증례 : 혈액종양 ; AML1-ETO 양성인 양표현형 급성 백혈병의 1예

서주희 ( Ju Hee Seo ),이혜원 ( Hye Won Lee ),임주은 ( Ju Eun Lim ),정주원 ( Joo Won Chung ),최종락 ( Jong Rak Choi ),양우익 ( Woo Ick Yang ),민유홍 ( Yoo Hong Min ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

BAL은 일반적으로 기타 급성 백혈병보다 예후가 나쁘다고 알려져 있으나, 그 치료방침이 아직 확립되어 있지 않다. AML1-ETO 유전자 재배열은 BAL에서도 좋은 예후인자 중 하나로 제시된 적이 있으며 본 증례에서도 1차례의 관해 유도요법 후 완전관해를 보였고, t(8:21) 즉, AML1-ETO 정량검사상 전사 정도가 현저히 감소함을 경험하였다. 특히, AML에 준한 치료만으로 성공적 관해가 유도되었으며, 이는 BAL에 있어서도 AML1-ETO 종양단백이 병태생리에 주 역할을 할 것임을 짐작할 수 있다. AML에서와 마찬가지로 AML1-ETO 유전자 재배열은 향후 BAL 환자의 치료 효과와 예후를 알 수 있는 지표로 사용될 수 있을 것이다. Biphenotypic acute leukemia (BAL) is a subtype of acute leukemia that expresses two different immunophenotypic lineages, most commonly myeloid and either B- or T-lymphoid lineages. This entity has been defined by a scoring system proposed by the European Group for the Immunological Characterization of Leukemias (EGIL). The prognosis of BAL is regarded as being worse than either acute lymphoid or myeloid leukemia that does not show lineage ambiguity. However, a treatment strategy for BAL has not yet been established. We experienced a case of BAL with the t(8;21) translocation, a favorable cytogenetic rearrangement in acute myeloid leukemia (AML). The patient was successfully treated with cytarabine and anthracycline for induction and consolidation. The quantitative value of the AML1-ETO gene decreased after achieving complete hematologic remission. Thus, the AML1-ETO gene rearrangement in BAL may be associated with an acceptable response to the treatment strategy for AML. (Korean J Med 76:617-621, 2009)

조혈림프조직의 종양성 질환 - 새로운 세계보건기구 분류법 -

양우익 대한병리학회 2002 Journal of Pathology and Translational Medicine Vol.36 No.3

Encouraged by the success of the Revised European American Classification of Lymphoid Neoplasms (REAL) which was published in 1994 by the International Lymphoma Study Group (ILSG), the European Association of Pathologists and the Society for Hematopathology have started a collaborative classification project in 1995 under the auspices of World Health Organization (WHO). The two collaborators employed the same consensus building process used by ILSG for the REAL to the classification of myeloid, histiocytic/dendritic, and mast cell neoplasms and listed real biologic entities defined by morphologic, immunophenotypic, cytogenetic, and clinical findings. In contrast to the REAL, Clinical Advisory Committee composed of expert hematologists and oncologists evaluated the clinical relevance of the classification scheme proposed by the pathologists before the publication of new WHO classification of hematologic malignancies. While the classification of lymphoid neoplasms contained minor changes compared with the REAL, there were major changes in the classification system of myeloid neoplasms compared with the previously used French-American-British (FAB) classification. The new WHO classification of hematologic malignancies, published last year, is a product of the first true worldwide consensus among leading pathologists and clinicians alike, and it overcomes the drawbacks of old fashioned classification schemes; therefore, we can expect progress in the understanding and treatment of hematologic malignancies.

폐동맥종양색전증에 의한 돌연사 부검 1예

양우익,이기범 中央醫學社 1987 中央醫學 Vol.52 No.9

This study is intended to recognize mental and physical health status of Nursing Junior Collegians. The sample data for the study have been collected applying C.M.I. from 462 collegians selected randomly at 4 nursing junior colleges in Taegu city and Kyungbuk province over a period of three months from September to November 1986. The data was treated by a computer (SPSS) using Mean, Standard Deviation, F Ratio, Chi-square test and Pearson's Correlation. The summary of the results in the study are as follows: 1) The relationship between general mental-physical health of Nursing students and places which they have grown up, showed to be not significant. 2) The relationship between mental(p < 0.01), physical (p < 0.05), general mental- physical health (p < 0.01) and living expense satisfaction showed to be significant. 3) In the relations to pride as a nurse, musculoskeletal system (p < 0.01), Fatigability(p < 0.05) Miscellaneous disease (p < 0.01), Inadequacy (p < 0.05), Depression (p < 0.001), Sensitivity(p < 0.01), Anger (p < 0.01), and Tension (p < 0.05) showed to be significant. 4) In the relation to anxiety on registered Nurses Examinication, The frequency of Respiratory (p < 0.05), Cardiovascular (p < 0.001), Digestive (p < 0.05), Musculoskeletal (p < 0.05), Nervous system(p < 0.05) and frequency illness (p < 0.05), Inadequacy (p < 0.05), Depression (p < 0.01), Anxiety (p < 0.05), Sensitivity (p < 0.05), Anger (p < 0.05) and Tension (p < 0.001) showed to be significant.

전종격동의 융모상피암 부검 1예

양우익,김한겸 中央醫學社 1987 中央醫學 Vol.52 No.10

A 21-year-old male, complaining of dyspnea, expired. An autopsy was performed to clarify, the cause of death. A huge tan tumor mass, measuring 13 x I1 x 7cm, was present at the anterior mediastinum in close anatomic relationship with the thymus. Large vessels around the heart were compressed by the tumor mass and hemopericardium by extensive hemorrhagic necrosis of the tumor was noted. The tumor was diagnosed as choriocarcinoma by histopathologic and immunoperoxidase method using HCG. The cause of death was right heart failure due to compression of large vessels and hemopericardium.

