포스터 전시 : 호흡기, 내분비-대사 ; 기관지내 지방종성 과오종

김소리,최광호,정치량,박성주,이흥범,이양근,이용철 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

F-160 Mitochondrial ROS ignites NLRP3 inflammasome activation via PI3K-HIF-VEGF signaling response in LPS-induced lung inflammation

김소리,이용철,김희정,김순하,이양근,이흥범,박성주,최영훈,박승용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

There is little information on which molecular mechanisms contribute to the assembly of NLRP3 inflammasome induced by mitochondrial ROS, especially in lung. In this study, we used LPS-instilled mice to define the molecular mechanisms implicated in mitochondrial ROS-induced NLRP3 inflammasome activation in lung inflammation, specifically in the relationship with PI3K-HIF-VEGF axis activation. The administration of mitochondrial ROS inhibitors, Nerox-5 or -7 decreased the features of LPS-induced lung inflammation including mitochondrial ROS generation and the levels of NLRP3 expression. In addition, the increases in phosphorylation of Akt, activation of HIF-1α and HIF-2α, and expression of VEGF in lung tissues from LPS-instilled mice were significantly inhibited with the administration of NecroX compounds. Our results also revealed that LPS-induced increases of nuclear translocation of NF-κB, infiltration of DCs, and TLR4 expression in the lung were significantly reduced by inhibition of NecroX compounds. TLR4 inhibition using TAK-242 decreased mitochondrial ROS and the phosphorylation of Akt and p85 expression in lung tissues and attenuates the LPS-inflammation. Interestingly, blockade of VEGF resulted in the substantial suppression of the activation of NLRP3 inflammasome. These findings suggest that mitochondrial ROS activates NLRP3 inflammasome, a crucial player in the pathogenesis of LPS-induced lung inflammation, at least in part through PI3K-HIF-VEGF axis.

P-109 Succesful cryoablation for the rapid growing recurrent hamartoma after excision using rigid bronchoscopy

김소리,이용철,최영훈,이양근,이흥범,박성주,박승용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Hamartoma is a clinically frequent benign lung tumor, accounting for 77% of all benign lung tumors. This abnormality is thought to be the result of variations in the quality, arrangement, or degree of differentiation of the tissues. The majority of pulmonary hamartomas are asymptomatic and show slow annual growth. Depending on the location of the tumor, surgical resection can be recommended, however, hamartoma is considered to be a benign tumor with a good prognosis and often followed up by observation without surgery due to slow annual growth. The mean transverse diameter of hamartomas at discovery was reported to be 21.7 ± 16.2 mm, and the average increase in transverse diameter was 3.2 ± 2.6 mm per year. In addition, the recurrence of hamartoma after surgical resection or excision is extreamly rare. Here, we report a case with an endobronchial hamartoma that was excised totally under rigid bronchoscopy and then recurred within one month after the excision. The rapid growing recurrent harmatoma was completely resected by bronchoscopic cryotherapy and there was no evidence of recurrence up to ten-month follow-up after the cryotherapy.

