IPO 전후 혁신의 효율성 비교 연구: 의약산업 중심으로

김은희,Kim, Eunhee 기술경영경제학회 2016 Journal of Technology Innovation Vol.24 No.1

본 연구에서는 IPO시점을 전후하여 기업의 혁신 활동과 성과의 변화에 대한 분석을 목적으로 연구개발 투자 비중이 높은 의료 및 의약 분야의 코스닥 IPO 상장 기업을 대상으로 7개의 투입, 산출 모형에 대한 효율성 분석과 비교를 실시하였다. 의약분야 기업의 IPO 전후 3년간의 혁신활동 효율성을 측정하고 차이를 분석하기 위해 DEA모형을 적용하였다. 본 논문의 주요한 결과는 첫째, 의약분야의 IPO 기업의 창업에서 IPO까지 평균 12.86년이 소요되었고, 혁신활동은 평균적으로 IPO 이전보다 더욱 활발해져 연구개발 투자액이 증가되었다. 출원특허의 수는 IPO 이전 3년 동안 8.43개에서 IPO 이후 3년 동안에는 상장기업 평균 16.67로 급증하였으며 기업의 기술 영역도 전후 3년 동안 상장기업 평균 11개에서 22개 기술분야로 크게 확대되는 모습을 보였으나, 재무적 측면에서 성장 추이와 수익성은 IPO 이전보다 낮아졌다. 둘째, 연구개발 투자와 특허출원 활동에 대한 재무적인 성과는 IPO 이후 효율성이 모두 약화되었으며, 최종적인 성과에 이르기까지 투자와 활동을 분리하여 연구개발투자에 따른 특허 출원 성과, 특허 출원 활동에 따른 재무적인 성과에 대한 효율성 역시 IPO 이전보다 모두 낮아진 것으로 분석되었다. 셋째, 특허활동에 따른 재무성과에 대한 효율성은 연구개발 투자에 따른 특허 출원 성과, 연구개발투자와 특허활동에 따른 재무성과에 대한 효율성에 비해 낮았고, 특히, IPO 이후 특허활동에 따른 재무성과의 비효율성은 규모의 비효율성으로 인해 발생되었음이 분석되었다. 마지막으로, 본 연구에서 IPO 이후 전체적인 효율성 하락은 IPO를 퉁한 연구개발투자 확대가 시장의 재무적 성과로 이어지지 못하였고, IPO 이후 전체적인 비효율성은 연구개발투자를 통한 혁신의 결과 도출 단계보다는 혁신활동의 결과물이 시장의 성과를 이끌어 내는 데 나타나는 비효율성으로 인한 것으로 분석되었다. The purpose of this study is to analyze changes of innovation activities and their performance in pre-IPO and post-IPO of KOSDAQ IPO listed companies in medical and pharmaceutical fields, which require high R&D investment, from 2000 to 2005 in Korea. The innovation efficiencies of the IPO companies were measured before and after three years based on the DEA model. The financial data and patent information of the listed company during total 6 years, which were 3 years before IPO and 3 years after IPO, were collected. The main results of this research are as follows. First, it took an average 12.86 years until IPO in the start-up of the IPO companies in the pharmaceutical sector, and innovation was on average more active than the IPO before. R&D investment was higher than the IPO before, and the number of the applied patent during 3 years after IPO was 16.67 which was increased from 8.43 during 3 years before IPO. In addition, the average scope of technology of the IPO companies was expanded from 11 to 22 technology fields during previous 3 year and after 3 year each, and financial growth after IPO was lower than the previous IPO. Second, the financial performance of R&D investment and the performance of patent activity were weakened in the efficiency after the IPO, and the integrated performance from the patenting activities and the R&D investment was decreased after the IPO. Finally, the efficiency of the financial performance of the patenting activity was lower than the efficiency of the financial performance of the patent and R&D investment and patent activities under the R&D investment. In particular, the inefficiency of the firms' patenting activities performance after the IPO was caused by the decreasing return to scale, according to the results of this study. This results implicate that the expansion of R&D investments through the IPO had not lead to the financial performance of the market, and that the overall inefficiency since the IPO is due to the inefficiencies at the stage for the outcome of innovation activity rather than the output obtained through the R&D investments that appear to lead the performance of the market.

