치매환자의 행동심리증상 관리를 위한 요양시설 간호제공자 대상 교육프로그램 분석

강민숙(Kang, Min Suk),박희옥(Park, Heeok) 계명대학교 간호과학연구소 2017 계명간호과학 Vol.20 No.3

Purpose: The purpose of this study was to review literature related to the effectiveness of staff education programs to reduce BPSD in long-term care facilities. Methods: Electronic database (Pubmed, CINAHL, Riss, Kiss, DBpia, Google scholar) was used for searching key words including dementia , alzheimer disease , aggression , ‘agitation’, behavioral psychological symptoms of dementia , ‘staff’, ‘education’ and ‘program’. A total of 19 studies were included for the analysis based on the inclusion criteria. Results: The most common research design was the cluster randomized controlled trial and types of education programs were ‘lecture’, ‘supervision’ and ‘feedback.’ Training programs provided for more than 8 weeks and 11 hours were significantly effective for BPSD. For the contents of educational programs, the concept of dementia and BPSD, factors, general strategies and skills to manage BPSD, non-pharmacological interventions, communication skills and changing the patients’ environment were included. The significant effects were shown on BPSD and staff’s management behaviors in the program. Conclusion: Based on the results of the review studies, future studies related to provision of education program consisting of the concept, factors, skills and management of dementia and BPSD are recommended.

조리전공학생 대상 ‘한식양념장과 활용음식 교육’에 대한 만족도 조사

강민숙(Kang, Min-sook),박정화(Park, Jeong Hwa),김양숙(Kim, Yang Suk),김수희(Kim, Soo Hee),최수근(Choi, Soo Keun),고은아(Ko, Eun A),김안나(Kim, An Na) 한국지역사회생활과학회 2015 한국지역사회생활과학회 학술대회 자료집 Vol.2015 No.11

대황 추출물이 갱년기 유도 흰쥐의 골 조직에 미치는 영향

박용수(Yong Soo Park),강민숙(Min Suk Kang),김보경(Bo Kyung Kim),김미향(Mihyang Kim) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.1