1930~1940년대 경기 굿거리

김소리 한양대학교 우리춤연구소 2007 우리춤과 과학기술 Vol.3 No.2

경기 굿거리는 서울을 비롯한 경기 지방의 삼현육각 음악으로 민간 음악의 대표적인 기악곡이다. 예로부터 경기 삼현육각 중 경기 굿거리는 도당굿, 사가의 큰 잔치, 춤 반주 등 서민들의 크고 작은 행사에 여러 기능을 가지고 연주되던 곡이다. 이 논문에서는 이러한 경기 굿거리 음악의 시간적인 변화를 알아보기 위해 1930~1940년대고 음반의 경기 굿거리를 살펴보았다. 경기 굿거리의 초기음반으로는 ‘취주악국거리’를 수록한 <Columbia 40216>, ‘무곡 굿거리’를 수록한 <Victor KA-3030>, ‘고악 굿거리’를 수록한 <Columbia 40904> 등 3종이다. 이 음반의 녹음 시기는 각각 1931년, 1930년대 후반, 1940년이다. 이상 1930~1940년대 경기 굿거리 3종의 음반 형태는 유성기 음반이며, 당시 감상(취주악), 전통음악의 계승(고악), 무용 반주(무곡) 등의 다양한 목적으로 녹음됨을 추정할 수 있다. 1930~1940년대 경기 굿거리의 음악적 특징으로는 반복 형식을 가지고 있으며, 반복시 시김새에 즉흥성을 가미하여 약간의 변화를 주어 반복한다. 음계는 ‘레’, ‘솔’, ‘라’, ‘도’, ‘레’, ‘미’, ‘솔’의 구성음에 ‘솔’, ‘레’, ‘미’ 음을 요성한다. 해금의 경우 역안법을 사용하지 않는 특징을 가지고 있어 ‘미’와 ‘솔’이 출현하지 않고 음역이 피리에 비해 4도 정도 좁다. 빠르기는 현재 연주되는 굿거리와 달리 시작 빠르기에서 점차 빨라져서 끝을 맺고 있는 점이 특징적이다. 선율 붙임새는 주로 장단과 선율이 일치하게 진행하며, 가끔 엇붙임의 형태가 출현한다. 1930~1940년대 경기 굿거리는 피리, 대금, 해금, 장구로 연주되었으며, 그 연주자는 그 당시 활동했었던 연주자들과 선율의 비교를 통하여 1931년에 연주한 팀과 1930년대 후반 및 1940년에 연주한 팀으로 나누어 생각할 수 있다. 1931년의 경기 굿거리 연주자는 피리에 한성준, 대금에 방용현, 해금에 지용구로 추정된다. 장구의 경우는 같은 팀이 아닐 것으로 추정되어 알 수 없다. 1930년대 후반과 1940년의 경기 굿거리 연주자는 지휘로 기재되어 있는 한성준이 장구를 연주했을 것이며, 피리에는 이 일선, 대금에는 방용현, 해금에는 김덕진 등이 연주했을 것으로 보인다. 1940년에 녹음된 경기 굿거리에는 피리가 두 명인데, 이는 이후 활동이 활발한 지영희가 아닐까 짐작한다. 1930~1940년대 경기 굿거리는 현재 연주되는 굿거리에 비해 반복시 정형화되어 있지 않은 점이 인상적이다. 즉흥성을 지니고 있는 경기 굿거리의 모습에서 현재와 달리 악보 없이 음악을 배웠던 점이 좀 더 음악을 창의적으로 연주할 수 있게 하는 것이 아닌가라는 생각을 했다. 또한 1930~1940년대 경기 굿거리는 빠르기에서 변화를 주고 있는 점도 특징적이었다. Kyonggi Gutgeori is a represantative intrumental music, Samhyunyukgak, of Kyonggi province. Kyonggi Gutgeori, one of Samhyunyukgak, was played at events such as Dodanggut, big party and dance accompaniment of many functions. To find out changes in time of Kyonggi Gutgeori, I studied 1930~1940 years Kyonggi Gutgeori disks. Early times of Kyonggi Gutgeori disks are <Columbia 40216>(1931), <Victo KA-3030>(late 1930s), and <Columbia 40904>(1940). These three kinds of Kyonggi Gutgeori disks are gramophonic records. Purposes of recording are appreciation, preservation of taditional music and dance accompaniment. Form of Kyonggi Gutgeori in 1930~40s is repetition with improvised changes. Scales consist of ‘re’, ‘sol’, ‘la’, ‘do’, ‘re’, ‘mi’, ‘sol’ and vibrate ‘sol’, ‘re’, ‘mi’. Haegum's range is narrower than Piri because of its playing technique. Tempo is getting faster gradually. Melodies of Kyonggi Gutgeori progress in accordance with rhythm. Kyonggi Gutgeori in 1930~1940s was performed with Piri, Daegum, Haegum and Jangoo. And plyers were Han Seong-Jun (Jangoo and Piri), Bang Yong-Hyun (Daegum), Ji Yong-Gu (Haegum), Yi Il-Sun (Piri), Kim Deok-Jin (Haegum) and Ji Young-Hee (Piri). Characteristics of Kyonggi Gutgeori in 1930~1940s are that it doesn't have fixed form in its repetitive playing style and changes in tempo.

F-157 Effects of anti-IL-5 antibody on severe asthma with fungal sensitization

김소리,이용철,박해진,이양근,이흥범,박성주,최영훈,박승용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Recently, a subphenotype of severe asthma with fungal sensitization (SAFS) has been described in adults and is associated with reduced lung function and increased morbidity. Anti-IL-5 antibody has been approved as a therapeutic agent for patients with severe eosinophilic asthma. In this study, we evaluated the molecular mechanisms associated with severe asthma with fungal sensitization focusing on the role of IL-5. The mice sensitized and challenged with Aspergillus fumigatus (Af-inhaled mice) showed the typical features of bronchial asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of Af-inhaled mice, and increased bronchial hyper-responsiveness. These asthmatic features were refractory to the treatment with oral dexamethasone. Interestingly, airway inflammatory cells including eosinophils, peribronchial and perivascular inflammation, the expression of IL-5 in lung tissues and airway hyperresponsiveness were reduced markedly by the administration of anti-IL-5 antibody intraperitoneally. However, the expression of other Th2 cytokines, IL-4 and IL-13 did not affected significantly by the treatment with anti-IL-5 antibody. These findings suggest that IL-5 plays more ciritcal roles in SAFS than other Th2 cytokines and that anti-IL-5 antibody can control its own expression of IL-5 in lung tissues maybe partly due to the reduction of source cells of IL-5.