전국 양호교사의 인력분포와 학교간호의 업무실태에 관한 조사연구

김은희,Kim, Eun-Hui 한국지역사회간호학회 1989 지역사회간호학회지 Vol.1 No.1

166Ho - chitosan 복합체를 이용한 낭성뇌종양 치료를 위한 베타선의 흡수선량 평가 : 구형 모델을 이용한 Monte Calro 모사계산

김은희,이창훈,임상무,박경배 ( Eun Hee Kim,Chang Hun Rhee,Sang Moo Lim,Kyung Bae Park ) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.4

노인요양병원 간호사의 섬망에 대한 지식, 섬망간호스트레스 및 섬망간호수행간의 관계

김은희,Kim, Eun-Hee 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.2

Purpose. The purpose of this study was to investigate knowledge, stress and nursing performance about care for delirium in geriatric hospital nurses. Methods. For this study, data were collected from 242 nurses employed at geriatric hospitals with the capacity of more than 100 beds which were located in A, P and Y cites. Frequency analysis, t-test and one-way ANOVA were utilized to analyze the data and Scheffe test was used to conduct post-hoc tests. Results. Nurses showed significant differences in the level of Knowledge, as well as terminal care performance by marital status, nursing experience. A significant relationship was found between knowledge, stress and Delirium care performance. Conclusion. This study found nurses perform delirium care with a high level of stress but with insuffiecient understanding, and thus, showed great needs for related training. Such findings can be useful to develop educational programs to improve knowledge on delirium and plans to reduce stress from delirium for geriatric hospital nurses.

형개련교탕(荊芥連翹湯) 추출물의 경구투여(經口投與)가 rat의 수태능(受胎能) 및 초기(初期) 배발생(胚發生)에 미치는 영향(影響)

김은희,황순이,김상찬,지선영,Kim, Eun-Hee,Hwang, Sun-Yi,Kim, Sang-Chan,Jee, Seon-Young 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.1

Objectives : this study was to access the effect of Hyeonggaeyeongyotang water extracts, a polyherbal formula has been used as folk medicine, on the fertility and early embryonic development of male and female Wistar rats when administered by oral gavage. Methods : In male rats, Hyeonggaeyeongyotang extract were dosed 4 weeks before pairing and 2 weeks after mating including the mating periods up to termination after necropsy of the majority of the females. In female rats, they were dosed 2 weeks before pairing, and from Day 0 to Day 7 of gestation. This study was conducted in accordance with the recommendations of the KFDA Guideline [2005-60] for Detection of Toxicity to Reproduction for Medicinal Products. Results: 1. No Hyeonggaeyeongyotang extract treatment-related changes on the clinical signs and mortalities, the Food consumptions, the Body weights and gains were demonstrated in all dosed levels tested in this study except for 500ml/kg-dosing male group in which a significant(p<0.05) increase of body gains was detected during day 0-7 after dosing. 2. No Hyeonggaeyeongyotang extract treatment-related changes on the pre-coital intervals, the estrus cycles, the mating index, conception rate and fertility index were demonstrated in all dosed levels tested in this study. 3. No Hyeonggaeyeongyotang extract treatment-related gross findings on reproductive organs, the weights of reproductive organs, histopathological findings on reproductive organs, the corpora lutea number, implantation site number, live fetus number, number of resorpted embryo and pre-and post-implatation loss were demonstrated in all dosed levels tested in this study. Conclusions : Base on the results, it is considered that the NOAEL (No-Observed-Adverse-Effect Level) for fertility and early embryonic development toxicity of Hyeonggaeyeongyotang extract was under 2000ml/kg/day in Wistar male and female rats because there no treatment-related changes on the fertility and early embryonic developmental index were demonstrated in all dosed levels tested.

탐방-임실치즈

김은희,Kim, Eun-Hui 한국낙농육우협회 2007 낙농·육우 Vol.27 No.8

한국과 유럽연합(EU)의 자유무역협정(FTA) 협상이 시작돼 국내낙농산업은 한미 FTA 타결에 이어 또 한번 철퇴를 맞을 것으로 예상된다. 특히 국내시유소비정체와는 대조적으로 성장세에 있는 치즈산업에 막대한 피해가 우려된다. 이에 따라 국내치즈산업에 대한 재조명이 필요한 때가 아닌가 싶다. 치즈는 특히 수천년전부터 이어져 오는 유럽의 전통이자 '문화의 산물'이었다. 최근 웰빙이 세계적인 추세로 변화의 바람을 타자 치즈를 또 하나의 건상상품이자 중요한 식품의 하나로 자리잡게 하는데 한 몫을 하고 있다.

연구논문 - 펄프 , 제지 , 피혁분과 : 제지공정에서 분리한 슬라임형성세균의 동정

김은희,정문기,오정수,조병묵 ( Eun Hee Kim,Mun Gi Jung,Jung Soo Oh,Byoung Muk Jo ) 한국공업화학회 1996 한국공업화학회 연구논문 초록집 Vol.1990 No.3