악성 림프종의 진단

楊宇翼 대한의학협회 1995 대한의학협회지 Vol.38 No.11

간외담도에서 발생한 악성혼합종양 1예

양우익,문상훈,최인준 대한병리학회 1984 Journal of Pathology and Translational Medicine Vol.18 No.4

Monocrotaline투여 백서 폐동맥고혈압에서 폐혈관내피세포와 폐신경내분비세포의 변화에 대한 형태학적 연구

양우익,조상호,최인준,이유복 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.6

다발성 점막하종양 형태로 발현된 원발성 직장 MALT 림프종 1예

문희선,박효진,이기병,정인수,양우익,홍순원,김정환 대한소화기내시경학회 2007 Clinical Endoscopy Vol.35 No.4

MALT (mucosa-associated lymphoid tissue) lymphomas are the most common primary gastrointestinal (GI) lymphomas. MALT lymphomas of the GI tract tend to occur most commonly in the stomach, followed by the small intestine, ileocecal area, colon and the esophagus. However, MALT lymphomas of the large intestine are rare. Previously, a diagnosis was commonly established by the surgical specimens but endoscopic biopsy specimens are currently used to make a diagnosis. A 61-year-old woman was found to have multiple submucosal tumors of the rectum during a screening colonoscopy. The tumors were removed by a polypectomy. The histology revealed the diffuse infiltration of centrocyte-like cells and a lymphoepithelial lesion. Immunohistochemical staining confirmed the diagnosis of a low grade B cell lymphoma of the MALT type. No other site of involvement was identified on the CT of the chest, abdomen and pelvis. (Korean J Gastrointest Endosc 2007;35:272-276) 위장관 림프종 중에서 MALT (mucosa-associated lymphoid tissue) 림프종이 가장 많다. 위장관 MALT 림프종은 위에서 가장 호발하고 위 이외의 부위에서는 드물게 발생하는데 그 빈도는 소장, 회맹판, 대장, 식도 순으로서 대장에 생기는 MALT 림프종은 드물다. 수술을 통해서 조직학적인 진단이 이루어지는 경우가 많았으나 최근에는 육안적인 소견이 많이 알려져서 내시경검사로 진단되는 경우가 많다. 61세 여자 환자가 건강 검진을 목적으로 시행한 대장내시경 검사에서 직장에 다발성 용종이 발견되어 본원으로 전원되었고 다발성 점막하종양이 의심되어 내시경 용종절제술 및 조직검사를 시행하였다. 병리 소견에서 전반적인 중심세포양 세포(centrocyte-like cell), 림프상피성 병변(lymphoepithelial lesion)이 관찰되었으며 면역조직학적 검사에서 저등급 B세포 MALT 림프종으로 진단되었다. 병기를 알아보기 위하여 시행한 복부 및 흉부 전산화단층촬영에서 이상 소견은 보이지 않았다. 저자 등은 다발성 점막하종양의 형태로 발현된 원발성 직장 MALT 림프종 1예를 치험하였기에 보고하는 바이다.

관골 주위 피하층에 발생한 결절성 근막염의 증례보고

양동현,차인호,양우익,김진,육종인,김현실 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.6

Nodular fasciitis is defined by the World Health Organization as a benign proliferative fibroblastic lesion. It was first described in 1955 by Konwaler et al. and also known as “nodular pseudosarcomatous fasciitis” and “infiltrative fasciitis”, which reflect the lesion’s rapid growth, dense cellularity, alarming mitotoic activity and lack of circumscription. Here, we report a case of nodular fasciitis, which appeared as subcutaneous mass of right perizygoma area in 40-year-old Korean female. She had no history of trauma or cosmetic surgery related with the lesion. She disclosed that the mass grew rapidly for last 2 months. Computed tomography showed relatively well-defined spherical mass with 1.2 cm in diameter. Under local anesthesia the mass was resected by intraoral approach. The histological examination revealed a relatively poor-dermacated mass with high cellularity, which was composed with infiltrative spindle-shaped cells without accompanying inflammatory reactions. The tumor cells were partially positive for α-smooth muscle actin and β-catenin, but negative for cytokeratin AE1/3, S-100, desmin, and CD34. Therefore, the lesion was pathologically diagnosed as nodular fasciitis. Although nodular fasciitis is known to pseudosarcomatous benign reactive lesion, the clinician need to follow up the patient periodically. The reasons are as follows; Nodular fasciitis may accompany nuclear accumulation of β-catenin, which imply neoplastic process rather than reactive process of the lesion. Moreover, it has many histological similarities with inflammatory myofibroblastic tumor which have malignant transformation tendency. Further research for mesenchymal tumor could help our understanding for the disease entity of nodular fasciitis

하악 전방부에 발생한 소세포 골육종의 증례보고

양동현,김형준,박혁,양우익,김현실 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.2

Small cell osteosarcoma of bone, which was first described in 1979, is an unusual variant of osteosarcoma. Osteoid production by tumor cells is frequently focal or minimal, making the differential diagnosis with other small round cell tumors of bone difficult. Here, we present a rare case of small cell osteosarcoma of the mandible appearing as bony bulging mass in 31-year-old male who has neither tenderness nor paresthesia. Histologically, the tumor contains hypercellular cartilage and abnormal osteoid associated with small round to ovoid malignant cells. Awareness of small cell osteosarcoma should be emphasized because it has worse prognosis than both other small round cell tumor and conventional osteosarcoma.