알레르기성 기도 질환에서 항산화제의 p38 MAPK를 통한 HO-1 유도

김소리,이용철,이경선,이양근,이흥범,박성주,민경훈,한효진,이민희,정치량,최경화,유혜민,문진창,김승범,전명신,홍민희 대한결핵 및 호흡기학회 2010 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.110 No.-

Current Epidemiological Data on Asthma Management in South Korea from Qualitative Assessment of Asthma Management by Health Insurance Review and Assessment Service (HIRA)

김소리,이용철,성명주,배혜원 대한결핵및호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3

Since 2015, the Health Insurance Review and Assessment Service (HIRA) has performed annual qualitative assessments of asthma management provided by all medical institutions that care for asthma patients in Korea. According to the third report of qualitative assessment of asthma management in 2017, the assessment appears to have contributed to improving the quality of asthma care provided by medical institutions, especially primary clinics. However, there is still a gap between the ideal goals of asthma management and actual health care policies/regulations in real clinical settings, which leads to the state of standstill with respect to the quality of asthma management despite considerable efforts such as the qualitative assessment of asthma management by national agencies such as the HIRA. At this point, a harmonized approach is needed to raise the level of asthma management among several components including medical policies, efforts of academic associations such as education and distribution of the guideline for management, and reliable financial support by the government.

Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogenperoxide-induced acute lung injury

김소리,Kyung Sun Lee,박성주,Kyung Hoon Min,Ka Young Lee,Yeong Hun Choe,Sang Hyun Hong,고규영,이용철 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.3

Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability, and plasma exudation are cardinal features of acute lung injury. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage and also has beneficial effects in several inflammatory disorders. Recently developed COMP-Ang1 is more potent than native Ang1 in phosphorylating tyrosine kinase with immunoglobulin and EGF homology domain 2 receptor in endothelial cells. However, there are no data on effects and related molecular mechanisms of COMP- Ang1 on ROS-induced acute lung injury. We used hydrogen peroxide (H2O2)-inhaled mice to evaluate the effect of COMP-Ang1 on pulmonary inflammation, bronchial hyper-responsiveness, and vascular leakage in acute lung injury. The results have revealed that VEGF expression, the levels of IL-4, TNF-α, IL-1β, intercellular adhesion molecule-1, and vascular cell adhesion molecule- 1 in lungs, the levels of hypoxia-inducible factor- 1α (HIF-1α) and NF-κB in nuclear protein extracts, phosphorylation of Akt, and vascular permeability were increased after inhalation of H2O2 and that the administration of COMP-Ang1 markedly reduced airway hyper-responsiveness, pulmonary inflammation, plasma extravasation, and the increases of cytokines, adhesion molecules, and VEGF in lungs treated with H2O2. We have also found that the activation of HIF-1α and NF-κB and the increase of phosphoinositide 3-kinase activity in lung tissues after H2O2 inhalation were decreased by the administration of COMP-Ang1. These results suggest that COMP-Ang1 ameliorates ROS-induced acute lung injury through attenuating vascular leakage and modulating inflammatory mediators. Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability, and plasma exudation are cardinal features of acute lung injury. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage and also has beneficial effects in several inflammatory disorders. Recently developed COMP-Ang1 is more potent than native Ang1 in phosphorylating tyrosine kinase with immunoglobulin and EGF homology domain 2 receptor in endothelial cells. However, there are no data on effects and related molecular mechanisms of COMP- Ang1 on ROS-induced acute lung injury. We used hydrogen peroxide (H2O2)-inhaled mice to evaluate the effect of COMP-Ang1 on pulmonary inflammation, bronchial hyper-responsiveness, and vascular leakage in acute lung injury. The results have revealed that VEGF expression, the levels of IL-4, TNF-α, IL-1β, intercellular adhesion molecule-1, and vascular cell adhesion molecule- 1 in lungs, the levels of hypoxia-inducible factor- 1α (HIF-1α) and NF-κB in nuclear protein extracts, phosphorylation of Akt, and vascular permeability were increased after inhalation of H2O2 and that the administration of COMP-Ang1 markedly reduced airway hyper-responsiveness, pulmonary inflammation, plasma extravasation, and the increases of cytokines, adhesion molecules, and VEGF in lungs treated with H2O2. We have also found that the activation of HIF-1α and NF-κB and the increase of phosphoinositide 3-kinase activity in lung tissues after H2O2 inhalation were decreased by the administration of COMP-Ang1. These results suggest that COMP-Ang1 ameliorates ROS-induced acute lung injury through attenuating vascular leakage and modulating inflammatory mediators.

만 5세반 실내 자유선택활동 시간에 나타난 유아 유머의 전반적 경향 및 유형 분석

김소리,이승연 한국육아지원학회 2012 한국육아지원학회 학술대회지 Vol.2012 No.4

서울 굿에서의 악기편성과 악사당주

김소리 한국퉁소연구회 2004 한국악기학 Vol.- No.2