top of the mountain and the largest number of the plant found in a 25m² survey square was 35. The acidity of found to be 4.21 which was very close to that of industrial areas or reported areas of heavy inhabitation of American pokeweed. There was no distinct relationship between the distribution of the American pokeweed and pH of the surrounding soil on the mountain. But the pH of Mt.Jiri and Mt.Nungdong from which there was yet no report of heavy growth of American pokeweed were both above 5.6 which was a big defference compared to 4.2 if Mt.Hwangryung.
Novel biological strategies to enhance the radiation therapeutic ratio
김재호,Kenneth A. Jenrow,Stephen L. Brown 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.3
Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.