관계의 렌즈로 들여다보기를 통한 교사의 사고 변화

김은희(Kim, Eun-Hee) 한국변형영유아교육학회 2009 변형영유아교육연구 Vol.3 No.1

본 연구는 관계의 본질적 의미를 탐색하고자 시도된 김은희(2008)의 연구에 참여하였던 공동체 T유치원 교사들이 ‘관계의 렌즈로 들여다보기’를 통해 관계를 재개념화하고 관계형성을 위한 교사의 역할을 반성, 사고와 실천의 변화를 가져오는 참여실천연구이다. 교사 11명과 본 연구자는 6주간 유치원 일과에서 참여관찰, 기록, 공유, 면담 과정을 거치면서 차원⋅요소(8×5)로 구성된 관계의 매트릭스에 근거하여 매주 차원별 요소별 관계의 상황과 내용 및 상호작용의 질을 반성하였다. 연구과정에서 도출된 참여관찰기록, 면담자료, 일일⋅주간 저널, 교사 협의록, 교사저널을 참여관찰, 면담, 내용분석 방법으로 질적 분석하였다. 이러한 과정은 교사들로 하여금 관계의 의미를 알고 교실의 관계를 돌아보면서 부족한 관계형성의 내용과 질을 향상시킬 수 있는 실천을 의식적으로 시도하게끔 하였다. 연구 결과, 연구과정에서 교사들은 관계의 본질적 의미를 탐색할 수 있었고, 관계의 개념 및 역할 뿐 아니라 교사자신의 역할에 대한 사고가 변화됨을 볼 수 있었다. 관계형성을 위한 교사의 실천 또한 연령에 따라 차원별, 요소별로 다르게 나타났다. 이를 토대로 연령별 서로 다른 관계차원의 양상과 요소 간 관계를 지원하는 현장교사를 위한 실천 tip을 제시하였다. This study was a participatory action research to investigate the change in the community T kindergarten teachers' thinking and practices on re-conceptualization of relationships by looking through the lens of relationships. The teachers who had been involved Dr. Kim's research(2008) to study the essential meaning of relationships. With 11 teachers who have been participated in this research in the community T kindergarten, this researcher had reflected weekly the situation and contents of dimensional and elemental relationships, and the quality of interaction based on the matrix of relationships composed of the dimensions and elements (8 x 5) over the period of 6 weeks by using participatory observation, documentation, sharing, and interviews. The interpretation and coding of the data from documentation of participatory observation, materials of interviews, daily journals, weekly journals, teacher's assembly records, and teacher's records were ongoing and based on a qualitative analysis of the participatory observation, interviews, and analysis of contents. This process gave opportunities for the teachers to understand the meaning of relationships, and improve the part of insufficient formation of relationships as well as the quality of the relationships in the classroom. In the results of this study, the teachers could investigate the essential meaning of relationships and they could be aware of the change in their thinking of the teacher's role. The results of the teacher's practices of relationship formation were different depending upon children's age in dimensional and elemental relationships. Based on the results, the researcher provided practical tips for classroom teachers who support the relation between different aspects and elements in dimensional relationships in each age group of children.

후천면역결핍증 환자에서 유리체염증이 주증상으로 나타난 눈매독 1예

김은희,이지은,Eun Hee Kim,Ji Eun Lee 대한안과학회 2006 대한안과학회지 Vol.47 No.7

Purpose: We report a patient of ocular syphilis with acquired immune deficiency syndrome(AIDS) who showed dense vitritis as the primary manifestation without signs of retinitis, and who underwent pars plana vitrectomy. Methods: A 65-year-old man known to have AIDS complaining of decreased vision in both eyes, was transferred for suspected CMV retinitis. Visual acuity was 0.2 in the right eye and 0.4 in the left eye. Ganciclovir was prescribed intravenously for 10 days and orally thereafter. After 2 months, the visual acuity of both eyes decreased to hand motion. As additional serologic tests such as TPHA and FTA-ABS were positive for syphilis, 5 MU of penicillin G was injected intravenously four times a day for 3 weeks. Results: Although active inflammation decreased with the antibiotic treatment, vitreous opacity persisted. Visual acuity was counting fingers in the right eye and 0.02 in the left eye. Pars plana vitrectomy was performed on the right eye. Analysis of the aspirated vitreous disclosed a VDRL titer of 1:8, and that TPHA was positive while PCR for CMV was negative. One month after the operation, the patient`s visual acuity had improved to 0.6. Conclusions: Ocular syphilis should be considered in AIDS patient showing dense vitritis as primary manifestation. Pars plana vitrectomy may be an option for early visual restoration of these patients.

간호대학생의 자아탄력성과 비판적 사고 성향 및 전공만족도에 관한 연구

김은희,Kim, Eun Hee 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.4

Purpose. This study was conducted to define Ego resilience, Critical thinking disposition and satisfaction in major, and to relationships among above variables. Methods. Participants in the study were selected as 163 P city nursing students in Korea. Data were collected from October 26 to December 16, 2016. Date were analyzed by frequencies, t-test, ANOVA, Scheffes' test and Pearson's correlation coefficients using SPSS WIN/PC 22.0. Results. It was found that there were significant differences in the ego resilience depending on relationship with friends and admission motivations. Satisfaction in major was significantly different according to relationship with friends. Significant correlations were found between ego resilience, critical thinking disposition, and satisfaction in major in nursing students. Conclusions. It is necessary to develop and implement program for improving ego resilience and critical thinking disposition in order to increase the satisfaction of major in nursing students.