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새로운 항균제로서 1 -(phenoxymethyl) benzotriazole 유도체의 합성과 정량적 구조활성관계(QSAR) 분석
권기성,최우영,성낙도,임치환,고동성 한국농화학회 1990 Applied Biological Chemistry (Appl Biol Chem) Vol.33 No.3
The structure-antifungal activity correlations between the structure of fourteen new 1-(phenoxymethyl)benzotriazoles (I) (Y=0), 1-(thiophenoxyrnethyl)benzotriazoles (II) (Y=S) and 1-(azidomethyl)benzotriazole (Ⅲ) derivatives were synthesized, and their activity, fifty percent inhibition of mycelial growth(pI_(50)), in vitro against Pyricularia oryzae, Fusarium axysporum f. sp swami, Valsa ceratosperma and Botrytis cinerea were investigated using a generalized QSAR method. The activity of (I) was superior to those of (II) and (Ⅲ). The effect of the substituents (X) on the phenoxy group (I) was rationalized by a parabolic function of electronic (σ), steric (B₁) and hydrophobic parameter(π), and hydrogen bonding (HB). Where the optimal values of substituent on the fungicidal activity againt P. oryzae and F. axcysporum f. sp. sesami are B₁=1.40A; (H) and σ=0.07∼0.15;(H), and those of substituent on the fungicidal activity against V. ceratosperma and B. dare σ=0.23∼0.28; (Cl), π=0.70; (Cl), respectively. The most effective compound ( I a) and ( I d) were examined in this study.
α-Bromobenzaldehyde-p-nitrophenylhydrazone의 알카리 가수분해 반응 메카니즘
권기성,이천배,박문규,성낙도 충남대학교 기초과학연구소 1980 연구논문집 Vol.1 No.-
The rate constants for the hydrolysis of the derivatives of α-bromobenzaldehyde-p-nitro-phenylhydrazone (p-H, p-OCH_3, p-Cl, p-NO_2) at various pH have been determined by UV spectrophotometry in 50% dioxane at 25℃ and the following rate equations which can be applied over wide pH range were obtained. i. e. α-bromobenzaldehyde-p-nitrophenylhydrazone; kobs.=1.25×10 exp (-7) + 7.92×10 exp (-11)/〔H^+〕+1.51×10 exp (-7) α-bromo-p-chlorobenzaldehyde-p-nitrophenylhydrazone; kobs.=1.06×10 exp (-7) + 1.08×10 exp (-10)/〔H^+〕+1.45×10 exp (-7) α-bromo-p-methoxybenzaldehyde-p-nitrophenylhydrazone; kobs.=1.79×10 exp (-7) + 1.40×10 exp (-10)/〔H^+〕+4.08×10 exp (-7) α-bromo-p-nitrobenzaldehyde-p-nitrophenylhydrazone; kobs.=7.10×10 exp (-8) + 2.89×10 exp (-10)/〔H^+〕+2.37×10 exp (-7) Below pH 2, the rate of hydrolysis of α-bromobenzaldehyde-p-nitrophenylhydrazone is accelerated by electron-donating group (ρ=-0.91). Above pH 5, however, this reaction is slowded down by electron-attracting group (ρ=0.37). From the rate equation and the effect of solvent and substituent upon the rate of reaction, below pH 2, the hydrolysis proceed through SN_1 mechanism. Above pH 5, the hydrolysis proceed through 1.3-dipolar ion mechanism. And in the range of pH 2∼5 these two reactions occur competitively.
권기성 光云大學校 1989 論文集 Vol.18 No.-
The purpose of this study is to find the relationships between organizational structure and organizational effectiveness. For this purpose, this thesis is studied and analyzed some problems such as followings; (1) the concepts of organizational structure, the variables of organizational structure and measurement indicates of organizational structure. (2) the concepts of organizational effectiveness and measurement indicates of organizational effectiveness. (3) the relationships between organizational structure and organizational effectiveness.
Ethylcrotonate에 對한 Iso-propylmercaptan의 親核性 添加反應
權奇星,朴文奎,成洛道 충남대학교 자연과학연구소 1974 學術硏究誌 Vol.1 No.1
The rate constants for the addition reaction of iso-propylmercaptan to ethylcrotonate have been measured by iodometry and for the proposed reaction mechanism a rate equation which can be applied over wide pH range was derived. From this rate equation, it was found that below pH 6.0 the reaction is started by addition of iso-propylmercaptan molecule and above pH 11.0 this reaction is proceeded by the iso-propylmercaptide ions and a t the range of pH 6.0-11.0 two reactions are competitive. Consequently, it is found that the observed data are satisfactorily accorded with the theoretical values over various pH range.
Ethylcinnamate에 對한 Iso-propylmercaptan의 親核性 添加反應에 關한 反應速度論的 硏究
權奇星,李天培,成洛道 圓光大學校 1977 論文集 Vol.11 No.-
ethylcinnamate에 대한 iso-propylmercaptan의 친핵성 첨가반응 속도상수를 측정하여 넓은 pH 범위에서 잘맞는 반응속도식을 얻었다. 이 식에 의하면 pH 6.5 이하에서는 iso-propylmercaptan과 iso-propylmercaptide ion의 첨가가 경쟁적으로 일어난다. pH 10이상에서는 ethylcinnamate에 iso-propylmercaptide ion의 첨가만이 일어남을 알수 있다. 그러므로 본 실험에서 구한 반응속도식으로부터 실험측정값과 계산 값(이론 값)이 여러 pH를 통하여 잘 맞기 때문에 넓은 pH범위내에서 일어나는 친핵성 첨가반은 mechanism을 잘 설명할 수 있었다. The rate constants of nucleophilic addition reaction of iso-propylmercaptan to ethylcinnamate were determined at various pH and a rate equation which can be applied overwide pH range was obtained; ?? The rate equation reveals that below pH 6.5 the reaction is initiated by addition of iso-propylmercaptan molecule, from pH 6.5 to 10.0 iso-propylmercaptan and iso-propylmercaptide ion are competitively added. Above pH 10.0 the addition reaction of iso-propylmercaptide ion occurs. From these rate equation, we found that observed data accorded satisifactorily with theoretical value over various pH range. Hence, the mechanism of nucleophilic addition reaction over wide pH range can be fully explained.