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제로 정(로녹시캄 4 mg)에 대한 로노캠 정의 생물학적 동등성
강현아,조혜영,이용복,Kang, Hyun-Ah,Cho, Hea-Young,Lee, Yong-Bok 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.1
Lornoxicam is a nonsteroidal anti-inflammatory drug that decreases prostaglandin synthesis by inhibiting cyclooxygenase. It has analgesic, antipyretic and antiinflammatory effects. The purpose of the present study was to evaluate the bioequivalence of two lornoxicam tablets, $Xefo^{\circledR}$ (Hyundai Pharmaceutical Ind. Co., Ltd.) and Lornocam (Samchundang Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of lornoxicam from the two lornoxicam formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty eight healthy male subjects, $24.39{\pm}1.95$ years in age and $68.63{\pm}7.25$ kg in body weight, were divided into two groups and a randomized $2\;{\time}\;2$ cross-over study was employed. After a single tablet containing 4 mg as lornoxicam was orally administered, blood samples were taken at predetermined time intervals and the concentrations of lornoxicam in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Xefo^{\circledR},$ were -1.56%, 2.16% and -17.12% for $AUC_t,\;C_{max}\;and\;T_{max},$ respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., $log\;0.90{\sim}log\;1.05$ and $log\; 0.88{\sim}log\;1.17$ for $AUC_t\;and\;C_{max},$ respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Lornocam tablet was bioequivalent to $Xefo^{\circledR}$ tablet.
직장내 성차별적 관행과 성평등의식의 딜레마 : 광주지역 사례 연구
강현아,김항심,이은주 전남대학교 사회과학연구소 2000 현대사회과학연구 Vol.11 No.1
This study is an investigation and analysis of sexual equality among Kwangju citizens at work. On the grounds that the social structure of sexual discrimination and the subsequent criticism about a work culture had been prevailing, we tried to look into substantial reality of sexual equality speculated by men and women of workplace. Additionally we analysed its relationship to sexist institutions and policies within workplace. Source data were gathered through the questionnaire research, then being analysed by statistic application. Summary of the result is as follows: Kwangju citizens of workplace seem to be highly inspired with seal equality in routine life and work life, but they still maintain the conservative viewpoint about socially-structured institutions like androcentric structure. In other words they are in a dilemma, hovering between maintenance of sexist traditions workplace and enhancement of sexual equality. Actually that can be recognized by their institutions and conventions at their work. So we conclude that positive education of sexual equality within work needs to be performed. That will make it possible for them to perceive discriminations against women workplace, then malting their critical eyes wide open to androcentric work culture and eventually malting them suggest the vision for a desirable sexuality culture workplace.
Construction of Linkage Map of the Silkworm , Bombyx mori , Using RAPD Markers
강현아,이진성,서동상,김호락,황재삼,이상몽,구태원 한국유전학회 1998 Genes & Genomics Vol.20 No.2
A genetic linkage map of the silkworm, Bombyx mori, was constructed by using RAPD markers. Fifty eight valuable polymorphic bands were detected in the silkworm strains (J111 and Galwon) by screening 100 decamer primers and selecting 35 decamer random primers. On the F₂ generation, segregation ratio of these bands was about 3:1 in a chi square test, showing Mendelian inheritance. The MAPMAKER program sorted 58 bands into 9 linkage groups and 28 unlinked loci at minimum LOD score 4.5 and determined orders of loci in each linkage group which contained 2 to 8 RAPD markers. The map consists of 30 markers and the sum of map distance was about 309.3 cM. The RAPD map has a low density of 10.3 cM on average, which correspond to 5.15 Mbps. And then results obtained above suggest that this linkage map is one of the fundamental index for the future genome analysis in the silkworm, Bombyx mori.