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아크릴로니트릴 제조공정에서 아세토니트릴 회수에 관한 연구
박동원,최성욱,김영일 한국자원리싸이클링학회 1999 資源 리싸이클링 Vol.8 No.3
아크릴로니트릴 제조공정 중 부산물로 생성되는 물과 아세토니트릴 공비혼합물을 분비, 회수하기 위하여 혼합용매로서 toluene-ethylacetate를 선택하여 $25^{\circ}C$에서 4성분계 toluene(1)-water(2)-acetonitrile(3)-ethylacetate(4)에 대한 액-액평형 데이터를 구하였다. Tie-line 계산치를 예측하기 위하여 실험치를 UNIFA 모델식의 파라미터와 상호연관시켜 비교하였다. 또한 용매의 성능을 비교하기 위하여 분배계수 및 선택도를 고찰하였다. In the process of manufacturing acrylonitrile, azeotrope of water-acetonitrile is formed as by-product. To1uene-ethylacetate mixture was selected as solvent to determine the liquid-liquid equilibria for to1uene(l)-water(2)-acetomtrile(3)-ethyjacetate(4) system. The experimental he-line data were correlated with the UNIFAC model. The distribution and selectivity for quaternary system was also studied.
한국의 폐암 선별 검사 집단에서의 하드코어 흡연자의 특성 연구
박동원,장지윤,정승준,여유미,박태선,이현,문지용,김상헌,김태형,손장원,강대용,윤호주 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: Screening for lung cancer using the National Lung Screening Trial (NLST) criteria reduces mortality in high-risk individuals. Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse prognosis. Recent findings suggest that hardcore smokers tend to continue smoking. The aim of this study was to examine the characteristics of hardcore smokers in lung cancer screening population in South Korea. Methods: We estimated the nationwide proportion of patients who met the NLST criteria using the 4th and 5th Korea National Health and Nutrition Examination Survey conducted during 2007-2012(KNHANES IV-V). Hardcore smoking was defined as (1) smoking >15 cigarettes per day, (2) having no plans of quitting, and (3) having no attempts to quit. Results: Among smokers aged 55-74 years, the proportion of heavy smokers with ≥30 pack years did not change significantly from 2007 to 2012 (49.3%-55.1%). About one-fourth of smokers (age 55-74 year) with ≥30 pack years satisfied the definition of hardcore smoking. The proportion of hardcore smokers for both gender decreased from 2007 to 2012. Male hardcore smokers were more than two times greater than that of female hardcore smokers, and this trend did not change over the year. Hardcore smokers were more often male gender, young, single, less educated, and experienced secondhand smoking more frequently in home and workplace. Conclusions: In Korean smoker who met the NLST criteria, hardcore smoking was prevalent and more prevalent among single men, and those aging 55-60 years
박동원,이성자,곽현정,문지용,김태형,김상헌,손장원,윤호주,신동호,박성수 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease, which is characterized by increase of pulmonary vascular resistance. Canonical Wnt signaling pathways may be suggested as an important determinent in pulmonary vascular remodeling of PAH. We examined whether inhibition of the canonical Wnt/β catenin signaling could attenuate PAH in a rat model of MCT-induced PAH. Methods: Male Sprague-Dawley rats were randomized to administer a single subcutaneous injection of 70 mg/kg MCT or the same dose of normal saline. Quantitative real-time PCR of β-catenin, TnC and PDGFR-α, β were conducted in rat lung tissues. To inhibit the Wnt/β catenin signaling, small interfering RNA(siRNA) for β catenin was administered into trachea 1hour before MCT injection and every 48 hours afterward until sacrifice on day 28. Results: Real-time PCR revealed that mRNA levels of β-catenin were significantly increased on days 14 and decreased on days 28 back to the baseline level, in the lung tissue of MCT-induced PAH group. Up-regulated mRNA levels of TnC were observed over time, significantly on days 14, 28. Intratracheal treatment with β-catenin siRNA significantly reduced β-catenin and TnC expression in a MCT-induced PAH model compared with controls. The β-catenin siRNA also significantly improved PAH, as judged by echocardiography. Conclusion: Blockade of canonical Wnt/β-catenin pathway by β-catenin siRNA reduced MCT-induced PAH in rat model. These findings suggest that Wnt/β-catenin signaling may be an effective therapeutic approach in the treatment of PAH.Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease, which is characterized by increase of pulmonary vascular resistance. Canonical Wnt signaling pathways may be suggested as an important determinent in pulmonary vascular remodeling of PAH. We examined whether inhibition of the canonical Wnt/β catenin signaling could attenuate PAH in a rat model of MCT-induced PAH. Methods: Male Sprague-Dawley rats were randomized to administer a single subcutaneous injection of 70 mg/kg MCT or the same dose of normal saline. Quantitative real-time PCR of β-catenin, TnC and PDGFR-α, β were conducted in rat lung tissues. To inhibit the Wnt/β catenin signaling, small interfering RNA(siRNA) for β catenin was administered into trachea 1hour before MCT injection and every 48 hours afterward until sacrifice on day 28. Results: Real-time PCR revealed that mRNA levels of β-catenin were significantly increased on days 14 and decreased on days 28 back to the baseline level, in the lung tissue of MCT-induced PAH group. Up-regulated mRNA levels of TnC were observed over time, significantly on days 14, 28. Intratracheal treatment with β-catenin siRNA significantly reduced β-catenin and TnC expression in a MCT-induced PAH model compared with controls. The β-catenin siRNA also significantly improved PAH, as judged by echocardiography. Conclusion: Blockade of canonical Wnt/β-catenin pathway by β-catenin siRNA reduced MCT-induced PAH in rat model. These findings suggest that Wnt/β-catenin signaling may be an effective therapeutic approach in the treatment of PAH.