갱년기 여성에는 여러 폐경 증후들이 나타나는데, 특히 estrogen의 감소로 인하여 급격한 골 소실로 골다공증의 위험성이 높아 이에 대한 예방 및 치료에 대한 연구가 활발히 이루어지고 있다. 본 연구에서는 갈조류인 대황 에탄올 추출물을 시료로 하여 in vivo 실험을 통하여 갱년기 장애 시 나타날 수 있는 골 손실 개선효과를 검토하기 위하여 골 형성 지표인 alkaline phosphatase(ALP) 활성, 결합조직 중의 콜라겐 함량 및 pyridinoline 함량을 측정하였다. 폴리페놀함량이 높은 추출물을 이용하는 것이 estrogen의 활성이 높을 것으로 예상되어, 대황의 열수와 에탄올 두 용매를 이용하여 추출한 결과 총 폴리페놀 함량은 에탄올 추출에서 더 높은 것으로 나타나, 동물 실험의 시료로 사용하였다. ALP는 폐경 시 estrogen의 결핍으로 인하여 골 전환이 증가하므로 골 형성의 지표로써 널리 사용되고 있다. 난소절제 시 estrogen 결핍으로 bone turnover가 증가되어 비 난소절제군에 비해 혈장 중의 ALP 활성이 증가되었으나, 난소 절제 후 대황 추출물을 투여한 군에서는 그 활성이 유의적으로 감소하는 경향이 나타났다. 이것은 난소절제 후 estrogen의 분비가 감소되는데 반해 대황 추출물이 estrogen 대체 작용을 함으로써 난소절제로 인한 골 손실 정도를 완화시킨 것으로 추측되어진다. 대황 추출물이 골 손실 회복에 미치는 영향을 검토하기 위해 연골 및 골 조직의 콜라겐 함량 및 콜라겐 성숙가교인 pyridinoline 함량을 측정하였다. 연골 및 골조직의 경우 비 난소절제군인 SHAM군에 비해 난소절제군인 OVX-CON군의 콜라겐 및 pyridinoline 함량이 유의적으로 감소하여, 난소절제로 인한 estrogen 결핍으로 그 생성량이 감소한 것으로 나타났다. 대황 추출물 투여에 의한 영향을 검토한 결과, 연골조직의 콜라겐 함량은 200 mg/kg/day 투여한 OVX-EB200군의 경우 대조군인 OVX-CON군에 비해 증가하는 경향을 나타내었으나 유의적인 수준은 아니었다. 반면 골 조직의 콜라겐 함량의 경우, 난소를 절제한 후 대황추출물을 50 mg/kg/day 투여한 OVX-EB50군에서 대조군에 비해 콜라겐 함량이 증가하는 경향이 나타났으며, 200mg/kg/day 투여한 OVX-EB200군의 경우 유의적으로 증가하는 결과가 나타났다. 또한 콜라겐 성숙가교인 pyridinoline 함량을 HPLC로 분석한 결과, 골 조직의 pyridinoline 함량이 난소절제 후 감소하였으나, 대황 추출물을 투여한 군(OVXEB50) 에서 대조군인 OVX-CON군과 비교하여 증가하는 결과가 나타났다. 이상의 실험 결과는 estrogen 부족 시 일어날 수 있는 골 손실에 대한 예방 소재로써 갈조류인 대황의 활용 가능성을 시사하고 있으며, 이를 활용한 기능성 소재 개발도 가능할 것으로 기대된다. Menopause is often associated with several chronic diseases, including osteoporosis, cardiovascular disease, and obesity. In this study, we investigated the ability of Eisenia bicyclis (EB) to prevent bone loss in ovariectomized rats, a model for postmenopausal osteoporosis. Extracts from EB obtained using ethanol or hot water were analyzed for total polyphenol content and osteoporosis effects in vivo. Total polyphenol content was higher with extraction by hot water compared to ethanol extraction. Fifty 8-week-old female Sprague-Dawley rats were randomly assigned to four groups: the group were sham-operated rats (SHAM), ovariectomized rats (OVX-CON), and ovariectomized rats that were treated with EB at 50 mg/kg body weight (OVX-EB50) and 200 mg/kg body weight (OVX-EB200), respectively. The diets were fed to rats for 6 weeks after their operation. We found that the alkaline phosphatase (ALP) activity was lower in the EB extract group compared to the OVX-CON group. Collagen and pyridinoline content, in bone and cartilage, were reduced by ovariectomy, but the supplemented EB extract groups exhibited higher concentrations in their bones. These results suggest that EB can be used for the industrial development of foods with therapeutic functions.

학령기 어린이와 청소년의 채소ㆍ과일 섭취 현황 및 섭취에 영향을 미치는 요인

김지현(Kim, Ji-Hyun),김양숙(Kim, Yang-Suk),김영(Kim, Young),강민숙(Kang, Min-Sook) 한국지역사회생활과학회 2013 한국지역사회생활과학회지 Vol.24 No.4

적송잎 열수 추출물이 사염화탄소를 투여한 흰쥐의 항산화 활성에 미치는 영향

Yong Soo Park(박용수),Mi-Ra Park(박미라),Min Hee Jeon(전민희),Hyun Jung Hwang(황현정),Min Suk Kang(강민숙),Bo kyung Kim(김보경),Sung Gu Kim(김성구),Sang-Hyeon Lee(이상현),Mihyang Kim(김미향) 한국생명과학회 2011 생명과학회지 Vol.21 No.4

최근 천연 항산화제로 phenolic compound를 함유한 솔잎 추출물에 관심이 많아지고 있다. 사전연구[20]에 의해 높은 항산화 활성 효과가 확인된 적송잎 열수 추출물의 in vivo차원에서의 항산화 효과를 알아보기 위해 적송잎 열수 추출물을 경구 투여한 흰 쥐에 사염화탄소를 투여하여 간독성을 유발시킨 후 생체 내에 미치는 영향을 혈청 중의 효소활성으로 관찰하였고, 간 조직의 SOD, GPX 및 catalase를 측정하여 항산화 활성에 미치는 영향을 검토 하였다. 혈청 중의 GOT 및 GPT 활성은 사염화탄소를 투여한 대조군이 정상군에 비하여 활성이 증가되었으나, 적송잎 열수 추출물의 투여로 인하여 대조군과 비교하여 감소하는 경향을 나타내었다. 이 수치는 positive control로 사용한 Vit C투여군과 비슷한 활성을 나타내었다. 간 조직 중의 항산화 효소 실험에서 SOD 활성은 사염화탄소를 투여한 대조군이 정상군에 비하여 활성이 감소하였으나, 적송잎 열수 추출물을 투여한 군에서 대조군에 비해 유의적으로 활성이 증가되는 결과를 나타내었다. 또한, catalase 활성은 사염화탄소 투여 대조군이 정상군에 비해 활성이 증가하였으나, 적송잎 열수 추출물의 투여군에서 대조군과 비교하여 유의적으로 감소하는 결과를 나타내었다. GPx 효소 활성은 사염화탄소 대조군이 정상군에 비해 활성이 증가되었고, 적송잎 추출물을 투여한 군에서는 감소하는 경향을 나타내었으나 대조군에 비해 유의적으로 감소하는 결과는 나타나지 않았다. 이상의 결과로부터 사염화탄소를 투여하여 간손상을 유도한 흰 쥐의 항산화 효소활성에 적송잎 열수 추출물의 투여가 긍정적인 영향을 미치는 것으로 나타났으며, 적송잎 열수 추출물이 체내 항산화능 개선에 효과가 있을 것으로 기대된다. Pine (pinus densiflora) needles have long been used as a traditional health-promoting medicinal food in Korea. This study was conducted to investigate the effects of pine needle extracts on the hepatic antioxidant system in the damaged liver of carbon tetrachloride (CCl₄)-treated rats. Nine-week-old Sprague Dawley rats were divided into four groups: normal group (NOR), CCl₄-treated group (CCL), pine needle hot water extract and CCl₄-treated group (CCL-P), and Vitamin C and CCl₄-treated group (CCL-V). The enzyme activities and antioxidant effects of the pine needle hot water extracts were investigated at the levels of liver homogenates and serum of rats intoxicated with CCl₄. Serum GOT and GPT activities by CCl₄ treatment increased compared to those of the NOR group. However, they tended to decrease in the hot water extract-administered group. Liver SOD activity in the CCL group was significantly lower than the NOR group (p<0.05). However, they increased in the CCL-P group compared to the CCL group. Further, the CAT and GPx activities of serum treated with CCl₄ were higher compared to those of the NOR group but lower in the CCL-P group compared to CCL group. These results suggest that pine needle hot water extract increases antioxidant activities.

전통막걸리로부터 분리된 효모균주를 이용해 제조된 막걸리의 물성 분석

전명제(Myong Je Jeon),김미향(Mihyang Kim),이동근(Dong-Gun Lee),황현정(Hyun-Jung Hwang),강민숙(Min Suk Kang),김보경(Bo Kyung Kim),이승우(Seung Woo Lee),장혜지(HyeJi Jang),이상현(Sang-Hyeon Lee) 한국생물공학회 2012 KSBB Journal Vol.27 No.1

Five yeast strains were isolated from traditional Makgeollies, Makgeollies were made by isolated yeasts after cultivation, and then property changes of Makgeollies were analyzed according to yeasts, storage temperatures and storage periods. Average pHs were shown to be 3.22~3.88 and statistically changed according to yeasts used, storage temperatures and storage periods. Total acidities were statistically changed according to storage periods. Amino-type nitrogen contents were in the ranges of 0.009~0.245% and statistically changed according to storage temperatures especially at 18 and 25℃ for 15 days. Average alcohol concentrations were in the ranges of 7.5~18.5% and reduced until 10 days and increased for 15 days according to yeasts used and storage periods. Consequently, Makgeollies, made by isolated yeast strains originated from traditional Makgeollies, revealed that alcohol concentrations and amino-type nitrogen contents were changed but pHs and total acidities were not dramatically changed according to yeasts used. It suggests that development of various Makgeollies would be possible using isolated yeast strains in this study, and optimal storage condition of ready-made Makgeollies to maintain its original property turned out to be at 4℃ for 5 days. Especially, Makgeolli made by F strain showed the best quality on its property, therefore Makgeolli which maintains its property stably until 10 days when stored at 4℃ could be made using this strain.

초임계 이산화탄소를 이용한 피트모스 추출물의 정제 및 생리활성 검증

김미향(Mihyang Kim),전명제(Myong Je Jeon),박미라(Mira Park),이승우(Seung Woo Lee),황현정(Hyun-Jung Hwang),장해지(HyeJi Jang),강민숙(Min Suk Kang),김보경(Bo Kyung Kim),최승태(Seung Tae Choi),박미연(Mi Yeon Park),이상현(Sang-Hyeon Lee) 한국생물공학회 2011 KSBB Journal Vol.26 No.5

In this study, the canadian peat moss extract was purified by a supercritical CO₂ using three different conditions and assessed its biological activities. Peat moss was extracted by acid-alkaline extraction method (sample 1) and purified by a supercritical CO₂ at 40℃ under pressure of 100 bar (sample 2), 120 bar (sample 3) or 150 bar (sample 4). We evaluated the antioxidant activities of the samples by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging, Fe<SUP>2+</SUP>/ ascorbate (FTC) and 2-thiobarbituric acid (TBA) methods. The antioxidant activities were examined by comparing the results with that of ascorbic acid as a positive control. Sample 3 showed relatively higher DPPH radical-scavenging activities than other samples. The antioxidant activity by FIC method exhibited similar results as the DPPH radicalscavenging activities. On the other hand, sample 2 showed higher antioxidant activity measured by TBA method of all. The whitening effects of the samples were examined using mushroom tyrosinase and B16F10 melanoma cells. Sample 3 exhibited overall significant whitening effects, however, other samples showed relatively lower effects. These results suggest that the peat moss extract purified by a supercritical CO₂ could be used as a cosmetic ingredient for the anti-aging and whitening effects.

미용업 종사자들의 피부, 호흡기 및 근골격계 자각증상에 관한 유병률

이종태,박봉진,엄상화,김성준,강동묵,손혜숙,정귀원,강민숙,박성희 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3

Objectives: Present study was conducted to evaluate work-related symptom prevalence among hairdressers. Methods: Exposed group comprised 184 employee employed 73 hair salons in 6 district of Pusan city, and non-exposed group comprised 119 people living recent apartments. A trained interviewer interviewed them with organised questionnaire which included dermatologic, respiratory and musculo-skeletal symptoms. Results : Prevalence of hand eczema was 28.3% in exposed group, and 5.8% in non-exposed group. Adjusted odds ratio for age and atopy history was 4.30(2.34-7.93). Prevalence of respiratory symptom (coughing) in exposed group was 22.1%, and 9.4% for non-exposed group. Adjusted odds ratio for coughing which was adjusted for age, smoking and atopy history was 2.76(1.32∼5.78). Prevalences of musculo-skeletal symptoms among exposed group were neck(59.9%), shoulder(76.6%), upper back(41.2%), lower back(72.2%), arm and elbow(31.3%), wrist(44.2%), finger(35.0%), leg(71.1%). Adjusted Odds Ratios for musculo-skeletal symptoms which was adjusted for age were neck 2.13(1.29∼3.51), shoulder 2.52(1.50∼4.24), upper back 1.71(1.01∼2.88), lower back1.78(1.06∼2.99), arm and elbow 3.10(1.62∼5.94), wrist 2.09(1.23∼3.57), finger 4.83(2.41∼9.68), leg 3.46(2.07∼5.79). Conclusions : These results show that employees in hair salon are likely to have high risk for work-related dermatologic, respiratory and musculo-skeletal symptoms and diseases. Hence, prevention methods from those work-related diseases are required to be developed. Also, the scope of occupational and environmental medicine should be expanded to service area including hairdressers.